Bu-Shen-Ning-Xin decoction alleviates premature ovarian insufficiency (POI) by regulating autophagy of granule cells through activating PI3K/AKT/mTOR pathway

References

• Qin Y, Jiao X, Simpson JL, et al. Genetics of primary ovarian insufficiency: new developments and opportunities. Hum Reprod Update. 2015;21(6):787–808.
   PubMed Web of Science ®Google Scholar
• Tsiligiannis S, Panay N, Stevenson JC. Premature ovarian insufficiency and long-term health consequences. Curr Vasc Pharmacol. 2019;17(6):604–609.
   PubMed Web of Science ®Google Scholar
• Paciuc J. Hormone therapy in menopause. Adv Exp Med Biol. 2020;1242:89–120.
   PubMed Web of Science ®Google Scholar
• Deligdisch L. Effects of hormone therapy on the endometrium. Mod Pathol. 1993;6:94–106.
   PubMed Web of Science ®Google Scholar
• Choi J, Jo M, Lee E, et al. Induction of apoptotic cell death via accumulation of autophagosomes in rat granulosa cells. Fertil Steril. 2011;95(4):1482–1486.
   PubMed Web of Science ®Google Scholar
• Glick D, Barth S, Macleod KF. Autophagy: cellular and molecular mechanisms. J Pathol. 2010;221(1):3–12.
   PubMed Web of Science ®Google Scholar
• Mattiolo P, Yuste VJ, Boix J, et al. Autophagy exacerbates caspase-dependent apoptotic cell death after short times of starvation. Biochem Pharmacol. 2015;98(4):573–586.
   PubMed Web of Science ®Google Scholar
• Cadwell K, Liu JY, Brown SL, et al. A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells. Nature. 2008;456(7219):259–263.
   PubMed Web of Science ®Google Scholar
• Song ZH, Yu HY, Wang P, et al. Germ cell-specific Atg7 knockout results in primary ovarian insufficiency in female mice. Cell Death Dis. 2015;6(1):e1589–e1589.
   PubMedGoogle Scholar
• Wang L, Qiu XM, Hao Q, et al. Anti-inflammatory effects of a Chinese herbal medicine in atherosclerosis via estrogen receptor beta mediating nitric oxide production and NF-kappaB suppression in endothelial cells. Cell Death Dis. 2013;4:e551.
   PubMed Web of Science ®Google Scholar
• Zhang H, Qin F, Liu A, et al. Kuntai capsule attenuates premature ovarian failure through the PI3K/AKT/mTOR pathway. J Ethnopharmacol. 2019;239:111885.
   PubMed Web of Science ®Google Scholar
• Wang Y, Cui K, Zhao H, et al. Bushen Ningxin Decoction pharmacological serum promotes the proliferation and suppresses the apoptosis of murine osteoblasts through MAPK pathway. J Ethnopharmacol. 2009;122(2):221–226.
   PubMed Web of Science ®Google Scholar
• Wang L, Qiu XM, Gui YY, et al. Bu-Shen-Ning-Xin decoction: inhibition of osteoclastogenesis by abrogation of the RANKL-induced NFATc1 and NF-kappaB signaling pathways via selective estrogen receptor alpha. Drug Des Devel Ther. 2015;9:3755–3766.
   PubMed Web of Science ®Google Scholar
• Cornejo-Cortes MA, Sanchez-Torres C, Vazquez-Chagoyan JC, et al. Rat embryo quality and production efficiency are dependent on gonadotrophin dose in superovulatory treatments. Lab Anim. 2006;40:87–95.
   PubMedGoogle Scholar
• Zhang H, Qin F, Liu A, et al. Electro-acupuncture attenuates the mice premature ovarian failure via mediating PI3K/AKT/mTOR pathway. Life Sci. 2019;217:169–175.
   PubMed Web of Science ®Google Scholar
• Ma Y, Ren Y, Dai ZJ, et al. IL-6, IL-8 and TNF-alpha levels correlate with disease stage in breast cancer patients. Adv Clin Exp Med. 2017;26(3):421–426.
   PubMed Web of Science ®Google Scholar
• Yao H, Xu JK, Zheng NY, et al. Intra-articular injection of magnesium chloride attenuates osteoarthritis progression in rats. Osteoarthritis Cartilage. 2019;27(12):1811–1821.
   PubMed Web of Science ®Google Scholar
• Lu X, Bao H, Cui L, et al. hUMSC transplantation restores ovarian function in POI rats by inhibiting autophagy of theca-interstitial cells via the AMPK/mTOR signaling pathway. Stem Cell Res Ther. 2020;11(1):268.
