Platelet count and mean volume in acute stroke: a systematic review and meta-analysis

References

• Bejot Y, Bailly H, Durier J, Giroud M. Epidemiology of stroke in Europe and trends for the 21st century. Presse Med 2016;45:e391–e398. DOI:10.1016/j.lpm.2016.10.003
   PubMed Web of Science ®Google Scholar
• Ovbiagele B, Nguyen-Huynh MN. Stroke epidemiology: advancing our understanding of disease mechanism and therapy. Neurotherapeutics 2011;8:319–329. DOI:10.1007/s13311-011-0053-1
   PubMed Web of Science ®Google Scholar
• Kaplan ZS, Jackson SP. The role of platelets in atherothrombosis. Hematology Am Soc Hematol Educ Program 2011;2011:51–61. DOI:10.1182/asheducation-2011.1.51
   PubMed Web of Science ®Google Scholar
• Schmalbach B, Stepanow O, Jochens A, Riedel C, Deuschl G, Kuhlenbaumer G. Determinants of platelet-leukocyte aggregation and platelet activation in stroke. Cerebrovasc Dis 2015;39:176–180. DOI:10.1159/000375396
   PubMed Web of Science ®Google Scholar
• Martin JF, Trowbridge EA, Salmon G, Plumb J. The biological significance of platelet volume: its relationship to bleeding time, platelet thromboxane B2 production and megakaryocyte nuclear DNA concentration. Thromb Res 1983;32:443–460. DOI:10.1016/0049-3848(83)90255-4
   PubMed Web of Science ®Google Scholar
• Brown AS, Hong Y, de Belder A, Beacon H, Beeso J, Sherwood R, Edmonds M, Martin JF, Erusalimsky JD. Megakaryocyte ploidy and platelet changes in human diabetes and atherosclerosis. Arterioscler Thromb Vasc Biol 1997;17:802–807. DOI:10.1161/01.ATV.17.4.802
   PubMed Web of Science ®Google Scholar
• Kovacs S, Csiki Z, Zsori KS, Bereczky Z, Shemirani AH. Characteristics of platelet count and size and diagnostic accuracy of mean platelet volume in patients with venous thromboembolism. A systematic review and meta-analysis. Platelets 2019;30:139-147.
   PubMed Web of Science ®Google Scholar
• Liu L, Lin Z, Shen Z, Zhang G, Li S, Cao P. Platelet hyperfunction exists in both acute non-haemorrhagic and haemorrhagic stroke. Thromb Res 1994;75:485–490. DOI:10.1016/0049-3848(94)90264-X
   PubMed Web of Science ®Google Scholar
• Lin CY, Chang CY, Sun CH, Li TY, Chen LC, Chang ST, Wu YT. Platelet count and early outcome in patients with spontaneous cerebellar hemorrhage: a retrospective study. PLoS One 2015;10:e0119109. DOI:10.1371/journal.pone.0119109
   PubMed Web of Science ®Google Scholar
• Ciancarelli I, De Amicis D, Di Massimo C, Pistarini C, Ciancarelli MG. Mean platelet volume during ischemic stroke is a potential pro-inflammatory biomarker in the acute phase and during neurorehabilitation not directly linked to clinical outcome. Curr Neurovasc Res 2016;13:177–183. DOI:10.2174/1567202613666160517122109
   PubMed Web of Science ®Google Scholar
• Farkkila MA, Rasi V, Tilvis RS, Ikkala E, Viinikka L, Ylikorkala O, Farkkila AM, Miettinen TA. Low platelet arachidonic acid in young patients with brain infarction. Thromb Res 1987;48:721–727. DOI:10.1016/0049-3848(87)90437-3
   PubMed Web of Science ®Google Scholar
• D’Erasmo E, Aliberti G, Celi FS, Romagnoli E, Vecci E, Mazzuoli GF. Platelet count, mean platelet volume and their relation to prognosis in cerebral infarction. J Intern Med 1990;227:11–14. DOI:10.1111/joim.1990.227.issue-1
   PubMed Web of Science ®Google Scholar
• Tohgi H, Suzuki H, Tamura K, Kimura B. Platelet volume, aggregation, and adenosine triphosphate release in cerebral thrombosis. Stroke 1991;22:17–21. DOI:10.1161/01.STR.22.1.17
   PubMed Web of Science ®Google Scholar
• Gokdemir MT, Karakilcik AZ, Gokdemir GS. Prognostic importance of paraoxonase, arylesterase and mean platelet volume efficiency in acute ischaemic stroke. J Pak Med Assoc 2017;67:1679–1683.
