Is the role of IgA in local immunity completely known?

References

• Abreu, M. T. (2010). Toll-like receptor signalling in the intestinal epithelium: How bacterial recognition shapes intestinal function. Nature Reviews Immunology, 10, 131–144. doi:10.1038/nri2707
   PubMed Web of Science ®Google Scholar
• Alvarez, N., Otero, O., Camacho, F., Borrero, R., Tirado, Y., Puig, A., … Acosta, A. (2013). Passive administration of purified secretory IgA from human colostrum induces protection against mycobacterium tuberculosis in a murine model of progressive pulmonary infection. BMC Immunology, 14, S3. doi:10.1186/1471-2172-14-S1-S3
   PubMed Web of Science ®Google Scholar
• Bäckhed, F., Ley, R. E., Sonnenburg, J. L., Peterson, D. A., & Gordon, J. I. (2005). Host-bacterial mutualism in the human intestine. Science, 307, 1915–1920. doi:10.1126/science.1104816
   PubMed Web of Science ®Google Scholar
• Bakema, J. E., & van Egmond, M. (2011). The human immunoglobulin A Fc receptor FcαRI: A multifaceted regulator of mucosal immunity. Mucosal Immunology, 4, 612–624. doi:10.1038/mi.2011.36
   PubMed Web of Science ®Google Scholar
• Bedoui, S., Kupz, A., Wijburg, O. L., Walduck, A. K., Rescigno, M., & Strugnell, R. A. (2010). Different bacterial pathogens, different strategies, yet the aim is the same: Evasion of intestinal dendritic cell recognition. Journal of Immunology, 184, 2237–2242. doi:10.4061/2011/182051
   PubMed Web of Science ®Google Scholar
• Bendelac, A., Bonneville, M., & Kearney, J. F. (2001). Autoreactivity by design: Innate B and T lymphocytes. Nature Reviews Immunology, 1, 177–186. doi:10.1038/35105052
   PubMed Web of Science ®Google Scholar
• Bobíková, K., Revajová, V., Karaffová, V., Levkutová, M., & Levkut, M. (2015). IgA gene expression and quantification of cecal IgA+, IgM+, and CD4+ cells in chickens treated with EFAL41 and infected with Salmonella Enteritidis. Acta Histochemica, 117, 629–634. doi:10.1016/j.acthis.2015.06.004
   PubMed Web of Science ®Google Scholar
• Bos, N. A., Cebra, J. J., & Kroese, F. G. (2000). B-1 cells and the intestinal microflora. Current Topics in Microbiology and Immunology, 252, 211–220. PMID:11125478
   PubMed Web of Science ®Google Scholar
• Bos, N. A., Jiang, H. Q., & Cebra J. J. (2001). T cell control of the gut IgA response against commensal bacteria. Gut, 48, 762–764. doi:10.1136/gut.48.6.762
   PubMed Web of Science ®Google Scholar
• Brandtzaeg, P., Baekkevold, E. S., & Morton, H. C. (2001). From B to A the mucosal way. Nature Immunology, 2, 1093–1094. doi:10.1038/ni1201-1093
   PubMed Web of Science ®Google Scholar
• Brandtzaeg, P., Farstad, I. N., Johansen, F. E., Morton, H. C., Norderhaug, I. N., & Yamanaka, T. (1999). The B-cell system of human mucosae and exocrine glands. Immunological Reviews, 171, 45–87. doi:10.1111/j.1600-065X.1999.tb01342.x
   PubMed Web of Science ®Google Scholar
• Brandtzaeg, P., & Prydz, H. (1984). Direct evidence for an integrated function of J chain and secretory component in epithelial transport of immunoglobulins. Nature, 311, 71–73. doi:10.1038/311071a0
   PubMed Web of Science ®Google Scholar
• Bry, L., Falk, P. G., Midtvedt, T., & Gordon, J. I. (1996). A model of host microbial interactions in an open mammalian ecosystem. Science, 273, 1380–1383. doi:10.1126/science.273.5280.1380
   PubMed Web of Science ®Google Scholar
• Cash, H. L., & Hooper, L. V. (2005). Commensal bacteria shape intestinal immune system development. ASM News, 71, 77–83.
