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Child Neuropsychology
A Journal on Normal and Abnormal Development in Childhood and Adolescence
Volume 24, 2018 - Issue 5
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Review Article

Neuropsychological outcomes of pediatric demyelinating diseases: a review

, , &
Pages 575-597 | Received 24 Jan 2017, Accepted 02 Jun 2017, Published online: 21 Jun 2017

References

  • Absoud, M., Cummins, C., Desai, N., Gika, A., McSweeney, N., Munot, P., … Wassmer, E. (2011). Childhood optic neuritis clinical features and outcome. Archives of Disease in Childhood, 96(9), 860–862. doi:10.1136/adc.2009.175422
  • Aliabadi, N., Messacar, K., Pastula, D. M., Robinson, C. C., Leshem, E., Sejvar, J. J., … Dominguez, S. R. (2016). Enterovirus D68 infection in children with acute flaccid myelitis, Colorado, USA, 2014. Emerging Infectious Diseases, 22(8), 1387–1394. doi:10.3201/eid2208.151949
  • Amato, M. P., Goretti, B., Ghezzi, A., Hakiki, B., Niccolai, C., & Lori, S. (2014). Neuropsychological features in childhood and juvenile multiple sclerosis: Five-year follow-up. Neurology, 83(16), 1432–1438. doi:10.1212/WNL.0000000000000885
  • Amato, M. P., Goretti, B., Ghezzi, A., Lori, S., Zipoli, V., Moiola, L., … Vecchio, R. (2010). Cognitive and psychosocial features in childhood and juvenile MS: Two-year follow-up. Neurology, 75(13), 1134–1140. doi:10.1212/WNL.0b013e3181f4d821
  • Amato, M. P., Goretti, B., Ghezzi, A., Lori, S., Zipoli, V., Portaccio, E., … Patti, F. (2008). Cognitive and psychosocial features of childhood and juvenile MS. Neurology, 70(20), 1891–1897. doi:10.1212/01.wnl.0000312276.23177.fa
  • Arnett, P., Rao, S., Grafman, J., Bernardin, L., Luchetta, T., Binder, J. R., & Lobeck, L. (1997). Executive functions in multiple sclerosis: An analysis of temporal ordering, semantic encoding, and planning abilities. Neuropsychology, 11, 535–544. doi:10.1037/0894-4105.11.4.535
  • Ascherio, A., & Munger, K. (2008). Epidemiology of multiple sclerosis: From risk factors to prevention. Seminars in Neurology, 28(1), 17–28. doi:10.1055/s-2007-1019126
  • Banwell, B., Arnold, D. L., Tillema, J. M., Rocca, M. A., Filippi, M., Weinstock-Guttman, B., … Sormani, M. P. (2016). MRI in the evaluation of pediatric multiple sclerosis. Neurology, 87(9), S88–S96. doi:10.1212/WNL.0000000000002787
  • Banwell, B., Ghezzi, A., Bar-Or, A., Mikaeloff, T., & Tardieu, M. (2007). Multiple sclerosis in children: Clinical diagnosis, therapeutic strategies, and future directions. The Lancet Neurology, 6(10), 887–902. doi:10.1016/S1474-4422(07)70242-9
  • Banwell, B., Krupp, L., Kennedy, J., Tellier, R., Tenembaum, S., Ness, J., … Bar-Or, A. (2007). Clinical features and viral serologies in children with multiple sclerosis: A multinational observational study. Lancet Neurology, 6, 773–781. doi:10.1016/S1474-4422(07)70196-5
  • Banwell, B. L., & Anderson, P. E. (2005). The cognitive burden of multiple sclerosis in children. Neurology, 64(5), 891–894. doi:10.1212/01.WNL.0000152896.35341.51
  • Baumann, M., Hennes, E. M., Schanda, K., Karenfort, M., Kornek, B., Seidl, R., … Rostasy, K. (2016). Children with multiphasic disseminated encephalomyelitis and antibodies to the myelin oligodendrocyte glycoprotein (MOG): Extending the spectrum of MOG antibody positive diseases. Multiple Sclerosis, 22(14), 1821–1829. doi:10.1177/1352458516631038
  • Beatty, C., Bowler, R. A., Farooq, O., Dudeck, L., Ramasamy, D., Yeh, E. A., … Parrish, J. B. (2016). Long-term neurocognitive, psychosocial, and magnetic resonance imaging outcomes in pediatric-onset acute disseminated encephalomyelitis. Pediatric Neurology, 57, 64–73. doi:10.1016/j.pediatrneurol.2016.01.003
  • Berman, M., Feldman, S., Alter, M., Zilber, N., & Kahana, E. (1981). Acute transverse myelitis: Incidence and etiologic considerations. Neurology, 31(8), 966–971. doi:10.1212/WNL.31.8.966