   PubMed Web of Science ®Google Scholar
• Ayas ZO, Can U. Alteration of mean platelet volume in the pathogenesis of acute ischemic stroke: cause or consequence? Ideggyogy Sz 2018;71:49–56. DOI:10.18071/isz.71.0049
   PubMedGoogle Scholar
• Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gotzsche PC, Ioannidis JP, Clarke M, Devereaux PJ, Kleijnen J, Moher D. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. J Clin Epidemiol 2009;62:e1–34. DOI:10.1016/j.jclinepi.2009.06.006
   PubMed Web of Science ®Google Scholar
• Stroup DF, Berlin JA, Morton SC, Olkin I, Williamson GD, Rennie D, Moher D, Becker BJ, Sipe TA, Thacker SB. Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group. JAMA 2000;283:2008–2012. DOI:10.1001/jama.283.15.2008
   PubMed Web of Science ®Google Scholar
• Stang A. Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol 2010;25:603–605. DOI:10.1007/s10654-010-9491-z
   PubMed Web of Science ®Google Scholar
• Wan X, Wang W, Liu J, Tong T. Estimating the sample mean and standard deviation from the sample size, median, range and/or interquartile range. BMC Med Res Methodol 2014;14:135. DOI:10.1186/1471-2288-14-135
   PubMed Web of Science ®Google Scholar
• Viechtbauer W. Conducting meta-analyses in R with the metafor package. Journal of Statistical Software 2010;36:48. doi: 10.18637/jss.v036.i03
   Web of Science ®Google Scholar
• Huzsvai L, Balogh P. Linear models using R. Debrecen, Hungary: Seneca; 2015.
   Google Scholar
• Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ 1997;315:629–634. DOI:10.1136/bmj.315.7109.629
   PubMed Web of Science ®Google Scholar
• D’Erasmo E, Celi FS, Acca M, Mazzuoli G. Relationship between platelet and white blood cell counts during the early phase of cerebral infarction. Stroke 1991;22:283. DOI:10.1161/str.22.2.283a
   PubMed Web of Science ®Google Scholar
• Falke P, Lindgärde F, Stavenow L. Differences in blood viscosity, glycosylated hemoglobin and platelet count between male patients with carotid territory transient ischemic attacks and minor strokes. Clinical Hemorheology 1991;11:35–40.
