253
Views
1
CrossRef citations to date
0
Altmetric
PROLACTIN AND SEXUALITY

Prolactin as a neuroendocrine clue in sexual function of women across the reproductive life cycle: an expert point of view

, &
Pages 490-496 | Received 23 Dec 2020, Accepted 27 Feb 2021, Published online: 11 Mar 2021

References

  • Bachelot A, Binart N. Reproductive role of prolactin. Reproduction. 2007;133(2):361–369.
  • Clapp C, Thebault S, Jeziorski MC, et al. Peptide hormone regulation of angiogenesis. Physiol Rev. 2009;89(4):1177–1215.
  • Macotela Y, Triebel J, Clapp C. Time for a new perspective on prolactin in metabolism. Trends Endocrinol Metab. 2020;31(4):276–286.
  • Melmed S, Casanueva FF, Hoffman AR, Endocrine Society, et al. Diagnosis and treatment of hyperprolactinemia: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2011;96(2):273–288.
  • Gillam MP, Molitch ME. Chapter 5 - Prolactin. In: Melmed S, editor. The pituitary. 3rd ed. Philadelphia: Elsevier; 2011. p. 119–166.
  • Hu Y, Ding Y, Yang M, et al. Serum prolactin levels across pregnancy and the establishment of reference intervals. Clin Chem Lab Med. 2018;56(5):803–807.
  • Ben-Jonathan N, Mershon JL, Allen DL, et al. Extrapituitary prolactin: distribution, regulation, functions, and clinical aspects. Endocr Rev. 1996;17(6):639–669.
  • Kelly MA, Rubinstein M, Asa SL, et al. Pituitary lactotroph hyperplasia and chronic hyperprolactinemia in dopamine D2 receptor-deficient mice. Neuron. 1997;19(1):103–113.
  • Lyons DJ, Broberger C. Tidal waves: Network mechanisms in the neuroendocrine control of prolactin release. Front Neuroendocrinol. 2014;35(4):420–438.
  • Reichlin S. Neuroendocrinology. In: Wilson J, Foster D, editors. Williams textbook of endocrinology. 8th ed. Philadelphia PA, USA: W B Saunders Company; 1992. p. 135–219.
  • Thorner MO, Round J, Jones A, et al. Serum prolactin and oestradiol levels at different stages of puberty. Clin Endocrinol (Oxf)). 1977;7(6):463–468.
  • Friesen HG. Human prolactin. Ann R Coll Physicians Surg Can. 1978;11:275–281.
  • Fink G, Pfaff DW, Levine J. Handbook of neuroendocrinology. Academic Press, Elsevier; 2012.
  • Richards JS, Midgley AR. Jr. Protein hormone action: a key to understanding ovarian follicular and luteal cell development. Biol Reprod. 1976;14(1):82–94.
  • Fritz MA, Speroff L. The endocrinology of the menstrual cycle: the interaction of folliculogenesis and neuroendocrine mechanisms. Fertil Steril. 1982;38(5):509–529.
  • Knobil E. The neuroendocrine control of the menstrual cycle. Recent Prog Horm Res. 1980;36:53–88.
  • Horseman ND, Zhao W, Montecino-Rodriguez E, et al. Defective mammopoiesis, but normal hematopoiesis, in mice with a targeted disruption of the prolactin gene. Embo J. 1997;16(23):6926–6935.
  • Risk M, Gibori G. Mechanisms of luteal cell regulation by prolactin. Prolactin: Springer. 2001; 265–295.
  • Binart N, Helloco C, Ormandy CJ, et al. Rescue of preimplantatory egg development and embryo implantation in prolactin receptor-deficient mice after progesterone administration. Endocrinology. 2000;141(7):2691–2697.
  • Frasor J, Gibori G. Prolactin regulation of estrogen receptor expression. Trends Endocrinol Metab. 2003;14(3):118–123.
  • Feltus FA, Groner B, Melner MH. Stat5-mediated regulation of the human type II 3beta-hydroxysteroid dehydrogenase/delta5-delta4 isomerase gene: activation by prolactin. Mol Endocrinol. 1999;13(7):1084–1093.
  • Landgraf R, Landraf-Leurs MM, Weissmann A, et al. Prolactin: a diabetogenic hormone. Diabetologia. 1977;13(2):99–104.
