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Original Articles

Immunological castration using a gonadotrophin‐releasing hormone analogue conjugated to PPD

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Pages 259-272 | Received 10 Nov 1994, Published online: 16 Sep 2008

References

  • Adams , T. E. and Adams , B. M. 1990 . Reproductive function and feedlot performance of beef heifers actively immunised against GnRH . Journal of Animal Science , 68 : 2793
  • Adashi , E. Y. 1990 . Potential utility of gonadotropin releasing hormone agonists in the management of ovarian hyperandrogenism . Fertility and Sterility , 53 : 777
  • Aithal , H. N. , Knigge , K. M. Kartha , S. 1988 . An alternative method utilizing small quantities of ligand for affinity purification of monospecific antibodies . Journal of Immunological Methods , 112 : 63
  • Awoniyi , C. A. , Santulli , R. Chandrashekar , V. 1989 . Quantitative restoration of advance spermatogenic cells in adult male rats made azospermic by active immunisation against LH or GnRH . Endocrinology , 125 : 1303
  • Besser , G. M. and Mortimer , C. H. 1976 . “ Clinical endocrinology ” . In Frontiers in Neuroendocrinology , Edited by: Martin , L. and Ganong , W. 227 New York, NY, , USA : Raven Press .
  • Braden , T. D. , Hawes , B. E. and Conn , P. M. 1989 . Synthesis of GnRH receptors by gonadotrope cell cultures . Endocrinology , 125 : 1623
  • Carelli , C. , Ralamboranto , L. Audibert , F. 1985 . Immunological castration by a totally synthetic vaccine: modification of biological properties of LHRH after conjugation to adjuvant active muramyl peptide . International Journal of Immunopharmacology , 7 : 215
  • Conn , P. M. , Huckle , W. R. , Andrews , W. V. and Mcardle , C. A. 1987 . “ The molecular mechanism of action of GnRH in the pituitary ” . In Recent Progress in Hormone Research , Edited by: Larke , J. H. Vol. 43 , 29 New York : Academic Press .
  • Deakin , H. , Ord , M. G. and Stockes , L. A. 1963 . Glucose‐6‐phosphate‐dehydrogenase activity and thiol content of thymus nuclei from control and X‐irradiated rats . Biochemical Journal , 89 : 296
  • Furr , B. J. A. and Nicholson , R. I. 1982 . Use of analogues of luteinizing hormone‐releasing hormone for the treatment of cancer . Journal of Reproduction and Fertility , 64 : 529
  • Giri , D. K. , Chaudhury , M. K. Jayashankar , R. 1990 . Histopathological changes in reproductive organs of male Wistar rats following active immunisation against LHRH . Experimental and Molecular Pathology , 52 : 54
  • Giri , D. K. , Jayaraman , S. Neelaram , G. S. 1991 . Prostatic hypoplasia in bonnet monkeys following active immunisation with semi‐synthetic anti‐LHRH vaccine . Experimental and Molecular Pathology , 54 : 255
  • Hashida , S. , Imagawa , M. , Inoue , S. , Ruan , K. H. and Ishikawa , E. 1984 . More useful malemide compounds for the conjugation of Fab’ to horseradish peroxidase through thiol groups in the hinge . Journal of Applied Biochemistry , 6 : 56
  • Jeffcoate , I. A. and Keeling , B. J. 1984 . Immunological Aspects of Reproduction in Mammals Edited by: Crichton , D. B. 363 – 377 .
  • Kastin , A. J. , Zarate , A. Midgley , A. R. 1971 . Ovulation confirmed by pregnancy after infusion of porcine LHRH . Journal of Clinical Endocrinology and Metabolism , 33 : 980
  • Lussow , A. R. , Giudice , G. D. Renia , L. 1990 . Use of a tuberculin purified protein derivative‐asn‐ala‐asn‐pro conjugate in bacillus Calmette‐Guerin primed mice overcomes H‐2 restriction of the antibody response and avoids the need for adjuvants . Proceedings of the National Academy of Sciences USA , 87 : 2960
  • Morrison , C. A. , Fishleigh , R. V. , Ward , D. J. and Robson , B. 1987 . Computer aided design and physiological testing of a LHRH analogue for ‘adjuvant‐free’ immunocastration . FEBS Letters , 214 : 65
  • Nicholson , R. I. and Golder , M. P. 1975 . The effect of synthetic anti‐oestrogens on the growth and biochemistry of rat mammary tumours . European Journal of Cancer , 11 : 571
  • Pelletier , G. , Cusan , L. and Auclair , C. 1978 . Inhibition of spermatogenesis in the rat by treatment with [D‐Ala6, DES‐Gly‐NH110] LHRH ethylamide . Endorcrinology , 103 : 641
  • Ravdin , P. M. and Jordan , V. C. 1988 . Active immunization to luteinizing hormone releasing hormone to inhibit the induction of mammary tumours in the rat . Life Sciences , 43 : 117
  • Robertson , I. S. , Fraser , H. M. , Innes , G. M. and Jones , A. S. 1982 . Effect of immunological castration on sexual and production characteristics of male cattle . Veterinary Record , 111 : 529
  • Sad , S. , Rao , K. , Arora , R. , Talwar , G. P. and Raghupathy , R. 1992 . Bypass of carrier‐induced epitope‐specific suppression using a T‐helper epitope . Immunology , 7 : 599
  • Schally , A. V. and Schally , A. M. 1987 . Male contraception involving testosterone supplementation: possible increased risks of prostrate cancer? . Lancet , 1 : 448
  • Schally , A. V. , Arimura , A. Kastin , A. J. 1971 . Gonadotropin‐releasing hormone: one polypeptide regulates secretion of luteinising and follicle stimulating hormones . Science , 173 : 1036
  • Schally , A. V. , Arimura , A. and Kastin , A. J. 1973 . Hypothalamic regulatory hormones . Science , 179 : 34
  • Schally , A. V. , Kastin , A. J. and Coy , D. H. 1976 . LHRH and its analogues: recent basic and clinical investigation . International Journal of Fertility , 21 : 1
  • Schriock , E. , Monroe , S. E. , Henzel , M. and Jaffe , R. B. 1985 . Treatment of endometriosis with a potent agonist of gonadotropin‐releasing hormone (nafarelin) . Fertility and Sterility , 44 : 583
  • Tcholakian , R. K. , De LA Cruz , A. Chowdhury , M. 1978 . Unusual anti‐reproductive properties of the analogue [D‐Leu6,DES‐gly‐NH210]‐luteinising hormone releasing hormone ethylamide in male rats . Fertility and Sterility , 30 : 600
  • Thau , R. 1992 . Anti‐LHRH and anti‐pituitary gonadotrophin vaccines: their development and clinical applications . Scandinavian Journal of Immunology , 36 : 127
  • Tiong , G. K. L. , Gill , H. S. , Lofthouse , S. and Puri , N. K. 1993 . Comparison of conventional adjuvants and ‘adjuvant‐free’ monoclonal antibody targeting for stimulating antibody responses against a conjugate of luteinizing hormone releasing hormone and avidin . Vaccine , 11 : 425

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