The ameliorative effect of CangFu Daotan Decoction on polycystic ovary syndrome of rodent model is associated with m6A methylation and Wnt/β-catenin pathway

References

• Kumariya S, Ubba V, Jha RK, et al. Autophagy in ovary and polycystic ovary syndrome: role, dispute and future perspective. Autophagy. 2021;17(10):1–12.
   PubMed Web of Science ®Google Scholar
• Teede H, Deeks A, Moran L. Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan. BMC Med. 2010;8:41.
   PubMed Web of Science ®Google Scholar
• Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil Sterility. 2003;81(1):19–25.
   Web of Science ®Google Scholar
• Dai X, Ren T, Zhang Y, et al. Methylation multiplicity and its clinical values in cancer. Expert Rev Mol. 2021;23:1–10.
   Web of Science ®Google Scholar
• Mu H, Zhang T, Yang Y, et al. METTL3-mediated mRNA N6-methyladenosine is required for oocyte and follicle development in mice. Cell Death Dis. 2021;12(11):989.
   PubMed Web of Science ®Google Scholar
• Chen J, Du B. Novel positioning from obesity to cancer: FTO, an m6A RNA demethylase, regulates tumour progression. J Cancer Res Clin Oncol. 2019;145(1):19–29.
   PubMed Web of Science ®Google Scholar
• Deng X, Su R, Stanford S, et al. Critical enzymatic functions of FTO in obesity and cancer. Front Endocrinol (Lausanne). 2018;9:396.
   PubMed Web of Science ®Google Scholar
• Lan N, Lu Y, Zhang Y, et al. FTO - a common genetic basis for obesity and cancer. Front Genet. 2020;11:559138.
   PubMed Web of Science ®Google Scholar
• Liu Y, Chen Y. Fat mass and obesity associated gene polymorphism and the risk of polycystic ovary syndrome: a meta-analysis. Iran J Public Health. 2017;46(1):4–11.
   PubMed Web of Science ®Google Scholar
• Liu AL, Xie HJ, Xie HY, et al. Association between fat mass and obesity associated (FTO) gene rs9939609 a/T polymorphism and polycystic ovary syndrome: a systematic review and meta-analysis. BMC Med Genet. 2017;18(1):89–95.
   PubMedGoogle Scholar
• Kowalska I, Malecki MT, Straczkowski M, et al. The FTO gene modifies weight, fat mass and insulin sensitivity in women with polycystic ovary syndrome, where its role may be larger than in other phenotypes. Diabetes Metab. 2009;35(4):328–331.
   PubMed Web of Science ®Google Scholar
• Tan S, Scherag A, Janssen OE, et al. Large effects on body mass index and insulin resistance of fat mass and obesity associated gene (FTO) variants in patients with polycystic ovary syndrome (PCOS). BMC Med Genet. 2010;11:12–20.
   PubMed Web of Science ®Google Scholar
• Li L, Shi X, Shi Y, et al. The signaling pathways involved in ovarian follicle development. Front Physiol. 2021;12:730196.
   PubMed Web of Science ®Google Scholar
• Liu X, Chen D, Wu Z, et al. Ghrelin inhibits high glucose-induced 16HBE cells apoptosis by regulating wnt/β-catenin pathway. Biochem Biophys Res Commun. 2016;477(4):902–907.
   PubMed Web of Science ®Google Scholar
• Wu XQ, Wang YQ, Xu SM, et al. The WNT/β-catenin signaling pathway may be involved in granulosa cell apoptosis from patients with PCOS in North China. J Gynecol Obstet Hum Reprod. 2017;46(1):93–99.
   PubMed Web of Science ®Google Scholar
• Ismail AB, Naji M’S, Nebih İ, et al. The expression profile of WNT/β-catanin signalling genes in human oocytes obtained from polycystic ovarian syndrome (PCOS) patients. Zygote. 2022;30(4):536–542.
   PubMed Web of Science ®Google Scholar
• Zhang S, Deng W, Liu Q, et al. Altered m6 a modification is involved in up-regulated expression of FOXO3 in luteinized granulosa cells of non-obese polycystic ovary syndrome patients. J Cell Mol Med. 2020;24(20):11874–11882.
   PubMed Web of Science ®Google Scholar
• Maiese K. Forkhead transcription factors: Formulating a FOXO target for cognitive loss. Curr Neurovasc Res. 2017;14(4):415–420.
   PubMed Web of Science ®Google Scholar
• Uddin MB, Wang Z, Yang C. The m6A RNA methylation regulates oncogenic signaling pathways driving cell malignant transformation and carcinogenesis. Mol Cancer. 2021;20(1):61.
   PubMed Web of Science ®Google Scholar
• Ding CF, Wang CY, Yang X, et al. Effect of modified cangfu daotan decoction in improving endometrial receptivity in infertility patients with polycystic ovarian syndrome. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2014;34(11):1297–1301.
   PubMedGoogle Scholar
• Wang C, Ding C, Hua Z, et al. Cangfudaotan decoction alleviates insulin resistance and improves follicular development in rats with polycystic ovary syndrome via IGF-1-PI3K/Akt-Bax/bcl-2 pathway. Mediators Inflamm. 2020;2020:8865647.
