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Original Article

The effects of aging, diabetes mellitus, and antiplatelet drugs on growth factors and anti-aging proteins in platelet-rich plasma

, , , &
Pages 773-792 | Received 20 Apr 2018, Accepted 27 Jul 2018, Published online: 25 Sep 2018

References

  • Etulain J. Platelets in wound healing and regenerative medicine. Platelets 2018;29(6):556–568
  • Mussano F, Genova T, Munaron L, Petrillo S, Erovigni F, Carossa S. Cytokine, chemokine, and growth factor profile of platelet-rich plasma. Platelets 2016;27(5):467–471. doi:10.3109/09537104.2016.1143922
  • Jing Q, Na A, Ouyang X. Quantification of growth factors in different platelet concentrates. Platelets 2017;28(8)774–778.
  • Cole BJ, Karas V, Hussey K, Pilz K, Fortier LA. Hyaluronic acid versus platelet-rich plasma: a prospective, double-blind randomized controlled trial comparing clinical outcomes and effects on intra-articular biology for the treatment of knee osteoarthritis. Am J Sports Med 2017;45(2):339. doi:10.1177/0363546517730547
  • Anitua E, Pino A, Orive G. Opening new horizons in regenerative dermatology using platelet-based autologous therapies. Int J Dermatol 2017;56(3):247–251. doi:10.1111/ijd.13510
  • Kazes I, Elalamy I, Sraer JD, Hatmi M, Nguyen G. Platelet release of trimolecular complex components MT1-MMP/TIMP2/MMP2: involvement in MMP2 activation and platelet aggregation. Blood 2000;96(9):3064–3069.
  • Bueno JL, Ynigo M, De Miguel MC, Gonzalo-Daganzo RM, Richart A, Vilches C, Regidor C, García-Marco JA, Flores-Ballester E, Cabrera JR. Growth differentiation factor 11 (GDF11) - a promising anti-ageing factor - is highly concentrated in platelets. Vox Sang 2016;111(4):434–436. doi:10.1111/vox.12438
  • Gentile P, Scioli MG, Bielli A, Orlandi A, Cervelli V. The use of adipose-derived stromal vascular fraction cells and platelet rich plasma in regenerative plastic surgery. Stem Cells 2016;35(1):117–134. doi:10.1002/stem.2498
  • Piccin A, Di PA, Canzian L, Primerano M, Corvetta D, Negri G. Platelet gel: a new therapeutic tool with great potential. Blood Transfus 2017;15(4):1–8. doi:10.2450/2016.0058-16
  • Kaux JF, Emondsalt T. The use of platelet-rich plasma to treat chronic tendinopathies: A technical analysis. Platelets 2018;29(3):213–227. doi:10.1080/09537104.2017.1336211.
  • Agrawal AA. Evolution, current status and advances in application of platelet concentrate in periodontics and implantology. World J Clin Cases 2017;5(5):159–171. doi:10.12998/wjcc.v5.i5.159
  • Jones CI. Platelet function and ageing:. Mamm Genome 2016;27(7):358–366. doi:10.1007/s00335-016-9629-8
  • Padalia M, Trivedi S, Karmur K, Kansagara B, Bhanderi P. Effect of aging on WBC count and platelet count. J Res Med Dental Sci 2014;2(4):67. doi:10.5455/jrmds.20142413
  • Sharpe PC, Trinick T. Mean platelet volume in diabetes mellitus. Q J Med 1993;86:739–742.
  • Anandhalakshmi S, Kalaivani A, Shivasekar G, Saravanan A. Evaluation of mean platelet volume and other platelet parameters in subjects with Type-2 diabetes mellitus. Natl J Physiol Pharm Pharmacol 2017;7(1): 51–54.
  • Ramsook RR, Danesh H. Timing of platelet rich plasma injections during antithrombotic therapy. Pain Physician 2016;19(7):E1055.
