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Research Article

Elevated Levels of Interleukin 6 in the Vitreous Fluid of Patients with Pars Planitis and Posterior Uveitis: The Massachusetts Eye & Ear Experience and Review of Previous Studies

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Pages 205-214 | Published online: 08 Jul 2009

References

  • Streilein JW. Immune privilege as the result of local tissue barriers and immunosuppresive microenvironments. Curr Opin Immunol. 1993;5: 428–432.
  • Cousins SW, Trattler WB and Streilein JW. Immune privilege and suppression of immunogenic inflammation in the anterior chamber of the eye. Curr Eye Res. 1991;10:287–297.
  • Kaiser CJ, Ksander BR and Streilein JW. Inhibition of lymphocyte proliferation of aqueous humor. Reg Immunol. 1989;2:42–49.
  • Cousins SW, McCabe MM, Danielpour D and Streilein JW. Identification of transforming growth factor-beta as immunosuppressive factor in aqueous humor. Invest Ophthalmol Vis ScL 1991;32:2201–2211.
  • Wilbanks JA and Streilein JW. Fluids from immune privileged sites endow macrophages with the capacity to induce antigen-specific immune deviation via a mechanism involving transforming growth factor-beta. Eur J Immunol. 1992; 22:1031–1036.
  • Murray PI, Hoekzema R, Haren MAC, Hon FD and Kijlstra A. Aqueous humor Interleukin-6 levels in uveitis. Invest Ophthalmol Vis ScL 1990;31: 917–920.
  • Hoekzema R, Murray PI and Kijlstra A. Cytokines and intraocular inflammation. Curr Eye Res. 1990;9:207–211.
  • Boer JH, Hare MAC, Vries-Knoppert WAEJ, Baarsma GS, Jong PVTMd, Postema FJ, Radermakers ABM and Kijlstra A. Analysis of IL-6 levels in human vitreous fluid obtained from uveitis patients, patients with proliferative intraocular disorders and eye bank eyes. Curr Eye Res. 1992;II:181–186.
  • Franks A, Limb GA, Stanford MR, Wolstencroft RA, HChignell A and Dumonde DC. Cytokines in human intraocular inflammtion. Curr Eye Res. 1992;11:187–191.
  • Ongkosuwito JV, Feron EJ, Doornik CEM, Lelij AV, Hoyng CB, Heij ECL and Kijlstra A. Analysis of Immunoregulatory Cytokines in Ocular Fluid Samples from Patients with Uveitis. Invest Ophthalmol Vis ScL 1998;39:2659–2665.
  • Smith JR, Levinson RD, Holland GN, Jabs DA, Robinson MR, Whitcup SM and Rosenbaum JT. Differential efficacy of tumor necrosis factor inhibition in the management of inflammatory eye disease and associated rheumatic disease. Arthritis Rheum. 2001;45: 252–257.
  • Heij ECL, Waarenburg MPHV, Blaauwgeers HGT, Kessels AGH, Vente JD, Liem ATA, Steinbusch H and Hendrikse E Levels of Basic Fibroblast Growth Factor, Glutamine Synthetase, and Interleukin-6 in Subretinal Fluid from Patients with Retinal Detachment. Am J Ophthalmol.2001;132:544–550.
  • Marinkovic SJ, Jahreis JP, Wong GG and Baumann M. IL-6 modulates the synthesis of a specific set of acute phase plasma proteins in vivo. J Immunol. 1989;142: 808–812.
  • Romano M, Sironi M and Tonatti C. Role of IL-6 and its soluble receptor in induction of chemokines and leucocyte recruitment. Immunity. 1997;6: 315–325.
  • Joseph SB, Miner KT and Croft M. Augmentation of naive, Thr and Th2 effector CD4 responses by IL-6, IL-I and TNF. Eur J Immunol. 1998;28: 277–289.
  • Flamme ACL and Pierce EJ. The absence of IL-6 does not affect Th2 cell development in vitro, but does lead to impaired proliferation, IL-2 receptor expression and B cell responses. J Immunol. 1999;162: 5829–5837.
  • Ohta K, Wiggert B, Yamagami S, Taylor AW and Streilein JW. Analysis of Immunomodulatory Activities of Aqueous Humor from Eyes of Mice with Experimental Autoimmune Uveitis. J Immunol. 2000;164:1185–1192.
  • Vos AFD, Hoekzema R, Haren MACv and Kijlstra A. Kinetics of intraocular tumor necrosis factor and interleukin-6 in endotoxin-induced uveitis in the rat. Invest Ophthalmol Vis ScL 1994;35: 1100–1107.
  • Ohta K, Yamagami S, Taylor AW and Streilein JW. IL-6 Antagonizes TGF-beta and Abolishes Immune Privilege in Eyes with Endotoxin-Induced Uveitis. Invest Ophthalmol Vis ScL 2000;41: 2591–2599.
  • Boer JHd, Limpens J, Orengo-Nania S, Jong PTVMd, Heij EL and Kijlstra A. Low Mature TGF-beta 2 Levels in Aqueous Humor During Uveitis. Invest Ophthalmol Vis ScL 1994;35: 3702–3710.

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