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ARTICLES

Inulin: therapeutic potential, prebiotic properties and immunological aspects

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Pages 21-31 | Received 12 May 2011, Accepted 11 Nov 2011, Published online: 07 Dec 2011

References

  • Abrams , S.A. 2005 . Calcium supplementation during childhood: Long-term effects on bone mineralization . Nutrition Reviews , 63 ( 7 ) : 251 – 255 .
  • Abrams , S.A. , Griffin , I.J. , Hawthorne , K.M. , Liang , L. , Gunn , S.K. Darlington , G. 2005 . A combination of prebiotic short- and long-chain inulin-type fructans enhances calcium absorption and bone mineralization in young adolescents . The American Journal of Clinical Nutrition , 82 ( 2 ) : 471 – 476 .
  • Alrawi , S.J. , Schiff , M. , Carroll , R.E. , Dayton , M. , Gibbs , J.F. Kulavlat , M. 2006 . Aberrant crypt foci . Anticancer Research , 26 : 107 – 119 .
  • Benyacoub , J. , Rochat , F. , Saudan , K.Y. , Rochat , I. , Antilles , N. Cherbut , C. 2008 . Feeding a diet containing a fructooligosaccharide mix can enhance Salmonella vaccine efficacy in mice . The Journal of Nutrition , 138 ( 1 ) : 123 – 129 .
  • Bodera , P. 2008 . Influence of prebiotics on the human immune system (GALT) . Recent Patents on Inflammation & Allergy Drug Discovery , 2 2 , 149 – 153 . doi: 10.2174/187221308784543656 .
  • Brasil . 2011 . Lei Orgânica da Saúde n° 8080, de 19 de setembro de 1990. Dispõe sobre as condições para a promoção, proteção e recuperação da saúde, a organização e o funcionamento dos serviços correspondentes e dá outras providências. Diário Oficial [da] República Federativa do Brasil, DF, 20 set. 1990 . Disponível em: Retrieved July 15, 2011, from http://www.senado.gov.br (In Portuguese only) .
  • de Vrese , M. & Schrezenmeir , J. 2008 . Probiotics, prebiotics, and synbiotics . Advances in Biochemical Engineering/Biotechnology , 111 , 1 – 66 . doi: 10.1007/10_2008_097 .
  • Euler , A.R , Mitchell , D.K , Kline , R. and Pickering , L.K. 2005 . Prebiotic effect of fructo-oligosaccharide supplemented term infant formula at two concentrations compared with unsupplemented formula and human milk . Journal of Pediatric Gastroenterology & Nutrition , 40 ( 2 ) : 157 – 164 .
  • Fanaro , S. , Chierici , R. , Guerrini , P. and Vigi , V. 2003 . Intestinal microflora in early infancy: Composition and development . Acta Pediatrica Supplement , 91 ( 441 ) : 48 – 55 .
  • Fuchs , R.H.B. , Borsato , D. , Bona , E. and Hauly , M.C.O. 2005 . “Iogurte” de soja suplementado com oligofrutose e inulina . Ciência e Tecnologia de Alimentos, Campinas , 25 ( 1 ) : 175 – 181 .
  • Furrie , E. , Macfarlane , S. , Kennedy , A. , Cummings , J.H. , Walsh , S.V. , et al. . 2005 . Synbiotic therapy (Bifidobacterium longum/Synergy 1) initiates resolution of inflammation in patients with active ulcerative colitis: A randomised controlled pilot trial , Gut , 54 , 242 – 249 . doi: 10.1136/gut.2004.044834 .
  • Gibson , G.R. , Beatty , E.B. , Wang , X. , & Cummings , J.H. 1995 . Selective stimulation of Bifidobacteria in the human colon by oligofructose and inulin . Gastroenterology , 108 4 , 975 – 982 . doi: 10.1016/0016-5085(95)90192-2 .
