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Gynecological Endocrinology Volume 36, 2020 - Issue 6
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POLYCYSTIC OVARY SYNDROME

Ceramide subclasses identified as novel lipid biomarker elevated in women with polycystic ovary syndrome: a pilot study employing shotgun lipidomics

Yihong JiangDepartment of Endocrinology and Metabolism, Renji Hospital, School of Medicine, Shanghai JiaoTong University, Shanghai, China; View further author information
,
Jia QiCenter for Reproductive Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China; ;Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai, China; View further author information
,
Xinli XueCAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences (SIBS), Chinese Academy of Sciences (CAS), Shanghai, China; View further author information
,
Rong HuangDepartment of Endocrinology and Metabolism, Renji Hospital, School of Medicine, Shanghai JiaoTong University, Shanghai, China; View further author information
,
Jun ZhengDepartment of Endocrinology and Metabolism, Renji Hospital, School of Medicine, Shanghai JiaoTong University, Shanghai, China; View further author information
,
Wei LiuDepartment of Endocrinology and Metabolism, Renji Hospital, School of Medicine, Shanghai JiaoTong University, Shanghai, China; View further author information
,
Huiyong YinCAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences (SIBS), Chinese Academy of Sciences (CAS), Shanghai, China; ;School of Life Science and Technology, ShanghaiTech University, Shanghai, China; ;Key Laboratory of Food Safety Risk Assessment, Ministry of Health, Beijing, ChinaCorrespondence[email protected]
View further author information
&
Shengxian LiDepartment of Endocrinology and Metabolism, Renji Hospital, School of Medicine, Shanghai JiaoTong University, Shanghai, China; Correspondence[email protected]
View further author information
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Pages 508-512 | Received 19 Aug 2019, Accepted 24 Nov 2019, Published online: 03 Dec 2019

References

  • Escobar-Morreale HF. Polycystic ovary syndrome: definition, aetiology, diagnosis and treatment. Nat Rev Endocrinol. 2018;14(5):270–284.
  • Rotterdam ESHRE/ASRM-Sponsored PCOS consensus workshop group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod (Oxford, England). 2004;19(1):41–47.
  • Norman RJ, Dewailly D, Legro RS, et al. Polycystic ovary syndrome. Lancet (London, England). 2007;370(9588):685–697.
  • Diamanti-Kandarakis E, Dunaif A. Insulin resistance and the polycystic ovary syndrome revisited: an update on mechanisms and implications. Endocr Rev. 2012;33(6):981–1030.
  • Moran LJ, Misso ML, Wild RA, et al. Impaired glucose tolerance, type 2 diabetes and metabolic syndrome in polycystic ovary syndrome: a systematic review and meta-analysis. Human Reproduction Update. 2010;16(4):347–363.
  • Anagnostis P, Tarlatzis BC, Kauffman RP. Polycystic ovarian syndrome (PCOS): long-term metabolic consequences. Metabolism. 2018;86:33–43.
  • Rizzo M, Berneis K, Spinas G, et al. Long-term consequences of polycystic ovary syndrome on cardiovascular risk. Fertil Steril. 2009;91(4)Suppl):1563–1567.
  • Carmina E, Bucchieri S, Esposito A, et al. Abdominal fat quantity and distribution in women with polycystic ovary syndrome and extent of its relation to insulin resistance. J Clin Endocrinol Metab. 2007;92(7):2500–2505.
  • Escobar-Morreale HF, San Millan JL. Abdominal adiposity and the polycystic ovary syndrome. Trends Endocrinol Metab: TEM. 2007;18(7):266–272.
  • Bellis C, Kulkarni H, Mamtani M, et al. Human plasma lipidome is pleiotropically associated with cardiovascular risk factors and death. Circ Cardiovasc Genet. 2014;7(6):854–863.
  • Meikle PJ, Wong G, Barlow CK, et al. Plasma lipid profiling shows similar associations with prediabetes and type 2 diabetes. PloS One. 2013;8(9):e74341.
  • Tonks KT, Coster AC, Christopher MJ, et al. Skeletal muscle and plasma lipidomic signatures of insulin resistance and overweight/obesity in humans. Obesity (Silver Spring, Md). 2016;24(4):908–916.
  • Haoula Z, Ravipati S, Stekel DJ, et al. Lipidomic analysis of plasma samples from women with polycystic ovary syndrome. Metabolomics. 2015;11(3):657–666.
  • Li S, Chu Q, Ma J, et al. Discovery of novel lipid profiles in PCOS: do insulin and androgen oppositely regulate bioactive lipid production? J Clin Endocrinol Metab. 2017;102(3):810–821.
  • Moran LJ, Mundra PA, Teede HJ, et al. The association of the lipidomic profile with features of polycystic ovary syndrome. J Mol Endocrinol. 2017;59(1):93–104.
  • Jove M, Pradas I, Naudi A, et al. Lipidomics reveals altered biosynthetic pathways of glycerophospholipids and cell signaling as biomarkers of the polycystic ovary syndrome. Oncotarget. 2018;9(4):4522–4536.
  • Matthews DR, Hosker JP, Rudenski AS, et al. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28(7):412–419.
  • Han X, Yang J, Cheng H, et al. Toward fingerprinting cellular lipidomes directly from biological samples by two-dimensional electrospray ionization mass spectrometry. Anal Biochem. 2004;330(2):317–331.
  • Han X, Yang K, Cheng H, et al. Shotgun lipidomics of phosphoethanolamine-containing lipids in biological samples after one-step in situ derivatization. J Lipid Res. 2005;46(7):1548–1560.
  • Li J, Xie LM, Song JL, et al. Alterations of sphingolipid metabolism in different types of polycystic ovary syndrome. Sci Rep. 2019;9(1):3204.
  • Merrill AH, Jr., Wang MD, Park M, et al. (Glyco)sphingolipidology: an amazing challenge and opportunity for systems biology. Trends Biochem Sci. 2007;32(10):457–468.
  • Galadari S, Rahman A, Pallichankandy S, et al. Role of ceramide in diabetes mellitus: evidence and mechanisms. Lipids Health Dis. 2013;12(1):98.
  • Boon J, Hoy AJ, Stark R, et al. Ceramides contained in LDL are elevated in type 2 diabetes and promote inflammation and skeletal muscle insulin resistance. Diabetes. 2013;62(2):401–410.
  • Lemaitre RN, Yu C, Hoofnagle A, et al. Circulating sphingolipids, insulin, HOMA-IR, and HOMA-B: the strong heart family study. Diabetes. 2018;67(8):1663–1672.
  • Sun L, Hu W, Liu Q, et al. Metabonomics reveals plasma metabolic changes and inflammatory marker in polycystic ovary syndrome patients. J Proteome Res. 2012;11(5):2937–2946.
  • Chalfant CE. Sphingosine 1-phosphate and ceramide 1-phosphate: expanding roles in cell signaling. J Cell Sci. 2005;118(20):4605–4612.
  • Rapizzi E, Taddei ML, Fiaschi T, et al. Sphingosine 1-phosphate increases glucose uptake through trans-activation of insulin receptor. Cell Mol Life Sci. 2009;66(19):3207–3218.

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