Advanced search
Publication Cover
AIDS Care
Psychological and Socio-medical Aspects of AIDS/HIV
Volume 34, 2022 - Issue 4
Submit an article Journal homepage
1,701
Views
2
CrossRef citations to date
0
Altmetric
Research Article

Point-of-care viral load testing among adolescents and young adults living with HIV in Haiti: a randomized control trial

Lindsey K. Reifa Department of Medicine, Center for Global Health, Weill Cornell Medicine, New York, NY, USA;e Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USACorrespondence[email protected]
View further author information
,
Marie Elmase Belizaireb GHESKIO Center, Port-au-Prince, HaitiView further author information
,
Vanessa Rouziera Department of Medicine, Center for Global Health, Weill Cornell Medicine, New York, NY, USA;b GHESKIO Center, Port-au-Prince, HaitiView further author information
,
Grace Seoa Department of Medicine, Center for Global Health, Weill Cornell Medicine, New York, NY, USAView further author information
,
Patrice Severeb GHESKIO Center, Port-au-Prince, HaitiView further author information
,
Joseph-Marie Bajo Josephb GHESKIO Center, Port-au-Prince, HaitiView further author information
,
Bernadette Josephb GHESKIO Center, Port-au-Prince, HaitiView further author information
,
Sandra Apollonb GHESKIO Center, Port-au-Prince, HaitiView further author information
,
Jean W. Papea Department of Medicine, Center for Global Health, Weill Cornell Medicine, New York, NY, USA;b GHESKIO Center, Port-au-Prince, HaitiView further author information
,
Margaret L. McNairya Department of Medicine, Center for Global Health, Weill Cornell Medicine, New York, NY, USA;g Division of General Medicine, Department of Medicine, Weill Cornell Medicine, New York, NY, USAView further author information
,
Batya Elule Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USAView further author information
,
Daniel W. Fitzgeralda Department of Medicine, Center for Global Health, Weill Cornell Medicine, New York, NY, USAView further author information
,
Stephen M. Arpadic ICAP at Columbia University, Mailman School of Public Health, Columbia University, NY, USA;d Gertrude H. Sergievsky Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA;e Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USAView further author information
,
Elaine J. Abramsc ICAP at Columbia University, Mailman School of Public Health, Columbia University, NY, USA;e Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA;f Department of Pediatrics, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USAView further author information
&
Louise Kuhnd Gertrude H. Sergievsky Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA;e Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USAView further author information
 show all
Pages 409-420 | Received 25 Nov 2020, Accepted 25 Aug 2021, Published online: 06 Oct 2021

References

  • Belzer, M. E., MacDonell, K. K., Ghosh, S., Naar, S., McAvoy-Banerjea, J., Gurung, S., Cain, D., Fan, C. A., & Parsons, J. T. (2018). Adaptive antiretroviral therapy adherence interventions for youth living With HIV through text message and cell phone support with and without incentives: Protocol for a sequential multiple assignment randomized trial (SMART). JMIR Research Protocols, 7(12), e11183. https://doi.org/10.2196/11183
  • Bikaako-Kajura, W., Luyirika, E., Purcell, D. W., Downing, J., Kaharuza, F., Mermin, J., Malamba, S., & Bunnell, R. (2006). Disclosure of HIV status and adherence to daily drug regimens among HIV-infected children in Uganda. AIDS and Behavior, 10(4 Suppl), S85–S93. https://doi.org/10.1007/s10461-006-9141-3
  • Bonner, K., Mezochow, A., Roberts, T., Ford, N., & Cohn, J. (2013). Viral load monitoring as a tool to reinforce adherence: A systematic review. Journal of Acquired Immune Deficiency Syndromes, 64(1), 74–78. https://doi.org/10.1097/QAI.0b013e31829f05ac
  • Castillo-Mancilla, J. R., Zheng, J. H., Rower, J. E., Meditz, A., Gardner, E. M., Predhomme, J., Fernandez, C., Langness, J., Kiser, J. J., Bushman, L. R., & Anderson, P. L. (2013). Tenofovir, emtricitabine, and tenofovir diphosphate in dried blood spots for determining recent and cumulative drug exposure. AIDS Research and Human Retroviruses, 29(2), 384–390. https://doi.org/10.1089/AID.2012.0089. Epub 2012 Oct 10.
