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Pregnancy

Iodine and thyroid hormones during pregnancy and postpartum

Pages 414-428 | Received 14 Mar 2006, Accepted 21 May 2007, Published online: 07 Jul 2009

References

  • Moghissi K S. Risks and benefits of nutritional supplements during pregnancy. Obstet Gynecol 1981; 58(Suppl)68S–78S
  • Dobson J E. The iodine factor in health and evolution. Geographical Rev 1998; 88: 1–14
  • Correia H R, Balseiro S C, de Areia M L. Are genes of human intelligence related to the metabolism of thyroid and steroids hormones? – endocrine changes may explain human evolution and higher intelligence. Med Hypotheses 2005; 65: 1016–1023
  • Richardson S J, Monk J A, Shepherdley C A, Ebbesson L OE, Sin F, Power D M, Frappell P B, Köhrle J, Renfree M B. Developmentally regulated thyroid hormone distributor proteins in marsupials, a reptile, and fish. Am J Physiol Regul Integr Comp Physiol 2005; 288: R1264–R1272
  • de Benoist B, Andersson M, Egli I, Takkouche B, Allen H, World Health Organization. Iodine Status Worldwide. The WHO global database on iodine deficiency. WHO, Geneva May, 2004, [Internet] Available from: http://whqlibdoc.who.int/publications/2004/9241592001.pdf[ Accessed 2 November 2006]
  • United Nations. World declaration on the survival, protection and development of children and a plan of action for implementing the development of children in the 1990s. United Nations, New York 1990
  • Amachi S, Kasahara M, Hanada S, Kamagata Y, Shinoyama H, Fujii T, Muramatsu Y. Microbial participation in iodine volatilization from soils. Environ Sci Technol 2003; 37: 3885–3890
  • Dai J L, Zhu Y G, Zhang M, Huang Y Z. Selecting iodine-enriched vegetables and the residual effect of iodate application to soil. Biol Trace Elem Res 2004; 101: 265–276
  • De Groef B, Decallonne B R, Van der Geyten S, Darras V M, Bouillon R. Perchlorate versus other environmental sodium/iodide symporter inhibitors: potential thyroid-related health effects. Eur J Endocrinol 2006; 155: 17–25
  • Skjoldebrand L, Brundin J, Carlstrom A, Pettersson T. Thyroid associated components in serum during normal pregnancy. Acta Endocrinol 1982; 100: 504–511
  • Hennemann G, Docter R, Friesema E CH, de Jong M, Krenning E P, Visser T J. Plasma membrane transport of thyroid hormones and its role in thyroid hormone metabolism and bioavailability. Endocr Rev 2001; 22: 451–476
  • Friesema E C, Ganguly S, Abdalla A, Manning Fox J E, Halestrap A P, Visser T J. Identification of monocarboxylate transporter 8 as a specific thyroid hormone transporter. J Biol Chem 2003; 278: 40128–40135
  • Friesema E C, Grueters A, Biebermann H, Krude H, von Moers A, Reeser M, Barrett T G, Mancilla E E, Svensson J, Kester M H, et al. Association between mutations in a thyroid hormone transporter and severe X-linked psychomotor retardation. Lancet 2004; 364: 1435–1437
  • Dumitrescu A M, Liao X H, Best T B, Brockmann K, Refetoff S. A novel syndrome combining thyroid and neurological abnormalities is associated with mutations in a monocarboxylate transporter gene. Am J Hum Genet 2004; 74: 168–175
  • Sánchez C A, Crump K S, Krieger R I, Khandaker N R, Gibbs J P. Perchlorate and nitrate in leafy vegetables of North America. Environ Sci Technol 2005; 39: 9391–9397
  • Dyke J V, Ito K, Obitsu T, Hisamatsu Y, Dasgupta P K, Blount B C. Perchlorate in dairy milk. Comparison of Japan versus the United States. Environ Sci Technol 2007; 41: 88–92
  • Kirk A B, Martinelango P K, Tian K, Dutta A, Smith E E, Das Dupta P K. Perchlorate and iodide in dairy and breast milk. Environ Sci Technol 2005; 39: 2011–2017
  • van Maanen J M, van Dijk A, Mulder K, de Baets M H, Menheere P C, van der Heide D, Mertens P L, Kleinjans D C. Consumption of drinking water with high nitrate levels causes hypertrophy of the thyroid. Toxicol Lett 1994; 72: 365–374
