1,905
Views
0
CrossRef citations to date
0
Altmetric
Research Article

Alantolactone induces platelet apoptosis by activating the Akt pathway

, , , , , , & ORCID Icon show all
Article: 2173505 | Received 18 Aug 2022, Accepted 23 Jan 2023, Published online: 22 Feb 2023

References

  • Liu X, Bian L, Duan X, Zhuang X, Sui Y, Yang L. Alantolactone: a sesquiterpene lactone with diverse pharmacological effects. Chem Biol Drug Des. 2021;98(6):1131–11. Epub 2021/10/09. doi:10.1111/cbdd.13972.
  • Kim M, Song K, Kim YS. Alantolactone improves prolonged exposure of Interleukin-6-Induced skeletal muscle inflammation associated glucose intolerance and insulin resistance. Front Pharmacol. 2017;8:405. Epub 2017/07/15. doi:10.3389/fphar.2017.00405.
  • Dang X, He B, Ning Q, Liu Y, Guo J, Niu G, Chen M. Alantolactone suppresses inflammation, apoptosis and oxidative stress in cigarette smoke-induced human bronchial epithelial cells through activation of Nrf2/HO-1 and inhibition of the NF-κB pathways. Respir Res. 2020;21(1):95. Epub 2020/04/24. doi:10.1186/s12931-020-01358-4.
  • Cai Y, Gao K, Peng B, Xu Z, Peng J, Li J, Chen X, Zeng S, Hu K, Yan Y. Alantolactone: a natural plant extract as a potential therapeutic agent for cancer. Front Pharmacol. 2021;12:781033. Epub 2021/12/14. doi:10.3389/fphar.2021.781033.
  • Fu Z, Li S, Liu J, Zhang C, Jian C, Wang L, Zhang Y, Shi C. Natural product alantolactone targeting AKR1C1 suppresses cell proliferation and metastasis in non-small-cell lung cancer. Front Pharmacol. 2022;13:847906. Epub 2022/04/05. doi:10.3389/fphar.2022.847906.
  • Kang X, Wang H, Li Y, Xiao Y, Zhao L, Zhang T, Zhou S, Zhou X, Li Y, Shou Z, et al. Alantolactone induces apoptosis through ROS-mediated AKT pathway and inhibition of PINK1-mediated mitophagy in human HepG2 cells. Artif Cells Nanomed Biotechnol. 2019;47(1):1961–1970. Epub 2019/05/23. doi:10.1080/21691401.2019.1593854.
  • Shi C, Lan W, Wang Z, Yang D, Wei J, Liu Z, Teng Y, Gu M, Yuan T, Cao F, et al. Alantolactone inhibits cell autophagy and promotes apoptosis via AP2M1 in acute lymphoblastic leukemia. Cancer Cell Int. 2020;20(1):442. Epub 2020/09/19. doi:10.1186/s12935-020-01537-9.
  • Zhang Y, Weng Q, Han J, Chen J. Alantolactone suppresses human osteosarcoma through the PI3K/AKT signaling pathway. Mol Med Rep. 2020;21:675–684. Epub 2020/01/25. doi:10.3892/mmr.2019.10882.
  • Zhang X, Zhang HM. Alantolactone induces gastric cancer BGC-823 cell apoptosis by regulating reactive oxygen species generation and the AKT signaling pathway. Oncol Lett. 2019;17:4795–4802. Epub 2019/06/13. doi:10.3892/ol.2019.10172.
  • He W, Cao P, Xia Y, Hong L, Zhang T, Shen X, Zheng P, Shen H, Zhao Y, Zou P. Potent inhibition of gastric cancer cells by a natural compound via inhibiting TrxR1 activity and activating ROS-mediated p38 MAPK pathway. Free Radic Res. 2019;53(1):104–114. Epub 2019/01/23. doi:10.1080/10715762.2018.1558448.
  • Yao Y, Xia D, Bian Y, Sun Y, Zhu F, Pan B, Niu M, Zhao K, Wu Q, Qiao J, et al. Alantolactone induces G1 phase arrest and apoptosis of multiple myeloma cells and overcomes bortezomib resistance. Apoptosis. 2015;20(8):1122–1133. Epub 2015/06/03. doi:10.1007/s10495-015-1140-2.
  • Babaei G, Aziz SGG, Bazl MR, Ansari MK. A comprehensive review of anticancer mechanisms of action of Alantolactone. Biomed Pharmacother. 2021;136:111231. Epub 2021/01/18. doi:10.1016/j.biopha.2021.111231.
  • Furie B, Furie BC. Thrombus formation in vivo. J Clin Invest. 2005;115(12):3355–3362. Epub 2005/12/03. doi:10.1172/JCI26987.
