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Gynecological Endocrinology Volume 36, 2020 - Issue 2
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Vitamin D Supplementation in Patients at Risk for Fractures and Falls

Is vitamin-D supplementation not useful in patients at risk of fractures and falls?

Javier Aguilar del ReyServicio de Reumatología, Hospital Clínico Virgen de la Victoria, Málaga, Spain;
,
Esteban Jódar GimenoServicio de Endocrinología, Hospital Universitario Quironsalud, Madrid, Spain;
,
Fátima Brañas BaztánSección de Geriatría, Hospital Universitario Infanta Leonor, Madrid, Spain;
,
Carlos Gómez AlonsoServicio de Metabolismo Óseo y Mineral, Hospital Universitario Central de Asturias, Oviedo, Spain;
,
Yago González LamaServicio de Gastroenterología y Hepatología, Hospital Universitario Puerta de Hierro, Madrid, Spain;
,
Jorge Malouf SierraDepartamento de Medicina Interna, Unidad de Metabolismo Mineral, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain;
,
Rafael Sánchez BorregoDIATROS, Clínica de Atención a la Mujer, Barcelona, Spain; Correspondence[email protected]
,
Julián Segura de la MorenaServicio de Nefrología, Hospital Universitario 12 de Octubre, Madrid, Spain;
,
Jorge Alonso Suárez PérezServicio de Dermatología, Hospital Universitario Virgen de la Victoria, Málaga, Spain;
&
Carmen Valdés y LlorcaMédico de Familia, Centro de Salud Fuencarral, SERMAS, Madrid, Spain
 show all
Pages 93-95 | Received 21 Jun 2019, Accepted 04 Jul 2019, Published online: 07 Aug 2019

References

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  • Lips P, Graafmans WC, Ooms ME, et al. Vitamin D supplementation and fracture incidence in elderly persons. A randomized, placebo-controlled clinical trial. Ann Intern Med. 1996;124:400–406.
  • Grossman DC, Curry SJ, Owens DK, et al. Vitamin D, calcium, or combined supplementation for the primary prevention of fractures in community-dwelling adults: US Preventive Services Task Force Recommendation Statement. JAMA. 2018;319:1592–1599.
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  • Grossman DC, Curry SJ, Owens DK, et al. Interventions to prevent falls in community-dwelling older adults: US Preventive Services Task Force Recommendation Statement. JAMA. 2018;319:1696–1704.
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  • International Osteoporosis Foundation. Positions and statements: don’t confuse vitamin D supplements with calcium AND vitamin D supplements; 2018 [cited 2019 Apr 11]. Available from: https://www.iofbonehealth.org/news/dont-confuse vitamin-d-supplements-calcium-and-vitamin-d-supplements
  • Gallagher JC. Vitamin D and bone density, fractures, and falls: the end of the story? Lancet Diabetes Endocrinol. 2018;6:834–835.
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  • Chiodini I, Gennari L. Falls, fractures and vitamin D: a never-ending story? Nat Rev Rheumatol. 2019;15:6–8.
  • Avenell A, Mak JC, O’Connell D. Vitamin D and vitamin D analogues for preventing fractures in post-menopausal women and older men. Cochrane Database Syst Rev. 2014;4:CD000227.
  • Bolland MJ, Grey A, Gamble GD, et al. Vitamin D supplementation and falls: a trial sequential meta-analysis. Lancet Diabetes Endocrinol. 2014;2:573–580.
  • Bolland MJ, Grey A. A case study of discordant overlapping meta-analyses: vitamin D supplements and fracture. PLoS One. 2014;9:e115934.
  • Murad MH, Elamin KB, Abu Elnour NO, et al. Clinical review: the effect of vitamin D on falls: a systematic review and meta-analysis. J Clin Endocrinol Metab. 2011;96:2997–3006.
  • Abrahamsen B, Masud T, Avenell A, et al. Patient level pooled analysis of 68,500 patients from seven major vitamin D fracture trials in US and Europe. BMJ. 2010;340:b5463.

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