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Original Article

Childhood-Onset Non-Infectious Uveitis in the “Biologic Era”. Results From Spanish Multicenter Multidisciplinary Real-World Clinical Settings

, B, MD, PhD, , MD, PhD, , MSc, , MD, , MD, , MD, , MD, , MD, , MD, PhD, , MD, PhD, , MD, , MD, PhD, , MD, , MD, , MD, PhD, FEBO, , MD, , MD, PhD, , MD, PhD, , MD, , MD, , MD, , MD, , MD, , MD, , MD, PhD, , MD, , MD, , MD, PhD, , MD, , MD, , MD, , MD, , MD, PhD, , MD, , MD, , MD, PhD, , MD, , MD, , MD, PhD, , MD, , MD, PhD, , MD, PhD, , MD, , MD, , MD, PhD, , MD, PhD, , MD, , MD, PhD & , MD show all
Received 11 Aug 2023, Accepted 25 Mar 2024, Published online: 10 May 2024

References

  • Chang MH, Shantha JG, Fondriest JJ, Lo MS, Angeles-Han ST. Uveitis in children and adolescents. Rheum Dis Clin North Am. 2021;47(4):619–641. doi:10.1016/j.rdc.2021.07.005.
  • Cunningham ET Jr. Uveitis in children. Ocul Immunol Inflamm. 2000;8(4):251–261. doi:10.1076/ocii.8.4.251.6459.
  • Maleki A, Anesi SD, Look-Why S, Manhapra A, Foster CS. Pediatric uveitis: a comprehensive review. Surv Ophthalmol. 2022;67(2):510–529. doi:10.1016/j.survophthal.2021.06.006.
  • Cann M, Ramanan AV, Crawford A, Dick AD, Clarke SLN, Rashed F, et al. Outcomes of non-infectious Paediatric uveitis in the era of biologic therapy. Pediatr Rheumatol. 2018;16(1):51. doi:10.1186/s12969-018-0266-5.
  • de Boer J. Visual loss in uveitis of childhood. British J Ophthalmol. 2003;87(7):879–884. doi:10.1136/bjo.87.7.879.
  • Rosenberg KD, Feuer WJ, Davis JL. Ocular complications of pediatric uveitis. Ophthalmology. 2004;111(12):2299–2306. doi:10.1016/j.ophtha.2004.06.014.
  • Smith JA, Mackensen F, Sen HN, Leigh JF, Watkins AS, Pyatetsky D, et al. Epidemiology and Course of Disease in Childhood Uveitis. Ophthalmology. 2009;116(8):1544–1551.e1. doi:10.1016/j.ophtha.2009.05.002.
  • Foeldvari I, Wierk A. Methotrexate is an effective treatment for chronic uveitis associated with juvenile idiopathic arthritis. J Rheumatol. 2005;32(2):362.
  • Cecchin V, Zannin ME, Ferrari D, Pontikaki I, Miserocchi E, Paroli MP, et al. Longterm safety and efficacy of adalimumab and infliximab for uveitis associated with juvenile idiopathic arthritis. J Rheumatol. 2018;45(8):1167–1172. doi:10.3899/jrheum.171006.
  • Bou R, Adán A, Borrás F, Bravo B, Calvo I, De Inocencio J, et al. Clinical management algorithm of uveitis associated with juvenile idiopathic arthritis: interdisciplinary panel consensus. Rheumatol Int. 2015;35(5):777–785. doi:10.1007/s00296-015-3231-3.
  • Angeles-Han ST, Ringold S, Beukelman T, Lovell D, Cuello CA, Becker ML, et al. 2019 American College of Rheumatology/Arthritis Foundation guideline for the screening, monitoring, and treatment of juvenile idiopathic arthritis-associated uveitis. Arthritis Rheumatol. 2019;71(6):864–877. doi:10.1002/art.40885.
  • Heiligenhaus A, Minden K, Tappeiner C, Baus H, Bertram B, Deuter C, et al. Update of the evidence based, interdisciplinary guideline for anti-inflammatory treatment of uveitis associated with juvenile idiopathic arthritis. Semin Arthritis Rheum. 2019;49(1):43–55. doi:10.1016/j.semarthrit.2018.11.004.