  • Dorea J G. Maternal thiocyanate and thyroid status during breast-feeding. J Am Coll Nutr 2004; 23: 97–101
  • Laurberg P, Nohr S, Pedersen K, Fuglsang E. Iodine nutrition in breast-fed infants is impaired by maternal smoking. J Clin Endocrinol Metab 2004; 89: 181–187
  • Ribas-Fito N, Sala M, Cardo E, Mazon C, De Muga M E, Verdu A, Marco A, Grimalt J D, Sunyer J. Organochlorine compounds and concentrations of thyroid stimulating hormone in newborns. Occupat Environ Med 2003; 60: 301–303
  • Foster W G, Holloway A C, Hughes C L, Jr. Dioxin-like activity and maternal thyroid hormone levels in second trimester maternal serum. Am J Obstet Gynecol 2005; 193: 1900–1907
  • Wang S L, Su P H, Jong S B, Guo Y L, Chou W L, Papke O. In utero exposure to dioxins and polychlorinated biphenyls and its relations to thyroid function and growth hormone in newborns. Environ Sci Technol 2005; 113: 1645–1650
  • Takser L, Mergler D, Baldwin M, de Grosbois S, Smargiassi A, Lafond J. Thyroid hormones in pregnancy in relation to environmental exposure to organochlorine compounds and mercury. Environ Sci Technol 2005; 113: 1039–1045
  • Toldy E, Locsei Z, Rigo E, Kneffel P, Szabolcs I, Kovacs G L. Comparative analytical evaluation of thyroid hormone levels in pregnancy and in women taking oral contraceptives: a study from an iodine deficient area. Gynecol Endocrinol 2004; 18: 219–226
  • Yen P M. Physiological and molecular basis of thyroid hormone action. Physiol Rev 2001; 81: 1097–1142
  • Muñoz A, Bernal J. Biological activities of thyroid hormone receptors. Eur J Endocrinol 1997; 137: 433–445
  • Peeters R P, van der Deure W M, Visser J. Genetic variation in thyroid hormone pathway genes; polymorphisms in the TSH receptor and the iodothyronine deiodinases. Eur J Endocrinol 2006; 155: 655–662
  • Hansen P S, Brix T H, Sorensen T I, Kyvik K O, Hegedus L. Major genetic influence on the regulation of the pituitary–thyroid axis: a study of healthy Danish twins. J Clin Endocrinol Metab 2004; 89: 1181–1187
  • Samollow P B, Perez G, Kammerer C M, Finegold D, Zwartjes P W, Havill L M, Comuzzie A G, Mahaney M C, Goring H H, Blangero J, et al. Genetic and environmental influences on thyroid hormone variation in Mexican Americans. J Clin Endocrinol Metab 2004; 89: 3276–3284
  • Knudsen N, Laurberg P, Rasmussen L B, Bulow I, Perrild H, Ovesen L, Jorgensen T. Small differences in thyroid function may be important for body mass index and the occurrence of obesity in the population. J Clin Endocrinol Metab 2005; 90: 4019–4024
  • Poppe K, Velkeniers B. Thyroid disorders in infertile women. Ann Endocrinol (Paris) 2003; 64: 45–50
  • Sieiro Netto L, Medina Coeli C, Micmacher E, Mamede Da Costa S, Nazar L, Galvao D, Buescu A, Vaisman M. Influence of thyroid autoimmunity and maternal age on the risk of miscarriage. Am J Reprod Immunol 2004; 52: 312–316
  • Bussen S, Steck T, Dietl J. Increased prevalence of thyroid antibodies in euthyroid women with a history of recurrent in-vitro fertilization failure. Hum Reprod 2000; 15: 545–554
  • la Marca A, Morgante G, De Leo V. Human chorionic gonadotropin, thyroid function, and immunological indices in threatened abortion. Obstet Gynecol 1998; 92: 206–211
  • Bischof P, Meisser A, Campana A. Paracrine and autocrine regulators of trophoblast invasion – a review. Placenta 2000; 21(Suppl A)S55–S60
  • Craven C M, Zhao L, Ward K. Lateral placental growth occurs by trophoblast cell invasion of decidual veins. Placenta 2000; 21: 160–169
  • Matsuo H, Maruo T, Murata K, Mochizuki M. Human early placental trophoblasts produce an epidermal growth factor-like substance in synergy with thyroid hormone. Acta Endocrinol 1993; 128: 225–229
