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Gynecological Endocrinology Volume 35, 2019 - Issue 8
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OPTIMAL TIMING OF EMBRYO TRANSFER FOR EMBRYOS AT CLEAVAGE STAGE

What is the optimal timing of embryo transfer when there are only one or two embryos at cleavage stage?

Jigal HaasTRIO Fertility Partners, Division of Reproductive Sciences, University of Toronto, Toronto, CanadaCorrespondence[email protected]
,
Jim MerianoTRIO Fertility Partners, Division of Reproductive Sciences, University of Toronto, Toronto, Canada
,
Rawad BassilTRIO Fertility Partners, Division of Reproductive Sciences, University of Toronto, Toronto, Canada
,
Eran BarzilayTRIO Fertility Partners, Division of Reproductive Sciences, University of Toronto, Toronto, CanadaORCID Iconhttp://orcid.org/0000-0001-5496-4866
ORCID Icon &
Robert F CasperTRIO Fertility Partners, Division of Reproductive Sciences, University of Toronto, Toronto, Canada
Pages 665-668 | Received 15 Sep 2018, Accepted 05 Feb 2019, Published online: 26 Feb 2019

References

  • Glujovsky D, Farquhar C, Quinteiro Retamar AM, et al. Cleavage stage versus blastocyst stage embryo transfer in assisted reproductive technology. Cochrane Database Syst Rev. 2016;CD002118.
  • Martins WP, Nastri CO, Rienzi L, et al. Blastocyst versus cleavage stage embryo transfer: a systematic review and meta-analysis of the reproductive outcomes. Ultrasound Obstet Gynecol. 2017;49:583–591.
  • De Vos A, Van Landuyt L, Santos-Ribeiro S, et al. Cumulative live birth rates after fresh and vitrified cleavage-stage versus blastocyst-stage embryo transfer in the first treatment cycle. Hum Reprod. 2016;31:2442–2449.
  • Racowsky C, Jackson KV, Cekleniak NA, et al. The number of eight-cell embryos is a key determinant for selecting day 3 or day 5 transfer. Fertil Steril. 2000;73:558–564.
  • Scott RT, Upham KM, Forman EJ, Jr, et al. Cleavage-stage biopsy significantly impairs human embryonic implantation potential while blastocyst biopsy does not: a randomized and paired clinical trial. Fertil Steril. 2013;100:624–630.
  • Dar S, Lazer T, Shah PS, et al. Neonatal outcomes among singleton births after blastocyst versus cleavage stage embryo transfer: a systematic review and meta-analysis. Hum Reprod Update. 2014;20:439–48.
  • Dar S, Librach CL, Gunby J, et al. Increased risk of preterm birth in singleton pregnancies after blastocyst versus Day 3 embryo transfer: Canadian ART Register (CARTR) analysis. Hum Reprod. 2013;28:924–928.
  • Ginstrom Ernstad E, Bergh C, Khatibi A, et al. Neonatal and maternal outcome after blastocyst transfer: a population-based registry study. Am J Obstet Gynecol. 2016;214:378e1–378e10.

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