82
Views
10
CrossRef citations to date
0
Altmetric
Uterus

Repressive effect of the phytoestrogen genistein on estradiol-induced uterine leiomyoma cell proliferation

, , , , , , & show all
Pages 403-409 | Received 27 Oct 2008, Accepted 07 Jan 2009, Published online: 21 Jul 2009

References

  • Wilcox L S, Koonin L M, Pokras R, Strauss L T, Xia Z, Peterson H B. Hysterectomy in the United States,1988–1990. Obstet Gynecol 1994; 83: 549–555
  • Lepine L A, Hillis S D, Marchbanks P A, Koonin L M, Morrow B, Kieke B A, Wilcox L S. Hysterectomy surveillance – United States,1980–1993. MMWR CDC Surveill Summ 1997; 46: 1–15
  • Walker C L, Stewart E A. Uterine fibroids: the elephant in the room. Science 2005; 308: 1589–1592
  • Rein M S. Advances in uterine leiomyoma research: the progesterone hypothesis. Environ Health Perspect 2000; 108(5 Suppl)791–793
  • Flake G P, Andersen J, Dixon D. Etiology and pathogenesis of uterine leiomyomas: a review. Environ Health Perspect 2003; 111: 1037–1054
  • Heim M, Frank O, Kampmann G, Sochocky N, Pennimpede T, Fuchs P, Hunziker W, Weber P, Martin I, Bendik I. The phytoestrogen genistein enhances osteogenesis and represses adeipogenic differentiation of human primary bone marrow stromal cells. Endocrinology 2004; 145: 848–859
  • Konstantakopoulos N, Montgomery K G, Chamberlain N, Quinn M A, Baker M S, Rice G E, Georgiou H M, Campbell I G. Changes in gene expressions elicited by physiological concentrations of genistein on human endometrial cancer cells. Mol Carcinog 2006; 45: 752–763
  • Moore A B, Castro L, Yu L, Zheng X, Di X, Sifre M I, Kissling G E, Newbold R R, Bortner C D, Dixon D. Stimulatory and inhibitory effects of genistein on human uterine leiomyoma cell proliferation are influenced by the concentration. Hum Reprod 2007; 22: 2623–2631
  • Nagata C, Takatsuka N, Kawakami N, Shimizu H. Soy product intake and premenopausal hysterectomy in a follow-up study of Japanese women. Eur J Clin Nutr 2001; 55: 773–777
  • Everitt J I, Wolf D C, Howe S R, Goldsworthy T L, Walker C. Rodent model of reproductive tract leiomyomata. Clinical and pathological features. Am J Pathol 1995; 146: 1556–1567
  • Walker C L, Hunter D, Everitt J I. Uterine leiomyoma in the Eker rat: a unique model for important diseases of women. Genes Chromosomes Cancer 2003; 38: 349–356
  • Howe S R, Gottardis M M, Everitt J I, Golesworthy T L, Wolf D C, Walker C. Rodent model of reproductive tract leiomyomata. Establishment and characterization of tumor-derived cell lines. Am J Pathol 1995; 146: 1568–1579
  • Severino M F, Murray M J, Brandon D D, Clinton G M, Burry K A, Novy M J. Rapid loss of oestrogen and progesterone receptors in human leiomyoma and myometrial explant cultures. Mol Hum Reprod 1996; 2: 823–828
  • Houston K D, Copland J A, Broaddus R R, Gottardis M M, Fischer S M, Walker C L. Inhibition of proliferation and estrogen receptor signaling by peroxisome proliferators – activated receptor γ ligands in uterine leiomyoma. Cancer Res 2003; 63: 1221–1227
  • Shushan A, Ben-Bassat H, Mishni E, Laufer N, Klein B Y, Rojansky N. Inhibition of leiomyoma cell proliferation in vitro by genistein and the protein tyrosine kenase inhibitor TKS050. Fertil Steril 2007; 87: 127–135
  • Gossner G, Choi M, Tan L, et al. Genistein-induced apoptosis and autophagocytosis in ovarian cancer cells. Gynecol Oncol 2007; 105: 23–30
  • Huang X, Chen S, Xu L, et al. Genistein inhibits p38 map kinase activation, matrix metalloproteinase type2, and cell invasion in human prostate epithelial cells. Cancer Res 2005; 65: 3470–3478
  • Katdare M, Osborne M, Telang N T. Soy isoflavone genistein modulates cell cycle progression and induces apoptosis in HER-2/neu oncogene expressing human breast epithelial cells. Int J Oncol 2002; 21: 809–815
  • Dang Z C, Audinot V, Papapoulos S E, Boutin J A, Lowik C WGM. Peroxisome proliferator-activated receptor γ (PPARγ) as a molecular target for the soy phytoestrogen genistein. J Biol Chem 2003; 278: 962–967
  • Setchell K D. Phytoestrogens: the biochemistry, physiology, and implications for human health of soy isoflavones. Am J Clin Nutr 1998; 68(6 Suppl)1333S–1346S
  • Izumi T, Piskula M K, Osawa S, Obata A, Tobe K, Saito M, Kataoka S, Kubota Y, Kikuchi M. Soy isoflavone aglycones are absorbed faster and in higher amounts than their glucosides in humans. J Nutr 2000; 130: 1695–1699
  • Sharma A M, Staels B. Review: peroxisome proliferator-activated receptor γ and adipose tissue – understanding obesity-related changes in the regulation of lipid and glucose metabolism. J Clin Endocrinol Metab 2007; 92: 386–395
  • Wright H M, Clish C B, Mikami T, Hauser S, Yanagi K, Hiramatsu R, Serhan C N, Spiegelman B M. A synthetic antagonist for the peroxisome proliferator-activated receptor γ inhibits adipocyte differentiation. J Biol Chem 2000; 275: 1873–1877
  • Takeda T, Sakata M, Isobe A, Miyake A, Nishimoto F, Ota Y, Kamiura S, Kimura T. Relationship between metabolic syndrome and uterine leiomyomata: a case-control study. Gynecol Obstet Invest 2008; 66: 14–17
  • Banerjee S, Li Y, Wang Z, Sarkar F H. Multi-targeted therapy of cancer by genistein. Cancer Lett 2008; 269: 226–242

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.