  • Velier M, Magalon J, Daumas A, Francois P, Ghazouane A. Production of platelet-rich plasma gel from elderly patients under antithrombotic drugs: perspectives in chronic wounds care. Platelets 2018;29(5):496–503. doi:10.1080/09537104.2017.1336212
  • Alice G, Maurizio D, Stefano C, Alessandra M, Pietro M. Antiplatelet agents inhibit the generation of platelet-derived microparticles. Front Pharmacol 2016;7:314. doi:10.3389/fphar.2016.00323
  • Lohmann M, Walenda G, Hemeda H, Joussen S, Drescher W, Jockenhoevel S, Hutschenreuter G, Zenke M, Wagner W, Prosper F. Donor age of human platelet lysate affects proliferation and differentiation of mesenchymal stem cells. PLoS One 2012;7(5):e37839. doi:10.1371/journal.pone.0037839
  • Dragoo JL, Korotkova T, Wasterlain AS, Pouliot MA, Kim HJ, Golish SR. Age-related changes of chondrogenic growth factors in platelet-rich plasma. Oper Tech Orthop 2012;22(2):49–55. doi:10.1053/j.oto.2011.11.004
  • Evanson JR, Guyton M, Oliver DL, Hire JM, Topolski RL, Zumbrun SD. Gender and age differences in growth factor concentrations from platelet-rich plasma in adults. J Mil Med 2014;179(7):799. doi:10.7205/MILMED-D-13-00336
  • Weibrich G, Kleis WKG, Hafner G, Hitzler WE. Growth factor levels in platelet-rich plasma and correlations with donor age, sex, and platelet count. J Cranio-Maxillofacial Surg 2002;30(2):97–102. doi:10.1054/jcms.2002.0285
  • Charmaine C, Christina Y, Chantal A, Vasiliki K, Paul M, Matthew L. Differences in the resting platelet proteome and platelet releasate between healthy children and adults. J Proteomics 2015;123:78–88. doi:10.1016/j.jprot.2015.04.003
  • Yajamanya SR, Chatterjee A, Babu CN, Karunanithi D. Fibrin network pattern changes of platelet- rich fibrin in young versus old age group of individuals: A cell block cytology study. J Indian Soc Periodontol 2016;20(2):151–156. doi:10.4103/0972-124X.176390
  • Pretorius E, Oberholzer HM, Spuy WJVD, Meiring JH. Age-related changes in fibrin networks and platelets of individuals over 75: a scanning electron microscopy study showing “thrombotic preparedness”. J Thromb Thrombolysis 2010;29(3):271–275. doi:10.1007/s11239-009-0433-0
  • Yajamanya SR, Chatterjee A, Babu CN, Karunanithi D. Fibrin network pattern changes of platelet-rich fibrin in young versus old age group of individuals: a cell block cytology study. J Indian Soc Periodontol 2016;20(2):151–156. doi:10.4103/0972-124X.176390
  • Xiong G, Lingampalli N, Koltsov J, Leung LL, Bhutani N, Robinson WH. Men and women differ in the biochemical composition of platelet-rich plasma. Am J Sports Med 2018;46(2):409–419. doi:10.1177/0363546517740845
  • Vincenzo S, Daniele V, Andrea P, Michele A. Platelet rich plasma therapy in non-insertional achilles tendinopathy: the efficacy is reduced in 60-years old people compared to young and middle-age individuals. Front Aging Neurosci 2015;7:e37839.
  • Zenker S. Platelet rich plasma (PRP) for facial rejuvenation. J Médesthetchirderm 2010;37:179–183.
  • Kurt H, Demirkiran D. Changing of hemoglobin A1c affects mean platelet volume in type-2 diabetes mellitus. Ulutas Med J. 2016;2(1):27–35. doi:10.5455/umj.20160211122820
  • Shilpi K, Potekar RMA. Study of platelet indices in type 2 diabetes mellitus patients. Indian J Hematol Blood Transfus 2018;34(1):115–120. doi:10.1007/s12288-017-0825-9.
  • Wu F, Liu Y, Li L, Lu Y, Yew DT, Xu J. Platelet mitochondrial dysfunction of DM rats and DM patients. Int J Clin Exp Med 2015;8(5):6937–6946.
