Underlying mechanism and specific prevention of hemolysis-induced platelet activation

References

• Allgood JW, Chaplin H, Jr. Idiopathic acquired autoimmune hemolytic anemia. A review of forty-seven cases treated from 1955 through 1965. Am J Med 1967;43:254–273.
   Google Scholar
• Ravichandran AK, Parker J, Novak E, Joseph SM, Schilling JD, Ewald GA, Silvestry S. Hemolysis in left ventricular assist device: a retrospective analysis of outcomes. J Heart Lung Transplant 2014;33:44–50.
   PubMed Web of Science ®Google Scholar
• Patel H, Madanieh R, Kosmas CE, Vatti SK, Vittorio TJ. Complications of continuous-flow mechanical circulatory support devices. Clin Med Insights Cardiol 2015;9:15–21.
   PubMed Web of Science ®Google Scholar
• Horne MK, 3rd, Cullinane AM, Merryman PK, Hoddeson EK. The effect of red blood cells on thrombin generation. Br J Haematol 2006;133:403–408.
   PubMed Web of Science ®Google Scholar
• Shet AS, Aras O, Gupta K, Hass MJ, Rausch DJ, Saba N, Koopmeiners L, Key NS, Hebbel RP. Sickle blood contains tissue factor-positive microparticles derived from endothelial cells and monocytes. Blood 2003;102:2678–2683.
   PubMed Web of Science ®Google Scholar
• Rother RP, Bell L, Hillmen P, Gladwin MT. The clinical sequelae of intravascular hemolysis and extracellular plasma hemoglobin: a novel mechanism of human disease. JAMA 2005;293:1653–1662.
   PubMed Web of Science ®Google Scholar
• Ataga KI, Cappellini MD, Rachmilewitz EA. Beta-thalassaemia and sickle cell anaemia as paradigms of hypercoagulability. Br J Haematol 2007;139:3–13.
   PubMed Web of Science ®Google Scholar
• Da Q, Teruya M, Guchhait P, Teruya J, Olson JS, Cruz MA. Free hemoglobin increases von Willebrand factor-mediated platelet adhesion in vitro: implications for circulatory devices. Blood 2015;126:2338–2341.
   PubMed Web of Science ®Google Scholar
• Jacquemin M, Peerlinck K. Free hemoglobin: a boost to platelet thrombi. Blood 2015;126:2262–2263.
   PubMed Web of Science ®Google Scholar
• Helms CC, Marvel M, Zhao W, Stahle M, Vest R, Kato GJ, Lee JS, Christ G, Gladwin MT, Hantgan RR, et al. Mechanisms of hemolysis-associated platelet activation. J Thromb Haemost 2013;11:2148–2154.
   PubMed Web of Science ®Google Scholar
• Eldor A, Rachmilewitz EA. The hypercoagulable state in thalassemia. Blood 2002;99:36–43.
   PubMed Web of Science ®Google Scholar
• Jakubowski JA, Zhou C, Jurcevic S, Winters KJ, Lachno DR, Frelinger AL, 3rd, Gupta N, Howard J, Payne CD, Mant TG. A phase 1 study of prasugrel in patients with sickle cell disease: effects on biomarkers of platelet activation and coagulation. Thromb Res 2014;133:190–195.
   PubMed Web of Science ®Google Scholar
• Wun T, Soulieres D, Frelinger AL, Krishnamurti L, Novelli EM, Kutlar A, Ataga KI, Knupp CL, McMahon LE, Strouse JJ, et al. A double-blind, randomized, multicenter phase 2 study of prasugrel versus placebo in adult patients with sickle cell disease. J Hematol Oncol 2013;6:17.
   PubMed Web of Science ®Google Scholar
• Gaarder A, Jonsen J, Laland S, Hellem A, Owren PA. Adenosine diphosphate in red cells as a factor in the adhesiveness of human blood platelets. Nature 1961; 192:531–532.
   PubMed Web of Science ®Google Scholar
• Marcus AJ, Broekman MJ, Drosopoulos JH, Olson KE, Islam N, Pinsky DJ, Levi R. Role of CD39 (NTPDase-1) in thromboregulation, cerebroprotection, and cardioprotection. Semin Thromb Haemost 2005;31:234–246.
   PubMed Web of Science ®Google Scholar
• Gremmel T, Calatzis A, Steiner S, Kaider A, Seidinger D, Koppensteiner R, Kopp CW, Panzer S. Is TRAP-6 suitable as a positive control for platelet reactivity when assessing response to clopidogrel? Platelets 2010;21:515–521.