  • McKinnon B, Li H, Richard K, Mortimer R. Synthesis of thyroid hormone binding proteins transthyretin and albumin by human trophoblast. J Clin Endocrinol Metab 2005; 90: 6714–6720
  • Kilby M D, Verhaeg J, Gittoes N, Somerset D A, Clark P M, Franklyn J A. Circulating thyroid hormone concentrations and placental thyroid hormone receptor expression in normal human pregnancy and pregnancy complicated by intrauterine growth restriction (IUGR). J Clin Endocrinol Metab 1998; 83: 2964–2971
  • Chan S -Y, Franklyn J A, Pemberton H N, Bulmer J N, Visser T J, McCabe C J, Kilby M D. Monocarboxylate transporter 8 expression in the human placenta: the effects of severe intrauterine growth restriction. J Endocrinol 2006; 189: 465–471
  • Di Cosmo C, Fanelli G, Tonacchera M, Ferrarini E, Dimida A, Agretti P, De Marco G, Vitti P, Pinchera A, Bevilacqua G, et al. The sodium–iodide symporter expression in placental tissue at different gestational age: an immunohistochemical study. Clin Endocrinol (Oxf) 2006; 65: 544–548
  • Bidart J M, Lacroix L, Evain-Brion D, Caillou B, Lazar V, Frydman R, Bellet D, Filetti S, Schlumberger M. Expression of Na+/I− symporter and Pendred syndrome genes in trophoblast cells. J Clin Endocrinol Metab 2000; 85: 4367–4372
  • Pérez-López F R, Abós M D, González Moreno C M, Corvo R H, Andonegui J A. Lack of effect of maternal administration of clebopride on fetal prolactin and thyrotropin serum levels. Neuroendocrinol Lett 1982; 4: 283–287
  • Pérez-López F R, Robert J, Teijeiro J. PRL, TSH, β-hCG and oestriol responses to repetitive (triple) LRH/TRH administration in the third trimester of human pregnancy. Acta Endocrinol 1984; 106: 400–404
  • Pérez-López F R, Aisa F, Urcia M, Martínez-Casamayor M F, Farjas M P. Circadian oscillations of thyrotrophin, prolactin, cortisol, placental lactogen and estriol in late human pregnancy. Neuroendocrinol Lett 1984; 6: 231–241
  • Vaidya B, Anthony S, Bilous M, Shields B, Drury J, Hutchison S, Bilous R. Detection of thyroid dysfunction in early pregnancy: universal screening or targeted high-risk case finding?. J Clin Endocrinol Metab 2007; 92: 203–207
  • Glinoer D, De Nayer P, Robyn C, Lejeune B, Kinthaert J, Meuris S. Serum levels of intact human chorionic gonadotropin (hCG) and its free α and β subunits, in relation to maternal thyroid stimulation during normal pregnancy. J Endocrinol Invest 1993; 16: 881–888
  • Glinoer D, de Nayer P, Bourdoux P, Lemone M, Robyn C, van Steirteghem A, Kinthaert J, Lejeune B. Regulation of maternal thyroid during pregnancy. J Clin Endocrinol Metab 1990; 71: 276–287
  • Glinoer D. The regulation of thyroid function in pregnancy: pathways of endocrine adaptation from physiology to pathology. Endocr Rev 1997; 18: 404–433
  • Ain K B, Mori Y, Refetoff S. Reduced clearance rate of thyroxine-binding globulin (TBG) with increased sialylation: a mechanism for estrogen-induced elevation of serum TBG concentration. J Clin Endocrinol Metab 1987; 65: 689–696
  • Roti E, Gardini E, Minelli R, Bianconi L, Flisi M. Thyroid function evaluation by different commercially available free thyroid hormone measurement kits in term pregnant women and their newborns. J Endocrinol Invest 1991; 14: 1–9
  • Ball R, Freedman D B, Holmes J C, Midgley J EM, Sheehan C P. Low-normal concentrations of free thyroxin in serum in late pregnancy: physiological fact, not detected artifact. Clin Chem 1989; 35: 1891–1896
  • Burrow G N. Thyroid function and hyperfunction during gestation. Endocr Rev 1993; 14: 194–202
  • Vermiglio F, Lo Presti V P, Castagna M G, Violi M A, Moleti M, Finocchiaro M D, Mattina F, Artemisia A, Trimarchi F. Increased risk of maternal thyroid failure with pregnancy progression in an iodine deficient area with major iodine deficiency disorders. Thyroid 1999; 9: 19–24
