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Review Paper

A systematic review and meta-analysis on the levels of brain-derived neurotrophic factor in insomnia patients with and without comorbid depression

ORCID Icon, , , , , & show all
Pages 467-478 | Received 14 Feb 2023, Accepted 01 Jun 2023, Published online: 07 Jun 2023

References

  • Abad VC, Guilleminault C. 2018. Insomnia in elderly patients: recommendations for pharmacological management. Drugs Aging. 35(9):791–817. doi:10.1007/s40266-018-0569-8.
  • Bachmann V, Klein C, Bodenmann S, Schäfer N, Berger W, Brugger P, Landolt H-P. 2012. The BDNF Val66Met polymorphism modulates sleep intensity: eEG frequency- and state-specificity. Sleep. 35(3):335–344. doi:10.5665/sleep.1690.
  • Ballesio A, Zagaria A, Curti DG, Moran R, Goadsby PJ, Rosenzweig I, Lombardo C. 2023. Peripheral brain-derived neurotrophic factor (BDNF) in insomnia: a systematic review and meta-analysis. Sleep Med Rev. 67:101738. doi:10.1016/j.smrv.2022.101738.
  • Bhaskar S, Hemavathy D, Prasad S. 2016. Prevalence of chronic insomnia in adult patients and its correlation with medical comorbidities. J Fam Med Primary Care. 5(4):780–784. eng. doi:10.4103/2249-4863.201153.
  • Björkholm C, Monteggia LM. 2016. BDNF - a key transducer of antidepressant effects. Neuropharmacology. 102:72–79. eng. doi:10.1016/j.neuropharm.2015.10.034.
  • Bollu PC, Kaur H. 2019. Sleep medicine: insomnia and sleep. Mo Med eng. 116(1):68–75.
  • Brownlow JA, Miller KE, Gehrman PR. 2020. Insomnia and cognitive performance. Sleep Med Clin. 15(1):71–76. eng. doi:10.1016/j.jsmc.2019.10.002.
  • Ciammola A, Sassone J, Cannella M, Calza S, Poletti B, Frati L, Squitieri F, Silani V. 2007. Low brain‐derived neurotrophic factor (BDNF) levels in serum of Huntington’s disease patients. Am J Med Genet. 144B(4):574–577. doi:10.1002/ajmg.b.30501.
  • Claudino FCA, Gonçalves L, Schuch FB, Martins HRS, da Rocha NS. 2020. The effects of individual psychotherapy in BDNF levels of patients with mental disorders: a systematic review. Front Psychiatry. 11:445. eng. doi:10.3389/fpsyt.2020.00445.
  • D’Aurea C, Poyares D, Piovezan RD, Passos GS, Tufik S, Mello M. 2015. Objective short sleep duration is associated with the activity of the hypothalamic-pituitary-adrenal axis in insomnia. Arq Neuropsiquiatr. 73(6):516–519. doi:10.1590/0004-282X20150053.
  • De Crescenzo F, D’Alò GL, Ostinelli EG, Ciabattini M, Di Franco V, Watanabe N, Kurtulmus A, Tomlinson A, Mitrova Z, Foti F, et al. 2022. Comparative effects of pharmacological interventions for the acute and long-term management of insomnia disorder in adults: a systematic review and network meta-analysis. Lancet eng. 400(10347):170–184. doi:10.1016/S0140-6736(22)00878-9.
  • Deuschle M, Schredl M, Wisch C, Schilling C, Gilles M, Geisel O, Hellweg R. 2018. Serum brain‐derived neurotrophic factor (BDNF) in sleep‐disordered patients: relation to sleep stage N3 and rapid eye movement (REM) sleep across diagnostic entities. J Sleep Res. 27(1):73–77. doi:10.1111/jsr.12577.
  • Ditmer M, Gabryelska A, Turkiewicz S, Białasiewicz P, Małecka-Wojciesko E, Sochal M. 2022. Sleep problems in chronic inflammatory diseases: prevalence, treatment, and new perspectives: a narrative review. J Clin Med. 11(1):67. doi:10.3390/jcm11010067.
  • Duman RS, Monteggia LM. 2006. A neurotrophic model for stress-related mood disorders. Biol Psychiatry. 59(12):1116–1127. doi:10.1016/j.biopsych.2006.02.013.
  • Eckert A, Karen S, Beck J, Brand S, Hemmeter U, Hatzinger M, Holsboer-Trachsler E. 2017. The link between sleep, stress and BDNF. Eur Psychiatr. 41(S1):S282–S282. doi:10.1016/j.eurpsy.2017.02.132.
  • Fan T-T, Chen W-H, Shi L, Lin X, Tabarak S, Chen S-J, Que J-Y, Bao Y-P, Tang X-D, Shi J. 2019. Objective sleep duration is associated with cognitive deficits in primary insomnia: bDNF may play a role. Sleep. 42(1):zsy192. doi:10.1093/sleep/zsy192.