  • Blanc, F., Noblet, V., Jung, B., Renard, F., Bourre, B., Longato, N., … de Seze, J. (2012). White matter atrophy and cognitive dysfunctions in neuromyelitis optica. PLoS ONE, 7(4), e33878. doi:10.1371/journal.pone.0033878
  • Blanc, F., Zephir, H., Lebrun, C., Labauge, P., Castelnovo, G., Fleury, M., … de Seze, J. (2008). Cognitive functions in neuromyelitis optica. Archives of Neurology, 65(1), 84–88. doi:10.1001/archneurol.2007.16
  • Blaschek, A., Storm van’s Gravesande, K., Heinen, F., Pritsch, M., Mall, V., & Calabrese, P. (2012). Neuropsychological aspects of childhood multiple sclerosis: An overview. Neuropediatrics, 43, 176–183. doi:10.1055/s-0032-1315429
  • Callen, D. J., Shroff, M. M., Branson, H. M., Lotze, T., Li, D. K., Stephens, D., & Banwell, B. L. (2009). MRI in the diagnosis of pediatric multiple sclerosis. Neurology, 72(11), 961–967. doi:10.1212/01.wnl.0000338629.01627.54
  • Charvet, L., Cersosimo, B., Schwarz, C., Belman, A., & Krupp, L. B. (2016). Behavioral symptoms in pediatric multiple sclerosis: Relation to fatigue and cognitive impairment. Journal of Child Neurology, 31(8), 1062–1067. doi:10.1177/0883073816636227
  • Charvet, L., O’Donnell, E., Belman, A., Chitnis, T., Ness, J., Parrish, J., … Krupp, L. (2014). Longitudinal evaluation of cognitive functioning in pediatric multiple sclerosis: Report from the US pediatric multiple sclerosis network. Multiple Sclerosis, 20(11), 1502–1510. doi:10.1177/1352458514527862
  • Charvet, L. E., Cleary, R. E., Vazquez, K., Belman, A. L., & Krupp, L. B. (2014). Social cognition in pediatric-onset multiple sclerosis (MS). Multiple Sclerosis, 20(11), 1478–1484. doi:10.1177/1352458514526942
  • Chitnis, T., Glanz, B., Jaffin, S., & Healy, B. (2009). Demographics of pediatric-onset multiple sclerosis in an MS center population from the Northeastern United States. Multiple Sclerosis, 15(5), 627–631. doi:10.1177/1352458508101933
  • Deery, B., Anderson, V., Jacobs, R., Neale, J., & Kornberg, A. (2010). Childhood MS and ADEM: Investigation and comparison of neurocognitive features in children. Developmental Neuropsychology, 35(5), 506–521. doi:10.1080/87565641.2010.494921
  • Flanagan, E. P., Cabre, P., Weinshenker, B. G., St Sauver, J., Jacobson, D. J., Majed, M., … Pittock, S. J. (2016). Epidemiology of aquaporin-4 autoimmunity and neuromyelitis optica spectrum. Annals Of Neurology, 79(5), 775–783. doi: 10.1002/ana.24617
  • Fuentes, A., Collins, D. L., Garcia-Lorenzo, D., Sled, J. G., Narayanan, S., Arnold, D. L., … Till, C. (2012). Memory performance and normalized regional brain volumes in patients with pediatric-onset multiple sclerosis. Journal of the International Neuropsychological Society, 18(3), 471–480. doi:10.1017/S1355617711001913
  • Goretti, B., Ghezzi, A., Portaccio, E., Lori, S., Zipoli, V., Razzolini, L., … Amato, M. P. (2010). Psychosocial issues in children and adolescents with multiple sclerosis. Neurological Sciences, 31(4), 467–470. doi:10.1007/s10072-010-0281-x
  • Goretti, B., Portaccio, E., Ghezzi, A., Lori, S., Mojola, L., Falautano, M., … Amato, M. (2012). Fatigue and its relationships with cognitive functioning and depression in paediatric multiple sclerosis. Multiple Sclerosis Journal, 18(3), 329–334. doi:10.1177/1352458511420846
  • Hahn, C. D., Miles, B. S., MacGregor, D. L., Blaser, S. I., Banwell, B. L., & Hetherington, C. R. (2003). Neurocognitive outcome after acute disseminated encephalomyelitis. Pediatric Neurology, 29(2), 117–123. doi:10.1016/S0887-8994(03)00143-7
  • Harder, L., Arenivas, A., Tan, A., Hughes, S., Plumb, P., & Greenberg, B. (2015). Neuropsychological and academic functioning in pediatric neuromyelitis optica. Archives of Clinical Neuropsychology, 30(6), 481.