  • Gourineni , V.P. , Verghese , M. , Boateng , J. , Shackelford , L. , & Bhat , K.N. 2011 . Chemopreventive potential of synergy 1 and soybean in reducing azoxymethane-induced aberrant crypt foci in fisher 344 male rats . Journal of Nutrition and Metabolism , Article ID 983038, 8 . doi: 10.1155/2011/983038 .
  • Gregory , K. 2008 . Inulin-Type Prebiotics – A Review: Part 1 . Alternative Medicine Review , 13 ( 4 ) : 315 – 329 .
  • Griffin , I.J. , Davila , P.M. , & Abrams , S.A. 2002 . Non-digestible oligosaccharides and calcium absorption in girls with adequate calcium intakes . The British Journal of Nutrition , 87 2 , S 187 – S191 . doi: 10.1079/BJN/2002536 .
  • Griffin , I.J. , Hicks , P.M.D. , Heaney , R.P. , & Abrams , S.A. 2003 . Enriched chicory inulin increases calcium absorption in girls with lower calcium absorption . Nutrition Research , 23 , 901 – 909 . doi: 10.1016/S0271-5317(03)00085-X .
  • Haschke , F. , Firmansyah , A. , Meng , M. , Steenhout , P. , & Carrié , A L. 2001 . Functional food for infants and children . Monatsschrift Kinderheilkunde , 149 13 , S 66 – S70 . doi: 10.1007/s001120170011 .
  • Hijova , E. , Chmelarova , A. , Bomba , A. and Zitnan , R. 2009 . Prebiotic foodstuffs and their health benefits in experiment . Bratislavské Lekárske Listy , 10 ( 9 ) : 523 – 525 .
  • Kapiki , A. , Costalos , C. , Oikonomidou , C. , Triantafyllidou , A. , Loukatou , E. and Pertrohilou , V. 2007 . The effect of a fructo-oligosaccharide supplemented formula on gut flora of preterm infants . Early Human Development , 83 ( 5 ) : 335 – 339 .
  • Kelly , G. 2008 . Inulin-type prebiotics: A review (Part 1) . Alternative Medicine Review , 13 ( 4 ) : 315 – 329 .
  • Kelly , G. 2009 . Inulin-type prebiotics: A review. (Part 2) . Alternative Medicine Review , 4 ( 1 ) : 36 – 55 .
  • Kim , Y.S. and Milner , J.A. 2007 . Dietary modulation of colon cancer risk . The Journal of Nutrition , 137 ( 11 ) : 2576S – 2579S .
  • Leenen , C.H. and Dieleman , L.A. 2007 . Inulin and oligofructose in chronic inflammatory bowel disease . The Journal of Nutrition , 137 ( 11 ) : 2572S – 2575S .
  • Limburg , P.J. , Mahoney , M.R. , Ziegler , K.L. , Sontag , S.J. , Schoen , R.E. Benya , R. 2011 . Randomized phase II trial of sulindac, atorvastatin, and prebiotic dietary fiber for colorectal cancer chemoprevention . Cancer Prevention Research (Phila) , 4 ( 2 ) : 259 – 269 .
  • Liu , J. , Waterhouse , A.L. , & Chatterton , N.J. 1993 . Proton and carbon NMR chemical-shift assignments for [beta-D-Fru f-(2-- > 1)]3-(2 < = = > 1)-alpha-D-Glc p (nystose) and [beta-D-Fru f-(2-- > 1)]4-(2 < = = > 1)-alpha-D-Glc p (1,1,1-kestopentaose) from two-dimensional NMR spectral measurements . Carbohydrate Research , 245 1 , 11 – 19 . doi: 10.1016/0008-6215(93)80056-K .
  • Lomax , A.R. , & Calder , P.C. 2009 . Prebiotics, immune function, infection and inflammation: A review of the evidence . British Journal of Nutrition , 101 , 633 – 658 . doi: 10.1017/S0007114508055608 .
  • Lugonja , N.M. , Martinov , O.B. , Rasovic , M.R. , Spasic , S.D. , Gojgic , G.D.J. , & Vrvic , M.M. 2010 . A comparative investigation of an in vitro and clinical test of the bificogenic effect of an infant formula . Journal of Clinical Biochemistry and Nutrition , 47 3 , 208 – 216 . doi: 10.3164/jcbn.10-54 .