  • Dick AD, Rosenbaum JT, Al-Dhibi HA, Belfort R, Brézin AP, Chee SP, et al. Guidance on noncorticosteroid systemic immunomodulatory therapy in noninfectious uveitis: fundamentals of care for uveitiS (FOCUS) initiative. Ophthalmology. 2018;125(5):757–773. doi:10.1016/j.ophtha.2017.11.017.
  • Quartier P, Baptiste A, Despert V, Allain-Launay E, Koné-Paut I, Belot A, et al. ADJUVITE: a double-blind, randomised, placebo-controlled trial of adalimumab in early onset, chronic, juvenile idiopathic arthritis-associated anterior uveitis. Ann Rheum Dis. 2018;77(7):1003–1011. doi:10.1136/annrheumdis-2017-212089.
  • Ramanan AV, Dick AD, Jones AP, McKay A, Williamson PR, Compeyrot-Lacassagne S, et al. Adalimumab plus Methotrexate for Uveitis in Juvenile Idiopathic Arthritis. N Engl J Med. 2017;376(17):1637–1646. doi:10.1056/NEJMoa1614160.
  • Jari M, Shiari R, Salehpour O, Rahmani K. Epidemiological and advanced therapeutic approaches to treatment of uveitis in pediatric rheumatic diseases: a systematic review and meta-analysis. Orphanet J Rare Dis. 2020;15(1):41. doi:10.1186/s13023-020-1324-x.
  • Jabs DA, Nussenblatt RB, Rosenbaum JT. Standardization of Uveitis Nomenclature (SUN) working group. Standardization of uveitis nomenclature for reporting clinical data. Results of the first international workshop. Am J Ophthalmol. 2005;140(3):509–516.
  • Llorenç V, Mesquida M, Sainz de la Maza M, Keller J, Molins B, Espinosa G, et al. Epidemiology of uveitis in a Western urban multiethnic population. The challenge of globalization. Acta Ophthalmol. 2015;93(6):561–567. doi:10.1111/aos.12675.
  • Morelle G, Gueudry J, Uettwiller F, Wouters C, Bader-Meunier B, Robert MP, et al. Chronic and recurrent non-infectious paediatric-onset uveitis: a French cohort. RMD Open. 2019;5(2):e000933. doi:10.1136/rmdopen-2019-000933.
  • Ferrara M, Eggenschwiler L, Stephenson A, Montieth A, Nakhoul N, Araùjo-Miranda R, et al. The challenge of pediatric uveitis: tertiary referral center experience in the United States. Ocul Immunol Inflamm. 2019;27(3):410–417. doi:10.1080/09273948.2017.1420202.
  • Saygın D, Syed AU, Lowder CY, Srivastava S, Maya JJ, Hajj-Ali RA. Characteristics of inflammatory eye disease associated with hidradenitis suppurativa. Eur J Rheumatol. 2018;5(3):165–168. doi:10.5152/eurjrheum.2018.17163.
  • Cooper GS, Stroehla BC. The epidemiology of autoimmune diseases. Autoimmun Rev. 2003;2(3):119–125. doi:10.1016/S1568-9972(03)00006-5.
  • Markomichelakis NN, Aissopou EK, Chatzistefanou KI Pediatric non-infectious uveitis: long-term outcomes and complications. Ocul Immunol Inflamm. 2023;1–8. doi:10.1080/09273948.2023.2179499.
  • Kump LI, Cervantes-Castañeda RA, Androudi SN, Foster CS. Analysis of pediatric uveitis cases at a tertiary referral center. Ophthalmology. 2005;112(7):1287–1292. doi:10.1016/j.ophtha.2005.01.044.
  • Suresh S, Tsui E. Ocular manifestations of Blau syndrome. Curr Opin Ophthalmol. 2020;31(6):532–537. doi:10.1097/ICU.0000000000000705.
  • Lévy E, Stolzenberg MC, Bruneau J, Breton S, Neven B, Sauvion S, et al. LRBA deficiency with autoimmunity and early onset chronic erosive polyarthritis. Clin Immunol. 2016;168:88–93. doi:10.1016/j.clim.2016.03.006.
  • Cocho L, Urbaneja E, Herreras JM. Vision-threatening bilateral panuveitis and TRAPS in a child: an uncommon association. Int Ophthalmol. 2019;39(1):219–223. doi:10.1007/s10792-017-0785-y.