  • Rivera J, Lozano ML, Navarro-Nunez L, Vicente V. Platelet receptors and signaling in the dynamics of thrombus formation. Haematologica. 2009;94(5):700–711. Epub 2009/03/17. doi:10.3324/haematol.2008.003178.
  • Lefrancais E, Ortiz-Munoz G, Caudrillier A, Mallavia B, Liu F, Sayah DM, Thornton EE, Headley MB, David T, Coughlin SR, et al. The lung is a site of platelet biogenesis and a reservoir for haematopoietic progenitors. Nature. 2017;544(7648):105–109. Epub 2017/03/23. doi:10.1038/nature21706.
  • Grozovsky R, Giannini S, Falet H, Hoffmeister KM. Regulating billions of blood platelets: glycans and beyond. Blood. 2015;126(16):1877–1884. Epub 2015/09/04. doi:10.1182/blood-2015-01-569129.
  • McArthur K, Chappaz S, Kile BT. Apoptosis in megakaryocytes and platelets: the life and death of a lineage. Blood. 2018;131(6):605–610. Epub 2017/12/21. doi:10.1182/blood-2017-11-742684.
  • Mason KD, Carpinelli MR, Fletcher JI, Collinge JE, Hilton AA, Ellis S, Kelly PN, Ekert PG, Metcalf D, Roberts AW, et al. Programmed anuclear cell death delimits platelet life span. Cell. 2007;128(6):1173–1186. Epub 2007/03/27. doi:10.1016/j.cell.2007.01.037.
  • Lebois M, Josefsson EC. Regulation of platelet lifespan by apoptosis. Platelets. 2016;27(6):497–504. Epub 2016/04/22. doi:10.3109/09537104.2016.1161739.
  • Thushara RM, Hemshekhar M, Kemparaju K, Rangappa KS, Devaraja S, Girish KS. Therapeutic drug-induced platelet apoptosis: an overlooked issue in pharmacotoxicology. Arch Toxicol. 2014;88(2):185–198. Epub 2013/12/24. doi:10.1007/s00204-013-1185-3.
  • De Silva E, Kim H. Drug-induced thrombocytopenia: focus on platelet apoptosis. Chem Biol Interact. 2018;284:1–11. Epub 2018/02/08. doi:10.1016/j.cbi.2018.01.015.
  • Liu L, Chen M, Zhao L, Zhao Q, Hu R, Zhu J, Yan R, Dai K. Ethanol induces platelet apoptosis. Alcohol Clin Exp Res. 2017;41(2):291–298. Epub 2017/01/13. doi:10.1111/acer.13295.
  • Zhang J, Chen M, Zhang Y, Zhao L, Yan R, Dai K. Carmustine induces platelet apoptosis. Platelets. 2015;26(5):437–442. Epub 2014/06/24. doi:10.3109/09537104.2014.928676.
  • Zhao L, Zhang W, Chen M, Zhang J, Zhang M, Dai K. Aspirin Induces platelet apoptosis. Platelets. 2013;24(8):637–642. Epub 2013/01/11. doi:10.3109/09537104.2012.754417.
  • Xiao W, Zhou K, Yang M, Sun C, Dai L, Gu J, Yan R, Dai K. Carbamazepine induces platelet apoptosis and thrombocytopenia through protein Kinase A. Front Pharmacol. 2021;12:749930. Epub 2021/10/19. doi:10.3389/fphar.2021.749930.
  • Chen M, Yan R, Zhou K, Li X, Zhang Y, Liu C, Jiang M, Ye H, Meng X, Pang N, et al. Akt-mediated platelet apoptosis and its therapeutic implications in immune thrombocytopenia. Proc Natl Acad Sci USA. 2018;115(45):E10682–E10691. Epub 2018/10/20. doi:10.1073/pnas.1808217115.
  • Manikanta K, Kumar SN, Hemshekhar M, Kemparaju K, Girish KS. ASK1 inhibition triggers platelet apoptosis via p38-MAPK-mediated mitochondrial dysfunction. Haematologica. 2020;105(8):e419–e423. Epub 2019/11/30. doi:10.3324/haematol.2019.233908.
  • Rukoyatkina N, Mindukshev I, Walter U, Gambaryan S. Dual role of the p38 MAPK/cPLA2 pathway in the regulation of platelet apoptosis induced by ABT-737 and strong platelet agonists. Cell Death Dis. 2013;4(11):e931. Epub 2013/11/23. doi:10.1038/cddis.2013.459.
  • Paul M, Manikanta K, Hemshekhar M, Sundaram MS, Naveen S, Ramesh TN, Kemparaju K, Girish KS. Bisdemethoxycurcumin promotes apoptosis in human platelets via activation of ERK signaling pathway. Toxicol In Vitro. 2020;63:104743. Epub 2019/12/07. doi:10.1016/j.tiv.2019.104743.