   Google Scholar
• Cazac, B. B., & Roes, J. (2000). TGF-beta receptor controls B cell responsiveness and induction of IgA in vivo. Immunity, 13, 443–451. doi:10.1016/S1074-7613(00)00044-3
   PubMed Web of Science ®Google Scholar
• Cerutti, A. (2008). The regulation of IgA class switching. Nature Reviews Immunology, 8, 421–434. doi:10.1038/nri2322
   PubMed Web of Science ®Google Scholar
• Cerutti, A., Chen, K., & Chorny, A. (2011). Immunoglobulin responses at the mucosal interface. Annual Reviews in Immunology, 29, 273–293. doi:10.1146/annurev-immunol-031210-101317
   PubMed Web of Science ®Google Scholar
• Chieppa, M., Rescigno, M., Huang, A. Y., & Germain, R. N. (2006). Dynamic imaging of dendritic cell extension into the small bowel lumen in response to epithelial cell TLR engagement. The Journal of Experimental Medicine, 203, 2841–2852. doi:10.1084/jem.20061884
   PubMed Web of Science ®Google Scholar
• Chow, J., Tang, H., & Mazmanian, S. K. (2011). Pathobionts of the gastrointestinal microbiota and inflammatory disease. Current Opinion in Immunology, 23, 473–480. doi:10.1016/j.coi.2011.07.010
   PubMed Web of Science ®Google Scholar
• Conley, M. E., & Delacroix, D. L. (1987). Intravascular and mucosal immunoglobulin A: Two separate but related systems of immune defense? Annals of Internal Medicine, 106, 892–899. doi:10.7326/0003-4819-106-6-892
   PubMed Web of Science ®Google Scholar
• Corthesy, B. (2007). Roundtrip ticket for secretory IgA: Role in mucosal homeostasis? Journal of Immunology, 178, 27–32. doi:10.4049/jimmunol.178.1.27
   PubMed Web of Science ®Google Scholar
• Corthésy, B. (2013). Multi-faceted functions of secretory IgA at mucosal surfaces. Frontiers in Immunology, 4, art. 185, 1–11. doi:10.3389/fimmu.2013.00185
   PubMed Web of Science ®Google Scholar
• Dullaers, M., Li, D., Xue, Y., Ni, L., Gayet, I., Morita, R., … Oh, S. K. (2009). A T cell-dependent mechanism for the induction of human mucosal homing IgA-secreting plasmablasts. Immunity, 30, 120–129. doi:10.1016/j.immuni.2008.11.008
   PubMed Web of Science ®Google Scholar
• Eberl, G., & Lochner, M. (2009). The development of intestinal lymphoid tissues at the interface of self and microbiota. Mucosal Immunology, 2, 478–485. doi:10.1038/mi.2009.114
   PubMed Web of Science ®Google Scholar
• Endt, K., Stecher, B., Chaffron, S., Slack, E., Tchitchek, N., Benecke, A., … Hardt, W. D. (2010). The microbiota mediates pathogen clearance from the gut lumen after non-typhoidal salmonella diarrhea. PLoS Pathogens, 6, e1001097. doi:10.1371/journal.ppat.1001097
   PubMed Web of Science ®Google Scholar
• Fagarasan, S., & Honjo, T. (2000). T-independent immune response: New aspects of B cell biology. Science, 290, 89–92. doi:10.1126/science.290.5489.89
   PubMed Web of Science ®Google Scholar
• Fagarasan, S., & Honjo, T. (2003). Intestinal IgA synthesis: Regulation of front-line body defences. Nature Reviews Immunology, 3, 63–72. doi:10.1038/nri982
   PubMed Web of Science ®Google Scholar