  • Ma L, Lee S, Montieth A, Stephenson A, Foster CS, Anesi SD. cryopyrin-associated periodic syndrome-associated uveitis and papillitis. Retin Cases Brief Rep. 2021;15(2):149–154. doi:10.1097/ICB.0000000000000756.
  • Xu XF, Zhang J, Cui L, Wang YH, Yue Y, Chi L, et al. The value of different antibodies detection in diagnosis of rheumatism with uveitis. Zhonghua Yi Xue Za Zhi. 2017;97(4):285–290. doi:10.3760/cma.j.issn.0376-2491.2017.04.010.
  • Huynh E, Elhusseiny AM, Nihalani BR. Paediatric anterior uveitis management in the USA: a single-centre, 10-year retrospective chart review exploring the efficacy and safety of systemic immunomodulatory therapy. Eye. 2023;37(7):1325–1330. doi:10.1038/s41433-022-02121-3.
  • Oray M, Khachatryan N, Ebrahimiadib N, Abu Samra K, Lee S, Foster CS. Ocular morbidities of juvenile idiopathic arthritis-associated uveitis in adulthood: results from a tertiary center study. Graefes Arch Clin Exp Ophthalmol. 2016;254(9):1841–1849. doi:10.1007/s00417-016-3340-z.
  • van Straalen JW, Akay G, Kouwenberg CV, de Roock S, Kalinina Ayuso V, Wulffraat NM, et al. Methotrexate therapy associated with a reduced rate of new-onset uveitis in patients with biological-naïve juvenile idiopathic arthritis. RMD Open. 2023;9(2):e003010. doi:10.1136/rmdopen-2023-003010.
  • Kouwenberg CV, Wennink RAW, Shahabi M, Bozkir I, Ayuso VKK, de Boer JH. Clinical course and outcome in pediatric idiopathic chronic anterior uveitis. Am J Ophthalmol. 2022;241:198–205. doi:10.1016/j.ajo.2022.04.015.
  • AlBloushi AF, Solebo AL, Gokhale E, Hayouti H, Ajamil-Rodanes S, Petrushkin H. Long-term outcomes of pediatric idiopathic intermediate uveitis. Am J Ophthalmol. 2022;237:41–48. doi:10.1016/j.ajo.2021.11.003.
  • Alzyoud R, Alsuwaiti M, Maittah H, Aladaileh B, Nobani M, Farhan A, et al. Pediatric noninfectious uveitis in a tertiary referral center in Jordan: clinical spectrum and immunomodulatory treatment. Cureus. 2022;14(6):e25841. doi:10.7759/cureus.25841.
  • Leal I, Romão VC, Mano S, Khmelinskii N, Campanilho-Marques R, Ponte C, et al. A non-infectious uveitis multidisciplinary clinic in a tertiary referral center: clinical impact and added value. J Multidiscip Healthc. 2021;14:695–704. doi:10.2147/JMDH.S292981.
  • Yalçındağ FN, Güngör SG, Değirmenci MFK, Sarıgül Sezenöz A, Özçakar ZB, Baskın E, et al. The clinical characteristics of pediatric non-infectious uveitis in two tertiary referral centers in Turkey. Ocul Immunol Inflammation. 2021;29(2):282–289. doi:10.1080/09273948.2019.1674890.
  • Murdaca G, Spanò F, Contatore M, Guastalla A, Penza E, Magnani O, et al. Immunogenicity of infliximab and adalimumab: what is its role in hypersensitivity and modulation of therapeutic efficacy and safety? Expert Opin Drug Saf. 2016;15(1):43–52. doi:10.1517/14740338.2016.1112375.
  • Ozdemir HB, Ozdal PC. Clinical characteristics and treatment of pars planitis: an adalimumab experience. Graefes Arch Clin Exp Ophthalmol. 2022;260(2):561–569. doi:10.1007/s00417-021-05398-4.
  • Carnahan MC, Goldstein DA. Ocular complications of topical, peri-ocular, and systemic corticosteroids. Curr Opin Ophthalmol. 2000;11(6):478–483. doi:10.1097/00055735-200012000-00016.

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