VDR, RANKL and OPG polymorphisms as possible predisposing cofactors of postmenopausal osteoporosis: explorative study in Italian population

References

• NIH. Osteoporosis prevention, diagnosis, and therapy. JAMA 2001;285:785–95.
   PubMed Web of Science ®Google Scholar
• Pansini F, Cervellati C, Guariento A, et al. Oxidative stress, body fat composition, and endocrine status in pre- and postmenopausal women. Menopause 2008;15:112–8.
   Google Scholar
• Takahashi TA, Johnson KM. Menopause. Med Clin North Am 2015;99:521–34.
   PubMed Web of Science ®Google Scholar
• Hofbauer LC, Neubauer A, Heufelder AE. Receptor activator of nuclear factor-kappaB ligand and osteoprotegerin: potential implications for the pathogenesis and treatment of malignant bone diseases. Cancer 2001;92:460–70.
   PubMed Web of Science ®Google Scholar
• Cervellati C, Romani A, Cremonini E, et al. Higher urinary levels of 8-Hydroxy-2′-deoxyguanosine are associated with a worse RANKL/OPG ratio in postmenopausal women with osteopenia. Oxid Med Cell Longev 2016;2016:6038798.
   PubMed Web of Science ®Google Scholar
• Kostenuik PJ. Osteoprotegerin and RANKL regulate bone resorption, density, geometry and strength. Curr Opin Pharmacol 2005; 5:618–25.
   PubMed Web of Science ®Google Scholar
• Christakos S, Hewison M, Gardner DG, et al. Vitamin D: beyond bone. Ann N Y Acad Sci 2013;1287:45–58.
   PubMed Web of Science ®Google Scholar
• Wu S, Liu Y, Zhang L, et al. Genome-wide approaches for identifying genetic risk factors for osteoporosis. Genome Med 2013;5:44.
   PubMed Web of Science ®Google Scholar
• Xiong D-H, Shen H, Zhao L-J, et al. Robust and comprehensive analysis of 20 osteoporosis candidate genes by very high-density single-nucleotide polymorphism screen among 405 white nuclear families identified significant association and gene-gene interaction. J Bone Miner Res 2006;21:1678–95.
   PubMed Web of Science ®Google Scholar
• Vidal C, Formosa R, Xuereb-Anastasi A. Functional polymorphisms within the TNFRSF11B (osteoprotegerin) gene increase the risk for low bone mineral density. J Mol Endocrinol 2011;47:327–33.
   PubMed Web of Science ®Google Scholar
• Mencej S, Albagha OME, Prezelj J, et al. Tumour necrosis factor superfamily member 11 gene promoter polymorphisms modulate promoter activity and influence bone mineral density in postmenopausal women with osteoporosis. J Mol Endocrinol 2008;40:273–9.
   PubMed Web of Science ®Google Scholar
• Morrison N. a, Qi JC, Tokita a, et al. Prediction of bone density from vitamin D receptor alleles. Nature 1994;367:284–7.
   PubMed Web of Science ®Google Scholar
• Riggs LB, Nguyen TV, Melton JL, et al. The contribution of vitamin D receptor gene alleles to the determination of bone mineral density in normal and osteoporotic women. J Bone Miner Res 1995;10:991–6.
   PubMed Web of Science ®Google Scholar
• Chen H-Y, Chen W-C, Hsu C-D, et al. Relation of vitamin D receptor FokI start codon polymorphism to bone mineral density and occurrence of osteoporosis in postmenopausal women in Taiwan. Acta Obstet Gynecol Scand 2002;81:93–8.
   PubMed Web of Science ®Google Scholar
• Horst-Sikorska W, Kalak R, Wawrzyniak A, et al. Association analysis of the polymorphisms of the VDR gene with bone mineral density and the occurrence of fractures. J. Bone Miner. Metab 2007;25:310–9.
   PubMed Web of Science ®Google Scholar
• Oei L, Estrada K, Duncan EL, et al. Genome-wide association study for radiographic vertebral fractures: a potential role for the 16q24 bmd locus versus lessons learned from challenging phenotype definition. Bone 2013;59:20–7.
   Web of Science ®Google Scholar
• Estrada K, Styrkarsdottir U, Evangelou E, et al. Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture. Nat Genet 2012;44:491–501.
   PubMed Web of Science ®Google Scholar
• Karasik D, Rivadeneira F, Johnson ML. The genetics of bone mass and susceptibility to bone diseases. Nat Rev Rheumatol 2016;12:496.
   PubMed Web of Science ®Google Scholar
• Harlow SD, Crawford S, Dennerstein L, et al. Recommendations from a multi-study evaluation of proposed criteria for staging reproductive aging. Climacteric 2007;10:112–19.
   PubMed Web of Science ®Google Scholar
• Cervellati C, Pansini FS, Bonaccorsi G, et al. Body mass index is a major determinant of abdominal fat accumulation in pre-, peri- and post-menopausal women. Gynecol Endocrinol 2009;25:413–17.
   PubMed Web of Science ®Google Scholar
• Lum A, Le Marchand L. A simple mouthwash method for obtaining genomic DNA in molecular epidemiological studies. Cancer Epidemiol Biomarkers Prev 1998;7:719–24.
   PubMed Web of Science ®Google Scholar
• Soufi M, Schoppet M, Sattler AM, et al. Osteoprotegerin gene polymorphisms in men with coronary artery disease. J Clin Endocrinol Metab 2004;89:3764–8.
   PubMed Web of Science ®Google Scholar
• Mencej S, Prezelj J, Kocijancic A, et al. Association of TNFSF11 gene promoter polymorphisms with bone mineral density in postmenopausal women. Maturitas 2006;55:219–26.
   PubMed Web of Science ®Google Scholar
• Bid HK, Konwar R, Aggarwal CG, et al. Vitamin D receptor (FokI, BsmI and TaqI) gene polymorphisms and type 2 diabetes mellitus: a North Indian study. Indian J Med Sci 2009;63:187–94.
   PubMedGoogle Scholar
• Sansoni V, Perego S, Colombini A, et al. Interplay between low plasma RANKL and VDR-FokI polymorphism in lumbar disc herniation independently from age, body mass, and environmental factors: a case-control study in the Italian population. Eur Spine J 2016;25:192–9.
   PubMed Web of Science ®Google Scholar
• Gennari L, Becherini L, Mansani R, et al. FokI polymorphism at translation initiation site of the vitamin D receptor gene predicts bone mineral density and vertebral fractures in postmenopausal Italian women. J Bone Miner Res 1999;14:1379–86.
   PubMed Web of Science ®Google Scholar
• Conti V, Russomanno G, Corbi G, et al. A polymorphism at the translation start site of the vitamin D receptor gene is associated with the response to anti-osteoporotic therapy in postmenopausal women from southern Italy. Int J Mol Sci 2015;16:5452–66.
   PubMed Web of Science ®Google Scholar