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Original Articles

Rethinking the Bioethical Enactment of Medically Drugged Bodies: Paradoxes of Using Anti-HIV Drug Therapy as a Technology for Prevention

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Pages 183-199 | Published online: 12 Mar 2010

References

  • AVAC (AIDS Vaccine Advocacy Coalition) . 2005 . Will a Pill a Day Prevent HIV? Anticipating the Results of ‘PREP’ Trials , New York : AVAC .
  • AVAC (AIDS Vaccine Advocacy Coalition) . 2007 . Summary Report of the December 12, 2007 Meeting of the AIDS Vaccine Research Subcommittee , New York : AVAC .
  • AVAC (AIDS Vaccine Advocacy Coalition) (2008) Anticipating the Results of PrEP Trials: A Powerful New HIV Prevention Tool may be on the Horizon. Are we Prepared? A publication from AVAC's Anticipating and Understanding Results series.
  • Bass , E. and Kahn , P. 2005 . “ Testing AIDS vaccines in people ” . In AIDS Vaccine Handbook: Global Perspectives , 2 , Edited by: Kahn , P. New York : AVAC .
  • Benatar , S. R. 2004 . Linking moral progress to medical progress: new opportunities for the Declaration of Helsinki . Journal of the World Medical Association , 50 ( 1 ) March : 11 – 13 .
  • Biagioli , M. 1992 . “ Science, modernity and ‘the final solution’ ” . In Probing the Limits of Representation , Edited by: Friedlander , S. Cambridge, MA : Harvard University Press .
  • Birke , L. , Arluke , A. and Michael , M. 2007 . The Sacrifice: How Scientific Experiments Transform Animals and People , West Lafayette, IN : Purdue University Press .
  • Cartwright , N. 2007 . Are RCTs gold standard? . Biosocieties , 2 : 11 – 20 .
  • Cassell , M. M. , Halperin , D. T. , Shelton , J. D. and Stanton , D. 2006 . Risk compensation: the Achilles' heel of innovations in HIV prevention? . British Medical Journal , 332 : 605 – 607 .
  • Chaya , N. 2006 . Cambodia and HIV: winning round two in a preventive fight, Research Commentary . Population Action International , 1 ( 7 ) July Available at: www.populationaction.org
  • De Laet , M. and Mol , A. 2000 . The Zimbabwe bush pump. Mechanics of a fluid technology . Social Studies of Science , 30 ( 2 ) : 225 – 263 .
  • Epstein , S. 1996 . Impure Science , Berkeley, CA : University of California Press .
  • Ghosn , J. , Viard , J. , Katlama , C. , de Almeida , M. , Tubiana , R. , Letourneur , F. , Aaron , L. , Giele , C. M. , Maw , R. , Carne , C. A. and Evans , B. G. On behalf of the British co-operative clinical group of the Medical Society for the Study of Venereal Diseases (2002) Post-exposure prophylaxis for non-occupational exposure to HIV: current clinical practice and opinions in the UK . Sexually Transmitted Infections , 78 ( 2 ) April : 130 – 132 .
  • Grant , R. M. , Buchbinder , S. , Cates , W. , Clarke , E. , Coates , T. , Cohen , M. S. , Delaney , M. , Flores , G. , Goicochea , P. , Gonsalves , G. , Harrington , M. , Lama , J. R. , MacQueen , K. M. , Moore , J. P. , Peterson , L. , Sanchez , J. , Thompson , M. and Wainberg , M. A. 2005 . AIDS: promote HIV chemoprophylaxis research, don't prevent it . Science , 30 September : 2170 – 2171 .
  • Harding , S. 1991 . Whose Science? Whose Knowledge? Thinking from Women's Lives , Ithaca, NY : Cornell University Press .
