Assessment of “corticophobia” as an indicator of non-adherence to topical corticosteroids: A pilot study

References

• Aubert-Wastiaux H, Moret L, Le Rhun A, et al. Topical corticosteroid phobia in atopic dermatitis: a study of its nature, origins and frequency. Br J Dermatol. 2011;165:808–14.
   PubMed Web of Science ®Google Scholar
• Morren MA, Bruwiere I, Lemmens M, et al. Lack of compliance to topical corticosteroid therapy: possible cause and solutions. J Pharm Bel. 2013;20–7.
   PubMedGoogle Scholar
• Gustavsen HE, Gjersvik P. Topical corticosteroid phobia among parents of children with atopic dermatitis in a semirural area of Norway. J Eur Acad Dermatol Venereol. 2016;30:168. doi: 10.1111/jdv.12670.
   PubMed Web of Science ®Google Scholar
• Charman CR, Morris AD, Williams HC. Topical corticosteroid phobia in patients with atopic eczema. Br J Dermatol. 2000;142:931–6.
   PubMed Web of Science ®Google Scholar
• Charman C, Williams H. The use of corticosteroids and corticosteroid phobia in atopic dermatitis. Clin Dermatol. 2003;21:193–200.
   PubMed Web of Science ®Google Scholar
• Kojima R, Fujiwara T, Matsuda A, et al. Factors associated with steroid phobia in caregivers of children with atopic dermatitis. Pediatr Dermatol. 2013;30:29–35.
   PubMed Web of Science ®Google Scholar
• Smith SD, Stephens AM, Werren JC, Fischer GO. Treatment failure in atopic dermatitis as a result of parental health belief. Med J Aust. 2013;199:467–9.
   PubMed Web of Science ®Google Scholar
• Smith SD, Hong E, Fearns S, et al. Corticosteroid phobia and other confounders in the treatment of childhood atopic dermatitis explored using parent focus groups. Aust J Dermatol. 2010;51:168–74.
   PubMed Web of Science ®Google Scholar
• Hon KL, Leung TF, Yau HC, Chan T. Paradoxical use of oral and topical steroids in steroid-phobic patients resorting to traditional Chinese medicines. World J Pediatr. 2012;8:263–7.
   PubMed Web of Science ®Google Scholar
• Hon KL, Kam WY, Leung TF, et al. Steroid fears in children with eczema. Acta Paediatr. 2006;95:1451–5.
   PubMed Web of Science ®Google Scholar
• Bewley A, Dermatology Working G. Expert consensus: time for a change in the way we advise our patients to use topical corticosteroids. Br J Dermatol. 2008;158:917–20.
   PubMed Web of Science ®Google Scholar
• Jenerowicz D, Czarnecka-Operacz M, Silny W. Corticosteroid phobia in patients with atopic dermatitis]. Wiad Lek. 2005;58:607–15.
   PubMedGoogle Scholar
• Hon KL, Tsang YC, Pong NH, et al. Correlations among steroid fear, acceptability, usage frequency, quality of life and disease severity in childhood eczema. J Dermatol Treatment. 2015;26:1–8.
   PubMed Web of Science ®Google Scholar
• Bertsche T, Schulz M. Between Cortisone anxiety and euphoria. Pharmaceutical surveillance of long-term medication. Pharm Unser Zeit. 2003;32:323–9.
   PubMedGoogle Scholar
• M D. Kortisonangst von Ärzten und Patienten. Eine Untersuchung zu Einschätzungsunterschieden bei inhalativen und oralen Kortikosteroiden. Münch Med Wochenschr. 1996;440–3.
   Google Scholar
• Mueller STD, Euler S, Vogt D, et al. Characteristics of topical corticosteroid phobia and the impact of patient information. Dermatology. 2016. [Epub ahead of print]. doi: 10.1159/000446068.
   Google Scholar
• Hirschbichler A, Spohn S, Petro W. Fear of cortisone: in pulmonary rehabilitation it is less than expected. Results of a patient survey. Pneumologie. 2000;54:68–71.