  • Paul M, Hemshekhar M, Thushara RM, Sundaram MS, NaveenKumar SK, Naveen S, Devaraja S, Somyajit K, West R, Basappa, et al. Methotrexate promotes platelet apoptosis via JNK-mediated mitochondrial damage: alleviation by N-Acetylcysteine and N-Acetylcysteine amide. PLoS One. 2015;10(6):e0127558. Epub 2015/06/18. doi:10.1371/journal.pone.0127558.
  • Wu Y, Dai J, Zhang W, Yan R, Zhang Y, Ruan C, Dai K. Arsenic trioxide induces apoptosis in human platelets via C-Jun NH2-terminal kinase activation. PLoS One. 2014;9(1):e86445. Epub 2014/01/28. doi:10.1371/journal.pone.0086445.
  • Wang J, Zhang Y, Liu X, Wang J, Li B, Liu Y, Wang J. Alantolactone enhances gemcitabine sensitivity of lung cancer cells through the reactive oxygen species-mediated endoplasmic reticulum stress and Akt/GSK3beta pathway. Int J Mol Med. 2019;44:1026–1038. Epub 2019/09/17. doi:10.3892/ijmm.2019.4268.
  • Liu YR, Cai QY, Gao YG, Luan X, Guan YY, Lu Q, Sun P, Zhao M, Fang C. Alantolactone, a sesquiterpene lactone, inhibits breast cancer growth by antiangiogenic activity via blocking VEGFR2 signaling. Phytother Res. 2018;32(4):643–650. Epub 2017/12/07. doi:10.1002/ptr.6004.
  • Lee SH, Meng XW, Flatten KS, Loegering DA, Kaufmann SH. Phosphatidylserine exposure during apoptosis reflects bidirectional trafficking between plasma membrane and cytoplasm. Cell Death Differ. 2013;20(1):64–76. Epub 2012/08/04. doi:10.1038/cdd.2012.93.
  • Chen Z, Li T, Kareem K, Tran D, Griffith BP, Wu ZJ. The role of PI3K/Akt signaling pathway in non-physiological shear stress-induced platelet activation. Artif Organs. 2019;43(9):897–908. Epub 2019/04/12. doi:10.1111/aor.13465.
  • Zhao L, Liu J, He C, Yan R, Zhou K, Cui Q, Meng X, Li X, Zhang Y, Nie Y, et al. Protein kinase a determines platelet life span and survival by regulating apoptosis. J Clin Invest. 2017;127(12):4338–4351. Epub 2017/10/31. doi:10.1172/JCI95109.
  • Savill J, Gregory C. Apoptotic PS to phagocyte TIM-4: eat me. Immunity. 2007;27(6):830–832. Epub 2007/12/21. doi:10.1016/j.immuni.2007.12.002.
  • Lin L, Li Z, Yan L, Liu Y, Yang H, Li H. Global, regional, and national cancer incidence and death for 29 cancer groups in 2019 and trends analysis of the global cancer burden, 1990–2019. J Hematol Oncol. 2021;14(1):197. Epub 2021/11/24. doi:10.1186/s13045-021-01213-z.
  • Ferlay J, Colombet M, Soerjomataram I, Dyba T, Randi G, Bettio M, Gavin A, Visser O, Bray F. Cancer incidence and mortality patterns in Europe: estimates for 40 countries and 25 major cancers in 2018. Eur J Cancer. 2018;103:356–387. Epub 2018/08/14. doi:10.1016/j.ejca.2018.07.005.
  • Cao P, Xia Y, He W, Zhang T, Hong L, Zheng P, Shen X, Liang G, Cui R, Zou P. Enhancement of oxaliplatin-induced colon cancer cell apoptosis by alantolactone, a natural product inducer of ROS. Int J Biol Sci. 2019;15(8):1676–1684. Epub 2019/07/31. doi:10.7150/ijbs.35265.
  • Tian H, Huang S, Luo Q, Lin Z, Liu H, Zhang Z, Fong W, Zhao J, Yu F. Akt pathway activation reduces platelet apoptosis and contributes to the increase of platelet counts in solid tumor patients. Platelets. 2022;33:1009–1017. Epub 2022/01/25.
  • Zhang S, Ye J, Zhang Y, Xu X, Liu J, Zhang SH, Kunapuli SP, Ding Z. P2Y12 protects platelets from apoptosis via PI3k-dependent Bak/Bax inactivation. J Thromb Haemost. 2013;11(1):149–160. Epub 2012/11/13. doi:10.1111/jth.12063.
  • Thon JN, Italiano JE. Platelets: production, morphology and ultrastructure. Handb Exp Pharmacol . 2012;210:3–22. Epub 2012/08/25.