• Fagarasan, S., Kawamoto, S., Kanagawa, O., & Suzuki, K. (2010). Adaptive immune regulation in the gut: T cell dependent and T cell-independent IgA synthesis. Annual Reviews of Immunology, 28, 243–273. doi:10.1146/annurev-immunol-030409-101314
   PubMed Web of Science ®Google Scholar
• Fayette, J., Dubois, B., Vandenabeele, S., Bridon, J. M., Vanbervliet, B., Durand, I., … Briere, F. (1997). Human dendritic cells skew isotype switching of CD40-activated naive B cells towards IgA1 and IgA2. Journal of Experimental Medicine, 185, 1909–1918. doi:10.1084/jem.185.11.1909
   PubMed Web of Science ®Google Scholar
• Fernandez, M. I., Pedron, T., Tournebize, R., Olivo-Marin, J. C., Sansonetti, P. J., Phalipon, A. (2003). Anti-inflammatory role for intracellular dimeric immunoglobulin A by neutralization of lipopolysaccharide in epithelial cells. Immunity, 18, 739–749. doi:10.1016/S1074-7613(03)00122-5
   PubMed Web of Science ®Google Scholar
• Forbes, S. J., Eschmann, M., & Mantis, N. J. (2008). Inhibition of salmonella enterica serovar typhimurium motility and entry into epithelial cells by a protective anti-lipopolysaccharide monoclonal immunoglobulin A antibody. Infection and Immunity, 76, 4137–4144. doi:10.1128/IAI.00416-08
   PubMed Web of Science ®Google Scholar
• Frank, D. N., St. Amand, A. L., Feldman, R. A., Boedeker, E. C., Harpaz, N., & Pace, N. R. (2007). Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases. Proceedings of the National Academy of Sciences USA, 104, 13780–13785. doi:10.1073/pnas.0706625104
   PubMed Web of Science ®Google Scholar
• Fritz, J. H., Rojas, O. L., Simard, N., McCarthy, D. D., Hapfelmeier, S., Rubino, S., … Gommerman, J. L. (2011). Acquisition of a multifunctional IgA+ plasma cell phenotype in the gut. Nature, 481, 199–203. doi:10.1038/nature10698
   PubMed Web of Science ®Google Scholar
• Gill, S. R., Pop, M., Deboy, R. T., Eckburg, P. B., Turnbaugh, P. J., Samuel, B. S., … Nelson, K. E. (2006). Metagenomic analysis of the human distal gut microbiome. Science, 312, 1355–1359. doi:10.1126/science.1124234
   PubMed Web of Science ®Google Scholar
• Hapfelmeier, S., Lawson, M. A., Slack, E., Kirundi, J. K., Stoel, M., Heikenwalder, M., … Macpherson, A. J. (2010). Reversible microbial colonization of germ-free mice reveals the dynamics of IgA immune responses. Science, 328, 1705–1709. doi:10.1126/science.1188454
   PubMed Web of Science ®Google Scholar
• Harris, N. L., Spoerri, I., Schopfer, J. F., Nembrini, C., Merky, P., Massacand, J., … Macpherson, A. J. (2006). Mechanisms of neonatal mucosal antibody protection. Journal of Immunology, 177, 6256–6262. doi:10.4049/jimmunol.177.9.6256
   PubMed Web of Science ®Google Scholar
• Hase, K., Kawano, K., Nochi, T., Pontes, G. S., Fukuda, S., Ebisawa, M., … Ohno, H. (2009). Uptake through glycoprotein 2 of FimH+ bacteria by M cells initiates mucosal immune response. Nature, 462, 226–230. doi:10.1038/nature08529
   PubMed Web of Science ®Google Scholar
• He, B., Xu, W., Santini, P. A., Polydorides, A. D., Chiu, A., Estrella, J., … Cerutti, A. (2007). Intestinal bacteria trigger T cell-independent immunoglobulin A(2) class switching by inducing epithelial-cell secretion of the cytokine APRIL. Immunity, 26, 812–826. doi:10.1016/j.immuni.2007.04.014
