Platelet reactivity in overweight and obese patients undergoing cardiac surgery

References

• Basili S, Pacini G, Guagnano MT, Manigrasso MR, Santilli F, Pettinella C, Ciabattoni G, Patrono C, Davì G. Insulin resistance as a determinant of platelet activation in obese women. J Am Coll Cardiol. 2006;48:2531–2538. doi:10.1016/j.jacc.2006.08.040.
   PubMed Web of Science ®Google Scholar
• De Pergola G, Pannaciulli N, Coviello M, Scarangella A, Di Roma P, Caringella M, Venneri MT, Quaranta M, Giorgino R. sP-selectin plasma levels in obesity: association with insulin resistance and related metabolic and prothrombotic factors. Nutr Metab Cardiovasc Dis. 2008;18:227–232. doi:10.1016/j.numecd.2006.09.010.
   PubMed Web of Science ®Google Scholar
• Bhatt DL. What makes platelets angry. J Am Coll Cardiol. 2008;52:1060–1061. doi:10.1016/j.jacc.2008.06.027.
   PubMed Web of Science ®Google Scholar
• Csongràdi E, Nagy B Jr, Fulop T, Varga Z, Karányi Z, Magyar MT, Oláh L, Papp M, Facskó A, Kappelmayer J, et al. Increased levels of platelet activation markers are positively associated with carotid wall thickness and other atherosclerotic risk factors in obese patients. Thromb Haemost. 2011;106:683–692. doi:10.1160/TH11-01-0030.
   PubMed Web of Science ®Google Scholar
• Santilli F, Vazzana N, Liani R, Guagnano MT, Davì G. Platelet activation in obesity and metabolic syndrome. Obes Rev. 2012;13:27–42. doi:10.1111/j.1467-789X.2011.00930.x.
   PubMed Web of Science ®Google Scholar
• Leite NR, Siqueira De Medeiros M, Mury WV, Matsuura C, Perszel MB, Noronha Filho G, Brunini TM, Mendes-Ribeiro AC. Platelet hyperaggregability in obesity: is there a role for nitric oxide impairment and oxidative stress? Clin Exp Pharmacol Physiol. 2016;43:738–744. doi:10.1111/1440-1681.12589.
   PubMed Web of Science ®Google Scholar
• Vazzana N, Guagnano MT, Cuccurullo C, Ferrante E, Lattanzio S, Liani R, Romano M, Davì G. Endogenous secretory RAGE in obese women: association with platelet activation and oxidative stress. J Clin Endocrinol Metab. 2012;97:E1726–1730. doi:10.1210/jc.2012-1473.
   PubMed Web of Science ®Google Scholar
• Vilahur G, Ben-Aicha S, Badimon L. New insights into the role of adipose tissue in thrombosis. Cardiovasc Res. 2017;113:1046–1054. doi:10.1093/cvr/cvx086.
   PubMed Web of Science ®Google Scholar
• Badimon L, Bugiardini R, Cenko E, Cubedo J, Dorobantu M, Duncker DJ, Estruch R, Milicic D, Tousoulis D, Vasiljevic Z, et al. Position paper of the European society of cardiology-working group of coronary pathophysiology and microcirculation: obesity and heart disease. Eur Heart J. 2017;38:1951–1958. doi:10.1093/eurheartj/ehx181.
   PubMed Web of Science ®Google Scholar
• Koller A, Balasko M, Bagi Z. Endothelial regulation of coronary microcirculation in health and cardiometabolic diseases. Intern Emerg Med. 2013;8(Suppl1):S51–54. doi:10.1007/s11739-013-0910-5.
   PubMedGoogle Scholar
• Berwick ZC, Dick GM, Tune JD. Heart of the matter: coronary dysfunction in metabolic syndrome. J Mol Cell Cardiol. 2012;52:848–856. doi:10.1016/j.yjmcc.2011.06.025.