  • Augustine RA, Grattan DR. Induction of central leptin resistance in hyperphagic pseudopregnant rats by chronic prolactin infusion. Endocrinology. 2008;149(3):1049–1055.
  • Ruiz-Herrera X, de Los Rios EA, Diaz JM, et al. Prolactin promotes adipose tissue fitness and insulin sensitivity in obese males. Endocrinology. 2017;158(1):56–68.
  • Ben-Jonathan N, Hugo E. Prolactin (PRL) in adipose tissue: regulation and functions. Adv Exp Med Biol. 2015;846:1–35.
  • Retnakaran R, Ye C, Kramer CK, et al. Maternal serum prolactin and prediction of postpartum β-cell function and risk of prediabetes/diabetes. Diabetes Care. 2016;39(7):1250–1258.
  • Corona G, Wu FC, Rastrelli G, EMAS Study Group, et al. Low prolactin is associated with sexual dysfunction and psychological or metabolic disturbances in middle-aged and elderly men: the European Male Aging Study (EMAS). J Sex Med. 2014;11(1):240–253.
  • Albu A, Florea S, Fica S. Is prolactin the missing link in adipose tissue dysfunction of polycystic ovary syndrome patients? Endocrine. 2016;51(1):163–173.
  • Li J, Rice MS, Huang T, et al. Circulating prolactin concentrations and risk of type 2 diabetes in US women. Diabetologia. 2018;61(12):2549–2560.
  • Park S, Kang S, Lee HW, et al. Central prolactin modulates insulin sensitivity and insulin secretion in diabetic rats. Neuroendocrinology. 2012;95(4):332–343.
  • Weaver JU, Noonan K, Kopelman PG. An association between hypothalamic-pituitary dysfunction and peripheral endocrine function in extreme obesity. Clin Endocrinol (Oxf)). 1991;35(1):97–102.
  • Defronzo RA. Bromocriptine: a sympatholytic, d2-dopamine agonist for the treatment of type 2 diabetes. Diabetes Care. 2011;34(4):789–794.
  • Kopelman PG. Physiopathology of prolactin secretion in obesity. Int J Obes Relat Metab Disord. 2000;24(Suppl 2):S104–S8.
  • Torner L. Actions of prolactin in the brain: from physiological adaptations to stress and neurogenesis to psychopathology. Front Endocrinol (Lausanne). 2016;7(25):1–6.
  • Gala RR. The physiology and mechanisms of the stress-induced changes in prolactin secretion in the rat. Life Sci. 1990;46(20):1407–1420.
  • Motta-Mena NV, Puts DA. Endocrinology of human female sexuality, mating, and reproductive behavior. Horm Behav. 2017;91:19–35.
  • Shingo T, Gregg C, Enwere E, et al. Pregnancy-stimulated neurogenesis in the adult female forebrain mediated by prolactin. Science. 2003;299(5603):117–120.
  • Larsen CM, Grattan DR. Prolactin, neurogenesis, and maternal behaviors. Brain Behav Immun. 2012;26(2):201–209.
  • Walker TL, Vukovic J, Koudijs MM, et al. Prolactin stimulates precursor cells in the adult mouse hippocampus. PLoS One. 2012;7(9):e44371.
  • Samperi I, Lithgow K, Karavitaki N. Hyperprolactinaemia. J Clin Med. 2019;8(12):1–24.
  • Kalsi AK, Halder A, Jain M, et al. Prevalence and reproductive manifestations of macroprolactinemia. Endocrine. 2019;63(2):332–340.
  • Shivaprasad KS, Siddardha K. Pituitary hyperplasia from primary hypothyroidism. N Engl J Med. 2019;380(8):e9.
  • Carmichael MS, Humbert R, Dixen J, et al. Plasma oxytocin increases in the human sexual response. J Clin Endocrinol Metab. 1987;64(1):27–31.
  • Brody S, Krüger TH. The post-orgasmic prolactin increase following intercourse is greater than following masturbation and suggests greater satiety. Biol Psychol. 2006;71(3):312–315.
  • Pfaus JG. Pathways of sexual desire. J Sex Med. 2009;6(6):1506–1533.