   PubMed Web of Science ®Google Scholar
• Hooper, L. V. (2004). Bacterial contributions to mammalian gut development. Trends in Microbiology, 12, 129–134. doi:10.1016/j.tim.2004.01.001
   PubMed Web of Science ®Google Scholar
• Hornquist, C. E., Ekman, L., Grdic, K. D., Schon, K., & Lycke, N. Y. (1995). Paradoxical IgA immunity in CD4-deficient mice. Lack of cholera toxin-specific protective immunity despite normal gut mucosal IgA differentiation. Journal of Immunology, 155, 2877–2887. Retrieved from http://www.jimmunol.org/content/155/6/2877.long
   Google Scholar
• Husakova, E., Bobikova, K., & Stasova, D. (2014). Total IgA in spleen, bursa and intestine of chickens pretreated with E. faecium AL41 and challenged with Salmonella Enteritidis PT4. Food and Agricultural Immunology, 26, 366–370. doi:10.1080/09540105.2014.918587
   Web of Science ®Google Scholar
• Jackson, S., Mestecky, J., Moldoveanu, Z., & Spearman, P. (1999). Collection and processing of human mucosal secretions. In P. L. Ogra, J. Mestecky, M. E. Lamm, W. Strober, J. Bienenstock, & J. R. McGhee (Eds.), Mucosal immunology (pp. 1567–1575). San Diego, FL: Academic Press.
   Google Scholar
• Johansson, M. E. V., Phillipson, M., Petersson, J., Velcich, A., Holm, L., & Hansson, G. C. (2008). The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria. Proceedings of the National Academy of Sciences USA, 105, 15064–15069. doi:10.1073/pnas.0803124105
   PubMed Web of Science ®Google Scholar
• Kadaoui, K. A., & Corthésy, B. (2007). Secretory IgA mediates bacterial translocation to dendritic cells in mouse Peyer’s patches with restriction to mucosal compartment. Journal of Immunology, 179, 7751–7757. doi:10.4049/jimmunol.179.11.7751
   PubMed Web of Science ®Google Scholar
• Kaetzel, C. S. (2005). The polymeric immunoglobulin receptor: Bridging innate and adaptive immune responses at mucosal surfaces. Immunology Reviews, 206, 83–99. doi:10.1111/j.0105-2896.2005.00278.x
   PubMed Web of Science ®Google Scholar
• Kaetzel, C. S., & Mostov, K. (2005). Immunoglobulin transport and the polymeric immunoglobulin receptor. In J. Mestecky, J. Bienenstock, M. E. Lamm, L. Mayer, J. R. McGhee, & W. Strober (Eds.), Mucosal immunology (pp. 211–250). Amsterdam: Elsevier/Academic Press.
   Google Scholar
• Kaetzel, C. S., Robinson, J. K., Chintalacharuvu, K. R., Vaerman, J. P., & Lamm, M. E. (1991). The polymeric immunoglobulin receptor (secretory component) mediates transport of immune complexes across epithelial cells: A local defense function for IgA. Proceedings of the National Academy of Sciences USA, 88, 8796–8800. doi:10.1073/pnas.88.19.8796
   PubMed Web of Science ®Google Scholar
• Karaffová, V., Pistl, J., Levkutová, M., Csank, T., Revajová, V., Nemcová, R., … Levkut, M. (2015, September). Expression of IgA and pIgR in ileum of GF mice after administration of L. reuteri and challenge with PCV. p. 41, ESVP-ECVP Annual Meeting, Helsinki, Finland.