  • Ceffa, S., Luhanga, R., Andreotti, M., Brambilla, D., Erba, F., Jere, H., Mancinelli, S., Giuliano, M., Palombi, L., & Marazzi, M. C. (2016). Comparison of the Cepheid GeneXpert and Abbott M2000 HIV-1 real time molecular assays for monitoring HIV-1 viral load and detecting HIV-1 infection. Journal of Virological Methods, 229, 35–39. https://doi.org/10.1016/j.jviromet.2015.12.007
  • Chesney, M. A., Ickovics, J. R., Chambers, D. B., Gifford, A. L., Neidig, J., Zwickl, B., & Wu, A. W. (2000). Self-reported adherence to antiretroviral medications among participants in HIV clinical trials: The AACTG adherence instruments. Patient Care Committee & Adherence Working Group of the outcomes Committee of the adult AIDS Clinical Trials Group (AACTG). AIDS Care, 12(3), 255–266. https://doi.org/10.1080/09540120050042891
  • Cluver, L. D., Toska, E., Orkin, F. M., Meinck, F., Hodes, R., Yakubovich, A. R., & Sherr, L. (2016). Achieving equity in HIV-treatment outcomes: Can social protection improve adolescent ART-adherence in South Africa? AIDS Care, 28(Suppl 2), 73–82. https://doi.org/10.1080/09540121.2016.1179008
  • Dillingham, R., Ingersoll, K., Flickinger, T. E., Waldman, A. L., Grabowski, M., Laurence, C., Wispelwey, E., Reynolds, G., Conaway, M., & Cohn, W. F. (2018). Positivelinks: A mobile Health intervention for retention in HIV care and clinical outcomes with 12-month follow-up. AIDS Patient Care and STDs, 32(6), 241–250. https://doi.org/10.1089/apc.2017.0303
  • Diress, G., Dagne, S., Alemnew, B., Adane, S., & Addisu, A. (2019). Viral load suppression after enhanced adherence counseling and Its predictors among high viral load HIV seropositive people in North Wollo Zone Public Hospitals, Northeast Ethiopia, 2019: Retrospective cohort study. AIDS Research and Treatment, 2020, 8909232. https://doi.org/10.1155/2020/8909232
  • Drain, P. K., Dorward, J., Violette, L. R., Quame-Amaglo, J., Thomas, K. K., Samsunder, N., Ngobese, H., Mlisana, K., Moodley, P., Donnell, D., Barnabas, R. V., Naidoo, K., Abdool Karim, S. S., Celum, C., & Garrett, N. (2020). Point-of-care HIV viral load testing combined with task shifting to improve treatment outcomes (STREAM): findings from an open-label, non-inferiority, randomised controlled trial. The Lancet. HIV, 7(4), e229–e237. https://doi.org/10.1016/S2352-3018(19)30402-3
  • Griffith, D. C., & Agwu, A. L. (2017). Caring for youth living with HIV across the continuum: Turning gaps into opportunities. AIDS Care, 29(10), 1205–1211. https://doi.org/10.1080/09540121.2017.1290211
  • Gueudin, M., Baron, A., Alessandri-Gradt, E., Lemée, V., Mourez, T., Etienne, M., & Plantier, J. C. (2016). Performance evaluation of the new HIV-1 quantification assay, Xpert HIV-1 viral load, on a wide panel of HIV-1 variants. JAIDS Journal of Acquired Immune Deficiency Syndromes, 72(5), 521–526. https://doi.org/10.1097/QAI.0000000000001003
  • ICAP at Columbia University. (2018). Viral load monitoring and enhanced adherence counseling flipchart: Adolescents. Retrieved May 2, 2018 from, http://icapcolumbiaedu/resources/detail/viral-load-toolkit-flipcharts
  • Intasan, J., Bunupuradah, T., Vonthanak, S., Kosalaraksa, P., Hansudewechakul, R., Kanjanavanit, S., Ngampiyaskul, C., Wongsawat, J., Luesomboon, W., Apornpong, T., Kerr, S., Ananworanich, J., Puthanakit, T., & PREDICT Study Group (2014). Comparison of adherence monitoring tools and correlation to virologic failure in a pediatric HIV clinical trial. AIDS Patient Care and STDs, 28(6), 296–302. https://doi.org/10.1089/apc.2013.0276
  • Jones, D., Cook, R., Rodriguez, A., & Waldrop-Valverde, D. (2013). Personal HIV knowledge, appointment adherence and HIV outcomes. AIDS and Behavior, 17(1), 242–249. https://doi.org/10.1007/s10461-012-0367-y