  • Goldstein I, Kim NN, Clayton AH, et al. Hypoactive sexual desire disorder: International Society for the Study of Women's Sexual Health (ISSWSH) expert consensus panel review. Mayo Clin Proc. 2017;92(1):114–128.
  • Matteo S, Rissman EF. Increased sexual activity during the midcycle portion of the human menstrual cycle. Horm Behav. 1984;18(3):249–255.
  • Bancroft J, Graham CA. The varied nature of women's sexuality: unresolved issues and a theoretical approach. Horm Behav. 2011;59(5):717–729.
  • Carosa E, Sansone A, Jannini EA. Management of endocrine disease: Female sexual dysfunction for the endocrinologist. Eur J Endocrinol. 2020;182(6):R101.
  • Wierman ME, Nappi RE, Avis N, et al. Endocrine aspects of women's sexual function. J Sex Med. 2010;7(1 Pt 2):561–585.
  • Levine S, Muneyyirci-Delale O. Stress-induced hyperprolactinemia: pathophysiology and clinical approach. Obstet Gynecol Int. 2018;2018:9253083.
  • Wang Y, Wang H. Effects of hypothyroidism and subclinical hypothyroidism on sexual function: a meta-analysis of studies using the Female Sexual Function Index. Sex Med. 2020;8(2):156–167.
  • Bhasin S, Enzlin P, Coviello A, et al. Sexual dysfunction in men and women with endocrine disorders. Lancet. 2007;369(9561):597–611.
  • Hulter B, Lundberg PO. Sexual function in women with hypothalamo-pituitary disorders. Arch Sex Behav. 1994;23(2):171–183.
  • Kadioglu P, Yalin AS, Tiryakioglu O, et al. Sexual dysfunction in women with hyperprolactinemia: a pilot study report. J Urol. 2005;174(5):1921–1925.
  • Wieck A, Haddad PM. Antipsychotic-induced hyperprolactinaemia in women: pathophysiology, severity and consequences. Selective literature review. Br J Psychiatry. 2003;182:199–204.
  • Krysiak R, Okopień B. Sexual functioning in hyperprolactinemic patients treated with cabergoline or bromocriptine. Am J Ther. 2019;26(4):e433–e440.
  • Shifren JL, Monz BU, Russo PA, et al. Sexual problems and distress in United States women: prevalence and correlates. Obstet Gynecol. 2008;112(5):970–978.
  • Nappi RE, Cucinella L. Advances in pharmacotherapy for treating female sexual dysfunction. Expert Opin Pharmacother. 2015;16(6):875–887.
  • Nappi RE, Martini E, Cucinella L, et al. Addressing vulvovaginal atrophy (VVA)/genitourinary syndrome of menopause (GSM) for healthy aging in women. Front Endocrinol (Lausanne)). 2019;10:561.
  • Maserejian NN, Shifren JL, Parish SJ, et al. The presentation of hypoactive sexual desire disorder in premenopausal women. J Sex Med. 2010;7(10):3439–3448.
  • Rosen RC, Maserejian NN, Connor MK, et al. Characteristics of premenopausal and postmenopausal women with acquired, generalized hypoactive sexual desire disorder: the Hypoactive Sexual Desire Disorder Registry for women. Menopause. 2012;19(4):396–405.
  • Bernard V, Young J, Binart N. Prolactin - a pleiotropic factor in health and disease. Nat Rev Endocrinol. 2019;15(6):356–365.
  • Deems NP, Leuner B. Pregnancy, postpartum and parity: resilience and vulnerability in brain health and disease. Front Neuroendocrinol. 2020;57:100820.
  • Neumann ID. The advantage of social living: brain neuropeptides mediate the beneficial consequences of sex and motherhood. Front Neuroendocrinol. 2009;30(4):483–496.
  • De Leo V, Musacchio MC, Cappelli V, et al. Hormonal contraceptives: pharmacology tailored to women's health. Hum Reprod Update. 2016;22(5):634–646.
  • Laan E, van Lunsen RH. Hormones and sexuality in postmenopausal women: a psychophysiological study. J Psychosom Obstet Gynaecol. 1997;18(2):126–133.
  • Lu W, Guo W, Cui D, et al. Effect of sex hormones on brain connectivity related to sexual function in perimenopausal women: a resting-state fMRI functional connectivity study. J Sex Med. 2019;16(5):711–720.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.