   Google Scholar
• King, C., Tangye, S. G., & Mackay, C. R. (2008). T follicular helper (TFH) cells in normal and dysregulated immune responses. Annual Reviews in Immunology, 26, 741–766. doi:10.1146/annurev.immunol.26.021607.090344
   PubMed Web of Science ®Google Scholar
• Kiyono, H., & Fukuyama, S. (2004). NALT- versus peyer’s-patch-mediated mucosal immunity. Natural Reviews in Immunology, 4, 699–710. doi:10.1038/nri1439
   PubMed Web of Science ®Google Scholar
• Kuchen, S., Robbins, R., Sims, G. P., Sheng, C., Phillips, T. M., Lipsky, P. E., & Ettinger, R. (2007). Essential role of IL-21 in B cell activation, expansion, and plasma cell generation during CD4+ T cell-B cell collaboration. Journal of Immunology, 179, 5886–5896. doi:10.4049/jimmunol.179.9.5886
   PubMed Web of Science ®Google Scholar
• Lamkhioued, B., Gounni, A. S., Gruart, V., Pierce, A., Capron, A., & Capron, M. (1995). Human eosinophils express a receptor for secretory component. Role in secretory IgA-dependent activation. European Journal of Immunology, 25, 117–125. PMID: 7843220 doi: 10.1002/eji.1830250121
   PubMed Web of Science ®Google Scholar
• Li, M. O., Wan, Y. Y., Sanjabi, S., Robertson, A. K., & Flavell R. A. (2006). Transforming growth factor-beta regulation of immune responses. Annual Reviews Immunology, 24, 99–146. doi:10.1146/annurev.immunol.24.021605.090737
   PubMed Web of Science ®Google Scholar
• Lindner, C., Wahl, B., Föhse, L., Suerbaum, S., Macpherson, A. J., Prinz, I., & Pabst, O. (2012). Age, microbiota, and T cells shape diverse individual IgA repertoires in the intestine. Journal of Experimental Medicine, 209, 365–377. doi:10.1084/jem.20111980
   PubMed Web of Science ®Google Scholar
• MacLennan, I. C. (1994). Germinal centers. Annual Reviews Immunology, 12, 117–139. doi:10.1146/annurev.iy.12.040194.001001
   PubMed Web of Science ®Google Scholar
• MacPherson, A. J., & Harris, N. L. (2004). Opinion: Interactions between commensal intestinal bacteria and the immune system. Nature Reviews Immunology, 4, 478–485. doi:10.1038/nri1373
   PubMed Web of Science ®Google Scholar
• Macpherson, A. J., McCoy, K. D., Johansen, F. E., & Brandtzaeg, P. (2008). The immune geography of IgA induction and function. Mucosal Immunology, 1, 11–22. doi:10.1038/mi.2007.6
   PubMed Web of Science ®Google Scholar
• Macpherson, A. J., & Slack, E. (2007). The functional interactions of commensal bacteria with intestinal secretory IgA. Current Opinion in Gastroenterology, 23, 673–678. doi:10.1097/MOG.0b013e3282f0d012
   PubMed Web of Science ®Google Scholar
• Macpherson, A. J., & Uhr, T. (2004). Induction of protective IgA by intestinal dendritic cells carrying commensal bacteria. Science, 303, 1662–1665. doi:10.1126/science.1091334
   PubMed Web of Science ®Google Scholar
• Manser, T. (2004). Textbook germinal centers? Journal of Immunology, 172, 3369–3375. doi:10.4049/jimmunol.172.6.3369
   PubMed Web of Science ®Google Scholar
• Martinoli, C., Chiavelli, A., & Rescigno, M. (2007). Entry route of Salmonella typhimurium directs the type of induced immune response. Immunity, 27, 975–984. doi:10.1016/j.immuni.2007.10.011
   PubMed Web of Science ®Google Scholar
• Mathias, A., & Corthésy, B. (2011). Recognition of gram-positive intestinal bacteria by hybridoma- and colostrum-derived secretory immunoglobulin A is mediated by carbohydrates. Journal of Biological Chemistry, 286, 17239–17247. doi:10.1074/jbc.M110.209015
   PubMed Web of Science ®Google Scholar
• Medzhitov, R. (2001). Toll-like receptors and innate immunity. Nature Reviews Immunology, 1, 135–145. doi:10.1038/35100529
   PubMed Web of Science ®Google Scholar
• Mestecky, J., Blumberg, R. S., Kiyono, H., & McGhee, J. R. (2003). The mucosal immune system. In: W. E. Paul (Ed.), Fundamental immunology (pp. 965–1020). Philadelphia, PA: Lippincott-Raven.