  • Kapogiannis, B. G., Koenig, L. J., Xu, J., Mayer, K. H., Loeb, J., Greenberg, L., Monte, D., Banks-Shields, M., Fortenberry, J. D., & Adolescent Medicine Trials Network for HIV/AIDS Interventions (2020). The HIV continuum of care for adolescents and young adults attending 13 urban US HIV care centers of the NICHD-ATN-CDC-HRSA SMILE collaborative. JAIDS Journal of Acquired Immune Deficiency Syndromes, 84(1), 92–100. https://doi.org/10.1097/QAI.0000000000002308
  • Lowenthal, E. D., Bakeera-Kitaka, S., Marukutira, T., Chapman, J., Goldrath, K., & Ferrand, R. A. (2014). Perinatally acquired HIV infection in adolescents from sub-Saharan Africa: A review of emerging challenges. The Lancet Infectious Diseases, 14(7), 627–639. https://doi.org/10.1016/S1473-3099(13)70363-3
  • Makadzange, A. T., Higgins-Biddle, M., Chimukangara, B., Birri, R., Gordon, M., Mahlanza, T., McHugh, G., van Dijk, J. H., Bwakura-Dangarembizi, M., Ndung'u, T., Masimirembwa, C., Phelps, B., Amzel, A., Ojikutu, B. O., Walker, B. D., & Ndhlovu, C. E. (2015). Clinical, virologic, immunologic outcomes and emerging HIV drug resistance patterns in children and adolescents in public ART care in Zimbabwe. PloS One, 10(12), e0144057. https://doi.org/10.1371/journal.pone.0144057
  • Mark, D., Armstrong, A., Andrade, C., Penazzato, M., Hatane, L., Taing, L., Runciman, T., & Ferguson, J. (2017). HIV treatment and care services for adolescents: A situational analysis of 218 facilities in 23 sub-Saharan african countries. Journal of the International AIDS Society, 20(Suppl 3), 21591. https://doi.org/10.7448/IAS.20.4.21591
  • Medecins Sans Frontieres Khayelisha. (2016). Youth linkage and retention interventions from HIV diagnosis to adult care transition: Report and toolkit. MSF.
  • Murray, K. R., Dulli, L. S., Ridgeway, K., Dal Santo, L., Darrow de Mora, D., Olsen, P., Silverstein, H., & McCarraher, D. R. (2017). Improving retention in HIV care among adolescents and adults in low- and middle-income countries: A systematic review of the literature. PloS one, 12(9), e0184879. https://doi.org/10.1371/journal.pone.0184879
  • Nachega, J. B., Hislop, M., Nguyen, H., Dowdy, D. W., Chaisson, R. E., Regensberg, L., Cotton, M., & Maartens, G. (2009). Antiretroviral therapy adherence, virologic and immunologic outcomes in adolescents compared with adults in Southern Africa. JAIDS Journal of Acquired Immune Deficiency Syndromes, 51(1), 65–71. https://doi.org/10.1097/QAI.0b013e318199072e
  • Nicholas, S., Poulet, E., Wolters, L., Wapling, J., Rakesh, A., Amoros, I., Szumilin, E., Gueguen, M., & Schramm, B. (2019). Point-of-care viral load monitoring: Outcomes from a decentralized HIV programme in Malawi. Journal of the International AIDS Society, 22(8), e25387. https://doi.org/10.1002/jia2.25387
  • Ownby, R. L., Waldrop-Valverde, D., Hardigan, P., Caballero, J., Jacobs, R., & Acevedo, A. (2013). Development and validation of a brief computer-administered HIV-Related Health Literacy Scale (HIV-HL). AIDS and Behavior, 17(2), 710–718. https://doi.org/10.1007/s10461-012-0301-3
  • Working Group on Modelling of Antiretroviral Therapy Monitoring Strategies in Sub-Saharan Africa, Phillips, A., Shroufi, A., Vojnov, L., Cohn, J., Roberts, T., Ellman, T., Bonner, K., Rousseau, C., Garnett, G., Cambiano, V., Nakagawa, F., Ford, D., Bansi-Matharu, L., Miners, A., Lundgren, J. D., Eaton, J. W., Parkes-Ratanshi, R., Katz, Z., … Revill, P. (2015). Sustainable HIV treatment in Africa through viral-load-informed differentiated care. Nature, 528(7580), S68–S76. https://doi.org/10.1038/nature16046
  • Reif, L. K., Belizaire, M. E., Seo, G., Rouzier, V., Severe, P., Joseph, J. M., Joseph, B., Apollon, S., Abrams, E. J., Arpadi, S. M., Elul, B., Pape, J. W., McNairy, M. L., Fitzgerald, D. W., & Kuhn, L. (2020). Point-of-care viral load testing among adolescents and youth living with HIV in Haiti: A protocol for a randomized trial to evaluate implementation and effect. BMJ Open, 10(8), e036147. https://doi.org/10.1136/bmjopen-2019-036147
