The modulating effects of Resveratrol on the expression of MMP-2 and MMP-9 in endometriosis women: a randomized exploratory trial

References

• Haas D, Chvatal R, Reichert B, et al. Endometriosis: a premenopausal disease? Age pattern in 42,079 patients with endometriosis. Arch Gynecol Obstet. 2012;286:667–670.
   PubMed Web of Science ®Google Scholar
• Vercellini P, Viganò P, Somigliana E, et al. Endometriosis: pathogenesis and treatment. Nat Rev Endocrinol. 2014;10:261.
   PubMed Web of Science ®Google Scholar
• Laganà AS, Vitale SG, Salmeri FM, et al. Unus pro omnibus, omnes pro uno: a novel, evidence-based, unifying theory for the pathogenesis of endometriosis. Med Hypotheses. 2017;103:10–20.
   PubMed Web of Science ®Google Scholar
• Vetvicka V, Lagana AS, Salmeri FM, et al. Regulation of apoptotic pathways during endometriosis: from the molecular basis to the future perspectives. Arch Gynecol Obstet. 2016;294:897–904.
   PubMed Web of Science ®Google Scholar
• Sofo V, Götte M, Laganà AS, et al. Correlation between dioxin and endometriosis: an epigenetic route to unravel the pathogenesis of the disease. Arch Gynecol Obstet. 2015;292:973–986.
   PubMed Web of Science ®Google Scholar
• Simon C, Gimeno MJ, Mercader A, et al. Cytokines-adhesion molecules-invasive proteinases. The missing paracrine/autocrine link in embryonic implantation. Mol Hum Reprod. 1996;2:405–424.
   PubMedGoogle Scholar
• Macer ML, Taylor HS. Endometriosis and infertility: a review of the pathogenesis and treatment of endometriosis-associated infertility. Obstet Gynecol Clin. 2012;39:535–549.
   PubMed Web of Science ®Google Scholar
• Collette T, Maheux R, Mailloux J, et al. Increased expression of matrix metalloproteinase-9 in the eutopic endometrial tissue of women with endometriosis. Hum Reprod. 2006;21:3059–3067.
   PubMed Web of Science ®Google Scholar
• Szymanowski K, Mikołajczyk M, Wirstlein P, et al. Matrix metalloproteinase-2 (MMP-2), MMP-9, tissue inhibitor of matrix metalloproteinases (TIMP-1) and transforming growth factor-β2 (TGF-β2) expression in eutopic endometrium of women with peritoneal endometriosis. Ann Agric Environ Med. 2016;23:649–653.
   PubMed Web of Science ®Google Scholar
• Chen Y, Tseng S-H. Review. Pro- and anti-angiogenesis effects of resveratrol . In Vivo. 2007;21:365–370.
   PubMed Web of Science ®Google Scholar
• Athar M, Back JH, Kopelovich L, et al. Multiple molecular targets of resveratrol: anti-carcinogenic mechanisms. Arch Biochem Biophys. 2009;486:95–102.
   PubMed Web of Science ®Google Scholar
• Yavuz S, Aydin NE, Celik O, et al. Resveratrol successfully treats experimental endometriosis through modulation of oxidative stress and lipid peroxidation. J Can Res Ther. 2014;10:324.
   PubMed Web of Science ®Google Scholar
• Taguchi A, Koga K, Kawana K, et al. Resveratrol enhances apoptosis in endometriotic stromal cells. Am J Reprod Immunol. 2016;75:486–492.
   PubMed Web of Science ®Google Scholar
• Kaneko H, Anzai T, Morisawa M, et al. Resveratrol prevents the development of abdominal aortic aneurysm through attenuation of inflammation, oxidative stress, and neovascularization. Atherosclerosis. 2011;217:350–357.
   PubMed Web of Science ®Google Scholar
• Ganapathy S, Chen Q, Singh KP, et al. Resveratrol enhances antitumor activity of TRAIL in prostate cancer xenografts through activation of FOXO transcription factor. PLoS One. 2010;5:e15627.
   PubMed Web of Science ®Google Scholar
• St-Pierre Y, Couillard J, Van Themsche C. Regulation of MMP-9 gene expression for the development of novel molecular targets against cancer and inflammatory diseases. Expert Opin Ther Targets. 2004;8:473–489.
   PubMed Web of Science ®Google Scholar
• Noyes RW, Hertig AT, Rock J. Dating the endometrial biopsy. Am J Obstet Gynecol. 1975;122:262–263.
