273
Views
1
CrossRef citations to date
0
Altmetric
Articles

Stability and utility of flow cytometric platelet activation tests: A modality to bridge the gap between diagnostic demand and supply

ORCID Icon, , , , , , & show all
Pages 1043-1051 | Received 20 Aug 2021, Accepted 11 Jan 2022, Published online: 28 Feb 2022

References

  • Quiroga T, Goycoolea M, Panes O, Aranda E, Martínez C, Belmont S, Muñoz B, Zúñiga P, Pereira J, Mezzano D. High prevalence of bleeders of unknown cause among patients with inherited mucocutaneous bleeding. A prospective study of 280 patients and 299 controls. Haematologica 2007;92(3):357–365. 10.3324/haematol.10816.
  • Cattaneo M. Inherited platelet-based bleeding disorders. J Thromb Haemost: JTH 2003;1(7):1628–1636. 10.1046/j.1538-7836.2003.00266.x.
  • Nurden A, Nurden P. Advances in our understanding of the molecular basis of disorders of platelet function. J Thromb Haemost: JTH 2011;9(Suppl 1):76–91. 10.1111/j.1538-7836.2011.04274.x.
  • Harrison P, Mackie I, Mumford A, Briggs C, Liesner R, Winter M, Machin S. British committee for standards in haematology. Guidelines for the laboratory investigation of heritable disorders of platelet function. Br J Haematol 2011;155(1):30–44. 10.1111/j.1365-2141.2011.08793.x.
  • Cattaneo M, Cerletti C, Harrison P, Hayward CPM, Kenny D, Nugent D, Nurden P, Rao AK, Schmaier AH, Watson SP, et al. Recommendations for the standardization of light transmission aggregometry: a consensus of the working party from the platelet physiology subcommittee of SSC/ISTH. J Thromb Haemost: JTH 2013 Apr 10;11(6):1183–1189. 10.1111/jth.12231
  • Hayward CPM. How I investigate for bleeding disorders. Int J Lab Hematol 2018;40(Suppl 1):6–14. 10.1111/ijlh.12822.
  • Cattaneo M, Hayward CPM, Moffat KA, Pugliano MT, Liu Y, Michelson AD. Results of a worldwide survey on the assessment of platelet function by light transmission aggregometry: a report from the platelet physiology subcommittee of the SSC of the ISTH. J Thromb Haemost: JTH 2009;7(6):1029. 10.1111/j.1538-7836.2009.03458.x.
  • Nieuwenhuis HK, Akkerman JW, Sixma JJ. Patients with a prolonged bleeding time and normal aggregation tests may have storage pool deficiency: studies on one hundred six patients. Blood 1987;70(3):620–623. 10.1182/blood.V70.3.620.620.
  • Hayward CPM, Moffat KA, Raby A, Israels S, Plumhoff E, Flynn G, Zehnder JL. Development of North American consensus guidelines for medical laboratories that perform and interpret platelet function testing using light transmission aggregometry. Am J Clin Pathol 2010;134(6):955–963. 10.1309/AJCP9V3RRVNZMKDS.
  • Gresele P, Harrison P, Bury L, Falcinelli E, Gachet C, Hayward CP, Kenny D, Mezzano D, Mumford AD, Nugent D, et al. Diagnosis of suspected inherited platelet function disorders: results of a worldwide survey. Journal of Thrombosis and Haemostasis 2014;12(9):1562–1569. 10.1111/jth.12650.
  • Stegnar M, Knezevic A, Bozic-Mijovski M. The effect of pre-analytical variables on light transmittance aggregometry in citrated platelet-rich plasma from healthy subjects. Clinical Chem Lab Med 2010;48(10):1463–1465. 10.1515/CCLM.2010.285.
  • Rubak P, Nissen PH, Kristensen SD, Hvas A-M. Investigation of platelet function and platelet disorders using flow cytometry. Platelets 2016;27(1):66–74. 10.3109/09537104.2015.1032919.
  • Podda G, Scavone M, Femia EA, Cattaneo M. Aggregometry in the settings of thrombocytopenia, thrombocytosis and antiplatelet therapy. Platelets 2018;29(7):644–649. 10.1080/09537104.2018.1445843.
  • van Bladel Er, Laarhoven AG, van der Heijden Lb, Heitink-Pollé KM, Porcelijn L, van der Schoot Ce, de Haas M, Roest M, Vidarsson G, de Groot Pg, et al. Functional platelet defects in children with severe chronic ITP as tested with 2 novel assays applicable for low platelet counts. Blood 2014;123(10):1556–1563. 10.1182/blood-2013-08-519686.
  • Frelinger AL, Grace RF, Gerrits AJ, Berny-Lang MA, Brown T, Carmichael SL, Neufeld EJ, Michelson AD. Platelet function tests, independent of platelet count, are associated with bleeding severity in ITP. Blood 2015;126(7):873–879. 10.1182/blood-2015-02-628461.
  • Giannini S, Cecchetti L, Mezzasoma AM, Gresele P. Diagnosis of platelet-type von Willebrand disease by flow cytometry. Haematologica 2010;95(6):1021–1024. 10.3324/haematol.2009.015990.
  • Giannini S, Mezzasoma AM, Leone M, Gresele P. Laboratory diagnosis and monitoring of desmopressin treatment of von Willebrand’s disease by flow cytometry. Haematologica 2007;92(12):1647–1654. 10.3324/haematol.11313.
  • Ignatova AA, Ponomarenko EA, Polokhov DM, Suntsova EV, Zharkov PA, Fedorova DV, Balashova EN, Rudneva AE, Ptushkin VV, Nikitin EA, et al. Flow cytometry for pediatric platelets. Platelets 2019;30(4):428–437. 10.1080/09537104.2018.1513473.