   Google Scholar
• O’Malley T, Langhorne P, Elton RA, Stewart C. Platelet size in stroke patients. Stroke 1995;26:995–999. DOI:10.1161/01.STR.26.6.995
   PubMed Web of Science ®Google Scholar
• Giroud M, Creisson E, Fayolle H, Andre N, Becker F, Martin D, Dumas R. Risk factors for primary cerebral hemorrhage: a population-based study–the Stroke Registry of Dijon. Neuroepidemiology 1995;14:20–26. DOI:10.1159/000109775
   PubMed Web of Science ®Google Scholar
• O’Malley T, Lahghorne P, Stehart C. Do large platelets cause stroke? Age and Aging 1994;23:P3-c-P3. doi: 10.1093/ageing/23.suppl_1.P3-c
   Google Scholar
• Butterworth RJ, Bath PM. The relationship between mean platelet volume, stroke subtype and clinical outcome. Platelets 1998;9:359–364. doi: 10.1080/09537109876429
   PubMed Web of Science ®Google Scholar
• Smith NM, Pathansali R, Bath PM. Altered megakaryocyte-platelet-haemostatic axis in patients with acute stroke. Platelets 2002;13:113–120. DOI:10.1080/09537100120111559
   PubMed Web of Science ®Google Scholar
• Ziai WC, Torbey MT, Kickler TS, Oh S, Bhardwaj A, Wityk RJ. Platelet count and function in spontaneous intracerebral hemorrhage. J Stroke Cerebrovasc Dis 2003;12:201–206. DOI:10.1016/S1052-3057(03)00075-2
   PubMedGoogle Scholar
• Cha JK, Jo WS, Shin HC, Bae HR, Ho JM, Kim JW. Increased platelet CD63 and P-selectin expression persist in atherosclerotic ischemic stroke. Platelets 2004;15:3–7. DOI:10.1080/09537100310001644024
   PubMed Web of Science ®Google Scholar
• Wolff V, Aleil B, Giroud M, Lorenzini JL, Meyer N, Wiesel ML, Cazenave JP, Lanza F. Soluble platelet glycoprotein V is a marker of thrombosis in patients with ischemic stroke. Stroke 2005;36:e17–19. DOI:10.1161/01.STR.0000155738.02753.4d
   PubMed Web of Science ®Google Scholar
• Sadreddini SA, Abolfathi AA, Khandagi R, Talebi M, Lakian A. C-reactive protein, fibrinogen, lipoprotein (a), and lipid profile levels and platelet counts in ischemic stroke patients. Neurosciences (Riyadh) 2007;12:202–206.
   PubMed Web of Science ®Google Scholar
• Ilhan D, Ozbabalik D, Gulcan E, Ozdemir O, Gulbacs Z. Evaluation of platelet activation, coagulation, and fibrinolytic activation in patients with symptomatic lacunar stroke. Neurologist 2010;16:188–191. DOI:10.1097/NRL.0b013e318198d8bc
   PubMed Web of Science ®Google Scholar
• Mayda-Domac F, Misirli H, Yilmaz M. Prognostic role of mean platelet volume and platelet count in ischemic and hemorrhagic stroke. J Stroke Cerebrovasc Dis DOI:2010;19:66–72. doi: 10.1016/j.jstrokecerebrovasdis.2009.03.003
   PubMed Web of Science ®Google Scholar
• Al-Tameemi WF, Ameen AMM. Significance of platelet indices in patients with acute ischemic stroke. Iraqi Journal of Medical Sciences 2011;10:383–389.
   Google Scholar
• Jaremo P, Eriksson M, Lindahl TL, Nilsson S, Milovanovic M. Platelets and acute cerebral infarction. Platelets 2013;24:407–411. DOI:10.3109/09537104.2012.712168
   PubMed Web of Science ®Google Scholar
• Cho SY, Jeon YL, Choi SK, Suh JT, Lee HJ, Park TS. Mean platelet volume in Korean patients with acute ischemic stroke: a gender difference. Platelets 2013;24:75–76. DOI:10.3109/09537104.2012.658109
   PubMed Web of Science ®Google Scholar
• Dogan NO, Keles A, Aksel G, Guler S, Demircan A, Bildik F, Kilicaslan I, Karakurt K, Ilhan M. Mean platelet volume as a risk stratification tool in the emergency department for evaluating patients with ischaemic stroke and TIA. J Pak Med Assoc 2013;63:581–584.