   PubMed Web of Science ®Google Scholar
• Hillmen P, Muus P, Duhrsen U, Risitano AM, Schubert J, Luzzatto L, Schrezenmeier H, Szer J, Brodsky RA, Hill A, et al. Effect of the complement inhibitor eculizumab on thromboembolism in patients with paroxysmal nocturnal hemoglobinuria. Blood 2007;110:4123–4128.
   PubMed Web of Science ®Google Scholar
• Hendrick AM. Auto-immune haemolytic anaemia–a high-risk disorder for thromboembolism? Hematology 2003;8:53–56.
   PubMedGoogle Scholar
• Frelinger AL, 3rd, Jakubowski JA, Brooks JK, Carmichael SL, Berny-Lang MA, Barnard MR, Heeney MM, Michelson AD. Platelet activation and inhibition in sickle cell disease (pains) study. Platelets 2014;25:27–35.
   PubMed Web of Science ®Google Scholar
• Michelson AD, Barnard MR, Krueger LA, Valeri CR, Furman MI. Circulating monocyte-platelet aggregates are a more sensitive marker of in vivo platelet activation than platelet surface P-selectin: studies in baboons, human coronary intervention, and human acute myocardial infarction. Circulation 2001;104:1533–1537.
   PubMed Web of Science ®Google Scholar
• Furman MI, Barnard MR, Krueger LA, Fox ML, Shilale EA, Lessard DM, Marchese P, Frelinger AL, 3rd, Goldberg RJ, Michelson AD. Circulating monocyte-platelet aggregates are an early marker of acute myocardial infarction. J Am Coll Cardiol 2001;38:1002–1006.
   PubMed Web of Science ®Google Scholar
• Born GV. Aggregation of blood platelets by adenosine diphosphate and its reversal. Nature 1962;194:927–929.
   PubMed Web of Science ®Google Scholar
• Born GV, Wehmeier A. Inhibition of platelet thrombus formation by chlorpromazine acting to diminish haemolysis. Nature 1979;282:212–213.
   PubMed Web of Science ®Google Scholar
• Born GV, Bergquist D, Arfors KE. Evidence for inhibition of platelet activation in blood by a drug effect on erythrocytes. Nature 1976;259:233–235.
   PubMed Web of Science ®Google Scholar
• Malato A, Saccullo G, Coco LL, Mancuso S, Santoro M, Martino S, Zammit V, Sprini D, Siragusa S. Thrombotic complications in paroxysmal nocturnal haemoglobinuria: a literature review. Blood Transfus 2012;10:428–435.
   PubMed Web of Science ®Google Scholar
• Peerschke EI, Silver RT, Weksler B, Grigg SE, Savion N, Varon D. Ex vivo evaluation of erythrocytosis-enhanced platelet thrombus formation using the cone and plate(let) analyzer: effect of platelet antagonists. Br J Haematol 2004;127:195–203.
   PubMed Web of Science ®Google Scholar
• Goldschmidt N, Spectre G, Brill A, Zelig O, Goldfarb A, Rachmilewitz E, Varon D. Increased platelet adhesion under flow conditions is induced by both thalassemic platelets and red blood cells. Thromb Haemost 2008;100:864–870.
   PubMed Web of Science ®Google Scholar
• Hellem AJ, Borchgrevink CF, Ames SB. The role of red cells in haemostasis: the relation between haematocrit, bleeding time and platelet adhesiveness. Br J Haematol 1961;7:42–50.
   PubMed Web of Science ®Google Scholar
• Montoro-Garcia S, Schindewolf M, Stanford S, Larsen OH, Thiele T. The Role of Platelets in Venous Thromboembolism. Semin Thromb Hemost 2016;42:242–251.
   PubMed Web of Science ®Google Scholar
• Shingal R, Annarapu GK, Pandey A, Chawla S, Ojha A, Gupta A, Cruz MA, Seth T, Guchhait P. Hemoglobin interaction with GP1bα induces platelet activation and apoptosis: a novel mechanism associated with intravascular hemolysis. Haematologica 2015;100:1526–1533.
   PubMed Web of Science ®Google Scholar
• Jakubowski JA, Zhou C, Winters KJ, Lachno DR, Howard J, Payne CD, Mant T, Jurcevic S, Frelinger AL, 3rd. The effect of prasugrel on ADP-stimulated markers of platelet activation in patients with sickle cell disease. Platelets 2015;26:474–479.
   PubMed Web of Science ®Google Scholar