192
Views
24
CrossRef citations to date
0
Altmetric
VVA Ospemifene treatment and Overactive Bladder Symptoms improvement

Retrospective analysis in 46 women with vulvovaginal atrophy treated with ospemifene for 12 weeks: improvement in overactive bladder symptoms

, , , , , , , , , , , & show all
Pages 942-945 | Received 03 Mar 2017, Accepted 24 Apr 2017, Published online: 11 May 2017

References

  • Abdelbary AM, El-Dessoukey AA, Massoud AM, et al. Combined vaginal pelvic floor electrical stimulation (PFS) and local vaginal estrogen for treatment of overactive bladder (OAB) in perimenopausal females. Randomized Controlled Trial (RCT). Urology 2015;86:482–6
  • Robinson D, Cardozo L, Milsom I, et al. Oestrogens and overactive bladder. Neurourol Urodyn 2014;33:1086–91
  • Robinson D, Toozs-Hobson P, Cardozo L. The effect of hormones on the lower urinary tract. Menopause Int 2013;19:155
  • Lüthje P, Brauner H, Ramos N, et al. Estrogen supports urothelial defense mechanism. Sci Trans Med 2013;5:190ra80
  • Portman DJ, Gass ML. Vulvovaginal atrophy terminology consensus conference panel. Genitourinary syndrome of menopause: new terminology for vulvovaginal atrophy from the International Society for the Study of Women’s Sexual Health and The North American Menopause Society. Climacteric 2014;17:557–63
  • Palacios S, Mej A, Neyro JL. Treatment of the genitourinary syndrome of menopause. Climacteric 2015;8:23–9
  • Lethaby A, Ayeleke RO, Roberts H. Local oestrogen for vaginal atrophy in postmenopausal women. Cochrane Database Syst Rev 2016;8:CD001500
  • Nappi RE, Palacios S, Particco M, Panay N. Results of the European REVIVE (REal women’s VIew of treatment options for menopausal Vulvar/Vaginal changEs) survey. Maturitas 2015;81:106–83
  • Goldstein SR, Bachmann GA, Koninckx PR, et al. Ospemifene 12-month safety and efficacy in postmenopausal women with vulvar and vaginal atrophy. Climacteric 2014;17:173–82
  • Bondi C, Ferrero S, Scala C, et al. Pharmacokinetics, pharmacodynamics and clinical efficacy of ospemifene for the treatment of dyspareunia and genitourinary syndrome of menopause. Expert Opin Drug Metabol Toxicol 2016;12:1233–46
  • Visco AG, Wei JT, McClure LA, et al. Effects of examination technique modifications on pelvic organ prolapse quantification (POP-Q) results. Int Urogynecol J Pelvic Floor Dysfunct 2003;14:136–40
  • Schiavi MC, Perniola GD, Donato V. Severe pelvic organ prolapse treated by vaginal native tissue repair: long-term analysis of outcomes in 146 patients. Arch Gynecol Obstet 2017;295:917–22
  • Rachaneni S, McCooty S, Middleton LJ, et al. Bladder ultrasonography for diagnosing detrusor overactivity: test accuracy study and economic evaluation. Health Tecnol Assess 2016;20:1–150
  • Shumaker S, Wyman JP, Uebersax JS, et al. Health-related quality of life measures for women with urinary incontinence: the Incontinence Impact Questionnaire and the Urogenital Distress Inventory. Qual Life Res 1994;3:291–306
  • Coyne K, Schmier J, Hunt T, et al. Developing a specific HRQL instrument for overactive bladder. Value Health 2000;3:141
  • Bachman G. Urogenital ageing: an old problem newly recognized. Maturitas 1995;22:S1–5
  • Lucas MG, Bosch RJ, Burkhard FC, et al. EAU guidelines on assessment and nonsurgical management of urinary incontinence. Eur Urol 2012;62:1130–42
  • Andersson KE. Antimuscarinics for treatment of overactive bladder. Lancet Neurol 2004;3:46–53
  • Sexton CC, Notte SM, Maroulis C, et al. Persistence and adherence in the treatment of overactive bladder syndrome with anticholinergic therapy: a systematic review of the literature. Int J Clin Pract 2011;65:567–85
  • Lüthje P, Hirschberg A, Brauner A. Estrogenic action on innate defense mechanisms in the urinary tract. Maturitas 2013;77:32–6
  • Perino A, Calligaro A, Forlani F, et al. Vulvo-vaginal atrophy: a new treatment modality using thermo-ablative fractional CO2 laser. Maturitas 2015;80:296–301
  • Zerbinati N, Serati M, Origoni M, et al. Microscopic and ultrastructural modifications of postmenopausal atrophic vaginal mucosa after fractional carbon dioxide laser treatment. Laser Med Sci 2015;30:429–36
  • Salvatore S, Nappi RE, Zerbinati N, et al. A 12-week treatment with fractional CO2 laser for vulvovaginal atrophy: a pilot study. Climacteric 2014;17:363–9
  • Bachmann GA, Komi JO. The Ospemifene Study Group. Ospemifene effectively treats vulvovaginal atrophy in postmenopausal women: results from a pivotal phase 3 study. Menopause 2010;17:480–6
  • Portman DJ, Bachmann GA, Simon JA. The Ospemifene Study Group. Ospemifene, a novel selective estrogen receptor modulator for treating dyspareunia associated with postmenopausal vulvar and vaginal atrophy. Menopause 2013;20:623–30
  • Portman D, Palacios S, Nappi RE, Mueck AO. Ospemifene, a non-oestrogen selective oestrogen receptor modulator for the treatment of vaginal dryness associated with postmenopausal vulvar and vaginal atrophy: a randomised, placebo-controlled, phase III trial. Maturitas 2014;78:91–8
  • David FA, Carr BR, Pinkerton JV, et al. Effects of ospemifene on the female reproductive and urinary tracts: translation from preclinical models into clinical evidence. Menopause 2015;22:786–96
  • Constantine G, Graham S, Portman DJ, et al. Female sexual function improved with ospemifene in postmenopausal women with vulvar and vaginal atrophy: results of a randomized, placebo-controlled trial. Climacteric 2015;18:226–32
  • Oelke M, Khullar V, Wijkstra H. Review on ultrasound measurement of bladder or detrusor wall thickness in women: techniques, diagnostic utility, and use in clinical trials. World J Urol 2013;31:1093–104
  • Taras TL, Wurz GT, DeGregorio MW. In vitro and in vivo biologic effects of ospemifene (FC-1271a) in breast cancer. J Steroid Biochem Mol Biol 2001;77:271–9
  • Lüthje P, Hirschbergb AL, Brauner A. Estrogenic action on innate defense mechanisms in the urinary tract. Maturitas 2014;77:32–6

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.