   PubMed Web of Science ®Google Scholar
• Yusuf S, Hawken S, Ounpuu S, Bautista L, Franzosi MG, Commerford P, Lang CC, Rumboldt Z, Onen CL, Lisheng L, et al.; INTERHEART Study Investigators. Obesity and the risk of myocardial infarction in 27,000 participants from 52 countries: a case-control study. Lancet. 2005;366:1640–1649. doi:10.1016/S0140-6736(05)67528-9.
   PubMed Web of Science ®Google Scholar
• Kindo M, Minh TH, Gerelli S, Meyer N, Schaeffer M, Perrier S, Bentz J, Announe T, Mommerot A, Collange O, et al. The prothrombotic paradox of severe obesity after cardiac surgery under cardiopulmonary bypass. Thromb Res. 2014;134:346–353. doi:10.1016/j.thromres.2014.06.008.
   PubMed Web of Science ®Google Scholar
• Diehl P, Olivier C, Haischeid C, Helbing T, Bode C, Moser M. Clopidogrel affects leukocyte dependent platelet aggregation by P2Y12 expressing leukocytes. Basic Res Cardiol. 2010;105:379–387. doi:10.1007/s00395-009-0073-8.
   PubMed Web of Science ®Google Scholar
• Mayer K, Orban M, Bernlochner I, Braun S, Schulz S, Gross L, Hadamitzky M, Schunkert H, Laugwitz KL, Massberg S, et al. Predictors of antiplatelet response to prasugrel during maintenance treatment. Platelets. 2015;26:53–58. doi:10.3109/09537104.2013.863857.
   PubMed Web of Science ®Google Scholar
• Ranucci M, Baryshnikova E, Soro G, Ballotta A, De Benedetti D, Conti D. Multiple electrode whole-blood aggregometry and bleeding in cardiac surgery patients receiving thienopyridines. Ann Thorac Surg. 2011;91:123–129. doi:10.1016/j.athoracsur.2010.09.022.
   PubMed Web of Science ®Google Scholar
• Agarwal S, Johnson RI, Kirmani BH. Pre- and post-bypass platelet function testing with multiple electrode aggregometry and TEG platelet mapping in cardiac surgery. J Cardiothorac Vasc Anesth. 2015;29:1272–1276. doi:10.1053/j.jvca.2015.01.028.
   PubMed Web of Science ®Google Scholar
• Pagano D, Milojevic M, Meesters MI, Benedetto U, Bolliger D, von Heymann C, Jeppsson A, Koster A, Osnabrugge RL, Ranucci M, et al. EACTS/EACTA Guidelines on patient blood management for adult cardiac surgery. Eur J Cardiothorac Surg. 2018;32:88–120.
   Web of Science ®Google Scholar
• Ranucci M, Colella D, Baryshnikova E, Di Dedda U. Effect of preoperative P2Y12 and thrombin platelet receptor inhibition on bleeding after cardiac surgery. Br J Anaesth. 2014;113:970–976. doi:10.1093/bja/aeu315.
   PubMed Web of Science ®Google Scholar
• Bath PM, Butterworth RJ. Platelet size: measurement, physiology and vascular disease. Blood Coagul Fibrinolysis. 1996;7:157–161.
   PubMed Web of Science ®Google Scholar
• Coban E, Ozdogan M, Yazicioglu G, Akcit F. The mean platelet volume in patients with obesity. Int J Clin Pract. 2005;59:981–982. doi:10.1111/j.1742-1241.2005.00500.x.
   PubMed Web of Science ®Google Scholar
• Sansanayudh N, Muntham D, Yamwong S, Sritara P, Akrawichien T, Thakkinstian A. The association between mean platelet volume and cardiovascular risk factors. Eur J Intern Med. 2016;30:37–42. doi:10.1016/j.ejim.2015.11.028.
