230
Views
6
CrossRef citations to date
0
Altmetric
Nitric Oxide Donors in Clomiphene Citrate Stimulation

Nitric oxide donors increase the pregnancy rate in patients with unexplained infertility undergoing clomiphene citrate stimulation and intrauterine insemination: a randomized controlled pilot study

, , , &
Pages 199-202 | Received 12 Jan 2016, Accepted 21 Sep 2016, Published online: 04 Nov 2016

References

  • Aboulghar M, Mansour R, Serour GI, Al-Inany HG. Diagnosis and management of unexplained infertility: an update. Arch Gynecol Obstet 2003;267:177–88
  • Veltman-Verhulst SM, Cohlen BJ, Hughes E, Heineman MJ. Intra-uterine insemination for unexplained subfertility. Cochrane Database Syst Rev 2012;9:CD001838
  • ESHRE Capri Workshop Group Intrauterine insemination. Hum Reprod Update 2009;15:265–77
  • Goswamy RK, Williams G, Stepto PC. Decreased uterine perfusion – a cause of infertility. Hum Reprod 1988;3:955–9
  • Takasaki A, Tamura H, Taketani T, et al. A pilot study to prevent a thin endometrium in patients undergoing clomiphene citrate treatment. J Ovarian Res 2013;6:9428
  • Devroey P, Bourgain C, Macklon NS, Fauser BC. Reproductive biology and IVF: ovarian stimulation and endometrial receptivity. Trends Endocrinol Metab 2004;15:84–90
  • Zaidi J, Jacobs H, Campbell S, Tan SL. Blood flow changes in ovarian and uterine arteries in women with polycystic ovary syndrome who respond to clomiphene citrate: correlation with serum hormone concentrations. Ultrasound Obstet Gynecol 1998;12:188–96
  • Kurjak A, Kupesic S, Schulman H, Zalud I. Transvaginal color flow Doppler in the assessment of ovarian and uterine blood flow in infertile women. Fertil Steril 1991;56:870–3
  • Edi-Osagie EC, Seif MW, Aplin JD, et al. Characterizing the endometrium in unexplained and tubal factor infertility: a multi-parametric investigation. Fertil Steril 2004;82:1379–89
  • Moncada S, Palmer RM, Higgs EA. Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol Rev 1991;43:109–42
  • Moncada S. The 1991 Ulf von Euler Lecture. The L-arginine: nitric oxide pathway. Acta Physiol Scand 1992;145:201–27
  • Tahler CD, Epel D. Nitric oxide in oocyte maturation, ovulation, fertilization, cleavage and implantation: a little dab'll do ya. Curr Pharm Des 2003;9:399–409
  • Chwalisz K, Garfield RE. Role of nitric oxide in implantation and menstruation. Hum Reprod 2000;3:96–111
  • Dubey PK, Tripathi V, Singh RP, Sharma GT. Influence of nitric oxide on in vitro growth, survival, steroidogenesis, and apoptosis of follicle stimulating hormone stimulated buffalo (Bubalus bubalis) preantral follicles. J Vet Sci 2011;12:257–65
  • Morlin B, Hammarstrom M. Nitric oxide increases endocervical secretion at the ovulatory phase in the female. Acta Obstet Gynecol Scand 2005;84:833–6
  • Tempfer C, Moreno RM, O'Brien WE, Gregg AR. Genetic contributions of the endothelial nitric oxide synthase gene to ovulation and menopause in a mouse model. Fertil Steril 2000;73:1025–31
  • Zamberlam G, Sahmi F, Price CA. Nitric oxide synthase activity is critical for the preovulatory epidermal growth factor-like cascade induced by luteinizing hormone in bovine granulosa cells. Free Radic Biol Med 2014;5849:270–6
  • Pallares P, Garcia-Fernandez RA, Criado LM, et al. Disruption of the endothelial nitric oxide synthase gene affects ovulation, fertilization and early embryo survival in a knockout mouse model. Reproduction 2008;136:573–9
  • Dubey PK, Tripathi V, Singh RP, et al. Expression of nitric oxide synthase isoforms in different stages of buffalo (Bubalus bubalis) ovarian follicles: effect of nitric oxide on in vitro development of preantral follicle. Theriogenology 2012;77:280–91
  • Hefler LA, Gregg AR. Inducible and endothelial nitric oxide synthase: genetic background affects ovulation in mice. Fertil Steril 2002;77:147–51
  • Cooper TG, Noonan E, von Eckardstein S, et al. World Health Organization reference values for human semen characteristics. Hum Reprod Update 2010;16:231–45
  • Ashrafi M, Rashidi M, Ghasemi A, et al. The role of infertility etiology in success rate of intrauterine insemination cycles: an evaluation of predictive factors for pregnancy rate. Int J Fertil Steril 2013;7:100–7
  • Leanza V, Coco L, Grasso F, et al. Ovulation induction with clomiphene citrate for infertile couple. Minerva Ginecol 2014;66:309–12
  • Van Buren GA, Yang DS, Clark KE. Estrogen-induced uterine vasodilatation is antagonized by L-nitroarginine methyl ester, an inhibitor of nitric oxide synthesis. Am J Obstet Gynecol 1992;167:828–33
  • Abdel Razik M, El-Berry S, Mostafa A. The effects of nitric oxide donors on uterine artery and sub-endometrial blood flow in patients with unexplained recurrent abortion. J Reprod Infertil 2014;15:142–6
  • Battaglia C, Regnani G, Marsella T, et al. Adjuvant L-arginine treatment in controlled ovarian hyperstimulation: a double-blind, randomized study. Hum Reprod 2002;17:659–65
  • Battaglia C, Salvatori M, Maxia N, et al. Adjuvant L-arginine treatment for in-vitro fertilization in poor responder patients. Hum Reprod 1999;14:1690–7
  • Hale SA, Jones CW, Osol G, et al. Sildenafil increases uterine blood flow in nonpregnant nulliparous women . Reprod Sci 2010;17:358–65
  • El-Far M, El-Metwally A-G, Hashem IA, Bakry N. Biochemical role on intravaginal sildenafil citrate as a novel anti-abortive agent in unexplained recurrent spontaneous miscarriage: first clinical study of four cases report from Egypt. Clin Chem Lap Med 2009;47:1433–8
  • Amin AF, Shaaban OM, Bediway MA. N. N-acetyl cysteine for treatment of recurrent unexplained pregnancy loss. Reprod Biomed Online 2008;17:722–6

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.