Association between leptin receptor polymorphisms and polycystic ovary syndrome risk: a meta-analysis based on 11 studies

References

• Fauser BC, Tarlatzis BC, Rebar RW, et al. Consensus on women’s health aspects of polycystic ovary syndrome (PCOS): the amsterdam ESHRE/ASRM-Sponsored 3rd PCOS consensus workshop group. Fertil Steril. 2012;97(1):1–7. doi: 10.1016/j.fertnstert.2011.09.024.
   Web of Science ®Google Scholar
• Cooney LG, Dokras A. Beyond fertility: polycystic ovary syndrome and long-term health. Fertil Steril. 2018;110(5):794–809. doi: 10.1016/j.fertnstert.2018.08.021.
   PubMed Web of Science ®Google Scholar
• Zheng SH, Du DF, Li XL. Leptin levels in women with polycystic ovary syndrome: a systematic review and a Meta-Analysis. Reprod Sci. 2017;24(5):656–670. doi: 10.1177/1933719116670265.
   PubMed Web of Science ®Google Scholar
• Li L, Lee KJ, Choi BC, et al. Relationship between leptin receptor and polycystic ovary syndrome. Gene. 2013;527(1):71–74. doi: 10.1016/j.gene.2013.05.074.
   PubMed Web of Science ®Google Scholar
• Wada N, Hirako S, Takenoya F, et al. Leptin and its receptors. J Chem Neuroanat. 2014;61-62:191–199. doi: 10.1016/j.jchemneu.2014.09.002.
   PubMed Web of Science ®Google Scholar
• Oksanen L, Tiitinen A, Kaprio J, et al. No evidence for mutations of the leptin or leptin receptor genes in women with polycystic ovary syndrome. Mol Hum Reprod. 2000;6(10):873–876. doi: 10.1093/molehr/6.10.873.
   PubMed Web of Science ®Google Scholar
• Erel CT, Cine N, Elter K, et al. Leptin receptor variant in women with polycystic ovary syndrome. Fertil Steril. 2002;78(6):1334–1335. doi: 10.1016/s0015-0282(02)04352-2.
   PubMed Web of Science ®Google Scholar
• Chen Y. The relationship between polymorphism of the Gln223Arg gene of leptin receptor and insulin resistance and lipid metabolism in polycystic ovary syndrome. Proc Clin Med. 2011;20:912–914.
   Google Scholar
• Yang MY, Song QQ, Zhao XK, et al. Association between polymorphism of leptin receptor gene Gln223Arg and polycystic ovary syndrome. Clin J Med Offic. 2015;43:855–858.
   Google Scholar
• Smaism MF. Assessment of leptin levels in the different genotypes and leptin receptor genes in the women with polycystic ovary syndrome and diabetes mellitus type 2 in Iraq population. Int J PharmTech Res. 2016;9:269–276.
   Google Scholar
• Tu X, Yu C, Gao M, et al. LEPR gene polymorphism and plasma soluble leptin receptor levels are associated with polycystic ovary syndrome in Han Chinese women. Per Med. 2017;14(4):299–307. doi: 10.2217/pme-2017-0016.
   PubMed Web of Science ®Google Scholar
• Daghestani MH, Daghestani MH, Daghistani MH, et al. The influence of the rs1137101 genotypes of leptin receptor gene on the demographic and metabolic profile of normal Saudi females and those suffering from polycystic ovarian syndrome. BMC Women’s Health. 2019;19:10.
   Google Scholar
• Dallel M, Douma Z, Finan RR, et al. Contrasting association of leptin receptor polymorphisms and haplotypes with polycystic ovary syndrome in Bahraini and Tunisian women: a case-control study. Biosci Rep. 2021;41(1):41.
   Web of Science ®Google Scholar
• Naseri R, Barzingarosi E, Sohrabi M, et al. The effect of leptin receptor gene polymorphisms (R223Q and P1019P) in susceptibility to polycystic ovarian syndrome in kurdish women. Int J Fertil Steril. 2021;15:123–127.
   PubMed Web of Science ®Google Scholar
• Kargasheh FB, Ansaripour S, Borumandnia N, et al. Association of leptin G2548A and leptin receptor Q223R polymorphisms and their serum levels with infertility and recurrent pregnancy loss in iranian women with polycystic ovary syndrome. PLoS One. 2021;16(8):e0255920. doi: 10.1371/journal.pone.0255920.
   PubMed Web of Science ®Google Scholar
• Villa J, Pratley RE. Adipose tissue dysfunction in polycystic ovary syndrome. Curr Diab Rep. 2011;11(3):179–184. doi: 10.1007/s11892-011-0189-8.
   PubMed Web of Science ®Google Scholar
• Atoum MF, Alzoughool F, Al-Hourani H. Linkage between obesity leptin and breast cancer. Breast Cancer (Auckl). 2020;14:1178223419898458. doi: 10.1177/1178223419898458.
   Web of Science ®Google Scholar
• Saxton RA, Caveney NA, Moya-Garzon MD, et al. Structural insights into the mechanism of leptin receptor activation. Nat Commun. 2023;14:1797.
   Google Scholar
• Cui Q, Zhang Y, Tian N, et al. Leptin promotes angiogenesis via pericyte STAT3 pathway upon intracerebral hemorrhage. Cells. 2022;11(17):11. doi: 10.3390/cells11172755.
   Web of Science ®Google Scholar
• Peng Y, Yang H, Song J, et al. Elevated serum leptin levels as a predictive marker for polycystic ovary syndrome. Front Endocrinol (Lausanne). 2022;13:845165. doi: 10.3389/fendo.2022.845165.
   PubMed Web of Science ®Google Scholar
• Rizk NM, Sharif E. Leptin as well as free leptin receptor is associated with polycystic ovary syndrome in young women. Int J Endocrinol. 2015;2015:927805–927810. doi: 10.1155/2015/927805.
   PubMed Web of Science ®Google Scholar
• Sandhofer A, Laimer M, Ebenbichler CF, et al. Soluble leptin receptor and soluble receptor-bound fraction of leptin in the metabolic syndrome. Obes Res. 2003;11(6):760–768. doi: 10.1038/oby.2003.106.
   PubMedGoogle Scholar
• Adiga U, Banawalikar N, Mayur S, et al. Association of insulin resistance and leptin receptor gene polymorphism in type 2 diabetes mellitus. J Chin Med Assoc. 2021;84(4):383–388. doi: 10.1097/JCMA.0000000000000507.
   PubMed Web of Science ®Google Scholar
• Aller R, Primo Martín D, Izaola O, et al. Association of the leptin receptor rs 1805134 polymorphism with obesity parameters, dietary intakes, and metabolic syndrome in Caucasian obese subjects. Nutr Hosp. 2023;40:35–40.
   PubMed Web of Science ®Google Scholar
• Liang J, Lan J, Li M, et al. Associations of leptin receptor and peroxisome Proliferator-activated receptor gamma polymorphisms with polycystic ovary syndrome: a meta-analysis. Ann Nutr Metab. 2019;75(1):1–8. doi: 10.1159/000500996.
   PubMed Web of Science ®Google Scholar