  • Fernandes BS, Molendijk ML, Köhler CA, Soares JC, Leite CM, Machado-Vieira R, Ribeiro TL, Silva JC, Sales PM, Quevedo J, et al. 2015. Peripheral brain-derived neurotrophic factor (BDNF) as a biomarker in bipolar disorder: a meta-analysis of 52 studies. BMC Med eng. 13(1):289. doi:10.1186/s12916-015-0529-7.
  • Furihata R, Saitoh K, Otsuki R, Murata S, Suzuki M, Jike M, Kaneita Y, Ohida T, Uchiyama M. 2020. Association between reduced serum BDNF levels and insomnia with short sleep duration among female hospital nurses. Sleep Med. 68:167–172. doi:10.1016/j.sleep.2019.12.011.
  • Giese M, Unternährer E, Hüttig H, Beck J, Brand S, Calabrese P, Holsboer-Trachsler E, Eckert A. 2014. BDNF: an indicator of insomnia? Mol Psychiatr. 19(2):151–152. doi:10.1038/mp.2013.10.
  • Gökçe E, Güneş E, Nalçaci E. 2019. Effect of exercise on major depressive disorder and schizophrenia: a BDNF focused approach. Noro psikiyatri arsivi. 56(4):302. doi:10.29399/npa.23369.
  • Gorgulu Y, Caliyurt O. 2009. Rapid antidepressant effects of sleep deprivation therapy correlates with serum BDNF changes in major depression. Brain Res Bull. 80(3):158–162. doi:10.1016/j.brainresbull.2009.06.016.
  • Gourgouvelis J, Yielder P, Clarke ST, Behbahani H, Murphy BA. 2018. Exercise leads to better clinical outcomes in those receiving medication plus cognitive behavioral therapy for major depressive disorder. Front Psychiatry. 9:37. doi:10.3389/fpsyt.2018.00037.
  • Hardison HG, Neimeyer RA, Lichstein KL. 2005. Insomnia and complicated grief symptoms in bereaved college students. Behav Sleep Med. 3(2):99–111. doi:10.1207/s15402010bsm0302_4.
  • Heitz U, Papmeyer M, Studerus E, Egloff L, Ittig S, Andreou C, Vogel T, Borgwardt S, Graf M, Eckert A. 2019. Plasma and serum brain-derived neurotrophic factor (BDNF) levels and their association with neurocognition in at-risk mental state, first episode psychosis and chronic schizophrenia patients. World J Biol Psychiatry. 20(7):545–554. doi:10.1080/15622975.2018.1462532.
  • Hill J, Hardy N, Jimenez D, Maynard K, Kardian A, Pollock C, Schloesser R, Martinowich K. 2016. Loss of promoter IV-driven BDNF expression impacts oscillatory activity during sleep, sensory information processing and fear regulation. Transl Psychiatry. 6(8):e873–e873. doi:10.1038/tp.2016.153.
  • Irwin MR. 2015. Why sleep is important for health: a psychoneuroimmunology perspective. Ann Rev Psychol. 66(1):143–172. doi:10.1146/annurev-psych-010213-115205.
  • Junior JFS, Eckeli AL, Ribeiro CCC, Batista RFL, da Silva AAM, Alves CMC. 2021. Influence of excessive daily sleeping and sleep quality on BDNF and NGF serum levels in adolescents. Sleep Med. 84:415–423. doi:10.1016/j.sleep.2021.06.024.
  • Kadoya M, Koyama H, Kurajoh M, Naka M, Miyoshi A, Kanzaki A, Kakutani M, Shoji T, Moriwaki Y, Yamamoto T, et al. 2016. Associations of sleep quality and awake physical activity with fluctuations in nocturnal blood pressure in patients with cardiovascular risk factors. PLos One. 11(5):e0155116. doi:10.1371/journal.pone.0155116.
  • Kraus C, Kadriu B, Lanzenberger R, Zarate CA Jr., Kasper S. 2019. Prognosis and improved outcomes in major depression: a review. Transl Psychiatry. 9(1):127. doi:10.1038/s41398-019-0460-3.
  • Kronenberg G, Bick-Sander A, Bunk E, Wolf C, Ehninger D, Kempermann G. 2006. Physical exercise prevents age-related decline in precursor cell activity in the mouse dentate gyrus. Neurobiol Aging. 27(10):1505–1513. doi:10.1016/j.neurobiolaging.2005.09.016.
  • Kushikata T, Fang J, Krueger JM. 1999. Brain-derived neurotrophic factor enhances spontaneous sleep in rats and rabbits. Am J Physiol Regul Integr Comp Physiol. 276(5):R1334–R1338. doi:10.1152/ajpregu.1999.276.5.R1334.