  • Macfarlane , G.T. , Steed , H. , & Macfarlane , S. 2008 . Bacterial metabolism and health-related effects of galacto-oligosaccharides and other prebiotics . Journal of Applied Microbiology , 104 2 , 305 – 344 . doi: 10.1016/S0271-5317(03)00085-X .
  • Madrigal , L. and Sangronis , E. 2007 . Inulin and derivates as key ingredients in functional foods . Archivos Latinoamericanos de Nutrición , 57 ( 4 ) : 387 – 396 .
  • Markowitz , S.D. , & Bertagnolli , M.M. 2009 . Molecular origins of cancer: Molecular basis of colorectal cancer . The New England Journal of Medicine , 361 25 , 2449 – 2460 . doi: 10.1056/NEJMra0804588 .
  • Marteau , P. , Jacobs , H. , Cazaubiel , M. , Signoret , C. , Prevel , J.M. , & Housez , B. 2011 . Effects of chicory inulin in constipated elderly people: A double-blind controlled trial . International Journal of Food Sciences and Nutrition , 62 2 , 164 – 170 . doi: 10.3109/09637486.2010.527323 .
  • Martin , F.P. , Wang , Y. , Sprenger , N. , Yap , I.K. , Rezzi , S. Ramadan , Z. 2008 . Top-down systems biology integration of conditional prebiotic modulated transgenomic interactions in a humanized microbiome mouse model . Molecular Systems Biology , 4 : 205
  • Meyer , D. , & Stasse-Wolthuis , M. 2009 . The bifidogenic effect of inulin and oligofructose and its consequences for gut health . European Journal of Clinical Nutrition , 63 11 , 1277 – 1289 . doi: 10.1038/ejcn.2009.64 .
  • Misikangas , M. , Tanayama , H. , Rajakangas , J. , Lindén , J. , Pajari , A.M. , & Mutanen , M. 2008 . Inulin results in increased levels of beta-catenin and cyclin D1 as the adenomas increase in size from small to large in the Min/ + mouse . The British Journal of Nutrition , 99 5 , 963 – 970 . doi: 10.1017/S0007114507853414 .
  • Moshfegh , A.J. , Friday , J.E. , Goldman , J.P. and Ahuja , J.K. 1999 . Presence of inulin and oligofructose in the diets of Americans . The Journal of Nutrition , 129 ( 7 ) : 1407S – 1411S .
  • Munjal , U. , Glei , M. , Pool-Zobel , B.L. , & Scharlau , D. 2009 . Fermentation products of inulin-type fructans reduce proliferation and induce apoptosis in human colon tumour cells of different stages of carcinogenesis . The British Journal of Nutrition , 102 5 , 663 – 671 . doi: 10.1017/S0007114509274770 .
  • Parnell , J.A. and Reimer , R.A. 2010 . Effect of prebiotic fibre supplementation on hepatic gene expression and serum lipids: A dose–response study in JCR:LA-cp rats . British Journal of Nutrition , 103 : 1577 – 1584 .
  • Pool-Zobel , B.L. 2005 . Inulin-type fructans and reduction in colon cancer risk: Review of experimental and human data . British Journal of Nutrition , 93 ( Suppl. 1 ) : S73 – S90 .
  • Pool-Zobel , B.L. and Sauer , J. 2007 . Overview of experimental data on reduction of colorectal cancer risk by inulin-type fructans . The Journal of Nutrition , 137 ( 11 ) : 2580S – 2584S .
  • Rafter , J. , Bennett , M. , Caderni , G. , Clune , Y. , Hughes , R. Karlsson , P.C. 2007 . Dietary synbiotics reduce cancer risk factors in polypectomized and colon cancer patients . American Journal of Clinical Nutrition , 85 ( 2 ) : 488 – 496 .