  • Busuttil-Crellin X, McCafferty C, Van Den Helm S, Yaw HP, Monagle P, Linden M, Ignjatovic V. Method article: guidelines for panel design, optimization, and performance of whole blood multi-color flow cytometry of platelet surface markers. Platelets 2020 Jan;6. 1–8. 10.1080/09537104.2019.1709630.
  • Youssefian T, Massé J-M, Rendu F, Guichard J, Cramer EM. platelet and megakaryocyte dense granules contain glycoproteins Ib and IIb-IIIa. Blood 1997;89(11):4047–4057. 10.1182/blood.V89.11.4047.
  • Israels SJ, McMillan-Ward EM, Easton J, Robertson C, McNicol A. CD63 associates with the αIIbβ3 integrin-CD9 complex on the surface of activated platelets. Thromb Haemost 2001;85(1):134–141. 10.1055/s-0037-1612916.
  • Elbatarny M, Mollah S, Grabell J, Bae S, Deforest M, Tuttle A, Hopman W, Clark DS, Mauer AC, Bowman M, et al. Normal range of bleeding scores for the ISTH-BAT: adult and pediatric data from the merging project. Haemophilia: Off J World Feder Hemophil 2014;20(6):831–835. 10.1111/hae.12503.
  • Rydz N, James PD. The evolution and value of bleeding assessment tools. J Thromb Haemost: JTH 2012;10(11):2223–2229. 10.1111/j.1538-7836.2012.04923.x.
  • Busuttil-Crellin X, McCafferty C, Helm SVD, Yaw HP, Monagle P, Linden M, Ignjatovic V. Guidelines for panel design, optimization, and performance of whole blood multi-color flow cytometry of platelet surface markers. Platelets 2020;31(7):845–852. 10.1080/09537104.2019.1709630.
  • van Asten I, Schutgens REG, Baaij M, Zandstra J, Roest M, Pasterkamp G, Huisman A, Korporaal SJA, Urbanus RT. Validation of flow cytometric analysis of platelet function in patients with a suspected platelet function defect. Journal of Thrombosis and Haemostasis 2018;16(4):689–698. 10.1111/jth.13952.
  • Dave RG, Geevar T, Mammen J, Kala M, Vijayan R, Singh S, and Nair SC . Spectrum of acquired platelet dysfunction with eosinophilia (APDE) in tertiary care centre in South India. 2021. https://academy.isth.org/isth/2021/isth-2021-virtual-congress/333635/rutvi.dave.spectrum.of.acquired.platelet.dysfunction.with.eosinophilia.%28apde%29.html (Accessed 03 December 2021)
  • Dovlatova N, Lordkipanidzé M, Lowe GC, Dawood B, May J, Heptinstall S, Watson SP, Fox SC, UK GAPP Study Group. Evaluation of a whole blood remote platelet function test for the diagnosis of mild bleeding disorders. J Thromb Haemost: JTH 2014;12(5):660–665. 10.1111/jth.12555.
  • Navred K, Martin M, Ekdahl L, Zetterberg E, Andersson NG, Strandberg K, Norstrom E, Zheng Y-W. A simplified flow cytometric method for detection of inherited platelet disorders-A comparison to the gold standard light transmission aggregometry. PloS One 2019;14(1):e0211130. 10.1371/journal.pone.0211130.
  • Khanduri U, Pulimood R, Sudarsanam A, Carman R, Jadhav M, Pereira S. Glanzmann’s thrombasthenia. a review and report of 42 cases from South India. Thrombosis and Haemostasis 1981;46(4):717–721.
  • Nelson EJR, Nair SC, Peretz H, Coller BS, Seligsohn U, Chandy M, Srivastava A. Diversity of Glanzmann thrombasthenia in southern India: 10 novel mutations identified among 15 unrelated patients. Journal of Thrombosis and Haemostasis 2006;4(8):1730–1737.
  • Kannan M, Ahmad F, Yadav BK, Anand M, Jain P, Kumar R, Saxena DR. Glanzmann’s thrombasthenia in North Indians: sub classification and carrier detection by flow cytometry. Platelets 2009;20(1):12–15.
  • Sandgren P, Hansson M, Gulliksson H, Shanwell A. Storage of buffy-coat-derived platelets in additive solutions at 4 °C and 22 °C: flow cytometry analysis of platelet glycoprotein expression. Vox Sang 2007;93(1):27–36.
  • Ramström S, Södergren AL, Tynngård N, Lindahl TL. Platelet function determined by flow cytometry: new perspectives? Semin Thromb Hemost 2016;42(3):268–281. 10.1055/s-0035-1570082.
  • Schmitz G, Rothe G, Ruf A, Barlage S, Tschöpe D, Clemetson KJ, Goodall AH, Michelson AD, Nurden AT, Shankey TV. European working group on clinical cell analysis: consensus protocol for the flow cytometric characterisation of platelet function. Thromb Haemost 1998;79(5):885–896. 10.1055/s-0037-1615088.
  • Ramström S. Arachidonic acid causes lysis of blood cells and ADP-dependent platelet activation responses in platelet function tests. Platelets 2019;30(8):1001–1007. 10.1080/09537104.2018.1557614.
  • Rukoyatkina N, Mindukshev I, Walter U, Gambaryan S. Dual role of the p38 MAPK/cPLA 2 pathway in the regulation of platelet apoptosis induced by ABT-737 and strong platelet agonists. Cell Death Dis 2013;4(11):e931. 10.1038/cddis.2013.459.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.