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Articles

Thrombocytopenia and platelet count recovery in patients with sepsis-3: a retrospective observational study

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Pages 612-620 | Received 05 Apr 2021, Accepted 04 Aug 2021, Published online: 27 Aug 2021

References

  • Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, Bellomo R, Bernard GR, Chiche JD, Coopersmith CM, et al. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA. 2016; 315:801–810 Epub 2016/ 02/24 10.1001/jama.2016.0287
  • Sharma B, Sharma M, Majumder M, Steier W, Sangal A, Kalawar M. Thrombocytopenia in septic shock patients–a prospective observational study of incidence, risk factors and correlation with clinical outcome. Anaesth Intensive Care 2007; 35: 874–880 Epub 2007/ 12/19 10.1177/0310057X0703500604
  • Vanderschueren S, De Weerdt A, Malbrain M, Vankersschaever D, Frans E, Wilmer A, Bobbaers H. Thrombocytopenia and prognosis in intensive care. Crit Care Med 2000; 28: 1871–1876 Epub 2000/ 07/13 10.1097/00003246-200006000-00031
  • Guclu E, Durmaz Y, Karabay O. Effect of severe sepsis on platelet count and their indices. Afr Health Sci. 2013; 13: 333–338 Epub 2013/ 11/16
  • Thiery-Antier N, Binquet C, Vinault S, Meziani F, Boisrame-Helms J, Quenot JP, Group E. Is Thrombocytopenia an Early Prognostic Marker in Septic Shock? Crit Care Med 2016; 44: 764–772 Epub 2015/ 12/17 10.1097/CCM.0000000000001520
  • Zhou H, Deng M, Liu Y, Yang C, Hoffman R, Zhou J, Loughran PA, Scott MJ, Neal MD, Billiar TR. Platelet HMGB1 is required for efficient bacterial clearance in intra-abdominal bacterial sepsis in mice. Blood Adv 2018; 2: 638–648 Epub 2018/ 03/23 10.1182/bloodadvances.2017011817
  • Assinger A, Schrottmaier WC, Salzmann M, Rayes J. Platelets in Sepsis: an Update on Experimental Models and Clinical Data. Front Immunol 2019; 10: 1687 Epub 2019/ 08/06 10.3389/fimmu.2019.01687
  • Fuchs TA, Bhandari AA, Wagner DD. Histones induce rapid and profound thrombocytopenia in mice. Blood 2011; 118: 3708–3714 Epub 2011/ 06/28 10.1182/blood-2011-01-332676
  • Semeraro F, Colucci M, Caironi P, Masson S, Ammollo CT, Teli R, Semeraro N, Magnoli M, Salati G, Isetta M, et al. Platelet Drop and Fibrinolytic Shutdown in Patients With Sepsis. Crit Care Med. 2018; 46:e221–e228 Epub 2017/ 12/21 10.1097/CCM.0000000000002919
  • Aslam R, Speck ER, Kim M, Crow AR, Bang KW, Nestel FP, Ni H, Lazarus AH, Freedman J, Semple JW. Platelet Toll-like receptor expression modulates lipopolysaccharide-induced thrombocytopenia and tumor necrosis factor-alpha production in vivo. Blood 2006; 107: 637–641 Epub 2005/ 09/24 10.1182/blood-2005-06-2202
  • Middleton EA, Rowley JW, Campbell RA, Grissom CK, Brown SM, Beesley SJ, Schwertz H, Kosaka Y, Manne BK, Krauel K, et al. Sepsis alters the transcriptional and translational landscape of human and murine platelets. Blood. 2019; 134:911–923 Epub 2019/ 08/02 10.1182/blood.2019000067
  • McDonald B, Davis RP, Kim SJ, Tse M, Esmon CT, Kolaczkowska E, Jenne CN. Platelets and neutrophil extracellular traps collaborate to promote intravascular coagulation during sepsis in mice. Blood 2017; 129: 1357–1367 Epub 2017/ 01/12 10.1182/blood-2016-09-741298
  • Fuchs TA, Brill A, Duerschmied D, Schatzberg D, Monestier M, Myers DD Jr., Wrobleski SK, Wakefield TW, Hartwig JH, Wagner DD. Extracellular DNA traps promote thrombosis. Proc Natl Acad Sci U S A 2010; 107: 15880–15885 Epub 2010/ 08/28 10.1073/pnas.1005743107
  • Kimball AS, Obi AT, Diaz JA, Henke PK. The Emerging Role of NETs in Venous Thrombosis and Immunothrombosis. Front Immunol 2016; 7: 236 Epub 2016/ 07/23 10.3389/fimmu.2016.00236
  • Nicolai L, Leunig A, Brambs S, Kaiser R, Weinberger T, Weigand M, Muenchhoff M, Hellmuth JC, Ledderose S, Schulz H, et al. Immunothrombotic Dysregulation in COVID-19 Pneumonia Is Associated With Respiratory Failure and Coagulopathy. Circulation. 2020; 142:1176–1189 Epub 2020/ 08/07 10.1161/CIRCULATIONAHA.120.048488
  • Middleton EA, He XY, Denorme F, Campbell RA, Ng D, Salvatore SP, Mostyka M, Baxter-Stoltzfus A, Borczuk AC, Loda M, et al. Neutrophil extracellular traps contribute to immunothrombosis in COVID-19 acute respiratory distress syndrome. Blood. 2020; 136:1169–1179 Epub 2020/ 07/01 10.1182/blood.2020007008