   PubMedGoogle Scholar
• Rahmioglu N, Fassbender A, Vitonis AF, et al. World Endometriosis Research Foundation endometriosis phenome and biobanking harmonization project: III. Fluid biospecimen collection, processing, and storage in endometriosis research. Fertil Steril. 2014;102:1233–1243.
   PubMed Web of Science ®Google Scholar
• Fassbender A, Rahmioglu N, Vitonis AF, et al. World endometriosis research foundation endometriosis phenome and biobanking harmonisation project: IV. Tissue collection, processing, and storage in endometriosis research. Fertil Steril. 2014;102:1244–1253.
   PubMed Web of Science ®Google Scholar
• Boomsma C, Kavelaars A, Eijkemans M, et al. Cytokine profiling in endometrial secretions: a non-invasive window on endometrial receptivity. Reprod Biomed Online. 2009;18:85–94.
   PubMed Web of Science ®Google Scholar
• Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 2001;25:402–408.
   PubMed Web of Science ®Google Scholar
• Chen Q, Jin M, Yang F, et al. Matrix metalloproteinases: inflammatory regulators of cell behaviors in vascular formation and remodeling. Mediators Inflamm. 2013;2013:1.
   Web of Science ®Google Scholar
• Hull ML, Escareno CR, Godsland JM, et al. Endometrial-peritoneal interactions during endometriotic lesion establishment. Am J Pathol. 2008;173:700–715.
   PubMed Web of Science ®Google Scholar
• Caley MP, Martins VL, O'Toole EA. Metalloproteinases and wound healing. Adv Wound Care (New Rochelle). 2015;4:225–234.
   PubMed Web of Science ®Google Scholar
• Russo LA, Peano BJ, Trivedi SP, et al. Regulated expression of matrix metalloproteinases, inflammatory mediators, and endometrial matrix remodeling by 17beta-estradiol in the immature rat uterus. Reprod Biol Endocrinol. 2009;7:124.
   PubMedGoogle Scholar
• Bałkowiec M, Maksym RB, Włodarski PK. The bimodal role of matrix metalloproteinases and their inhibitors in etiology and pathogenesis of endometriosis (Review). Mol Med Rep. 2018;18:3123–3136.
   PubMed Web of Science ®Google Scholar
• Vitale SG, Capriglione S, Peterlunger I, et al. The role of oxidative stress and membrane transport systems during endometriosis: a fresh look at a busy corner. Oxid Med Cell Longev. 2018;2018:1.
   Web of Science ®Google Scholar
• Huang H-F, Hong L-H, Tan Y, et al. Matrix metalloproteinase 2 is associated with changes in steroid hormones in the sera and peritoneal fluid of patients with endometriosis. Fertil Steril. 2004;81:1235–1239.
   PubMed Web of Science ®Google Scholar
• Tang L, Xiang Y, Zhou Y, et al. The DNA methylation status of genes encoding matrix metalloproteinases and tissue inhibitors of Matrix metalloproteinases in endometriosis. Mol Reprod Dev. 2018;85:17–25.
   PubMed Web of Science ®Google Scholar
• Salata IM, Stojanovic N, Cajdler-Łuba A, et al. Gelatinase A (MM-2), gelatinase B (MMP-9) and their inhibitors (TIMP 1, TIMP-2) in serum of women with endometriosis: significant correlation between MMP-2, MMP-9 and their inhibitors without difference in levels of matrix metalloproteinases and tissue inhibitors of metalloproteinases in relation to the severity of endometriosis. Gynecol Endocrinol. 2008;24:326–330.
   PubMed Web of Science ®Google Scholar
• Bruner KL, Matrisian LM, Rodgers WH, et al. Suppression of matrix metalloproteinases inhibits establishment of ectopic lesions by human endometrium in nude mice. J Clin Invest. 1997;99:2851–2857.
   PubMed Web of Science ®Google Scholar
• Jana S, Chatterjee K, Ray AK, et al. Regulation of matrix metalloproteinase-2 activity by COX-2-PGE2-pAKT axis promotes angiogenesis in endometriosis. PLoS One. 2016;11:e0163540.
   PubMed Web of Science ®Google Scholar
• Yar A, Menevse S, Alp E. The effects of resveratrol on cyclooxygenase-1 and-2, nuclear factor kappa beta, matrix metalloproteinase-9, and sirtuin 1 mRNA expression in hearts of streptozotocin-induced diabetic rats. Genet Mol Res. 2011;10:2962–2975.