  • Horwood , J. 2007 . Cellulose sulphate microbicide trial halted . The Lancet Infectious Diseases , 7 ( 3 ) : 183
  • Human Rights Watch and Thai AIDS Treatment Action Group . 2007 . Deadly Denial: Barriers to HIV/AIDS Treatment for People Who Use Drugs in Thailand , 19 ( 17 ) November
  • IAS (International AIDS Society) . 2005 . Building Collaboration to Advance HIV Prevention. Global Consultation on Tenofovir Pre-Exposure Prophylaxis Research , US National Institutes of Health and US Centers for Disease Control and PreventionSeptember . Report of a Consultation Convened by the International Aids Society on Behalf of the Bill and Melinda Gates Foundation
  • Irwin , A. and Michael , M. 2003 . Science, Social Theory and Public Knowledge , Maidenhead, Berks : Open University Press/McGraw-Hill .
  • Jintarkanon , S. , Nakapiew , S. , Tienudom , N. , Suwannawong , P. and Wilson , D. 2005 . Unethical clinical trials in Thailand: a community response . Lancet , 365 : 1617 – 1618 .
  • Kahn , P. 2005 . “ AVAC report adapted, vaccine trials: leaving communities better off ” . In AIDS Vaccine Handbook: Global Perspectives , 2 , Edited by: Kahn , P. New York : AVAC .
  • MacQueen , K. M. , Namey , E. , Chilongozi , D. A. , Mtweve , S. P. , Mlingo , M. , Morar , N. , Reid , C. , Ristow , A. , Sahay , S. and HPTN 035 Standard of Care Assessment Team . 2007 . Community perspectives on care options for HIV prevention trial participants . AIDS Care , 19 ( 4 ) : 554 – 560 .
  • Mansky , L. M . 2002 . HIV mutagenesis and the evolution of antiretroviral drug resistance . Drug Resistance Updates , 5 ( 6 ) December : 219 – 223 .
  • Mayer , K. H. , Maslankowski , L. A. , Gai , F. , El-Sadr , W. M. , Justman , J. , Kwiecien , A. , Masse , B. , Eshleman , S. H. , Hendrix , C. , Morrow , K. , Rooney , J. F. , Soto-Torres , L. and the HPTN 050 Protocol Team . 2006 . Safety and tolerability of Tenofovir vaginal gel in abstinent and sexually active HIV-uninfected and infected women . AIDS , 20 ( 4 ) : 543 – 551 .
  • Mills , E. , Nixon , S. , Singh , S. , Dolma , S. , Nayyar , A. and Kapoor , S. 2006 . Enrolling women into HIV preventive vaccine trials: an ethical imperative but a logistical challenge . PLoS Medicine , 3 ( 3 ) March : 1 – 4 . e94
  • Mills , E. , Rachlis , B. , Wu , P. , Wong , E. , Wilson , K. and Singh , S. 2005a . Media reporting of Tenofovir trials in Cambodia and Cameroon . BMC International Health and Human Rights , 5 ( 6 ) : 1 – 7 .
  • Mills , E. J. , Sing , S. , Sing , J. A. , Orbinski , J. J. , Warren , M. and Upshur , R. E. 2005b . Designing research in vulnerable populations: lessons from HIV prevention trials that stopped early . British Medical Journal , 331 : 1404
  • Mol , A. 2003 . The Body Multiple: Ontology in Medical Practice , Durham, NC : Duke University Press .
  • Moodley , K. 2007 . Microbicide research in developing countries: have we given the ethical concerns due consideration? . BMC Medical Ethics , 8 ( 10 ) : 3 – 7 .
  • Page-Shafer , K. , Saphonn , V. , Penh Sun , L. , Chhi Vun , M. , Cooper , D. A. and Kaldor , J. M. 2005 . HIV prevention research in a resource-limited setting: the experience of planning a trial in Cambodia . The Lancet , 366 : 1499 – 1503 .
  • Paxton , L. A. , Hope , T. and Jaffe , H. W. 2007 . Pre-exposure prophylaxis for HIV infection: what if it works? . Lancet , 370 : 89 – 93 .
