64
Views
58
CrossRef citations to date
0
Altmetric
Original Article

Effects of ospemifene, a novel SERM, on biochemical markers of bone turnover in healthy postmenopausal women

, , , , &
Pages 152-158 | Published online: 07 Jul 2009

References

  • Melton 14 3rd, Chrischilles EA, Cooper C, et al. Perspective. How many women have osteoporosis? J Bone Miner Res 1992;7:1005–10
  • Grady D, Rubin SM, Petitti DB, et al. Hormone therapy to prevent disease and prolong life in post-menopausal women. Ann Intern Med 1992;117: 1016–37
  • Black DM, Cummings SR, Karpf DB, et al. Randomised trial of effect of alendronate on risk of fracture in women with existing vertebral fractures. Fracture Intervention Trial Research Group. Lancet 1996;348:1535–41
  • McClung MR, Geusens P, Miller PD, et al. Effect of risedronate on the risk of hip fracture in elderly women. Hip Intervention Program Study Group. N Engl J Med 2001;344:333–40
  • Ettinger B, Black DM, Mitlak BH, etal. Reduction of vertebral fracture risk in postmenopausal women with osteoporosis treated with ralcodfene: results from a 3-year randomized clinical trial. Multiple Outcomes of Ralcodfene Evaluation (MORE) Investigators. J Am Med Assoc 1999;282:637–45
  • Chesnut CH 3rd, Silverman S, Andriano K, et al. A randomized trial of nasal spray salmon calcitonin in postmenopausal women with established osteo-porosis: the Prevent Recurrence of Osteoporotic Fractures study. PROOF Study Group. Am J Med 2000;109: 267–76
  • Wells G, Tugwell P, Shea B, et al.; Osteoporosis Methodology Group and The Osteoporosis Research Advisory Group. V. Meta-analysis of the efficacy of hormone replacement therapy in treating and preventing osteoporosis in postmenopausal women. Endocr Rev 2002;23:529–39
  • Writing Group for the Women's Health Initiative Investigators. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women's Health Initiative randomized controlled trial. J Am Med Assoc 2002; 288:321–33
  • Saitta A, Morabito N, Frisina N, et al. Cardiovascular effects of ralcodfene hydrochloride. Cardiovasc Drug Rev 2001;19:57–74
  • Qu Q, Zheng H, Dahllund J, etal. Selective estrogenic effects of a novel triphenylethylene compound, FC1271a, on bone, cholesterol level, and repro-ductive tissues in intact and ovariectomized rats. Endocrinology 2000;141:809–20
  • Qu Q, Härkonen PL, Väändnen HK. Comparative effects of estrogen and antiestrogens on differentiation of osteoblasts in mouse bone marrow culture. J Cell Biochem 1999;73:500–7
  • Parikka V, Lehenkari PP, Härkönen PL, et al. The effect of two selective estrogens ralcodfene and FC1271a on osteoclast survival and resorption in vitro. J Bone Miner Res 1998;23: 5552
  • Voipio SK, Komi J, Kangas L, et al. Effects of ospemifene (FC-1271a) on uterine endometrium, vaginal maturation index, and hormonal status in healthy postmenopausal women. Maturitas 2002;43: 207–14
  • Rutanen E-M, Heikkinen J, Halonen K, et al. Effects of ospemifene, a novel SERM, on hormones, genital tract, climacteric symptoms, and on quality of life in postmenopausal women: a double-blind randomized trial. Menopause 2003;10:433–9
  • Delmas PD, Eastell R, Garnero P, et al. The use of biochemical markers of bone turnover in osteo-porosis. Committee of Scientific Advisors of the International Osteoporosis Foundation. Osteoporos Int 2000;11:S2–17
  • Delmas PD. Markers of bone turnover for monitoring treatment of osteoporosis with antiresorptive drugs. Osteoporos Int 2000;11:566–76
  • Ylikorkala O, Cacciatore B, Halonen K, et al. Effects of ospemifene, a novel SERM, on vascular markers and function in healthy postmenopausal women. Menopause 2003;10:440–7
  • Simberg N, Tiitinen A, Silfvast A, et al. High bone density in hyperandrogenic women: effect of gonadotropin-releasing hormone agonist alone or in conjunction with estrogen—progestin replacement. J Clin Endocrinol Metab 1996;81:646–51
  • Marttunen MB, Hietanen P, Tiitinen A, et al. Com-parison of effects of tamoxifen and toremifene on bone biochemistry and bone mineral density in post-menopausal breast cancer patients. J Clin Endocrinol Metab 1998;83:1158–62
  • Garnero P, Shih WJ, Gineyts E, et al. Comparison of new biochemical markers of bone turnover in late postmenopausal osteoporotic women in response to alendronate treatment. J Clin Endocrinol Metab 1994; 79:1693–700
  • Chesnut CH 3rd, Bell NH, Clark GS, et al. Hormone replacement therapy in postmenopausal women: urinary N-telopeptide of type I collagen monitors therapeutic effect and predicts response of bone mineral density. Am J Med 1997;102: 29–37
  • Peacock M, Liu G, Carey M, etal. Effect of calcium or 250H vitamin D3 dietary supplementation on bone loss at the hip in men and women over the age of 60. J Clin Endocrinol Metab 2000;85:3011–19
  • Delmas PD, Bjarnason NH, Mitlak BH, et al. Effects of ralcodfene on bone mineral density, serum choles-terol concentrations, and uterine endometrium in postmenopausal women. N Engl J Med 1997;337: 1641–7
  • Lufkin EG, Whitaker MD, Nickelsen T, et al. Treatment of established postmenopausal osteo-porosis with ralcodfene: a randomized trial. J Bone Miner Res 1998;13:1747–54

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.