  • Ramirez-Farias , C. , Slezak , K. , Fuller , Z. , Duncan , A. , Holtrop , G. , & Louis , P. 2009 . Effect of inulin on the human gut microbiota: Stimulation of Bifidobacterium adolescents and Faecalibacterium prausnitzii . The British Journal of Nutrition , 101 4 , 541 – 550 . doi: 10.1017/S0007114508019880 .
  • Roberfroid , M.B. 1999 . Concept in functional foods: The case of inulin and oligofructose . Journal of Nutrition , 129 ( Suppl ) : 1398 – 1401 .
  • Roberfroid , M.B. 2007 . Inulin-type fructans: Functional food ingredients . The Journal of Nutrition , 137 ( 11 ) : 2493S – 2502S .
  • Ryz , N.R. , Meddings , J.B. , & Taylor , C.G. 2009 . Long-chain inulin increases dendritic cells in the Peyer's patches and increases ex vivo cytokine secretion in the spleen and mesenteric lymph nodes of growing female rats, independent of zinc status . The British Journal of Nutrition , 101 11 , 1653 – 1663 . doi: 10.1017/S000711450812342X .
  • Sherman , P.M. , Cabana , M. , Gibson , G.R. , Koletzko , B.V. , Neu , J. , et al. 2010 . Potential roles and clinical utility of prebiotics in newborns, infants, and children: Proceedings from a global prebiotic summit meeting, New York City, June 27–28, 2008 . Journal of Pediatric , 155 5 , S 61 – S70 . doi: 10.1016/j.jpeds.2009.08.022 .
  • Silva , D.O. , Engstrom , E.M. , Zaborowski , E.L. 2002 . Sisvan: Instrumento para o combate aos distúrbios nutricionais na atenção à saúde: o diagnóstico coletivo . Rio de Janeiro : Fiocruz , 187 p . (In Portuguese only) .
  • Stoyanova , S. , Geuns , J. , Hideg , E. , & Van Den Ende , W. 2010 . The food additives inulin and stevioside counteract oxidative stress . International Journal of Food Sciences and Nutrition , 62 3 , 207 – 214 . doi: 10.3109/09637486.2010.523416 .
  • Trushina , E.N. , Martynova , E.A. , Nikitiuk , D.B. , Mustafina , O.K. and Baı˘garin , E.K. 2005 . The influence of dietary inulin and oligofructose on the cell-mediated and humoral immunity in rats . Voprosy pitaniya , 74 ( 3 ) : 22 – 27 .
  • Van den Heuvel , E.G. , Muys , T. , van Dokkum , W. and Schaafsma , G. 1999 . Oligofructose stimulates calcium absorption in adolescents . The American Journal of Clinical Nutrition , 69 ( 3 ) : 544 – 548 .
  • Van Loo , J. , Coussement , P. , de Leenheer , L. , Hoebregs , H. , & Smits , G. 1995 . On the presence of inulin and oligofructose as natural ingredients in the western diet . Critical Reviews in Food Science and Nutrition , 35 6 , 525 – 552 . doi: 10.1080/10408399509527714 .
  • Vos , A.P. , Haarman , M. , Buco , A. , Govers , M. , Knol , J. , et al. 2006 . A specific prebiotic oligosaccharide mixture stimulates delayed-type hypersensitivity in a murine influenza vaccination model . International Immunopharmacology , 6 8 , 1277 – 1286 . doi: 10.1016/j.intimp.2006.03.010 .
  • Waligora-Dupriet , A.J. , Campeotto , F. , Nicolis , I. , Bonet , A. , Soulaines , P. Dupont , C. 2007 . Effect of oligofructose supplementation on gut microflora and well-being in young children attending a day care centre . International Journal of Food Microbiology , 113 ( 1 ) : 108 – 113 .
  • Wattenberg , L. 1992 . Inhibition of carcinogenicity by minor dietary constituents . Cancer Research , 52 ( 7 ) : 2085s – 2091s .
  • Watzl , B. , Girrbach , S. , & Roller , M. 2005 . Inulin, oligofructose and immunomodulation . The British Journal of Nutrition , 93 1 , S49 – S55 . doi: 10.1079/BJN20041357 .

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