  • Goodwin T M, Hershman J M. Hyperthyroidism due to inappropriate production of human chorionic gonadotropin. Clin Obstet Gynecol 1997; 40: 32–44
  • Kennedy R L, Darne J. The role of hCG in regulation of the thyroid gland in normal and abnormal pregnancy. Obstet Gynecol 1991; 78: 298–307
  • Utiger R D. Maternal hypothyroidism and fetal development. N Engl J Med 1999; 341: 601–602
  • Foulk R A, Musci T J, Schriock E D, Taylor R N. Does human chorionic gonadotropin have human thyrotropic activity in vivo?. Gynecol Endocrinol 1997; 11: 195–201
  • Eltom A, Eltom M, Elnagar B, Elbagir M, Gebre-Medhin M. Changes in iodine metabolism during late pregnancy and lactation: a longitudinal study among Sudanese women. Eur J Clin Nutr 2000; 54: 429–433
  • Eltom A, Eltom M, Idris M, Gebre-Medhin M. Thyroid function in the newborn in relation to maternal thyroid status during labour in a mild iodine deficiency endemic area in Sudan. Clin Endocrinol (Oxf) 2001; 55: 485–490
  • Contempré B, Jauniaux E, Calvo R, Jurkovic D, Campbell S, Morreale de Escobar G. Detection of thyroid hormones in human embryonic cavities during the first trimester of pregnancy. J Clin Endocrinol Metab 1993; 77: 1719–1722
  • Vulsma T, Gons M H, de Vijlder J J. Maternal–fetal transfer of thyroxine in congenital hypothyroidism due to a total organification defect or thyroid agenesis. N Engl J Med 1989; 321: 13–16
  • Thorpe-Beeston J G, Nicolaides K H, Felton C V, Butler J, McGregor A M. Maturation of the secretion of thyroid hormone and thyroid-stimulating hormone in the fetus. N Engl J Med 1991; 324: 532–536
  • Ballard P L, Ballard R A, Ning Y, Cnann A, Boardman C, Pinto-Martin J, Polk D, Phibbs R H, Davis D J, Mannino F L, et al. Plasma thyroid hormones in premature infants: effect of gestational age and antenatal thyrotropin releasing hormone treatment. Pediatr Res 1998; 44: 642–649
  • Nohr S B, Laurber P. Opposite variations in maternal and neonatal thyroid function induced by iodine supplementation during pregnancy. J Clin Endocrinol Metab 2000; 85: 623–627
  • Radaelli T, Cetin I, Zamperini P, Ferrazzi E, Pardi G. Intrauterine growth of normal thyroid. Gynecol Endocrinol 2002; 16: 427–430
  • Hume R, Simpson J, Delahunty C, van Toor H, Wu S Y, Williams F LR, Visser T J, collaboration from the Scottish Preterm Thyroid Group. Human fetal and cord serum thyroid hormones: developmental trends and interrelationships. J Clin Endocrinol Metab 2004; 89: 4097–4103
  • Calvo R M, Jauniaux E, Gulbis B, Asuncion M, Gervy C, Contempre B, Morreale de Escobar G. Fetal tissues are exposed to biologically relevant free thyroxine concentrations during early phases of development. J Clin Endocrinol Metab 2002; 87: 1768–1777
  • Kester M HA, de Mena R M, Obregón M J, Marinkovic D, Howatson A, Visser T J, Hume R, Morreale de Escobar G M. Iodothyronine levels in the human developing brain: major regulatory roles of iodothyronine deiodinases in different areas. J Clin Endocrinol Metab 2004; 89: 3117–3128
  • Ballibio M, Nicolini U, Jowett T, Ruiz de Elvira M C, Ekins R P, Rodeck C H. Maturation of thyroid function in normal human foetuses. Clin Endocrinol (Oxf) 1989; 31: 565–571
  • Koopdonk-Kool J M, De Vijlder J JM, Veenboer G JM, Ris-Stalpers C, Kok J H, Vulsma T, Boer K, Visser T J. Type II and type III deiodinase activity in human placenta as function of gestational age. J Clin Endocrinol Metab 1996; 81: 2154–2158
  • Kohrle J. Thyroid hormone deiodinases – a selenoenzyme family acting as gate keepers to thyroid hormone action. Acta Med Austr 1996; 23: 17–30
  • Chan S S, Hams G, Wiley V, Wilcken B, McElduff A. Postpartum maternal iodine status and the relationship to neonatal thyroid function. Thyroid 2003; 13: 873–876