   Google Scholar
• Mestecky, J., & McGhee, J. R. (1989). New strategies for oral immunization. Current Topics in Microbiology and Immunology, 146, 3–11. PMID:2659273
   PubMed Web of Science ®Google Scholar
• Mestecky, J., & Russell, M. W. (2009). Specific antibody activity, glycan heterogeneity and polyreactivity contribute to the protective activity of S-IgA at mucosal surfaces. Immunology Letters, 124, 57–62. doi:10.1016/j.imlet.2009.03.013
   PubMed Web of Science ®Google Scholar
• Mestecky, J., Russell, M. W., & Elson, C. O. (2007). Perspectives on mucosal vaccines: Is mucosal tolerance a barrier? Journal of Immunology, 179, 5633–5638. doi:10.4049/jimmunol.179.9.5633
   PubMed Web of Science ®Google Scholar
• Moreau, M. C., Ducluzeau, R., Guy-Grand, D., & Muller, M. C. (1978). Increase in the population of duodenal immunoglobulin A plasmocytes in axenic mice associated with different living or dead bacterial strains of intestinal origin. Infection and Immunity, 21, 532–539. PMID:357289
   PubMed Web of Science ®Google Scholar
• Moura, I. C., Centelles, M. N., Arcos-Fajardo, M., Malheiros, D. M., Collawn, J. F., Cooper, M. D., & Monteiro, R. C. (2001). Identification of the transferin receptor as a novel immunoglobulin (Ig)A1 receptor and its enhanced expression on mesangial cells in IgA nephropathy. Journal of Experimental Medicine, 194, 417–426. doi:10.1084/jem.194.4.417
   PubMed Web of Science ®Google Scholar
• Neutra, M. R., & Kozlowski, P. A. (2006). Mucosal vaccines: The promise and the challenge. Nature Reviews Immunology, 6, 148–158. doi:10.1038/nri1777
   PubMed Web of Science ®Google Scholar
• Obata, T., Goto, Y., Kunisawa, J., Sato, S., Ivanov, I. I., Lamichhane, A., … Kiyono H. (2010). Indigenous opportunistic bacteria inhabit mammalian gut-associated lymphoid tissues and share a mucosal antibody-mediated symbiosis. Proceedings of the National Academy of Sciences USA, 107, 7419–7424. doi:10.1126/science.1254009
   Google Scholar
• Pabst, R., Russell, M. W., & Brandtzaeg, P. (2008). Tissue distribution of lymphocytes and plasma cells and the role of the gut. Trends in Immunology, 29, 206–208. doi:10.1016/j.it.2008.02.006
   PubMed Web of Science ®Google Scholar
• Pasquier, B., Launay, P., Kanamaru, Y., Moura, I. C., Pfirsch, S., Ruffié, C., … Monteiro, R. C. (2005). Identification of FcαRI as an inhibitory receptor that controls inflammation: Dual role of FcRγ ITAM. Immunity, 22, 31–42. doi:10.1016/j.immuni.2004.11.017
   PubMed Web of Science ®Google Scholar
• Pene, J., Gauchat, J. F., Lecart, S., Drouet, E., Guglielmi, P., Boulay, V., … Yssel, H. (2004). Cutting edge: IL-21 is a switch factor for the production of IgG1 and IgG3 by human B cells. Journal of Immunology, 172, 5154–5157. doi:10.4049/jimmunol.172.9.5154
   PubMed Web of Science ®Google Scholar
• Peterson, D. A., McNulty, N. P., Guruge, J. L., & Gordon, J. I. (2007). IgA response to symbiotic bacteria as a mediator of gut homeostasis. Cell Host Microbe, 2, 328–339. doi:10.1016/j.chom.2007.09.013
   PubMed Web of Science ®Google Scholar