  • Harder, L. L., Holland, A. A., Frohman, F., Graves, D., & Greenberg, B. M. (2012). Cognitive functioning in pediatric transverse myelitis. Multiple Sclerosis, 19(7), 947–952. doi:10.1177/1352458512466606
  • He, D., Chen, X., Zhao, D., & Zhou, H. (2011). Cognitive function, depression, fatigue, and activities of daily living in patients with neuromyelitis optica after acute relapse. International Journal of Neuroscience, 121(12), 677–683. doi:10.3109/00207454.2011.608456
  • Hirtz, D., Thurman, D. J., Gwinn-Hardy, K., Mohamed, M., Chaudhuri, A. R., & Zalutsky, R. (2007). How common are the “common” neurologic disorders? Neurology, 68, 326–337. doi:10.1212/01.wnl.0000252807.38124.a3
  • Holland, A. A., Graves, D., Greenberg, B. M., & Harder, L. L. (2012). Fatigue, emotional functioning, and executive dysfunction in pediatric multiple sclerosis. Child Neuropsychology, 20(1), 71–85. doi:10.1080/09297049.2012.748888
  • Hosseini, B., Flora, D. B., Banwell, B. L., & Till, C. (2014). Age of onset as a moderator of cognitive decline in pediatric-onset multiple sclerosis. Journal of the International Neuropsychological Society, 20(8), 796–804. doi:10.1017/S1355617714000642
  • Hynson, J. L., Kornberg, A. J., Coleman, L. T., Shield, L., Harvey, A. S., & Kean, M. J. (2001). Clinical and neuroradiologic features of acute disseminated encephalomyelitis in children. Neurology, 56, 1308–1312. doi:10.1212/WNL.56.10.1308
  • Jacobs, R. K., Anderson, V. A., Neale, J. L., Shield, L. K., & Kornberg, A. J. (2004). Neuropsychological outcome after acute disseminated encephalomyelitis: Impact of age at illness onset. Pediatric Neurology, 31, 191–197. doi:10.1016/j.pediatrneurol.2004.03.008
  • Julian, L., Serafin, D., Charvet, L., Ackerson, J., Benedict, R., Braaten, E., … Krupp, L. B. (2013). Cognitive impairment occurs in children and adolescents with multiple sclerosis: Results from a United States network. Journal of Child Neurology, 28(1), 102–107. doi:10.1177/0883073812464816
  • Julian, L. J., & Arnett, P. A. (2009). Relationships among anxiety, depression, and executive functioning in multiple sclerosis. The Clinical Neuropsychologist, 23, 794–804. doi:10.1080/13854040802665808
  • Kalb, R. C., Dilorenzo, T. A., Larocca, N. G., LaRocca, N. G., Caruso, L. S., Shawaryn, M. A., … Dince, W. M. (1999). The impact of early-onset multiple sclerosis on cognitive and psychosocial indices. International Journal of MS Care, 1(1), 2–18. doi:10.7224/1537-2073-1.1.2
  • Kerr, D. A., Krishnan, C., & Pidcock, F. (2005). Acute transverse myelitis. In H. S. Singer, E. H. Kossoff, A. L. Hartman, & T. O. Crawford (Eds.), Treatment of pediatric neurologic disorders (pp. 445–451). Boca Raton: Taylor and Francis.