   PubMed Web of Science ®Google Scholar
• Liu PL, Tsai JR, Charles AL, et al. Resveratrol inhibits human lung adenocarcinoma cell metastasis by suppressing heme oxygenase 1‐mediated nuclear factor‐κB pathway and subsequently downregulating expression of matrix metalloproteinases. Mol Nutr Food Res. 2010;54:S196–S204.
   PubMed Web of Science ®Google Scholar
• Kumar A, Sharma SS. NF-kappaB inhibitory action of resveratrol: a probable mechanism of neuroprotection in experimental diabetic neuropathy. Biochem Biophys Res Commun. 2010;394:360–365.
   PubMed Web of Science ®Google Scholar
• Celik O, Celik E, Turkcuoglu I, et al. Surgical removal of endometrioma decreases the NF-kB1 (p50/105) and NF-kB p65 (Rel A) expression in the eutopic endometrium during the implantation window. Reprod Sci. 2013;20:762–770.
   PubMed Web of Science ®Google Scholar
• Tekin YB, Guven S, Kirbas A, et al. Is resveratrol a potential substitute for leuprolide acetate in experimental endometriosis? Eur J Obstet Gynecol Reprod Biol. 2015;184:1–6.
   PubMed Web of Science ®Google Scholar
• Samadi AK, Bilsland A, Georgakilas AG, editors., et al. A multi-targeted approach to suppress tumor-promoting inflammation. Seminars in Cancer Biology. New York: Elsevier; 2015.
   Google Scholar
• Cohen M, Meisser A, Haenggeli L, et al. Involvement of MAPK pathway in TNF-α-induced MMP-9 expression in human trophoblastic cells. MHR: Basic Sci Reprod Med. 2006;12:225–232.
   Google Scholar
• Bedaiwy MA, Falcone T, Sharma R, et al. Prediction of endometriosis with serum and peritoneal fluid markers: a prospective controlled trial. Hum Reprod. 2002;17:426–431.
   PubMed Web of Science ®Google Scholar
• Yu H, Pan C, Zhao S, et al. Resveratrol inhibits tumor necrosis factor-alpha-mediated matrix metalloproteinase-9 expression and invasion of human hepatocellular carcinoma cells. Biomed Pharmacother. 2008;62:366–372.
   PubMed Web of Science ®Google Scholar
• Kim JE, Kim HS, Shin Y-J, et al. LYR71, a derivative of trimeric resveratrol, inhibits tumorigenesis by blocking STAT3-mediated matrix metalloproteinase 9 expression. Exp Mol Med. 2008;40:514.
   PubMed Web of Science ®Google Scholar
• Xie D, Zheng G-Z, Xie P, et al. Antitumor activity of resveratrol against human osteosarcoma cells: a key role of Cx43 and Wnt/β-catenin signaling pathway. Oncotarget. 2017;8:111419.
   PubMedGoogle Scholar
• Pazhohan A, Amidi F, Akbari-Asbagh F, et al. The Wnt/β-catenin signaling in endometriosis, the expression of total and active forms of β-catenin, total and inactive forms of glycogen synthase kinase-3β, WNT7a and DICKKOPF-1. Eur J Obstet Gynecol Reprod Biol. 2018;220:1–5.
   PubMed Web of Science ®Google Scholar
• Liu H, Wang J, Wang H, et al. Correlation between matrix metalloproteinase-9 and endometriosis. Int J Clin Exp Pathol. 2015;8:13399.
   PubMed Web of Science ®Google Scholar
• Somigliana E, Vercellini P, Vigano P, et al. Should endometriomas be treated before IVF–ICSI cycles? Hum Reprod Update. 2006;12:57–64.
   PubMed Web of Science ®Google Scholar
• Alborzi S, Momtahan M, Parsanezhad ME, et al. A prospective, randomized study comparing laparoscopic ovarian cystectomy versus fenestration and coagulation in patients with endometriomas. Fertil Steril. 2004;82:1633–1637.
   PubMed Web of Science ®Google Scholar
• Loo T-C, Lin MY-S, Chen S-H, et al. Endometrioma undergoing laparoscopic ovarian cystectomy: its influence on the outcome of in vitro fertilization and embryo transfer (IVF–ET). J Assist Reprod Genet. 2005;22:329–333.
   PubMed Web of Science ®Google Scholar