34
Views
0
CrossRef citations to date
0
Altmetric
Brief Report

An Atypical Case of Severe Toxicity, Anterior Chamber Inflammation, and Transient Subretinal Fluid Formation Induced by the Subconjunctival Injection of 5-FU

, PhD, , PhD, , MD, , PhD & , MD
Received 25 Mar 2024, Accepted 13 Jun 2024, Published online: 25 Jun 2024

References

  • Maestrini HA, Cronemberger S, Matoso HDS, Reis JRC, Mérula RV, Diniz AF, et al. Late needling of flat filtering blebs with adjunctive mitomycin C: efficacy and safety for the corneal endothelium. Ophthalmology. 2011;118(4):755–762. doi:10.1016/j.ophtha.2010.08.020.
  • Pasternack JJ, Wand M, Shields MB, Abraham D. Needle revision of failed filtering blebs using 5-fluorouracil and a combined ab-externo and ab-interno approach. J Glaucoma. 2005;14(1):47–51. doi:10.1097/00061198-200502000-00009.
  • Chen X, Suo L, Hong Y, Zhang C. Safety and efficacy of bleb needling with antimetabolite after trabeculectomy failure in glaucoma patients: a systemic review and meta-analysis. J Ophthalmol. 2020;2020:4310258. doi:10.1155/2020/4310258.
  • Kapasi MS, Birt CM. The efficacy of 5-fluorouracil bleb needling performed 1 year or more posttrabeculectomy: a retrospective study. J Glaucoma. 2009;18(2):144–148. doi:10.1097/IJG.0b013e318170a71c.
  • Halili A, Kessel L, Subhi Y, Bach-Holm D. Needling after trabeculectomy - does augmentation by anti-metabolites provide better outcomes and is Mitomycin C better than 5-Fluoruracil? A systematic review with network meta-analyses. Acta Ophthalmol (Copenh). 2020;98(7):643–653. doi:10.1111/aos.14452.
  • Montolío-Marzo S, Fernández-López E, Piá-Ludeña JV, Davó-Cabrera JM, Alfonso-Muñoz EA, Peris-Martínez C. Intracameral 5-fluorouracil and viscous dispersive viscoelastic for diffuse epithelial downgrowth management in aphakia. Int J Ophthalmol. 2020;13(5):845–847. doi:10.18240/ijo.2020.05.23.
  • Bukhari DA, Alessa SK, Beheiri SI. Corneal epithelial hyperplasia after 5-fluorouracil injection. Case Rep Ophthalmol. 2018;9(1):254–256. doi:10.1159/000487474.
  • Rashad MA. Efficacy of repeated 5-fluorouracil needling for failing and failed filtering surgeries based on simple gonioscopic examination. Clin Ophthalmol Auckl NZ. 2013;7:15–22. doi:10.2147/OPTH.S34848.
  • Gil JL, Quintana LUG. Transient cataract and permanent iris atrophy after subconjunctival 5-fluorouracil injection. An Méd Asoc Médica Cent Méd ABC. 2020;65(4):301–304. doi:10.35366/97468.
  • Libre PE. Transient, profound cataract associated with intracameral 5-fluorouracil. Am J Ophthalmol. 2003;135(1):101–102. doi:10.1016/S0002-9394(02)01828-7.
  • Huhtala A, Rönkkö S, Teräsvirta M, Puustja¨rvi T, Sihvola R, Vehanen K, et al. The effects of 5-fluorouracil on ocular tissues in vitro and in vivo after controlled release from a multifunctional implant. Invest Ophthalmol Vis Sci. 2009;50(5):2216–2223. doi:10.1167/iovs.08-3016.
  • Huhtala A, Tähti H, Salminen L, Uusitalo H. Evaluation of adverse ocular effects of 5-fluorouracil by using human corneal epithelial cell cultures. J Toxicol Cutan Ocul Toxicol. 2002;21(4):283–292. doi:10.1081/CUS-120015900.
  • Mannerström M, Zorn-Kruppa M, Diehl H, Engelke M, Toimela T, Mäenpää H, et al. Evaluation of the cytotoxicity of selected systemic and intravitreally dosed drugs in the cultures of human retinal pigment epithelial cell line and of pig primary retinal pigment epithelial cells. Toxicol Vitro Int J Publ Assoc BIBRA. 2002;16(2):193–200. doi:10.1016/S0887-2333(01)00113-8.
  • Longley DB, Harkin DP, Johnston PG. 5-fluorouracil: mechanisms of action and clinical strategies. Nat Rev Cancer. 2003;3(5):330–338. doi:10.1038/nrc1074.
  • Hsu ST, Ponugoti A, Deaner JD, Vajzovic L. Update on retinal drug toxicities. Curr Ophthalmol Rep. 2021;9(4):168–177. doi:10.1007/s40135-021-00277-x.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.