   PubMed Web of Science ®Google Scholar
• Celikbilek A, Ismailogullari S, Zararsiz G. Neutrophil to lymphocyte ratio predicts poor prognosis in ischemic cerebrovascular disease. J Clin Lab Anal 2014;28:27–31. DOI:10.1002/jcla.2014.28.issue-1
   PubMed Web of Science ®Google Scholar
• Li B, Liu X, Cao ZG, Li Y, Liu TM, Wang RT. Elevated mean platelet volume is associated with silent cerebral infarction. Intern Med J 2014;44:653–657. DOI:10.1111/imj.12454
   PubMed Web of Science ®Google Scholar
• Ozkan B, Arik OZ, Gozukara MY, Sahin DY, Topal S, Uysal OK, Elbasan Z, Epceliden T, Cayli M, Gur M. Mean platelet volume is related with ischemic stroke in patients with sinus rhythm. Blood Coagul Fibrinolysis 2016;27:490–493. DOI:10.1097/MBC.0000000000000108
   PubMed Web of Science ®Google Scholar
• Wang D, Zhang FH, Zhao YT, Xiao XG, Liu S, Shi HB, Lin AL, Wang YJ, Han Q, Sun QM. Association of polymorphism in ICAM-1 (K469E) and cytology parameters in patients’ initial blood test with acute ischemic stroke. Genet Mol Res 2015;14:15520–15529. DOI:10.4238/2015.December.1.2
   PubMedGoogle Scholar
• Lee JM, Siddique J, Kim HC, Green D, Van Horn L, Allison M, Wassertheil-Smoller S, Greenland P. Hemostatic markers and long-term risk of intracerebral hemorrhage in postmenopausal women. J Stroke Cerebrovasc Dis 2016;25:1639–1643. DOI:10.1016/j.jstrokecerebrovasdis.2016.03.013
   PubMed Web of Science ®Google Scholar
• Oz II, Yucel M, Bilici M, Serifoglu I, Sayin R, Ilikhan SU, Acikgoz M. Is mean platelet volume a reliable marker to predict ischemic stroke in the follow-up of patients with carotid stenosis? J Stroke Cerebrovasc Dis 2016;25:404–409. DOI:10.1016/j.jstrokecerebrovasdis.2015.10.012
   PubMedGoogle Scholar
• Elsayed AM, Mohamed AG. Mean platelet volume and mean platelet volume/platelet count ratio as a risk stratification tool in the assessment of severity of acute ischemic stroke. Alexandria Journal of Medicine 2017;53:67–70. DOI:10.1016/j.ajme.2016.03.003
   Web of Science ®Google Scholar
• Wan JL, Ma ZW. The value of mean platelet volume for prognosis of patients with acute cerebral infarction. Clin Lab 2017;63:1801–1807. DOI:10.7754/Clin.Lab.2017.170419
   PubMed Web of Science ®Google Scholar
• Patel V, Parmar M, Shah K, Joshi R. A study on mean platelet volume in ischemic cerebrovascular stroke. International Journal of Advances in Medicine 2018;5:316–320. DOI:10.18203/2349-3933.ijam20180474
   Google Scholar
• Farah R, Samra N. Mean platelets volume and neutrophil to lymphocyte ratio as predictors of stroke. J Clin Lab Anal 2018;32. DOI:10.1002/jcla.22189
   Web of Science ®Google Scholar
• Sarkar RN, Das CK, Bhattacharjee U, Banerjee M. Platelet indices as a marker of severity in non-diabetic nonhypertensive acute ischemic stroke patients. J Assoc Physicians India 2018;66:40–42.