  • Institute of Medicine, Food and Nutrition Board. Iodine. Dietary reference intakes for vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium and zinc. National Academy Press, Washington, DC 2001; 258–289
  • World Health Organization/United Nations Children's Fund/International Council for the Control of Iodine Deficiency Disorders. Assessment of the iodine deficiency disorders and monitoring their elimination. WHO, Geneva 2001; 1–107, WHO/NHD/01.1
  • Ares S, Quero J, Duran S, Presas M J, Herruzo R, Morreale de Escobar G. Iodine content of infant formulas and iodine intake of premature babies: high risk of iodine deficiency. Arch Dis Child Fetal Neonatal Ed 1994; 71: F184–F191
  • Terry A J, Hague W M. Postpartum thyroiditis. Semin Perinatol 1998; 22: 497–502
  • Gerstein H C. How common is postpartum thyroiditis?. Arch Inter Med 1990; 150: 1397–1400
  • DeLong G R, Xue-Yi C, Xin-Min J. Iodine supplementation of a cross-section of iodine-deficient pregnant women: does the human fetal brain undergo metamorphosis?. Iodine in pregnancy, J B Stanbury, F Delange, J T Dunn, C S Pandav. Oxford University Press, Delhi 1998; 55–78
  • European Commission, Health & Consumer Protection Directorate-General. Opinion of the Scientific Committee on Food on the tolerable upper intake level of iodine. European Union, Brussels Oct 7, 2002; 1–25, SCF/CS/NUT/UPPLEV/26 Final
  • Haddow J E, Palomaki G E, Allan W C, Williams J R, Knight G J, Gagnon J, O'Heir C E, Mitchell M L, Hermos R J, Waisbren S E, et al. Maternal thyroid deficiency during pregnancy and subsequent neuropsychological development of the child. N Engl J Med 1999; 341: 549–555
  • Pop V J, Kuijpens J L, van Baar A L, Verkerk G, van Son M M, de Vijlder J J, Vulsma T, Wiersinga W M, Drexhage H A, Vader H L. Low maternal free thyroxine concentrations during early pregnancy are associated with impaired psychomotor development in infancy. Clin Endocrinol (Oxf) 1999; 50: 149–155
  • Pop V J, Brouwers E P, Vader H L, Vulsma T, van Baar A L, de Vijlder J J. Maternal hypothyroxinemia during early pregnancy and subsequent child development: a 3-year follow-up study. Clin Endocrinol (Oxf) 2003; 59: 282–288
  • Kooistra L, Crawford S, van Baar A L, Brouwers E P, Pop V J. Neonatal effects of maternal hypothyroxinemia during early pregnancy. Pediatrics 2006; 117: 161–167
  • Morreale de Escobar G, Obregón M J, Escobar del Rey F. Role of thyroid hormone during early brain development. Eur J Endocrinol 2004; 151(Suppl 3)U25–U37
  • Visser T J. The elemental importance of sufficient iodine intake: a trace is not enough. Endocrinology 2006; 147: 2095–2097
  • Van Vliet G. Neonatal hypothyroidism: treatment and outcome. Thyroid 1999; 9: 79–84
  • Klein R Z, Haddow J E, Faix J D, Brown R S, Hermos R J, Pulkkinen A, Mitchell M L. Prevalence of thyroid deficiency in pregnant women. Clin Endocrinol (Oxf) 1991; 35: 41–46
  • Derksen-Lubsen G, Verkerk P H. Neuropsychologic development in early treated congenital hypothyroidism: analysis of literature data. Pediatric Res 1996; 39: 561–566
  • Rovet J F. Congenital hypothyroidism: long-term outcome. Thyroid 1999; 9: 741–748
  • Bernal J, Pekonen F. Ontogenesis of the nuclear 3,5,3′-triiodothyronine receptor in the human fetal brain. Endocrinology 1984; 114: 677–679
  • Chan S, Kilby M D. Thyroid hormone and central nervous system development. J Endocrinol 2000; 165: 1–8
  • Lavado-Autric R, Auso E, Garcia-Velasco J V, Arufe M C, Escobar del Rey F, Berbel P, Morreale de Escobar G. Early maternal hypothyroxinemia alters histogenesis and cerebral cortex cytoarchitecture of the progeny. J Clin Invest 2003; 111: 1073–1082
  • Santini F, Pinchera A, Ceccarini G, Castagna M, Rosellini V, Mammoli C, Montanelli L, Zucchi V, Chopra I J, Chiovato L. Evidence for a role of the type III-iodothyronine deiodinase in the regulation of 3,5,3′-triiodothyronine content in the human central nervous system. Eur J Endocrinol 2001; 144: 577–583