  • Mohammadi MH, Molavi B, Mohammadi S, Nikbakht M, Mohammadi AM, Mostafaei S, Norooznezhad AH, Ghorbani Abdegah A, Ghavamzadeh A. Evaluation of wound healing in diabetic foot ulcer using platelet-rich plasma gel: A single-arm clinical trial. Transfus Apher Sci 2017;56(2):160–164. doi:10.1016/j.transci.2016.10.020
  • Babaei V, Afradi H, Gohardani HZ, Nasseri F, Azarafza M, Teimourian S. Management of chronic diabetic foot ulcers using platelet-rich plasma. J Wound Care 2017;26:784–787. doi:10.12968/jowc.2017.26.12.784
  • Ahmed M, Reffat S, Hassan A, Eskander F. Platelet rich plasma for the treatment of clean diabetic foot ulcers. Ann Vasc Surg 2017;38:206–211. doi:10.1016/j.avsg.2016.04.023
  • Ribeiro MVMR, Barbosa FT, Ribeiro LEF, Lacet CMC, Guedes VDL. Platelet-rich plasma in diabetic dry eye disease. Rev Bras Oftalmol 2016;75(4):308-313. doi: 10.5935/0034-7280.20160061
  • Mehrannia M, Vaezi M, Yousefshahi F, Rouhipour N. Platelet rich plasma for treatment of nonhealing diabetic foot ulcers: a case report. Can J Diabetes 2014;38(1):5–8. doi:10.1016/j.jcjd.2013.08.271
  • Driver VR, Hanft J, Fylling CP, Beriou JM. A prospective, randomized, controlled trial of autologous platelet-rich plasma gel for the treatment of diabetic foot ulcers. Ostomy Wound Manage 2006;52(6):68–70.
  • Martinez-Zapata MJ, Marti-Carvajal AJ, Sola I, Exposito JA, Bolívar I, Rodríguez L. Autologous platelet rich‐plasma for treating chronic wounds. Cochrane Database Syst Rev. 2016;(5):CD006899.doi:10.1002/14651858.CD006899.pub3
  • Keshavarzi A, Larijani B, Mohajeri Tehrani M. New treatments for diabetic foot ulcers. J Med Counc Iran 2011;29(4):376–390.
  • Cohn CS, Lockhart E. Autologous platelet-rich plasma: evidence for clinical use. Curr Opin Hematol 2015;22(6):527–532. doi:10.1097/MOH.0000000000000183
  • Brick N. Autologous platelet-rich plasma for treating chronic wounds. Cochrane Database Syst Rev 2013;10(10):54–55.
  • Anitua E, Prado R, Orive G. Platelet-rich plasma therapy and antithrombotic drugs. Pain Physician 2017;20(2):E335.
  • Di Matteo B, Filardo G, Filardo G, Lo Presti M, Kon E, Marcacci M. Chronic anti-platelet therapy: a contraindication for platelet-rich plasma intra-articularinjections? Eur Rev Med Pharmacol Sci 2014;18:55–59.
