The relationship between IL-18 and atherosclerotic cardiovascular risk in Egyptian lean women with polycystic ovary syndrome

References

• Spritzer PM, Lecke SB, Satler F, Morsch DM. Adipose tissue dysfunction, adipokines, and low-grade chronic inflammation in polycystic ovary syndrome. Reproduction 2015;149:R219–27.
   PubMed Web of Science ®Google Scholar
• Rojas J, Chávez M, Olivar L, et al. Polycystic ovary syndrome, insulin resistance, and obesity: navigating the pathophysiologic labyrinth. Int J Reprod Med 2014;2014:719050.
   PubMedGoogle Scholar
• Parker J. Emerging concepts in the pathogenesis and treatment of polycystic ovary syndrome. ACNEM J 2015;34:12–17.
   Google Scholar
• De Leo V, Musacchio MC, Cappelli V, et al. Genetic, hormonal and metabolic aspects of PCOS: an update. Reprod Biol Endocrinol 2016;14:38.
   PubMed Web of Science ®Google Scholar
• Baldani DP, Skrgatic L, Ougouag R. Polycystic ovary syndrome: important underrecognised cardiometabolic risk factor in reproductive-age women. Int J Endocrinol 2015;2015:786362.
   PubMed Web of Science ®Google Scholar
• Escobar-Morreale HF, Luque-Ramírez M, González F. Circulating inflammatory markers in polycystic ovary syndrome: a systematic review and metaanalysis. Fertil Steril 2011;95:1048–58.e1–2.
   PubMed Web of Science ®Google Scholar
• Marino JS, Iler J, Dowling AR, et al. Adipocyte dysfunction in a mouse model of polycystic ovary syndrome (PCOS): evidence of adipocyte hypertrophy and tissue-specific inflammation. PLoS One 2012;7:e48643.
   PubMed Web of Science ®Google Scholar
• Blankenberg S, Tiret L, Bickel C, et al. Interleukin-18 is a strong predictor of cardiovascular death in stable and unstable angina. Circulation 2002;106:24–30.
   PubMed Web of Science ®Google Scholar
• Hong L, Zhangb Y, Wangc Q, et al. Effects of interleukin 6 and tumor necrosis factor-α on the proliferation of porcine theca interna cells: possible role of these cytokines in the pathogenesis of polycystic ovary syndrome. Taiwan J Obstet Gynecol 2016;55:183–7.
   PubMed Web of Science ®Google Scholar
• Kahn HS, Valdez R. Metabolic risks identified by the combination of enlarged waist and elevated triacylglycerol concentration. Am J Clin Nutr 2003;78:928–34.
   PubMed Web of Science ®Google Scholar
• Lee H, Oh JY, Sung YA. Adipokines, insulin-like growth factor binding protein-3 levels, and insulin sensitivity in women with polycystic ovary syndrome. Korean J Intern Med 2013;28:456–63.
   PubMed Web of Science ®Google Scholar
• Hillman JK, Johnson LN, Limaye M, et al. Black women with polycystic ovary syndrome (PCOS) have increased risk for metabolic syndrome and cardiovascular disease compared with white women with PCOS. Fertil Steril 2014;101:530–5.
   PubMed Web of Science ®Google Scholar
• Yang Y, Qiao J, Li R, Li M. Is interleukin-18 associated with polycystic ovary syndrome? Reprod Biol Endocrinol 2011;9:7.
   PubMed Web of Science ®Google Scholar
• Lindholm Å, Blomquist C, Bixo M, et al. No difference in markers of adipose tissue inflammation between overweight women with polycystic ovary syndrome and weight-matched controls. Hum Reprod 2011;26:1478–85.
   PubMed Web of Science ®Google Scholar
• Nascimento JX, Chein MB, de Sousa RM, et al. Importance of lipid accumulation product index as a marker of CVD risk in PCOS women. Lipids Health Dis 2015;14:62.
   PubMed Web of Science ®Google Scholar
• Ojeda-Ojeda M, Murri M, Insenser M, Escobar-Morreale HF. Mediators of low-grade chronic inflammation in polycystic ovary syndrome (PCOS). Curr Pharm Des 2013;19:5775–91.
   PubMed Web of Science ®Google Scholar
• Samy N, Hashim M, Sayed M, Said M. Clinical significance of inflammatory markers in polycystic ovary syndrome: their relationship to insulin resistance and body mass index. Dis Markers 2009;26:163–70.
   PubMed Web of Science ®Google Scholar
• Badimon L. Interleukin-18: a potent pro-inflammatory cytokine in atherosclerosis. Cardiovasc Res 2012;96:172–5.
   PubMed Web of Science ®Google Scholar
• Escobar-Morreale HF, Villuendas G, Botella-Carretero JI, et al. Obesity, and not insulin resistance, is the major determinant of serum inflammatory cardiovascular risk markers in pre-menopausal women. Diabetologia 2003;46:625–33.
   PubMed Web of Science ®Google Scholar
• Kretowski A, Kinalska I. Serum levels of interleukin-18 – a potential marker of cardiovascular death – could be determined by genetic predisposition. Circulation 2003;107:e206–7.
   PubMed Web of Science ®Google Scholar
• Whitman SC, Ravisankar P, Daugherty A. Interleukin-18 enhances atherosclerosis in apolipoprotein E(-/-) mice through release of interferon-gamma. Circ Res 2002;90:E34–8.
   PubMed Web of Science ®Google Scholar
• Elhage R, Jawien J, Rudling M, et al. Reduced atherosclerosis in interleukin-18 deficient apolipoprotein E-knockout mice. Cardiovasc Res 2003;59:234–40.
   PubMed Web of Science ®Google Scholar
• Dhawan V, Mahajan N, Jain S. Role of C-C chemokines in Takayasu’s arteritis disease. Int J Cardiol 2006;112:105–11.
   PubMed Web of Science ®Google Scholar
• Morel JC, Park CC, Woods JM, Koch AE. A novel role for interleukin-18 in adhesion molecule induction through NF kappa B and phosphatidylinositol (PI) 3-kinase-dependent signal transduction pathways. J Biol Chem 2001;276:37069–75.
   PubMed Web of Science ®Google Scholar
• Joosten LA, van De Loo FA, Lubberts E, et al. An IFN-gamma independent pro-inflammatory role of IL-18 in murine streptococcal cell wall arthritis. J Immunol 2000;165:6553–8.
   PubMed Web of Science ®Google Scholar
• Raeburn CD, Dinarello CA, Zimmerman MA, et al. Neutralization of IL-18 attenuates lipopolysaccharide-induced myocardial dysfunction. Am J Physiol Heart Circ Physiol 2002;283:H650–7.
   PubMed Web of Science ®Google Scholar
• Platis A, Yu Q, Moore D, et al. The effect of daily administration of IL-18 on cardiac structure and function. Perfusion 2008;23:237–42.
   PubMed Web of Science ®Google Scholar
• Pigarevskii PV, Maltseva SV, Snegova VA, Davydova NG. Role of interleukin-18 in destabilization of the atherosclerotic plaque in humans. Bull Exp Biol Med 2014;157:821–4.
   PubMed Web of Science ®Google Scholar
• Mallat Z, Heymes C, Corbaz A, et al. Evidence for altered interleukin 18 (IL)-18 pathway in human heart failure. FASEB J 2004;18:1752–4.
   PubMed Web of Science ®Google Scholar