   PubMed Web of Science ®Google Scholar
• Panova-Noeva M, Schulz A, Hermanns MI, Grossmann V, Pefani E, Spronk HM, Laubert-Reh D, Binder H, Beutel M, Pfeiffer N, et al. Sex-specific differences in genetic and nongenetic determinants of mean platelet volume: results from the Gutenmberg health study. Blood. 2016;127:251–259. doi:10.1182/blood-2015-07-660308.
   PubMed Web of Science ®Google Scholar
• Campello E, Spiezia L, Zabeo E, Maggiolo S, Vettor R, Simioni P. Hypercoagulability detected by whole blood thromboelastometry (ROTEM®) and impedance aggregometry (MULTIPLATE®) in obese patients. Thromb Res. 2015;135:548–553. doi:10.1016/j.thromres.2015.01.003.
   PubMed Web of Science ®Google Scholar
• Gaglia MA Jr, Torguson R, Pakala R, Xue Z, Sardi G, Mahmoudi M, Suddath WO, Kent KM, Satler LF, Pichard AD, et al. Relation of body mass index to on-treatment (clopidogrel + aspirin) platelet reactivity. Am J Cardiol. 2011;108:766–771. doi:10.1016/j.amjcard.2011.04.029.
   PubMed Web of Science ®Google Scholar
• Siasos G, Oikonomou E, Zaromitidou M, Kioufis S, Kokkou E, Mourouzis K, Vlasis K, Vavuranakis M, Stone PH, Papavassiliou AG, et al. Clopidogrel response variability is associated with endothelial dysfunction in coronary artery disease patients receiving dual antiplatelet therapy. Atherosclerosis. 2015;242:102–108. doi:10.1016/j.atherosclerosis.2015.07.009.
   PubMed Web of Science ®Google Scholar
• Bae JP, Candrilli SD, Fortenberry J, Meyers JL, Jakubowski JA, Drenning D. Point-of-care platelet reactivity determination with VerifyNow-P2Y12 following administration of clopidogrel or prasugrel: data from a real-world, clinical care inpatient setting. Hosp Pract. 1995;2014(42):7–15.
   Google Scholar
• Ang L, Palakodeti V, Khalid A, Tsimikas S, Idrees Z, Tran P, Clopton P, Zafar N, Bromberg-Marin G, Keramati S, et al. Elevated plasma fibrinogen and diabetes mellitus are associated with lower inhibition of platelet reactivity with clopidogrel. J Am Coll Cardiol. 2008;52:1052–1059. doi:10.1016/j.jacc.2008.05.054.
   PubMed Web of Science ®Google Scholar
• Wu ZK, Wang JJ, Wang T, Zhu SS, Chen XL, Liu C, Zhang WG. Clopidogrel resistance response in patients with coronary artery disease and metabolic syndrome: the role of hyperglycemia and obesity. J Geriatr Cardiol. 2015;12:378–382. doi:10.11909/j.issn.1671-5411.2015.04.009.
   PubMedGoogle Scholar
• Ranucci M, Ballotta A, La Rovere MT, Castelvecchio S. Surgical and clinical outcome research (SCORE) Group. Postoperative hypoxia and length of intensive care unit stay after cardiac surgery: the underweight paradox? PLoS One. 2014;9:e93992. doi:10.1371/journal.pone.0093992.
   PubMed Web of Science ®Google Scholar
• Russo I, Traversa M, Bonomo K, De Salve A, Mattiello L, Del Mese P, Doronzo G, Cavalot F, Trovati M, Anfossi G. In central obesity, weight loss restores platelet sensitivity to nitric oxide and prostacyclin. Obesity (Silver Spring). 2010;18:788–797. doi:10.1038/oby.2009.302.
   PubMed Web of Science ®Google Scholar
• Puurunen MK, Hwang SJ, Larson MG, Vasan RS, O’Donnell CJ, Tofler G, Johnson AD. ADP Platelet hyperreactivity predicts cardiovascular disease in the FHS (Framingham Heart Study). J Am Heart Assoc. 2018;7:pii: e008522. doi:10.1161/JAHA.118.008522.
   PubMed Web of Science ®Google Scholar