  • Anitua E, Troya M, Zalduendo MM, Orive G. The effect of different drugs on the preparation and biological outcomes of plasma rich in growth factors. Ann Anat 2014;196(6):423–429. doi:10.1016/j.aanat.2014.06.002
  • Anitua E, Troya M, Zalduendo M, Orive G. Effects of anti-aggregant, anti-inflammatory and anti-coagulant drugconsumption on the preparation and therapeutic potential of plasma rich in growth factors (PRGF). Growth Factors 2015;33(1):57–64. doi:10.3109/08977194.2014.977437
  • Willeit P, Zampetaki A, Dudek K, Kaudewitz D, King A, Kirkby NS, Crosby-Nwaobi R, Prokopi M, Drozdov I, Langley SR, et al. Circulating MicroRNAs as novel biomarkers for platelet activation. Circ Res 2013;112(4):595–600. doi:10.1161/CIRCRESAHA.111.300539
  • Dugrillon A, Eichler H, Kern S, Klüter H. Autologous concentrated platelet-rich plasma (cPRP) for local application in bone regeneration. Int J Oral Maxillofac Surg 2002;31:615–619. doi:10.1054/ijom.2002.0322
  • Conboy IM, Conboy MJ, Wagers AJ, Girma ER, Weissman IL, Rando TA. Rejuvenation of aged progenitor cells by exposure to a young systemic environment. Nature 2005;433:760–764. doi:10.1038/nature03260
  • Castellano JM, Mosher KI, Abbey RJ, Mcbride AA, James ML, Berdnik D. Human umbilical cord plasma proteins revitalize hippocampal function in aged mice. Nature 2017;544(7651):488. doi:10.1038/544161d
  • Loffredo FS, Steinhauser ML, Jay SM, Gannon J, Pancoast JR, Yalamanchi P, Sinha M, Dall’Osso C, Khong D, Shadrach JL, et al. Growth differentiation factor 11 is a circulating factor that reverses age-related cardiac hypertrophy. Cell 2013;153:828–839. doi:10.1016/j.cell.2013.04.015
  • Sinha M, Jang YC, Oh J, Khong D, Wu EY, Manohar R, Miller C, Regalado SG, Loffredo FS, Pancoast JR, et al. Restoring systemic GDF11 levels reverses age-related dysfunction in mouse skeletal muscle. Science 2014;344:649–652. doi:10.1126/science.1251152
  • Schafer MJ, Atkinson EJ, Vanderboom PM, Kotajarvi B, White TA, Moore MM, Bruce CJ, Greason KL, Suri RM, Khosla S, et al. Quantification of GDF11 and Myostatin in Human Aging and Cardiovascular Disease. Cell Metabolism 2016;23(6):1207–1215. doi:10.1016/j.cmet.2016.05.023
  • Zhang L, Chen S, Chang P, Bao N, Yang C, Ti Y, Zhou L, Zhao J. Harmful effects of leukocyte-rich platelet-rich plasma on rabbit tendon stem cells in vitro. Am J Sports Med 2016;44(8):1941–1951. doi:10.1177/0363546516644718
  • Yaşar DŞ, Yılmaz İ, İsyar M, Öznam K, Mahiroğulları M. Does leukocyte-poor or leukocyte-rich platelet-rich plasma applied with biopolymers have superiority to conventional platelet-rich plasma applications on chondrocyte proliferation? Eklem Hastalik Cerrahisi 2017;28(3):142–151.
  • Kobayashi Y, Saita Y, Nishio H, Ikeda H, Takazawa Y, Nagao M, Takaku T, Komatsu N, Kaneko K. Leukocyte concentration and composition in platelet-rich plasma (PRP) influences the growth factor and protease concentrations. J Orthopaedic Sci Off J Jpn Orthopaedic Assoc 2016;21(5):683–689. doi:10.1016/j.jos.2016.07.009
  • Fijnheer R, Pietersz RN, K D D, Gouwerok CW, Dekker WJ, Reesink HW. Platelet activation during preparation of platelet concentrates: a comparison of the platelet-rich plasma and the buffy coat methods. Transfusion 2010;30(7):634–638. doi:10.1046/j.1537-2995.1990.30790385523.x
  • Cowman J, Dunne E, Oglesby I, Byrne B, Ralph A, Voisin B, Müllers S, Ricco AJ, Kenny D. Age-related changes in platelet function are more profound in women than in men. Sci Rep 2015;5(1):12235. doi:10.1038/srep12235
  • Willecke F, Nagareddy PR, Murphy AJ. Mechanisms of platelet activation in diabetes mellitus. 2017.
  • Larsen SB, Grove EL, Neergaard-Petersen S, Wã¼Rtz M, Hvas AM, Kristensen SD. Thrombopoietin and platelet aggregation in patients with stable coronary artery disease. Platelets 2017;28(8):1–3. doi:10.1080/09537104.2017.1277107
  • Higaki T, Kurisu S, Watanabe N, Ikenaga H, Shimonaga T, Iwasaki T, Mitsuba N, Ishibashi K, Dohi Y, Fukuda Y, et al. Influence of dual antiplatelet therapy on mean platelet volume in patients with coronary artery disease undergoing percutaneous coronary intervention. Heart & Vessels 2016;31(3):269–274. doi:10.1007/s00380-014-0599-z

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