Efficacy of dehydroepiandrosterone (DHEA) supplementation for in vitro fertilization and embryo transfer cycles: a systematic review and meta-analysis

References

• Cabry R, Merviel P, Hazout A, et al. Management of infertility in women over 40. Maturitas 2014;78:17–21.
   PubMed Web of Science ®Google Scholar
• Inhorn MC, Patrizio P. Infertility around the globe: new thinking on gender, reproductive technologies and global movements in the 21st century. Hum Reprod Update 2015;21:411–26.
   PubMed Web of Science ®Google Scholar
• Castillo J, Estanyol JM, Ballescà JL, Oliva R. Human sperm chromatin epigenetic potential: genomics, proteomics, and male infertility. Asian J Androl 2015;17:601.
   PubMed Web of Science ®Google Scholar
• Hansen KR, He ALW, Styer AK, et al. Predictors of pregnancy and live-birth in couples with unexplained infertility after ovarian stimulation–intrauterine insemination. Fertil Steril. 2016;105:1575–83.
   PubMed Web of Science ®Google Scholar
• Artini PG, Obino MER, Carletti E, et al. Conventional IVF as a laboratory strategy to rescue fertility potential in severe poor responder patients: the impact of reproductive aging. Gynecol Endocrinol 2013;29:997–1001.
   PubMed Web of Science ®Google Scholar
• Ulug U, Ben-Shlomo I, Turan E, et al. Conception rates following assisted reproduction in poor responder patients: a retrospective study in 300 consecutive cycles. Reprod Biomed 2003;6:439–43.
   PubMedGoogle Scholar
• Frattarelli JL, Hill MJ, McWilliams GD, et al. A luteal estradiol protocol for expected poor-responders improves embryo number and quality. Fertil Steril 2008;89:1118–22.
   PubMed Web of Science ®Google Scholar
• Kailasam C, Keay S, Wilson P, et al. Defining poor ovarian response during IVF cycles, in women aged <40 years, and its relationship with treatment outcome. Hum Reprod 2004;19:1544–7.
   PubMed Web of Science ®Google Scholar
• Casson PR, Lindsay MS, Pisarska MD, et al. Dehydroepiandrosterone supplementation augments ovarian stimulation in poor responders: a case series. Hum Reprod 2000;15:2129–32.
   PubMed Web of Science ®Google Scholar
• Burger HG. Androgen production in women. Fertil Steril 2002;77:3–5.
   PubMed Web of Science ®Google Scholar
• Yakin K, Urman B. DHEA as a miracle drug in the treatment of poor responders; hype or hope?. Hum Reprod 2011;26:1941–4.
   PubMed Web of Science ®Google Scholar
• Mamas L, Mamas E. Dehydroepiandrosterone supplementation in assisted reproduction: rationale and results. Curr Opin Obstet Gynecol 2009;21:306–8.
   PubMed Web of Science ®Google Scholar
• Gleicher N, Weghofer A, Barad DH. Improvement in diminished ovarian reserve after dehydroepiandrosterone supplementation. Reprod Biomed Online 2010;21:360–5.
   PubMed Web of Science ®Google Scholar
• Brill H, Barad D, Gleicher N. O-289: Dehydroepiandrosterone (DHEA) supplementation and pregnancy outcome: effect on pregnancy rate and speed of conception. Fertil Steril 2006;86:S124–S5.
   PubMed Web of Science ®Google Scholar
• Tartagni M, De Pergola G, Damiani G, et al. Potential benefit of dehydroepiandrosterone supplementation for infertile but not poor responder patients in a IVF program. Minerva Ginecol 2015;67:7–12.
   PubMed Web of Science ®Google Scholar
• Fusi FM, Ferrario M, Bosisio C, et al. DHEA supplementation positively affects spontaneous pregnancies in women with diminished ovarian function. Gynecol Endocrinol 2013;29:940–3.
   PubMed Web of Science ®Google Scholar
• Kara M, Aydin T, Aran T, et al. Does dehydroepiandrosterone supplementation really affect IVF-ICSI outcome in women with poor ovarian reserve?. Eur J Obstet Gynecol Reprod Biol 2014;173:63–5.
   PubMed Web of Science ®Google Scholar
• Li J, Ren CE, Zhang A, et al. Effect of dehydroepiandrosterone (DHEA) supplementation on IVF-ET of patients with diminished ovarian reserve (DOR). J Liaoning Medical University 2014;35:51–3.
   Google Scholar
• Wiser A, Gonen O, Ghetler Y, et al. Addition of dehydroepiandrosterone (DHEA) for poor-responder patients before and during IVF treatment improves the pregnancy rate: a randomized prospective study. Hum Reprod 2010;25:2496–500.
   PubMed Web of Science ®Google Scholar
• Moher D, Liberati A, Tetzlaff J, Altman DG, Group P. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. BMJ 2009;339:b2535.
   PubMed Web of Science ®Google Scholar
• Higgins JPTGS. Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration. 2011. Available from www.cochrane-handbook.org.
   Google Scholar
• Jadad AR, Moore RA, Carroll D, et al. Assessing the quality of reports of randomized clinical trials: Is blinding necessary? Controlled Clin Trials 1996;17:1–12.
   PubMedGoogle Scholar
• Kjaergard LL, Villumsen J, Gluud C. Reported methodologic quality and discrepancies between large and small randomized trials in meta-analyses. Ann Intern Med 2001;135:982–9.
   PubMed Web of Science ®Google Scholar
• Tartagni M, Cicinelli MV, Baldini D, et al. Dehydroepiandrosterone decreases the age-related decline of the in vitro fertilization outcome in women younger than 40 years old. Reprod Biol Endocrinol 2015;13:18.
   PubMed Web of Science ®Google Scholar
• An J, Wang Y, Ni Y-L, Chai S-M. Application of dehydroepiandrosterone (DHEA) supplementation in in vitro fertilization and embryo transfer cycles. Reprod Contracep 2013;2:006.
   Google Scholar
• Moawad A, Shaeer M. Long-term androgen priming by use of dehydroepiandrosterone (DHEA) improves IVF outcome in poor-responder patients. A randomized controlled study. Middle East Fertil Soc J 2012;17:268–74.
   Google Scholar
• Sonmezer M, Cil AP, Oktay K. Ongoing pregnancies from early retrieval of prematurely developing antral follicles after DHEA supplementation. Reprod Biomed Online 2009;19:816–19.
   PubMed Web of Science ®Google Scholar
• Barad D, Brill H, Gleicher N. Update on the use of dehydroepiandrosterone supplementation among women with diminished ovarian function. J Assist Reprod Genet 2007;24:629–34.
   PubMed Web of Science ®Google Scholar
• Barad D, Gleicher N. Effect of dehydroepiandrosterone on oocyte and embryo yields, embryo grade and cell number in IVF. Hum Reprod 2006;21:2845–9.
   PubMed Web of Science ®Google Scholar
• Casson PR, Santoro N, Elkind-Hirsch K, et al. Postmenopausal dehydroepiandrosterone administration increases free insulin-like growth factor-I and decreases high-density lipoprotein: a six-month trial. Fertil Steril 1998;70:107–10.
   PubMed Web of Science ®Google Scholar
• Narkwichean A, Maalouf W, Campbell BK, Jayaprakasan K. Efficacy of dehydroepiandrosterone to improve ovarian response in women with diminished ovarian reserve: a meta-analysis. Reprod Biol Endocrinol 2013;11:44.
   PubMed Web of Science ®Google Scholar