  • Kim, S.-H., Kwak, K., Jeong, I. H., Hyun, J.-W., Jo, H.-J., Joung, A., ... Kim, H. J. (2016). Cognitive impairment differs between neuromyelitis optica spectrum disorder and multiple sclerosis. Multiple Sclerosis Journal. 22(15), 1850–1858.
  • Krishnan, C., Kaplin, A. I., & Deshpande, D. (2004). Transverse myelitis: Pathogenesis, diagnosis and treatment. Frontiers in Bioscience, 9, 1483–1499. doi:10.2741/1351
  • Krupp, L. B., Banwell, B., & Tenembaum, S. (2007). Consensus definitions proposed for pediatric multiple sclerosis and related disorders. Neurology, 68, S7–S12. doi:10.1212/01.wnl.0000259422.44235.a8
  • Kuni, B. J., Banwell, B. L., & Till, C. (2012). Cognitive and behavioral outcomes in individuals with a history of acute disseminated encephalomyelitis (ADEM). Developmental Neuropsychology, 37(8), 682–696. doi:10.1080/87565641.2012.690799
  • Leake, J. A., Albani, S., Kao, A. S., Senac, M. O., Billman, G. F., Nespeca, M. P., … Bradley, J. S. (2004). Acute disseminated encephalomyelitis in childhood: Epidemiologic, clinical and laboratory features. The Pediatric Infectious Disease Journal, 23(8), 756–764. doi:10.1097/01.inf.0000133048.75452.dd
  • Lennon, V. A., Wingerchuk, D. M., Kryzer, T. J., Pittock, S. J., Lucchinetti, C. F., Fujihara, K., … Weinshenker, B. G. (2004). A serum autoantibody marker of neuromyelitis optica: Distinction from multiple sclerosis. Lancet, 364(9451), 2106–2112. doi:10.1016/S0140-6736(04)17551-X
  • MacAllister, W. S., Belman, A. L., Milazzo, M., Weisbrot, D. M., Christodoulou, C., Scherl, W. F., … Krupp, L. B. (2005). Cognitive functioning in children and adolescents with multiple sclerosis. Neurology, 64(8), 1422–1425. doi:10.1212/01.WNL.0000158474.24191.BC
  • MacAllister, W. S., Christodoulou, C., Milazzo, M., & Krupp, L. B. (2007). Longitudinal neuropsychological assessment in pediatric multiple sclerosis. Developmental Neuropsychology, 32(2), 625–644. doi:10.1080/87565640701375872
  • MacAllister, W. S., Christodoulou, C., Milazzo, M., Preston, T. E., Serafin, D., Krupp, L. B., & Harder, L. (2013). Pediatric multiple sclerosis: What we know and where are we headed? Child Neuropsychology, 19(1), 1–22. doi:10.1080/09297049.2011.639758
  • Marin, S., Banwell, B., & Till, C. (2013). Cognitive trajectories in 4 patients with pediatric-onset multiple sclerosis: Serial evaluation over a decade. Journal of Child Neurology, 28(12), 1577–1586. doi:10.1177/0883073812465010
  • Nunan-Saah, J., Paulraj, S. R., Waubant, E., Krupp, L. B., & Gomez, R. G. (2015). Neuropsychological correlates of multiple sclerosis across the lifespan. Multiple Sclerosis Journal, 21(11), 1355–1364. doi:10.1177/1352458515586088
  • Olsson, T., Barcellos, L. F., & Alfredsson, L. (2017). Interactions between genetic, lifestyle and environmental risk factors for multiple sclerosis. Nature Reviews Neurology, 13(1), 25–36. doi:10.1038/nrneurol.2016.187
  • Pasto, L., Portaccio, E., Goretti, B., Ghezzi, A., Lori, S., Hakiki, B., … Amato, M. P. (2016). The cognitive reserve theory in the setting of pediatric-onset multiple sclerosis. Multiple Sclerosis Journal, 22(13), 1741–1749. doi:10.1177/1352458516629559
  • Penman, M. F. (1991). Assessing the prevalence of cognitive impairment in multiple sclerosis: Implications for patient management. Axone, 13(2), 45–49.
