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Gynecological Endocrinology Volume 35, 2019 - Issue 8
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ANDROGENS IN AUTOPHAGY OF PCOS GRANULOSA CELLS

The role of androgen in autophagy of granulosa cells from PCOS

Xiaoxue LiCenter for Reproductive Medicine, School of Medicine, Renji Hospital, Shanghai Jiao Tong University, Shanghai, PR China; ;Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai, PR ChinaView further author information
,
Jia QiCenter for Reproductive Medicine, School of Medicine, Renji Hospital, Shanghai Jiao Tong University, Shanghai, PR China; ;Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai, PR ChinaView further author information
,
Qinling ZhuCenter for Reproductive Medicine, School of Medicine, Renji Hospital, Shanghai Jiao Tong University, Shanghai, PR China; ;Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai, PR ChinaView further author information
,
Yaqiong HeCenter for Reproductive Medicine, School of Medicine, Renji Hospital, Shanghai Jiao Tong University, Shanghai, PR China; ;Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai, PR ChinaView further author information
,
Yuan WangCenter for Reproductive Medicine, School of Medicine, Renji Hospital, Shanghai Jiao Tong University, Shanghai, PR China; ;Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai, PR ChinaView further author information
,
Yao LuCenter for Reproductive Medicine, School of Medicine, Renji Hospital, Shanghai Jiao Tong University, Shanghai, PR China; ;Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai, PR ChinaView further author information
,
Hasiximuke WuCenter for Reproductive Medicine, School of Medicine, Renji Hospital, Shanghai Jiao Tong University, Shanghai, PR China; ;Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai, PR ChinaView further author information
&
Yun SunCenter for Reproductive Medicine, School of Medicine, Renji Hospital, Shanghai Jiao Tong University, Shanghai, PR China; ;Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai, PR ChinaCorrespondence[email protected]
View further author information
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Pages 669-672 | Received 26 Jan 2018, Accepted 22 Oct 2018, Published online: 06 May 2019

References

  • Franks S. Polycystic ovary syndrome. N Engl J Med. 1995;333:853–861.
  • Shi Y, Zhao H, Shi Y, et al. Genome-wide association study identifies eight new risk loci for polycystic ovary syndrome. Nat Genet. 2012;44:1020–1025.
  • Diamanti-Kandarakis E, Dunaif A. Insulin resistance and the polycystic ovary syndrome revisited: an update on mechanisms and implications. Endocr Rev. 2012;33:981–1030.
  • Ji SY, Liu XM, Li BT, et al. The polycystic ovary syndrome-associated gene Yap1 is regulated by gonadotropins and sex steroid hormones in hyperandrogenism-induced oligo-ovulation in mouse. Mol Hum Reprod. 2017;23:698–707.
  • Kanninen TT, de Andrade Ramos BR, Witkin SS. The role of autophagy in reproduction from gametogenesis to parturition. Eur J Obstet Gynecol Reprod Biol. 2013;171:3–8.
  • Choi JY, Jo MW, Lee EY, et al. The role of autophagy in follicular development and atresia in rat granulosa cells. Fertil Steril. 2010;93:2532–2537.
  • Li D, You Y, Bi FF, et al. Autophagy is activated in the ovarian tissue of polycystic ovary syndrome. Reproduction. 2018;155:85–92.
  • Choi J, Jo M, Lee E, et al. Induction of apoptotic cell death via accumulation of autophagosomes in rat granulosa cells. Fertil Steril. 2011;95:1482–1486.
  • Bas D, Abramovich D, Hernandez F, et al. Altered expression of Bcl-2 and Bax in follicles within dehydroepiandrosterone-induced polycystic ovaries in rats. Cell Biol Int. 2011;35:423–429.
  • Anderson E, Lee GY. The polycystic ovarian (PCO) condition: apoptosis and epithelialization of the ovarian antral follicles are aspects of cystogenesis in the dehydroepiandrosterone (DHEA)-treated rat model. Tissue Cell. 1997;29:171–189.
  • Maixner N, Bechor S, Vershinin Z, et al. Transcriptional dysregulation of adipose tissue autophagy in obesity. Physiology (Bethesda). 2016;31:270–282.
  • Kang YH, Cho MH, Kim JY, et al. Impaired macrophage autophagy induces systemic insulin resistance in obesity. Oncotarget. 2016;7:35577–35591.
  • Shi Y, Han JJ, Tennakoon JB, et al. Androgens promote prostate cancer cell growth through induction of autophagy. Mol Endocrinol. 2013;27:280–295.
  • Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil Steril. 2004;81:19–25.
  • Dang X, Zhu Q, He Y, et al. IL-1beta upregulates StAR and progesterone production through the ERK1/2- and p38-mediated CREB signaling pathways in human granulosa-lutein cells. Endocrinology. 2017;158:3281–3291.
  • Komatsu M, Ichimura Y. Physiological significance of selective degradation of p62 by autophagy. FEBS Lett. 2010;584:1374–1378.
  • Sumarac-Dumanovic M, Apostolovic M, Janjetovic K, et al. Downregulation of autophagy gene expression in endometria from women with polycystic ovary syndrome. Mol Cell Endocrinol. 2017;440:116–124.
  • Manneras L, Cajander S, Holmang A, et al. A new rat model exhibiting both ovarian and metabolic characteristics of polycystic ovary syndrome. Endocrinology. 2007;148:3781–3791.
  • Johansson J, Feng Y, Shao R, et al. Intense electroacupuncture normalizes insulin sensitivity, increases muscle GLUT4 content, and improves lipid profile in a rat model of polycystic ovary syndrome. Am J Physiol Endocrinol Metab. 2010;299:E551–E559.
  • Blessing AM, Rajapakshe K, Reddy Bollu L, et al. Transcriptional regulation of core autophagy and lysosomal genes by the androgen receptor promotes prostate cancer progression. Autophagy. 2017;13:506–521.
  • Mei Y, Glover K, Su M, et al. Conformational flexibility of BECN1: essential to its key role in autophagy and beyond. Protein Sci. 2016;25:1767–1785.

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