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POLYCYSTIC OVARY SYNDROME

Fibroblast growth factor 23 and 25(OH)D levels are related to abdominal obesity and cardiovascular risk in patients with polycystic ovarian syndrome

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Pages 402-405 | Received 15 Feb 2019, Accepted 03 Nov 2019, Published online: 10 Nov 2019

References

  • Norman RJ, Davies MJ, Lord J, et al. The role of lifestyle modification in polycystic ovary syndrome. Trends Endocrinol Metab. 2002;13(6):251–257.
  • Yildiz BO, Knochenhauer ES, Azziz R. Impact of obesity on the risk for polycystic ovary syndrome. J ClinEndocrinolMetab. 2008;93(1):162–168.
  • Vigil P, Contreras P, Alvarado J, et al. Evidence of subpopulations with different levels of insulin resistance in women with polycystic ovary syndrome. Hum Reprod. 2007;22(11):2974–2980.
  • Escobar-Morreale H, San Millan J. Abdominal adiposity and the polycystic ovary syndrome. Trends Endocrinol Metabol. 2007;18(7):266–272.
  • Gambineri A, Pelusi C, Vicennati V, et al. Obesity and the polycystic ovary syndrome. Int J Obes. 2002;26(7):883–896.
  • Lord J, Thomas R, Fox B, et al. The central issue? Visceral fat mass is a good marker of insulin resistance and metabolic disturbance in women with polycystic ovary syndrome. BJOG. 2006;113(10):1203–1209.
  • Donate-Correa J, Muros-de-Fuentes M, Mora-Fernández C, et al. FGF23/Klotho axis: phosphorus, mineral metabolism and beyond. Cytokine Growth Factor Rev. 2012;23:37–46.
  • Kuro M. Endocrine FGFs and Klothos: emerging concepts. Trends Endocrinol Metab. 2008;19:239–245.
  • Kuro-O M, Matsumura Y, Aizawa H, et al. Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature. 1997;390(6655):45–51.
  • Kurosu H, Yamamoto M, Clark JD, et al. Suppression of aging in mice by the hormone Klotho. Science. 2005;309(5742):1829–1833.
  • Kuro M. Overview of the FGF23-Klotho axis. PediatrNephrol. 2010;25(4):583–590.
  • Urakawa I, Yamazaki Y, Shimada T, et al. Klotho converts canonical FGF receptor into a specific receptor for FGF23. Nature. 2006;444(7120):770–774.
  • Jing X, Li DQ, Olofsson CS, et al. Cav2.3 calcium channels control second-phase insulin release. J Clin Invest. 2005;115(1):146–154.
  • Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. FertilSteril. 2004;81(1):19–25.
  • Wild RA, Carmina E, Diamanti-Kandarakis E, et al. Assessment of cardiovascular risk and prevention of cardiovascular disease in women with the polycystic ovary syndrome: a consensus statement by the androgen excess and polycystic ovary syndrome (AE-PCOS) society. J ClinEndocrinolMetab. 2010;95(5):2038–2049.
  • Holick MF, Binkley NC, Bischoff-Ferrari HA, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an endocrine society clinical practice guideline. J ClinEndocrinol Metab. 2011;96(7):1911–1930.
  • Alberti KG, Eckel RH, Grundy SM, et al. International diabetes federation task force on epidemiology and prevention; Hational Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; International Association for the Study of Obesity. Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation. 2009;120(16):1640–1645.
  • Stöhr R, Schuh A, Heine GH, et al. FGF23 in cardiovascular disease: innocent bystander or active mediator? Front Endocrinol (Lausanne). 2018;9:351.
  • Zwakenberg SR, van der Schouw YT, Schalkwijk CG, et al. Bone markers and cardiovascular risk in type 2 diabetes patients. Cardiovasc Diabetol. 2018;17(1):45.
  • Quercioli A, Montecucco F, Bertolotto M, et al. Coronary artery calcification and cardiovascular risk: the role of RANKL/OPG signalling. Eur J Clin Invest. 2010;40(7):645–654.
  • Lu X, Hu MC. Klotho/FGF23 axis in chronic kidney disease and cardiovascular disease. Kidney Dis. 2017;3(1):15–23.
  • Elsheikh N, Sherif N, Zeid SA, et al. The link between bone disease and cardiovascular complications in hemodialysis patients. Electron Physician. 2016;8(6):2483–2488.