  • Pidcock, F. S., Krishnan, C., Crawford, T. O., Salori, C. F., Trovato, M., & Kerr, D. A. (2007). Acute transverse myelitis in childhood: Center-based analysis of 47 cases. Neurology, 68(18), 1474–1480. doi:10.1212/01.wnl.0000260609.11357.6f
  • Pohl, D., Alper, G., Van Haren, K., Kornberg, A. J., Lucchinetti, C. F., Tenembaum, S., & Belman, A. L. (2016). Acute disseminated encephalomyelitis: Updates on an inflammatory CNS syndrome. Neurology, 87(9 Suppl 2), S38–S45. doi:10.1212/WNL.0000000000002825
  • Portaccio, E., Goretti, B., Lori, S., Zipoli, V., Centorrino, S., Ghezzi, A., … Amato, M. P. (2009). The brief neuropsychological battery for children: A screening tool for cognitive impairment in childhood and juvenile multiple sclerosis. Multiple Sclerosis, 15(5), 620–626. doi:10.1177/1352458508101950
  • Prakash, R. S., Snook, E. M., Lewis, J. M., Motl, R. W., & Kramer, A. F. (2008). Cognitive impairments in relapsing-remitting multiple sclerosis: A meta-analysis. Multiple Sclerosis, 14(9), 1250–1261. doi:10.1177/1352458508095004
  • Rao, S. M., Leo, G. J., Bernardin, L., & Unverzagt, F. (1991). Cognitive dysfunction in multiple sclerosis. I. Frequency, patterns, and prediction. Neurology, 41(5), 685–691. doi:10.1212/WNL.41.5.685
  • Rao, S. M., Leo, G. J., Ellington, L., Nauertz, T., Bernardin, L., & Unverzagt, F. (1991). Cognitive dysfunction in multiple sclerosis. II. Impact on employment and social functioning. Neurology, 41(5), 692–696. doi:10.1212/WNL.41.5.692
  • Rocca, M. A., De Meo, E., Amato, M. P., Copetti, M., Moiola, L., Ghezzi, A., … Fliippi, M. (2015). Cognitive impairment in paediatric multiple sclerosis patients is not related to cortical lesions. Multiple Sclerosis, 21(7), 956–959. doi:10.1177/1352458514557303
  • Ross, K. A., Schwebel, D. C., Rinker, J., II, Ness, J., & Ackerson, J. (2010). Neurocognitive sequelae in African American and Caucasian children with multiple sclerosis. Neurology, 75(23), 1134–1140. doi:10.1212/WNL.0b013e318200d7b9
  • Saji, E., Arakawa, M., Yanagawa, K., Toyoshima, Y., Yokoseki, A., & Okamoto, K. (2012). Cognitive impairment and cortical degeneration in neuromyelitis optica. Annals of Neurology, 73(1), 65–76. doi:10.1002/ana.23721
  • Sanfilipo, M. P., Benedict, R. H., Weinstock-Guttman, B., & Bakshi, R. (2006). Gray and white matter brain atrophy and neuropsychological impairment in multiple sclerosis. Neurology, 66(5), 685–692. doi:10.1212/01.wnl.0000201238.93586.d9
  • Smerbeck, A. M., Parrish, J., Serafin, D., Yeh, E. A., Weinstock-Guttman, B., Hoogs, M., … Benedict, R. H. B. (2011). Visual-cognitive processing deficits in pediatric multiple sclerosis. Multiple Sclerosis, 17(4), 449–456. doi:10.1177/1352458510391689
  • Suchy, Y. (2009). Executive functioning: Overview, assessment, and research issues for non-neuropsychologists. Annals of Behavioral Medicine, 37(2), 106–116. doi:10.1007/s12160-009-9097-4
  • Suppiej, A., & Cainelli, E. (2014). Cognitive dysfunction in pediatric multiple sclerosis. Neuropsychiatric Disease and Treatment, 10, 1385–1392. doi:10.2147/NDT
  • Suppiej, A., Cainelli, E., Casara, G., Cappellari, A., Nosadini, M., & Sartori, S. (2014). Long-term neurocognitive outcome and quality of life in pediatric acute disseminated encephalomyelitis. Pediatric Neurology, 50(4), 363–367. doi:10.1016/j.pediatrneurol.2013.12.006
  • Tenenbaum, S. (2013). Acute disseminated encephalomyelitis. Handbook of Clinical Neurology, 112, 1253–1262.
