Inverse relationship between erythrocyte size and platelet reactivity in elderly

References

• Reimers RC, Sutera SP, Joist JH. Potentiation by red blood cells of shear-induced platelet aggregation: relative importance of chemical and physical mechanisms. Blood 1984;64:1200–2006.
   PubMed Web of Science ®Google Scholar
• Aarts PA, van den Broek SA, Prins GW, Kuiken GD, Sixma JJ, Heethaar RM. Blood platelets are concentrated near the wall and red blood cells in the center in flowing blood. Arteriosclerosis 1988;8:819–824.
   PubMedGoogle Scholar
• Eugster M, Reinhart WH. The influence of the haematocrit on primary haemostasis in vitro. Thromb Haemost. 2005;94:1213–1218.
   PubMed Web of Science ®Google Scholar
• Jordan A, David T, Homer-Vanniasinkam S, Graham A, Walker P. The effects of margination and red cell augmented platelet diffusivity on platelet adhesion in complex flow. Biorheology 2004;41:641–653.
   PubMed Web of Science ®Google Scholar
• Aarts PA, Heethaar RM, Sixma JJ. Red blood cell deformability influences platelets-vessel wall interaction in flowing blood. Blood 1984;64:1228–1233.
   PubMed Web of Science ®Google Scholar
• Aarts PA, Bolhuis PA, Sakariassen KS, Heethaar RM, Sixma JJ. Red blood cell size is important for adherence of blood platelets to artery subendothelium. Blood 1983;62:214–217.
   PubMed Web of Science ®Google Scholar
• Järemo P. Computerized method for recording platelet density distribution. Eur J Haematol. 1995;54:304–309.
   PubMed Web of Science ®Google Scholar
• Chamberlain KG, Seth P, Jones MK, Penington DG. Subcellular composition of platelet density sub-populations prepared using continuous Percoll gradients. Br J Haematol. 1989;72:199–207.
   PubMed Web of Science ®Google Scholar
• Karpatkin S. Heterogeneity of human platelets. II. Functional evidence suggestive of young and old platelets. J Clin Invest. 1969;48:1083–1087.
   PubMed Web of Science ®Google Scholar
• Polanowska-Grabowska R, Raha S, Gear AR. Adhesion efficiency, platelet density and size. Br J Haematol. 1992;82:715–720.
   PubMed Web of Science ®Google Scholar
• Milovanovic M, Lysen J, Ramström S, Lindahl TL, Richter A, Järemo P. Identification of low-density platelet populations with increased reactivity and elevated alpha-granule content. Thromb Res. 2003;111:75–80.
   PubMed Web of Science ®Google Scholar
• Milovanovic M, Lotfi K, Lindahl T, Hallert C, Järemo P. Platelet density subpopulations in essential thrombocythemia and healthy volunteers. Pathophysiol Haemost Thromb. 2010;37:35–42.
   PubMedGoogle Scholar
• Andrews RK, Berndt MC. Platelet physiology and thrombosis. Thromb Res. 2004;114:447–453.
   PubMed Web of Science ®Google Scholar
• Henn V, Slupsky JR, Gräfe M, Anagnostopoulos I, Förster R, Müller-Berghaus G, Kroczek RA. CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells. Nature 1998;391:591–594.
   PubMed Web of Science ®Google Scholar
• McEver RP. Adhesive interactions of leukocytes, platelets, and the vessel wall during hemostasis and inflammation. Thromb Haemost. 2001;86:746–756.
   PubMed Web of Science ®Google Scholar
• Otterdal K, Pedersen TM, Solum NO. Release of soluble CD40 ligand after platelet activation: studies on the solubilization phase. Thromb Res. 2004;114:167–177.
   PubMed Web of Science ®Google Scholar
• Järemo P, Lindahl TL, Fransson SG, Richter A. Individual variations of platelet inhibition after loading doses of clopidogrel. J Int Med. 2002;252:233–238.
   PubMed Web of Science ®Google Scholar
• Järemo P, Eriksson M, Lindahl TL, Nilsson S, Milovanovic M. Platelets and acute cerebral infarctions. Platelets 2013;24:407–411.
   PubMed Web of Science ®Google Scholar
• Järemo P, Milovanovic M, Nilsson S, Buller C, Post C, Winblad B. Alzheimer´s disease is characterized by more low density erythrocytes with increased volume and enhanced β-amyloid X-40 content. J Int Med. 2011;270:489–492.
   PubMed Web of Science ®Google Scholar
• Kiko T, Nakagawa K, Satoh A, Tsuduki T, Furukawa K, Arai H, Miyazawa T. Amyloid β levels in human red blood cells. PLoS One 2012;7:e49620.
   PubMed Web of Science ®Google Scholar
• Lan J, Liu J, Zhao Z, Xue R, Zhang N, Zhang P, Zhao P, Zheng F, Sun X. The peripheral blood of Aβ binding RBC as a biomarker for diagnosis of Alzheimer’s disease. Age Ageing 2015: electronic publication ahead of print.
   Google Scholar
• Järemo P, Milovanovic M, Buller C, Nilsson S, Winblad B. Alzheimer’s disease and granulocyte density diversity. Eur J Clin Invest. 2013;43:545–548.
   PubMed Web of Science ®Google Scholar
• Järemo P, Milovanovic M, Buller C, Nilsson S, Winblad B. Platelet heterogeneity and Alzheimer´s disease: low density platelets populations demonstrate low in vivo activity. Platelets 2012;23:116–120.
   PubMed Web of Science ®Google Scholar
• Järemo P, Milovanovic M, Buller C, Nilsson S, Winblad B. P-Selectin paradox and dementia of the Alzheimer type: circulating P-Selectin is increased but platelet-bound P-Selectin after agonist provocation is compromised. Scand J Clin Lab Invest. 2013;73:170–174.
   PubMed Web of Science ®Google Scholar
• Milovanovic M, Eriksson K, Winblad B, Nilsson S, Lindahl TL, Post C, Järemo P. Alzheimer and platelets: Low-density platelet populations reveal increased serotonin content in Alzheimer type dementia. Clin Biochem. 2014;47:51–53.
   PubMed Web of Science ®Google Scholar
• Gamaldo AA, Ferrucci L, Rifkind J, Longo DL, Zonderman AB. Relationship between mean corpuscular volume and cognitive performance in older adults. J Am Geriatr Soc. 2013;61:84–89.
   PubMed Web of Science ®Google Scholar
• Engström I, Ronquist G, Pettersson L, Waldenström A. Alzheimer amyloid beta-peptides exhibit ionophore-like properties in human erythrocytes. Eur J Clin Invest. 1995;25:471–476.
   PubMed Web of Science ®Google Scholar
• Gardella JE, Ghiso J, Gorgone GA, Marratta D, Kaplan AP, Frangione B, Gorevic PD. Intact Alzheimer amyloid precursor protein (APP) is present in platelet membranes and is encoded by platelet mRNA. Biochem Biophys Res Commun. 1990;173:1292–1298
   PubMed Web of Science ®Google Scholar
• Franczuk P, Kaczorowski M, Kucharska K, Franczuk J, Josiak K, Zimoch W, Kosowski M, Reczuch K, Majda J, Banasiak W, et al. Could an analysis of mean corpuscular volume help to improve a risk stratification in non-anemic patients with acute myocardial infarction? Cardiol J. 2015: epub ahead of print.
   Google Scholar