• Phalipon, A., & Corthésy, B. (2003). Novel functions of the polymeric Ig receptor: Well beyond transport of immunoglobulins. Trends in Immunology, 24, 55–58. doi:10.1016/S1471-4906(02)00031-5
   PubMed Web of Science ®Google Scholar
• Quan, C. P., Berneman, A., Pires, R., Avrameas, S., & Bouvet, J. P. (1997). Natural polyreactive secretory immunoglobulin A autoantibodies as a possible barrier to infection in humans. Infection and Immunity, 65, 3997–4004. PMID:9316998
   PubMed Web of Science ®Google Scholar
• Rimoldi, M., Chieppa, M., Salucci, V., Avogadri, F., Sonzogni, A., Sampietro, G. M., … Rescigno, M. (2005). Intestinal immune homeostasis is regulated by the crosstalk between epithelial cells and dendritic cells. Nature Immunology, 6, 507–514. doi:10.1038/ni1192
   PubMed Web of Science ®Google Scholar
• Sansonetti, P. J. (2004). War and peace at mucosal surfaces. Nature Reviews Immunology, 4, 953–964. doi:10.1038/nri1499
   PubMed Web of Science ®Google Scholar
• Savage, D. G. (2005). Mucosal microbiota. In J. Mestecky, J. Bienenstock, M. E. Lamm, L. Mayer, J. R. McGhee, & W. Strober (Eds.), Mucosal immunology (Vol. 3, pp. 19–33). Amsterdam: Elsevier/Academic Press.
   Google Scholar
• Shibuya, A., Sakamoto, N., Shimizu, Y., Shibuya, K., Osawa, M., Hiroyama, T., … Nakauchi, H. (2000). Fc alpha/mu receptor mediates endocytosis of IgM-coated microbes. Nature Immunology, 1, 441–446. doi:10.1038/80886
   PubMed Web of Science ®Google Scholar
• Shroff, K. E., Meslin, K., & Cebra, J. J. (1995). Commensal enteric bacteria engender a self-limiting humoral mucosal immune response while permanently colonizing the gut. Infection and Immunity, 63, 3904–3913. PMID:7558298
   PubMed Web of Science ®Google Scholar
• Slack, E. M. L., Balmer, J. H., Fritz, S., & Hapfelmeier, S. (2012). Functional flexibility of intestinal IgA – broadening the fine line. Frontiers in Immunology, 3, art 100, 1–10. doi:10.3389/fimmu.2012.00100
   PubMed Web of Science ®Google Scholar
• Stockert, R. J., Kressner, M. S., Collins, J. C., Sternlieb, I., & Morell, A. G. (1982). IgA interaction with the asialoglycoprotein receptor. Proceedings of the National Academy of Sciences USA, 79, 6229–6231. PMID:6292896
   Google Scholar
• Stoel, M., Jiang, H.-Q., van Diemen, C. C., Bun, J. C. A. M., Dammers, P. M., Thurnheer, M., … Bos, N. A. (2005). Restricted IgA repertoire in both B-1 and B-2 cell-derived gut plasmablasts. Journal of Immunology, 174, 1046–1054. doi:10.4049/jimmunol.174.2.1046
   PubMed Web of Science ®Google Scholar
• Suzuki K, & Fagarasan S. (2009). Diverse regulatory pathways for IgA synthesis in the gut. Mucosal Immunology, 2, 468–471. doi:10.1038/mi.2009.107
   PubMed Web of Science ®Google Scholar
• Suzuki, K., Meek, B., Doi, Y., Muramatsu, M., Chiba, T., Honjo T, & Fagarasan, S. (2004). Aberrant expansion of segmented filamentous bacteria in IgA-deficient gut. Proceedings of the National Academy of Sciences USA, 101, 1981–1986. doi:10.1073/pnas.0307317101
   PubMed Web of Science ®Google Scholar
• Swidsinski, A., Weber, J., Loening-Baucke, V., Hale, L. P., & Lochs, H. (2005). Spatial organization and composition of the mucosal flora in patients with inflammatory bowel disease. Journal of Clinical Microbiology, 43, 3380–3389. doi:10.1128/JCM.43.7.3380-3389.2005