  • Kuro-O M. Klotho and endocrine fibroblast growth factors: marker of chronic kidney disease progression and cardiovascular complications? Nephrol Dial Transplant. 2019;34(1):15–21.
  • Parker BD, Schurgers LJ, Brandenburg VM, et al. The associations of fibroblast growth factor 23 and uncarboxylated matrix Gla protein with mortality in coronary artery disease: the heart and soul study. Ann Intern Med. 2010;152(10):640–648.
  • Brandenburg VM, Kleber ME, Vervloet MG, et al. Fibroblast growth factor 23 (FGF23) and mortality: the Ludwigshafen Risk and Cardiovascular Health Study. Atherosclerosis. 2014;237(1):53–59.
  • Souma N, Isakova T, Lipiszko D, et al. Fibroblast growth factor 23 and cause-specific mortality in the general population: the Northern Manhattan study. J ClinEndocrinol Metab. 2016;101(10):3779–3786.
  • Sit D, Tanrıverdi E, Kayabasi H, et al. Is FGF23 effective on insulin resistance in individuals with metabolic syndrome? Horm Mol BiolClin Investig. 2018;35(2).
  • Bär L, Feger M, Fajol A, et al. Insulin suppresses the production of fibroblast growth factor 23 (FGF23). Proc Natl Acad Sci USA. 2018;115(22):5804–5809.
  • Gateva A, Assyov Y, Tsakova A, et al. Prediabetes is characterized by higher FGF23 levels and higher prevalence of vitamin D deficiency compared to normal glucose tolerance subjects. Horm Metab Res. 2019;51(2):106–111.
  • Shaw LJ, Bairey Merz CN, Azziz R, et al. Postmenopausal women with a history of irregular menses and elevated androgen measurements at high risk for worsening cardiovascular event-free survival: results from the National Institutes of Health—National Heart, Lung, and Blood Institute Sponsored Women’s Ischemia Syndrome Evaluation. J Clin Endocrinol Metab. 2008;93:1276–1284.
  • Talbott E, Zborowski J, Rager J, et al. Is there an independent effect of polycystic ovary syndrome (PCOS) and menopause on the prevalence of subclinical atherosclerosis in middle aged women? VHRM. 2008;4(2):453–462.
  • Solomon CG, Hu FB, Dunaif A, et al. Menstrual cycle irregularity and risk for future cardiovascular disease. J Clin Endocrinol Metab. 2002;87(5):2013–2017.
  • Escobar-Morreale HF, Botella-Carretero JI, Martínez-García MA, et al. Serum osteoprotegerin concentrations are decreased in women with the polycystic ovary syndrome. Eur J Endocrinol. 2008;159(3):225–232.
  • Saklamaz A, Calan M, Yilmaz O, et al. Polycystic ovary syndrome is associated with increased osteopontin levels. Eur J Endocrinol. 2016;174(4):415–423.
  • Wang Y, Zhou W, Wu C, et al. Circulating osteopontin and its association with liver fat content in non-obese women with polycystic ovary syndrome: a case control study. Reprod Biol Endocrinol. 2018;16(1):31.
  • Kan K, Kızılgül M, Çulha C, et al. Fibroblast growth factor-23 concentrations in polycystic ovary syndrome. Turk J Biochem. 2018;43(1):83.
  • Marthi A, Donovan K, Haynes R, et al. Fibroblast growth factor-23 and risks of cardiovascular and noncardiovascular diseases: a meta-analysis. JASN. 2018;29(7):2015–2027.
  • Thomson RL, Spedding S, Buckley JD. Vitamin D in the aetiology and management of polycystic ovary syndrome. Clin Endocrinol. 2012;77(3):343–350.
  • Moini A, Shirzad N, Ahmadzadeh M, et al. Comparison of 25-hydroxyvitamin D and calcium levels between polycystic ovarian syndrome and normal women. Int J Fertil Steril. 2015;9(1):1–8.
  • Krul-Poel YH, Snackey C, Louwers Y, et al. The role of vitamin D in metabolic disturbances in polycystic ovary syndrome: a systematic review. Eur J Endocrinol. 2013;169(6):853–665.
  • Tsakova A, Gateva A, Kamenov Z. 25(OH) vitamin D levels in premenopausal women with polycystic ovary syndrome and/or obesity. Int J Vitam Nutr Res. 2012;82(6):399–404.

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