  • Petryna , A. 2007 . Clinical trials offshored: on private sector science and public health . BioSocieties , 2 : 21 – 40 .
  • Proctor , R. 1989 . Racial Hygiene , Cambridge, MA : Harvard University Press .
  • Richens , J. , Edwards , S. G. and Sadiq , S. T. 2005 . Can the promotion of post-exposure prophylaxis following sexual exposure to HIV (PEPSE) cause harm? . Sexually Transmitted Infections , 81 : 190 – 191 .
  • Robertson , M. , Mehrotra , D. , Fitzgerald , D. , Duerr , A. , Casimiro , D. R. , Mcelrath , J. , Lawrence , D. and Buchbinder , S. 2008 . “ Efficacy results from the STEP Study (Merck V520 protocol 023/HVTN 502): a phase II test-of-concept trial of the MRKad5 HIV-1 gag/pol/nef trivalent vaccine ” . In Fifteenth Conference on Retroviruses and Opportunistic Infections Boston Abstract 88LB, 2008
  • Rosengarten , M. and Michael , M. 2009 . “ HIV: pre-exposure prophylaxis or PrEP and the complexities of biomedical prevention ” . In HIV, Technology and Subjectivity: International Cases Studies of HIV Treatment and Prevention , Edited by: Davis , M. D. M. and Squire , C. New York : Palgrave .
  • Shapiro , H. T. and Meslin , E. M. 2001 . Ethical issues in the design and conduct of clinical trials in developing countries . New England Journal of Medicine , 345 ( 2 ) : 139 – 142 .
  • Singh , J. A. and Mills , E. J. 2005 . The abandoned trials of pre-exposure prophylaxis for HIV: what went wrong? . PLoS Medicine , 2 ( 9 ) : 0001 – 0004 . e234
  • Stephenson , J. 2008 . HIV prevention studies yield mixed results . Journal of the American Medical Association , 299 ( 13 ) : 1529 – 1530 .
  • The Thai AIDS Treatment Action Group (TTATAG) (2004) Letter, 8 December. Available at: http://www.aidsinfonyc.org/tag/activism/thaiTenofovir.html
  • UNAIDS . 2006 . Creating effective partnerships for HIV prevention trials: report of the UNAIDS consultation, Geneva, 20–21 June 2005 . AIDS , 20 : W1 – W11 .
  • UNAIDS . 2007 . Fact Sheet AIDS Epidemic Update—Regional Summary Available at: http://data.unaids.org/pub/FactSheet/2008/epi07_fs_regionalsummary_asia_en.pdf (accessed April 2008)
  • UNAIDS and AVAC . 2007 . Good Participatory Practice Guidelines for Biomedical HIV Prevention Trials 18 May, draft report
  • Van de Ven , P. , Crawford , J. , Kippax , S. , Knox , S. and Prestage , G. 2000 . A scale of optimism–scepticism in the context of HIV treatments . AIDS Care , 12 : 171 – 176 .
  • Weijer , C. and LeBlanc , G. 2005 . “ Revisiting the ethics of HIV prevention research in developing countries ” . UNAIDS background paper, 7 June
  • WHO (World Health Organisation) (2007) Available at: http://www.who.int/hiv/pub/guidelines/pmtct/en/index.html (accessed 2007).
  • WHO (World Health Organisation) . 2007 . Cellulose Sulfate Microbicide Trial Stopped Available at: http://www.who.int/mediacentre/news/statements/2007/s01/en/ (accessed 29 April 2008)
  • WHO/UNAIDS . 2004 . Treating people with intercurrent infection in HIV prevention trials . AIDS , 18 ( 15 ) 21 October : W1 – 12 . Report from a WHO/UNAIDS consultation, Geneva, 17–18 July 2003 p. 1
  • Women's Network for Unity (WNU) . 2004 . Protests Drug Trial Recruitment Tactics , Public statement released by WNU Secretariat . 15 June

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