   PubMed Web of Science ®Google Scholar
• Guo Y, Zhu X, Sun X. COTI-2 induces cell apoptosis in pediatric acute lymphoblastic leukemia via upregulation of miR-203. Bioengineered. 2020;11(1):201–208.
   PubMed Web of Science ®Google Scholar
• Liu P, Feng Y, Dong D, et al. Enhanced renoprotective effect of IGF-1 modified human umbilical cord-derived mesenchymal stem cells on gentamicin-induced acute kidney injury. Sci Rep. 2016;6:20287.
   PubMed Web of Science ®Google Scholar
• Zhao L, Feng Y, Chen X, et al. Effects of IGF-1 on neural differentiation of human umbilical cord derived mesenchymal stem cells. Life Sci. 2016;151:93–101.
   PubMed Web of Science ®Google Scholar
• Durlej M, Duda M, Knapczyk K, et al. Effects of transferrin on aromatase activity in porcine granulosa cells in vitro. Folia Histochem Cytobiol. 2008;46(4):423–428.
   PubMed Web of Science ®Google Scholar
• Shultz JC, Vu N, Shultz MD, et al. The proto-oncogene PKCiota regulates the alternative splicing of Bcl-x pre-mRNA. Mol Cancer Res. 2012;10(5):660–669.
   PubMed Web of Science ®Google Scholar
• Chen J, Yu Y, Li S, et al. MicroRNA-30a ameliorates hepatic fibrosis by inhibiting Beclin1-mediated autophagy. J Cell Mol Med. 2017;21(12):3679–3692.
   PubMed Web of Science ®Google Scholar
• Cao LB, Liu HB, Lu G, et al. Hormone-like effects of 4-vinylcyclohexene diepoxide on follicular development. Front Cell Dev Biol. 2020;8:587.
   PubMed Web of Science ®Google Scholar
• Chen Z, Kang X, Wang L, et al. Rictor/mTORC2 pathway in oocytes regulates folliculogenesis, and its inactivation causes premature ovarian failure. J Biol Chem. 2015;290(10):6387–6396.
   PubMed Web of Science ®Google Scholar
• Van Kempen TA, Gorecka J, Gonzalez AD, et al. Characterization of neural estrogen signaling and neurotrophic changes in the accelerated ovarian failure mouse model of menopause. Endocrinology. 2014;155(9):3610–3623.
   PubMed Web of Science ®Google Scholar
• Sun S, Chen H, Zheng X, et al. Analysis on the level of IL-6, IL-21, AMH in patients with auto-immunity premature ovarian failure and study of correlation. Exp Ther Med. 2018;16:3395–3398.
   PubMed Web of Science ®Google Scholar
• Zhang H, Luo Q, Lu X, et al. Effects of hPMSCs on granulosa cell apoptosis and AMH expression and their role in the restoration of ovary function in premature ovarian failure mice. Stem Cell Res Ther. 2018;9(1):20.
   PubMedGoogle Scholar
• Wang J, Davis S, Zhu M, et al. Autophagosome formation: where the secretory and autophagy pathways meet. Autophagy. 2017;13(5):973–974.
   PubMed Web of Science ®Google Scholar
• Zhou C, Qian X, Hu M, et al. STYK1 promotes autophagy through enhancing the assembly of autophagy-specific class III phosphatidylinositol 3-kinase complex I. Autophagy. 2020;16(10):1786–1806.
   PubMed Web of Science ®Google Scholar
• Ichimura Y, Kirisako T, Takao T, et al. A ubiquitin-like system mediates protein lipidation. Nature. 2000;408(6811):488–492.
   PubMed Web of Science ®Google Scholar
• Tiwari M, Prasad S, Tripathi A, et al. Apoptosis in mammalian oocytes: a review. Apoptosis. 2015;20(8):1019–1025.
   PubMed Web of Science ®Google Scholar
• Zhang DM, Liu JS, Deng LJ, et al. Arenobufagin, a natural bufadienolide from toad venom, induces apoptosis and autophagy in human hepatocellular carcinoma cells through inhibition of PI3K/Akt/mTOR pathway. Carcinogenesis. 2013;34(6):1331–1342.
   PubMed Web of Science ®Google Scholar
• Yahiro K, Tsutsuki H, Ogura K, et al. DAP1, a negative regulator of autophagy, controls SubAB-mediated apoptosis and autophagy. Infect Immun. 2014;82(11):4899–4908.
   PubMed Web of Science ®Google Scholar