  • Till, C., Ghassemi, R., Kerbrat, A., Collins, D. L., Narayanan, S., & Arnold, D. L. (2011). MRI correlates of cognitive impairment in childhood-onset multiple sclerosis. Neuropsychology, 25(3), 319–332.
  • Till, C., Ho, C., Dudani, A., Garcia-Lorenzo, D., Collins, D. L., & Banwell, B. L. (2012). Magnetic resonance imaging predictors of executive functioning in patients with pediatric-onset multiple sclerosis. Archives of Clinical Neuropsychology, 27(5), 495–509.
  • Till, C., Noguera, A., Verhey, L. H., O’Mahony, J., Yet, E. A., Mah, J. K., … Banwell, B. L. (2016). Cognitive and behavioral functioning in childhood acquired demyelinating syndromes. Journal of International Neuropsychological Society, 22(10), 105–1060.
  • Till, C., Racine, N., Araujo, D., Narayanan, S., Collins, D. L., Aubert-Broche, B., … Banwell, B. (2013). Changes in cognitive performance over a 1-year period in children and adolescents with multiple sclerosis. Neuropsychology, 27(2), 210–219.
  • Till, C., Udler, E., Ghassemi, R., Narayanan, S., Arnold, D. L., & Banwell, B. L. (2012). Factors associated with emotional and behavioral outcomes in adolescents with multiple sclerosis. Multiple Sclerosis, 18(8), 1170–1180.
  • Torisu, H., Kira, R., Ishizaki, Y., Sanefuji, M., Yamaguchi, Y., Yasumoto, S., … Hara, T. (2010). Clinical study of childhood acute disseminated encephalomyelitis, multiple sclerosis, and acute transverse myelitis in Fukuoka Prefecture, Japan. Brain Development, 32(6), 454–462.
  • Trecker, C. C., Kozubal, D. E., Ouigg, M., Hammond, E., Krishnan, C., Sim, P. A., & Kaplin, A. J. (2009). Quality care in transverse myelitis: A responsive protocol. Journal of Child Neurology, 24(5), 577–583.
  • Vanotti, S., Cores, E. V., Eizaguirre, B., & Melamud, L. (2013). Cognitive performance of neuromyelitis optica patients: Comparison with multiple sclerosis. Arquivos de Neuro-Psiquiatria, 71(6), 357–361.
  • Vleugels, L., Lafosse, C., van Nunen, A., Nachtergaele, S., Ketelaer, P., Charlier, M., & Vandenbussche, E. (2000). Visuoperceptual impairment in multiple sclerosis patients diagnosed with neuropsychological tasks. Multiple Sclerosis, 6(4), 241–254. doi:10.1191/135245800678827879
  • Waubant, E., Chabas, D., Okuda, D. T., Glenn, O., Mowry, E., Henry, R. G., … Pelletier, D. (2009). Difference in disease burden and activity in pediatric patients on brain magnetic resonance imaging at time of multiple sclerosis onset vs adults. Archives of Neurology, 66(8), 967–971.
  • Wingerchuk, D. M., Hogancamp, W. F., O’Brien, P. C., & Weinshenker, B. G. (1999). The clinical course of neuromyelitis optica (Devic’s syndrome). Neurology, 53(5), 1107–1114.
  • Wingerchuk, D. M., Lennon, V. A., Lucchinetti, C. F., Pittock, S. J., & Weinshenker, B. G. (2007). The spectrum of neuromyelitis optica. Lancet Neurology, 6(9), 805–815.
  • Yeh, E. A., Chitnis, T., Krupp, L., Ness, J., Chabas, D., Kuntz, N., & Waubant, E. (2009). Pediatric multiple sclerosis. Nature Reviews Neurology, 5(11), 621–631.
  • Zhang, N., Li, Y. J., Fu, Y., Shao, J. H., Luo, L. L., Yang, L., … Liu, Y. (2015). Cognitive impairment in Chinese neuromyelitis optica. Multiple Sclerosis, 21(14), 1839–1846.

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