  • Kyrou I, Chrousos GP, Tsigos C. 2006. Stress, visceral obesity, and metabolic complications. Ann N Y Acad Sci. 1083(1):77–110. doi:10.1196/annals.1367.008.
  • Martinowich K, Manji H, Lu B. 2007. New insights into BDNF function in depression and anxiety. Nat Neurosci. 10(9):1089–1093. doi:10.1038/nn1971.
  • Mikoteit T, Brand S, Eckert A, Holsboer-Trachsler E, Beck J. 2019a. Brain-derived neurotrophic factor is a biomarker for subjective insomnia but not objectively assessable poor sleep continuity. J Psychiatr Res. 110:103–109. doi:10.1016/j.jpsychires.2018.12.020.
  • Mikoteit T, Brand S, Eckert A, Holsboer-Trachsler E, Beck J. 2019b. Brain-derived neurotrophic factor is a biomarker for subjective insomnia but not objectively assessable poor sleep continuity. J Psychiatr Res. 110:103–109. doi:10.1016/j.jpsychires.2018.12.020.
  • Monteiro BC, Monteiro S, Candida M, Adler N, Paes F, Rocha N, Nardi AE, Murillo-Rodriguez E, Machado S. 2017. Relationship between brain-derived neurotrofic factor (Bdnf) and sleep on depression: a critical review. Clin Pract Epidemiol Mental Health. 13(1):213. doi:10.2174/1745017901713010213.
  • Murri MB, Pariante C, Mondelli V, Masotti M, Atti AR, Mellacqua Z, Antonioli M, Ghio L, Menchetti M, Zanetidou S. 2014. HPA axis and aging in depression: systematic review and meta-analysis. Psychoneuroendocrinology. 41:46–62. doi:10.1016/j.psyneuen.2013.12.004.
  • Nicolaides NC, Vgontzas AN, Kritikou I, Chrousos G. 2020. HPA axis and sleep. Endotext. Book. Feingold Kenneth R. editor. South Dartmouth (MA): MDText.com, Inc. www.endotext.org
  • Ohayon MJS. 1996. Epidemiological study on insomnia in the general population. Sleep. 19(suppl_3):S7–S15. doi:10.1093/sleep/19.suppl_3.S7.
  • Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, Shamseer L, Tetzlaff JM, Akl EA, Brennan S. 2021. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. Int J Surg. 88:105906. doi:10.1016/j.ijsu.2021.105906.
  • Palagini L, Hertenstein E, Riemann D, Nissen C. 2022. Sleep, insomnia and mental health. J Sleep Res. 31(4):e13628. doi:10.1111/jsr.13628.
  • Pariante CM, Lightman SL. 2008. The HPA axis in major depression: classical theories and new developments. Trends Neurosci. 31(9):464–468. doi:10.1016/j.tins.2008.06.006.
  • Riemann D, Berger M, Voderholzer U. 2001. Sleep and depression—results from psychobiological studies: an overview. Biol Psychol. 57(1–3):67–103. doi:10.1016/S0301-0511(01)00090-4.
  • Roth T, Roehrs T. 2003. Insomnia: epidemiology, characteristics, and consequences. Clin Cornerstone. 5(3):5–15. doi:10.1016/S1098-3597(03)90031-7.
  • Schmidt HD, Duman RS. 2007. The role of neurotrophic factors in adult hippocampal neurogenesis, antidepressant treatments and animal models of depressive-like behavior. Behav Pharmacol. 18(5–6):391–418. doi:10.1097/FBP.0b013e3282ee2aa8.
  • Schmitt K, Holsboer-Trachsler E, Eckert A. 2016a. BDNF in sleep, insomnia, and sleep deprivation. Ann Med. 48(1–2):42–51. doi:10.3109/07853890.2015.1131327.
  • Schmitt K, Holsboer-Trachsler E, Eckert A. 2016b. BDNF in sleep, insomnia, and sleep deprivation. Ann Med. 48(1–2):42–51. doi:10.3109/07853890.2015.1131327.
  • Swanson LM, Kalmbach DA, Raglan GB, O’Brien LM. 2020. Perinatal insomnia and mental health: a review of recent literature. Curr Psychiatry Rep. 22(12):73. doi:10.1007/s11920-020-01198-5.
  • Thorpy MJ. 2012. Classification of sleep disorders. Neurother. 9(4):687–701. doi:10.1007/s13311-012-0145-6.
  • Van Someren EJW. 2021. Brain mechanisms of insomnia: new perspectives on causes and consequences. Physiol Rev. 101(3):995–1046. doi:10.1152/physrev.00046.2019.
  • Vgontzas AN, Tsigos C, Bixler EO, Stratakis CA, Zachman K, Kales A, Vela-Bueno A, Chrousos GP. 1998. Chronic insomnia and activity of the stress system: a preliminary study. J Psychosom Res. 45(1):21–31. doi:10.1016/S0022-3999(97)00302-4.

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