   PubMedGoogle Scholar
• Thompson CB, Eaton KA, Princiotta SM, Rushin CA, Valeri CR. Size dependent platelet subpopulations: relationship of platelet volume to ultrastructure, enzymatic activity, and function. Br J Haematol 1982;50:509–519. DOI:10.1111/j.1365-2141.1982.tb01947.x
   PubMed Web of Science ®Google Scholar
• Rajajee V, Brown DM, Tuhrim S. Coagulation abnormalities following primary intracerebral hemorrhage. J Stroke Cerebrovasc Dis 2004;13:47–51. DOI:10.1016/j.jstrokecerebrovasdis.2004.01.002
   PubMedGoogle Scholar
• Weymann A, Ali-Hasan-Al-Saegh S, Sabashnikov A, Popov AF, Mirhosseini SJ, Nombela-Franco L, Testa L, Lotfaliani M, Zeriouh M, Liu T, et al., Surgery, Cardiology-Group Imcsc-Group IM. Platelets cellular and functional characteristics in patients with atrial fibrillation: a comprehensive meta-analysis and systematic review. Med Sci Monit Basic Res 2017;23:58–86. DOI:10.12659/MSMBR.902557
   PubMed Web of Science ®Google Scholar
• Lin WY, Lu X, Fan FJ, Hu Y. Predictive effect of mean platelet volume in patients with portal vein thrombosis: a meta-analysis of case-control studies. Curr Med Sci 2018;38:575–581. DOI:10.1007/s11596-018-1916-z
   PubMed Web of Science ®Google Scholar
• Gasparyan AY, Ayvazyan L, Mikhailidis DP, Kitas GD. Mean platelet volume: a link between thrombosis and inflammation? Curr Pharm Des 2011;17:47–58. DOI:10.2174/138161211795049804
   PubMed Web of Science ®Google Scholar
• Li Z, Wang J, Han X, Yuan J, Guo H, Zhang X, Zheng D, Tang Y, Yang H, He M. Association of mean platelet volume with incident type 2 diabetes mellitus risk: the Dongfeng-Tongji cohort study. Diabetol Metab Syndr 2018;10:29. DOI:10.1186/s13098-018-0333-6
   PubMed Web of Science ®Google Scholar
• Varol E, Aksoy F, Bas HA, Ari H, Ozaydin M. Mean platelet volume is elevated in patients with low high-density lipoprotein cholesterol. Angiology 2014;65:733–736. DOI:10.1177/0003319713504024
   PubMed Web of Science ®Google Scholar
• Gang L, Yanyan Z, Zhongwei Z, Juan D. Association between mean platelet volume and hypertension incidence. Hypertens Res 2017;40:779–784. DOI:10.1038/hr.2017.30
   PubMed Web of Science ®Google Scholar
• Varol E, Icli A, Kocyigit S, Erdogan D, Ozaydin M, Dogan A. Effect of smoking cessation on mean platelet volume. Clin Appl Thromb Hemost 2013;19:315–319. DOI:10.1177/1076029612436675
   PubMed Web of Science ®Google Scholar
• Zaccardi F, Rocca B, Pitocco D, Tanese L, Rizzi A, Ghirlanda G. Platelet mean volume, distribution width, and count in type 2 diabetes, impaired fasting glucose, and metabolic syndrome: a meta-analysis. Diabetes Metab Res Rev 2015;31:402–410. DOI:10.1002/dmrr.v31.4
   PubMed Web of Science ®Google Scholar
• Sansanayudh N, Numthavaj P, Muntham D, Yamwong S, McEvoy M, Attia J, Sritara P, Thakkinstian A. Prognostic effect of mean platelet volume in patients with coronary artery disease. A systematic review and meta-analysis. Thromb Haemost 2015;114:1299–1309. doi: 10.1160/TH15-04-0280
   PubMed Web of Science ®Google Scholar
• Chu SG, Becker RC, Berger PB, Bhatt DL, Eikelboom JW, Konkle B, Mohler ER, Reilly MP, Berger JS. Mean platelet volume as a predictor of cardiovascular risk: a systematic review and meta-analysis. J Thromb Haemost 2010;8:148–156. DOI:10.1111/jth.2009.8.issue-1
   PubMed Web of Science ®Google Scholar
• Kamath S, Blann AD, Lip GY. Platelet activation: assessment and quantification. Eur Heart J 2001;22:1561–1571. DOI:10.1053/euhj.2000.2515
   PubMed Web of Science ®Google Scholar
• Thon JN, Italiano JE Jr. Does size matter in platelet production? Blood 2012;120:1552–1561. DOI:10.1182/blood-2012-04-408724
   PubMed Web of Science ®Google Scholar
• McCabe DJ, Harrison P, Mackie IJ, Sidhu PS, Purdy G, Lawrie AS, Watt H, Brown MM, Machin SJ. Platelet degranulation and monocyte-platelet complex formation are increased in the acute and convalescent phases after ischaemic stroke or transient ischaemic attack. Br J Haematol 2004;125:777–787. DOI:10.1111/j.1365-2141.2004.04983.x
   PubMed Web of Science ®Google Scholar
• McCabe DJ, Harrison P, Sidhu PS, Brown MM, Machin SJ. Circulating reticulated platelets in the early and late phases after ischaemic stroke and transient ischaemic attack. Br J Haematol 2004;126:861–869. DOI:10.1111/j.1365-2141.2004.05137.x
   PubMed Web of Science ®Google Scholar
• Mulley GPHS, Taylor PM, Mitchell JR. ADP-induced platelet release reaction in acute stroke. Thrombosis and Haemostasis 1983;50:3.