  • Reif, L. K., Bertrand, R., Benedict, C., Lamb, M. R., Rouzier, V., Verdier, R., Johnson, W. D., Pape, J. W., Fitzgerald, D. W., Kuhn, L., & McNairy, M. L. (2016). Impact of a youth-friendly HIV clinic: 10 years of adolescent outcomes in Port-au-Prince, Haiti. Journal of the International AIDS Society, 19(1), 20859. https://doi.org/10.7448/IAS.19.1.20859
  • Reynolds, N. R., Sun, J., Nagaraja, H. N., Gifford, A. L., Wu, A. W., & Chesney, M. A. (2007). Optimizing measurement of self-reported adherence with the ACTG adherence questionnaire: A cross-protocol analysis. JAIDS Journal of Acquired Immune Deficiency Syndromes, 46(4), 402–409. https://doi.org/10.1097/qai.0b013e318158a44f
  • Roberts, T., Cohn, J., Bonner, K., & Hargreaves, S. (2016). Scale-up of routine viral load testing in resource-poor settings: Current and future implementation challenges. Clinical Infectious Diseases, 62(8), 1043–1048. https://doi.org/10.1093/cid/ciw001
  • Simoni, J. M., Kurth, A. E., Pearson, C. R., Pantalone, D. W., Merrill, J. O., & Frick, P. A. (2006). Self-report measures of antiretroviral therapy adherence: A review with recommendations for HIV research and clinical management. AIDS and Behavior, 10(3), 227–245. https://doi.org/10.1007/s10461-006-9078-6
  • Slogrove, A. L., Mahy, M., Armstrong, A., & Davies, M. A. (2017). Living and dying to be counted: What we know about the epidemiology of the global adolescent HIV epidemic. Journal of the International AIDS Society, 20(Suppl 3), 21520. https://doi.org/10.7448/IAS.20.4.21520
  • Stirratt, M. J., Dunbar-Jacob, J., Crane, H. M., Simoni, J. M., Czajkowski, S., Hilliard, M. E., Aikens, J. E., Hunter, C. M., Velligan, D. I., Huntley, K., Ogedegbe, G., Rand, C. S., Schron, E., & Nilsen, W. J. (2015). Self-report measures of medication adherence behavior: Recommendations on optimal use. Translational Behavioral Medicine, 5(4), 470–482. https://doi.org/10.1007/s13142-015-0315-2
  • Tique, J. A., Howard, L. M., Gaveta, S., Sidat, M., Rothman, R. L., Vermund, S. H., & Ciampa, P. J. (2017). Measuring health literacy among adults with HIV infection in Mozambique: Development and validation of the HIV literacy test. AIDS and Behavior, 21(3), 822–832. https://doi.org/10.1007/s10461-016-1348-3
  • UNAIDS. (2018). Youth and HIV. Mainstreaming a three-lens approach to youth participation. https://wwwunaidsorg/sites/default/files/media_asset/youth-and-hiv_enpdf
  • Wilson, D., Keiluhu, A. K., Kogrum, S., Reid, T., Seriratana, N., Ford, N., Kyawkyaw, M., Talangsri, P., & Taochalee, N. (2009). HIV-1 viral load monitoring: An opportunity to reinforce treatment adherence in a resource-limited setting in Thailand. Transactions of the Royal Society of Tropical Medicine and Hygiene, 103(6), 601–606. https://doi.org/10.1016/j.trstmh.2008.11.007
  • World Health Organization. (2013). Consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection.
  • World Health Organization. (2017). Topics at a glance. Adolescent Health. HIV and Youth. Geneva: World Health Organization. Retrieved 11/11/2017, from http://www.who.int/maternal_child_adolescent/topics/adolescence/hiv/en/
  • World Health Organization. (2017). Adapting and implementing new recommendation on HIV patient monitoring. Geneva. World Health Organization. Available from: https://apps.who.int/iris/bitstream/handle/10665/255867/WHO-HIV-2017.13-eng.pdf?sequence=1.
  • World Heatlh Organization. (2015). HIV treatment and care, what's New in service delivery fact sheet. WHO. http://apps.who.int/iris/bitstream/10665/204461/1/WHO_HIV_2015.46_eng.pdf?ua=1

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.