  • Claushuis TA, van Vught LA, Scicluna BP, Wiewel MA, Klein Klouwenberg PM, Hoogendijk AJ, Ong DS, Cremer OL, Horn J, Franitza M, et al. Thrombocytopenia is associated with a dysregulated host response in critically ill sepsis patients. Blood. 2016; 127:3062–3072 Epub 2016/ 03/10 10.1182/blood-2015-11-680744
  • Menard CE, Kumar A, Houston DS, Turgeon AF, Rimmer E, Houston BL, Doucette S, Zarychanski R. Evolution and Impact of Thrombocytopenia in Septic Shock: a Retrospective Cohort Study. Crit Care Med 2019; 47(4): 558–565 Epub 2019/ 03/12 10.1097/CCM.0000000000003644
  • Johnson AEW, Pollard TJ, Shen L, Lehman L-WH, Feng M, Ghassemi M, Moody B, Szolovits P, Celi LA, Mark RG. MIMIC-III, a freely accessible critical care database. Sci Data 2016; 3(1): 160035 Epub 2016/ 05/25 10.1038/sdata.2016.35
  • Vandenbroucke JP. Strengthening the Reporting of Observational Studies in Epidemiology (STROBE): explanation and elaboration. Ann Intern Med 2007; 147(8): W163–194 Epub 2007/ 10/17 10.7326/0003-4819-147-8-200710160-00010-
  • Johnson AEW, Aboab J, Raffa JD, Pollard TJ, Deliberato RO, Celi LA, Stone DJ. A Comparative Analysis of Sepsis Identification Methods in an Electronic Database. Crit Care Med 2018; 46(4): 494–499 Epub 2018/ 01/06 10.1097/CCM.0000000000002965
  • Feng M, McSparron JI, Kien DT, Stone DJ, Roberts DH, Schwartzstein RM, Vieillard-Baron A, Celi LA. Transthoracic echocardiography and mortality in sepsis: analysis of the MIMIC-III database. Intensive Care Medicine 2018; 44(6): 884–892 Epub 2018/ 05/29 10.1007/s00134-018-5208-7
  • Chou EH, Mann S, Hsu T-C, Hsu W-T, Liu CC-Y, Bhakta T, Hassani DM, Lee -C-C, Mayr FB. Incidence, trends, and outcomes of infection sites among hospitalizations of sepsis: a nationwide study. PLoS One 2020; 15(1): e0227752 Epub 2020/ 01/14 10.1371/journal.pone.0227752
  • Graafsma YP, Prins MH, Lensing AWA, de Haan RJ, Huisman MV, Buller HR. Bleeding classification in clinical trials: observer variability and clinical relevance. Thromb Haemost 1997; 78: 1189–1192 Epub 1997/ 11/19 10.1055/s/0038/1657713
  • Daniel HKI, Gary King EA, Stuart. MatchIt: nonparametric Preprocessing for Parametric Causal Inference. J Stat Softw, 2011; 42 (8): 1–28E. pub 2011/06/14 10.18637/jss.v042.i08
  • Caudrillier A, Kessenbrock K, Gilliss BM, Nguyen JX, Marques MB, Monestier M, Toy P, Werb Z, Looney MR. Platelets induce neutrophil extracellular traps in transfusion-related acute lung injury. J Clin Invest 2012; 122(7): 2661–2671 Epub 2012/ 06/12 10.1172/JCI61303
  • Ma AC, Kubes P. Platelets, neutrophils, and neutrophil extracellular traps (NETs) in sepsis. J Thromb Haemost 2008; 6(3): 415–420 Epub 2007/ 12/20 10.1111/j.1538-7836.2007.02865.x
  • Ware J, Post SR. Platelets: balancing the septic triad. Blood 2014; 124(25): 3670–3672 Epub 2014/ 12/17 10.1182/blood-2014-10-606640
  • Clark SR, Ma AC, Tavener SA, McDonald B, Goodarzi Z, Kelly MM, Patel KD, Chakrabarti S, McAvoy E, Sinclair GD, et al. Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood. Nat Med. 2007; 13(4):463–469 Epub 2007/ 03/27 10.1038/nm1565
  • Koupenova M, Clancy L, Corkrey HA, Freedman JE. Circulating Platelets as Mediators of Immunity, Inflammation, and Thrombosis. Circ Res 2018; 122(2): 337–351 Epub 2018/ 01/20 10.1161/CIRCRESAHA.117.310795
  • Venkata C, Kashyap R, Farmer JC, Afessa B. Thrombocytopenia in adult patients with sepsis: incidence, risk factors, and its association with clinical outcome. J Intensive Care. 2013; 1(1): Epub 2013/ 01/01 10.1186/2052-0492-1-9
  • Moreau D, Timsit J-F, Vesin A, Garrouste-Orgeas M, de Lassence A, Zahar J-R, Adrie C, Vincent F, Cohen Y, Schlemmer B, et al. Platelet count decline: an early prognostic marker in critically ill patients with prolonged ICU stays. Chest. 2007; 131(6):1735–1741 Epub 2007/ 05/04 10.1378/chest.06-2233
  • Thiolliere F, Serre-Sapin AF, Reignier J, Benedit M, Constantin JM, Lebert C, Guelon D, Timsit JF, Souweine B. Epidemiology and outcome of thrombocytopenic patients in the intensive care unit: results of a prospective multicenter study. Intensive Care Medicine 2013; 39(8): 1460–1468 Epub 2013/ 06/07 10.1007/s00134-013-2963-3
  • Zhou Z, Feng T, Xie Y, Zhang X, Du J, Tian R, Qian B, Wang R. Prognosis and rescue therapy for sepsis-related severe thrombocytopenia in critically ill patients. Cytokine 2020; 136: 155227 Epub 2020/ 08/19 10.1016/j.cyto.2020.155227

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