   PubMed Web of Science ®Google Scholar
• Yi W, Li X, Chen K, et al. Effects of cangfu daotan decoction on obese polycystic ovary syndrome and its mechanism. Steroids. 2021;165:108740.
   PubMed Web of Science ®Google Scholar
• Ru J, Li P, Wang J, et al. TCMSP: a database of systems pharmacology for drug discovery from herbal medicines. J Cheminf. 2014;6:13.
   PubMed Web of Science ®Google Scholar
• Xu W, Tang M, Wang J, et al. Identification of the active constituents and significant pathways of cangfu daotan decoction for the treatment of PCOS based on network pharmacology. Evid Based Complement Altern Med. 2020;2020:4086864.
   PubMed Web of Science ®Google Scholar
• Yang XD, Ge XC, Jiang SY, et al. Potential lipolytic regulators derived from natural products as effective approaches to treat obesity. Front Endocrinol (Lausanne. 2022;13:1000739.
   PubMed Web of Science ®Google Scholar
• Wang LY, Cheng KC, Li Y, et al. Glycyrrhizic acid increases glucagon like peptide-1 secretion via TGR5 activation in type 1-like diabetic rats. Biomed Pharmacother. 2017;95:599–604.
   PubMed Web of Science ®Google Scholar
• Gandhi GR, Vasconcelos ABS, Wu DT, et al. Citrus flavonoids as promising phytochemicals targeting diabetes and related complications: a systematic review of in vitro and in vivo studies. Nutrients. 2020;12(10):2907.
   PubMed Web of Science ®Google Scholar
• Zhang J, Zhang H, Xin X, et al. Efficacy of flavonoids on animal models of polycystic ovary syndrome: a systematic review and meta-analysis. Nutrients. 2022;14(19):4128.
   PubMed Web of Science ®Google Scholar
• Gao Y, Dai H, Zhang N, et al. The ameliorative effect of mahuang fuzi and shenzhuo decoction on membranous nephropathy of rodent model is associated with autophagy and wnt/β-Catenin pathway. Front Pharmacol. 2022;13:820130.
   PubMed Web of Science ®Google Scholar
• Song L, Yu J, Zhang D, et al. Androgen excess induced mitochondrial abnormality in ovarian granulosa cells in a rat model of polycystic ovary syndrome. Front Endocrinol (Lausanne. 2022;13:789008.).
   PubMed Web of Science ®Google Scholar
• He S, Tang S. WNT/β-catenin signaling in the development of liver cancers. Biomed Pharmacother. 2020;132:110851.
   PubMed Web of Science ®Google Scholar
• Xu X, Zhang M, Xu F, et al. Wnt signaling in breast cancer: biological mechanisms, challenges and opportunities. Mol Cancer. 2020;19(1):165.
   PubMed Web of Science ®Google Scholar
• Yang F, Xiong H, Duan L, et al. MiR-1246 promotes metastasis and invasion of A549 cells by targeting GSK-3β–mediated wnt/β-Catenin pathway. Cancer Res Treat. 2019;51(4):1420–1429.
   PubMed Web of Science ®Google Scholar
• Pecoraro C, Faggion B, Balboni B, et al. GSK3β as a novel promising target to overcome chemoresistance in pancreatic cancer. Drug Resist Updates. 2021;58:100779.
   PubMed Web of Science ®Google Scholar
• Vermeulen K, Berneman ZN, Van Bockstaele DR. Cell cycle and apoptosis. Cell Prolif. 2003;36(3):165–175.
   PubMed Web of Science ®Google Scholar
• Zhou J, Peng X, Mei S. Autophagy in ovarian follicular development and atresia. Int J Biol Sci. 2019;15(4):726–737.
   PubMed Web of Science ®Google Scholar
• Chu CW, Ko HJ, Chou CH, et al. Thioridazine enhances P62-Mediated autophagy and apoptosis through wnt/β-Catenin signaling pathway in glioma cells. Int J Mol Sci. 2019;20(3):473.
   PubMed Web of Science ®Google Scholar
• Sui X, Hu Y, Ren C, et al. METTL3-mediated m6A is required for murine oocyte maturation and maternal-to-zygotic transition. Cell Cycle. 2020;19(4):391–404.
   PubMed Web of Science ®Google Scholar
• Zhang SY, Zhang SW, Fan XN, et al. Global analysis of N6-methyladenosine functions and its disease association using deep learning and network-based methods. PLoS Comput Biol. 2019;15(1):e1006663.
   PubMed Web of Science ®Google Scholar
• Shen S, Zhang R, Jiang Y, et al. Comprehensive analyses of m6A regulators and interactive coding and non-coding RNAs across 32 cancer types. Mol Cancer. 2021;20(1):67.
   PubMed Web of Science ®Google Scholar
• Lan Q, Liu PY, Haase J, et al. The critical role of RNA mA methylation in cancer. Cancer Res. 2019;79(7):1285–1292.
   PubMed Web of Science ®Google Scholar
• Yue Y, Liu J, He C. RNA N6-methyladenosine methylation in post-transcriptional gene expression regulation. Genes Dev. 2015;29(13):1343–1355.
   PubMed Web of Science ®Google Scholar