  • Huang S A, Dorfman D M, Genest D R, Salvatore D, Larsen P R. Type 3 iodothyronine deiodinase is highly expressed in the human uteroplacental unit and in fetal epithelium. J Clin Endocrinol Metab 2003; 88: 1384–1388
  • Bernal J. Thyroid hormones and brain development. Vitam Horm 2005; 71: 95–122
  • Kilby M D, Gittoes N, McCabe C, Verhaeg J, Franklyn J A. Expression of thyroid receptor isoforms in the human fetal central nervous system and the effects of intrauterine growth restriction. Clin Endocrinol (Oxf) 2000; 53: 469–477
  • Bürgi H, Supersaxo Z, Selz B. Iodine deficiency disease in Switzerland one hundred years after Theodor Kocher's survey: a historical review with some new goitre prevalence data. Acta Endocrinol 1990; 13: 577–590
  • Dahl L, Johansson L, Julshamn K, Meltzer H M. The iodine content of Norwegian foods and diets. Public Health Nutr 2004; 7: 569–576
  • Varo P, Saari E, Paaso A, Koivistoinen P. Iodine in Finnish foods. Int J Vitam Nutr Res 1982; 52: 80–89
  • Buhling K J, Schaff J, Bertram H, Hansen R, Muller C, Wascher C, Heinze T, Dudenhausen J W. [Supply of iodine during pregnancy – an inventory in Berlin, Germany]. Zeitschrift Geburtsh Neonatol 2003; 207: 12–16
  • Ministerio de Sanidad y Consumo. Prevención de la deficiencia de yodo durante el embarazo y la lactancia. Ministerio de Sanidad y Consumo, Madrid, [Internet] undated [cited Jan 3 2007]Available from: http://www.msc.es/profesionales/saludPublica/prevPromocion/docs/yodoEmbarazo.pdf
  • Foz M. La deficiencia de yodo en España: un problema todavía no resuelto. Med Clín (Barc) 2004; 122: 459–460
  • Pérez-López F R. Prescribir yodo durante el embarazo. Siete Días Médicos 2006; 684: 60
  • Becker D V, Braverman L E, Delange F, Dunn J T, Franklyn J A, Hollowell J G, Lamm S H, Mitchell M L, Pearce E, Robbins J, et al. Iodine supplementation for pregnancy and lactation-United States and Canada: recommendations of the American Thyroid Association. Thyroid 2006; 16: 949–951
  • van Netten C, Hoption Cann S A, Morley D R, van Netten J P. Elemental and radioactive analysis of commercially available seaweed. Sci Total Environ 2000; 255: 169–175
  • Aquaron R, Delange F, Marchal P, Lognone V, Ninane L. Bioavailability of seaweed iodine in human beings. Cell Mol Biol 2002; 48: 563–569
  • DeLong G R, Leslie P W, Wang S -H, Jiang X M, Zhang M L, Rakerman M, Jiang J Y, Ma T, Cao X Y. Effect on infant mortality of iodination of irrigation water in a severely iodine-deficient area of China. Lancet 1997; 350: 771–773
  • Mahomed K, Gulmezoglu A M. Maternal iodine supplements in areas of deficiency. Cochrane Database Syst Rev 2000, 2, CD000135
  • Bader N, Moller U, Leiterer M, Franke K, Jahreis G. Pilot study: tendency of increasing iodine content in human milk and cow's milk. Exp Clin Endocrinol Diabetes 2005; 113: 8–12
  • Kohn L A. The midwestern American ‘epidemic’ of iodine-induced hyperthyroidism in the 1920s. Bull N Y Acad Med 1976; 52: 770–781
  • Galofré J C, Fernández-Calvet L, Ríos M, García-Mayor R V. Increased incidence of thyrotoxicosis after iodine supplementation in an iodine sufficient area. J Endocrinol Invest 1994; 17: 23–27
  • Pedersen I B, Laurberg P, Knudsen N, Jørgensen T, Perrild H, Ovesen L, Rasmussen L B. Increase in incidence of hyperthyroidism predominantly occurs in young people after iodine fortification of salt in Denmark. J Clin Endocrinol Metab 2006; 91: 3830–3834
  • Teng W, Shan Z, Teng X, Guan H, Li Y, Teng D, Jin Y, Yu X, Fan C, Chong W, et al. Effect of iodine intake on thyroid diseases in China. N Engl J Med 2006; 354: 2783–2793
  • Utiger R D. Iodine nutrition – more is better …. N Engl J Med 2006; 354: 2819–2821

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