   PubMed Web of Science ®Google Scholar
• Takeda, K., Kaisho, T., & Akira S. (2003). Toll-like receptors. Annuals Reviews Immunology, 21, 335–376. doi:10.1146/annurev.immunol.21.120601.141126
   PubMed Web of Science ®Google Scholar
• Talham, G. L., Jiang, H. Q., Bos, N. A., & Cebra, J. J. (1999). Segmented filamentous bacteria are potent stimuli of a physiologically normal state of the murine gut mucosal immune system. Infection and Immunity, 67, 1992–2000. PMID:10085047
   PubMed Web of Science ®Google Scholar
• Tezuka, H., Abe, Y., Iwata, M., Takeuchi, H., Ishikawa, H., Matsushita, M., … Ohteki, T. (2007). Regulation of IgA production by naturally occurring TNF/iNOS-producing dendritic cells. Nature, 448, 929–933. doi:10.1038/nature06033
   PubMed Web of Science ®Google Scholar
• Tlaskalova-Hogenova, H., Tuckova, L., Mestecky, J., Kolinska, J., Rossmann, P., Stepankova, R., … Kverka, M. (2005). Interaction of mucosal microbiota with the innate immune system. Scandinavian Journal of Immunology, 62(Suppl. 1), 106–113. doi:10.1111/j.1365-3083.2005.01618.x
   PubMed Web of Science ®Google Scholar
• Uematsu, S., Fujimoto, K., Jang, M. H., Yang, E. G., Jung, Y. J., Nishiyama, M., … Akira, S. (2008). Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing toll-like receptor 5. Nature Immunology, 9, 769–776. doi:10.1038/ni.1622
   PubMed Web of Science ®Google Scholar
• Van der Sluis, M., De Koning, B. A. E., De Bruijn, A. C. J. M., Velcich, A., Meijerink, J. P. P., Van Goudoever, J. B., … Einerhand, A. W. (2006). Muc2-deficient mice spontaneously develop colitis, indicating that MUC2 is critical for colonic protection. Gastroenterology, 131, 117–129. doi:10.1053/j.gastro.2006.04.020
   PubMed Web of Science ®Google Scholar
• van der Waaij, L. A., Kroese, F. G., Visser, A., Nelis, G. F., Westerveld, B. D., Jansen, P. L., & Hunter, J. O. (2004). Immunoglobulin coating of faecal bacteria in inflammatory bowel disease. European Journal of Gastroenterology and Hepatology, 16, 669–674. PMID:15201580 doi: 10.1097/01.meg.0000108346.41221.19
   PubMed Web of Science ®Google Scholar
• van der Waaij, L. A., Limburg, P. C., Mesander, G., & van der Waaij, D. (1996). In vivo IgA coating of anaerobic bacteria in human faeces. Gut, 38, 348–354. PMID:8675085 doi: 10.1136/gut.38.3.348
   PubMed Web of Science ®Google Scholar
• Vogelzang, A., McGuire, H. M., Yu, D., Sprent, J., Mackay, C. R., & King, C. A. (2008). A fundamental role for interleukin-21 in the generation of T follicular helper cells. Immunity, 29, 127–137. doi:10.1016/j.immuni.2008.06.001
   PubMed Web of Science ®Google Scholar
• Wijburg, O. L., Uren, T. K., Simpfendorfer, K., Johansen, F. E., Brandtzaeg, P., & Strugnell, R. A. (2006). Innate secretory antibodies protect against natural Salmonella typhimurium infection. Journal of Experimental Medicine, 203, 21–26. doi:10.1084/jem.20052093
   PubMed Web of Science ®Google Scholar
• Woof, J. M., & Mestecky, J. (2005). Mucosal immunoglobulins. Immunology Reviews, 206, 64–82. doi:10.1111/j.0105-2896.2005.00290.x
   PubMed Web of Science ®Google Scholar