224
Views
6
CrossRef citations to date
0
Altmetric
MENOPAUSE

Local ultra-low-dose estriol gel treatment of vulvo-vaginal atrophy: efficacy and safety of long-term treatment

, , , , , , & show all
Pages 535-539 | Received 26 Aug 2019, Accepted 04 Dec 2019, Published online: 17 Dec 2019

References

  • Santoro N, Komi J. Prevalence and impact of vaginal symptoms among postmenopausal women. J Sex Med. 2009;6(8):2133–2142.
  • Palma F, Volpe A, Villa P, et al. Writing group of AGATA study. Vaginal atrophy of women in postmenopause. Results from a multicentric observational study: the AGATA study. Maturitas. 2016;83:40–44.
  • Stika CS. Atrophic vaginitis. Dermatol Ther. 2010;23(5):514–522.
  • Krychman ML. Vaginal estrogens for the treatment of dyspareunia. J Sex Med. 2011;8(3):666–674.
  • Mac Bride MB, Rhodes DJ, Shuster LT. Vulvovaginal atrophy. Mayo Clin Proc. 2010;85(1):87–94.
  • North American Menopause Society. Management of symptomatic vulvovaginal atrophy: 2013 position statement of The North American Menopause Society. Menopause. 2013;20:888–902.
  • North American Menopause Society. The 2012 hormone therapy position statement of: the North American menopause society. Menopause. 2012;19:257–271.
  • North American Menopause Society. The role of local vaginal estrogen for treatment of vaginal atrophy in postmenopausal women: 2007 position statement of The North American menopause society. Menopause. 2007;14:357–369.
  • Sturdee DW, Panay N. International menopause society writing group. recommendations for the management of postmenopausal vaginal atrophy. Climacteric. 2010;13(6):509–522.
  • Smith RN, Studd JW. Recent advances in hormone replacement therapy. Br J Hosp Med. 1993;49(11):799–808.
  • Board of the International Menopause Society, Pines A, Sturdee DW, et al. IMS updated recommendations on postmenopausal hormone therapy. Climateric. 2007;10:181–194.
  • SOGC Clinical Practice Guidelines. Menopause and osteoporosis update 2009. [accessed June 2019]. Available form: https://www.jogc.com/article/S1701-2163(16)34079-8/pdf
  • Bachmann G. The estradiol vaginal ring–a study of existing clinical data. Maturitas. 1995;22:S21–S29.
  • Cano A, Estevez J, Usandizaga R, et al. The therapeutic effect of a new ultra low concentration estriol gel formulation (0.005% estriol vaginal gel) on symptoms and signs of postmenopausal vaginal atrophy: results from a pivotal phase III study. Menopause. 2012;19:1130–1139.
  • Gerbaldo D, Ferraiolo A, Croce S, et al. Endometrial morphology after 12 months of vaginal oestriol therapy in postmenopausal women. Maturitas. 1991;13(4):269–274.
  • Heimer G, Englund D. Effects of vaginally-administered oestriol on postmenopausal urogenital disorders: a cytohormonal study. Maturitas. 1992;14(3):171–179.
  • Vooijts GP, Geurts T. Review of the endometrial safety during intravaginal treatment with estriol. Obstet Gynecol. 1995;62:101–106.
  • Bachman GA, Nevadunsky NS. Diagnosis and treatment of atrophic vaginitis. Am Fam Physician. 2000;61(10):3090–3096.
  • Dessole S, Rubattu G, Ambrosini G, et al. Efficacy of low-dose intravaginal estriol on urogenital aging in postmenopausal women. Menopause. 2004;11(1):49–56.
  • Rueda C, Osorio AM, Avellaneda AC, et al. The efficacy and safety of estriol to treat vulvovaginal atrophy in postmenopausal women: a systematic literature review. Climacteric. 2017;20(4):321–330.
  • Chollet JA, Carter G, Meyn LA, et al. Efficacy and safety of vaginal estriol and progesterone in postmenopausal women with atrophic vaginitis. Menopause. 2009;16(5):978–983.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.