   Web of Science ®Google Scholar
• Reardon DM, Hutchinson D, Preston FE, Trowbridge EA. The routine measurement of platelet volume: a comparison of aperture-impedance and flow cytometric systems. Clin Lab Haematol 1985;7:251–257. DOI:10.1111/ijlh.1985.7.issue-3
   PubMedGoogle Scholar
• White JG. Effects of ethylenediamine tetracetic acid (EDTA) on platelet structure. Scand J Haematol 1968;5:241–254. DOI:10.1111/j.1600-0609.1968.tb01743.x
   PubMedGoogle Scholar
• Diaz-Ricart M, Brunso L, Pino M, Navalon F, Jou JM, Heras M, White JG, Escolar G. Preanalytical treatment of EDTA-anticoagulated blood to ensure stabilization of the mean platelet volume and component measured with the ADVIA counters. Thromb Res 2010;126:e30–35. DOI:10.1016/j.thromres.2010.04.002
   PubMed Web of Science ®Google Scholar
• Gachet C, Hanau D, Spehner D, Brisson C, Garaud JC, Schmitt DA, Ohlmann P, Cazenave JP. Alpha IIb beta 3 integrin dissociation induced by EDTA results in morphological changes of the platelet surface-connected canalicular system with differential location of the two separate subunits. J Cell Biol 1993;120:1021–1030. DOI:10.1083/jcb.120.4.1021
   PubMed Web of Science ®Google Scholar
• Kecskemetine G, Csiki Z, Mile M, Zsori KS, Shemirani AH. The clinical significance of pneumatic tube transport system on platelet indices: EDTA or citrate anticoagulant? Int J Lab Hematol 2017;39:e102–e105. DOI:10.1111/ijlh.2017.39.issue-4
   PubMed Web of Science ®Google Scholar
• McShine RL, Sibinga S, Brozovic B. Differences between the effects of EDTA and citrate anticoagulants on platelet count and mean platelet volume. Clin Lab Haematol 1990;12:277–285. DOI:10.1111/j.1365-2257.1990.tb00038.x
   PubMedGoogle Scholar
• Trowbridge EA, Reardon DM, Hutchinson D, Pickering C. The routine measurement of platelet volume: a comparison of light-scattering and aperture-impedance technologies. Clin Phys Physiol Meas 1985;6:221–238. DOI:10.1088/0143-0815/6/3/003
   PubMedGoogle Scholar
• Mannuss S, Schuff-Werner P, Dreissiger K, Kohlschein P. Magnesium sulfate as an alternative in vitro anticoagulant for the measurement of platelet parameters? Am J Clin Pathol 2016;145:806–814. DOI:10.1093/ajcp/aqw066
   PubMed Web of Science ®Google Scholar