   PubMedGoogle Scholar
• Deuchert M, Hirschbichler A, Petermann F, Petro W. Cortisone anxiety in chronic obstructive respiratory tract diseases: a patient survey. Z Klin Psychol Psychopathol Psychother. 1994;42:16–26.
   PubMedGoogle Scholar
• Skoner JD, Schaffner TJ, Schad CA, et al. Addressing steroid phobia: improving the risk-benefit ratio with new agents. Aller Asthma Proc. 2008;29:358–64.
   PubMed Web of Science ®Google Scholar
• Bahna SL. Is it time to reduce our phobia of inhaled corticosteroids? Pediatrics. 2004;113:1813–14.
   PubMed Web of Science ®Google Scholar
• Gillissen A, Lecheler J. Corticophobia in asthma. Med Klin (Munich). 2003;98:417–22.
   PubMedGoogle Scholar
• Della Bella LA. Steroidphobia and the pulmonary patient. Am J Nursing. 1992;92:26–9.
   PubMed Web of Science ®Google Scholar
• Woller W, Kruse J, Winter P, et al. Cortisone image and emotional support by key figures in patients with bronchial asthma. An empirical study. Psychother Psychosom. 1993;59:190–6.
   PubMed Web of Science ®Google Scholar
• Woller W, Kruse J, Arnolds S, et al. Negative cortisone attitude in patients with bronchial asthma. Pneumologie. 1992;46:326–9.
   PubMedGoogle Scholar
• Niggemann B. How can we improve compliance in pediatric pneumology and allergology? Allergy. 2005;60:735–8.
   PubMed Web of Science ®Google Scholar
• Bosse K, Kaiser H, Lamparter-Lang R. The so-called cortisone fear. Med Klin (Munich). 1992;87:540–3.
   PubMedGoogle Scholar
• Morin C, Fardet L. Systemic glucocorticoid therapy: risk factors for reported adverse events and beliefs about the drug. A cross-sectional online survey of 820 patients. Clin Rheumatol. 2015;34:2119–26.
   PubMed Web of Science ®Google Scholar
• Reilly DT. Ask the doctor. I'm in my late 70s and have been getting about four cortisone shots a year for the past several years for the arthritis in my left knee. They really help with the pain, but I've heard that long-term, there could be bad side effects. Should I be worried? Harv Health Lett. 2012;37:99.
   PubMedGoogle Scholar
• Patterson R, Walker CL, Greenberger PA, Sheridan EP. Prednisonephobia. Allergy Proc. 1989;10:423–8.
   PubMedGoogle Scholar
• Aubert H, Barbarot S. Non adherence and topical steroids. Ann Dermatol Venereol. 2012;139:S7–12.
   PubMed Web of Science ®Google Scholar
• Moret L, Anthoine E, Aubert-Wastiaux H, et al. TOPICOP(c): a new scale evaluating topical corticosteroid phobia among atopic dermatitis outpatients and their parents. PloS One. 2013;8:e76493.
   PubMed Web of Science ®Google Scholar
• Vrijens B, De Geest S, Hughes DA, et al. A new taxonomy for describing and defining adherence to medications. Br J Clin Pharmacol. 2012;73:691–705.
   PubMed Web of Science ®Google Scholar
• Ohya Y, Williams H, Steptoe A, et al. Psychosocial factors and adherence to treatment advice in childhood atopic dermatitis. J Invest Dermatol. 2001;117:852–7.
   PubMed Web of Science ®Google Scholar
• Fischer G. Compliance problems in paediatric atopic eczema. Aust J Dermatol. 1996;37:S10–S13.
   PubMedGoogle Scholar
• Brown KK, Rehmus WE, Kimball AB. Determining the relative importance of patient motivations for nonadherence to topical corticosteroid therapy in psoriasis. J Am Acad Dermatol. 2006;55:607–13.
   PubMed Web of Science ®Google Scholar
• Mooney E, Rademaker M, Dailey R, et al. Adverse effects of topical corticosteroids in paediatric eczema: Australasian consensus statement. Aust J Dermatol. 2015;56:241–51.
   PubMed Web of Science ®Google Scholar
• Feldman SR, Horn EJ, Balkrishnan R, et al. Psoriasis: improving adherence to topical therapy. J Am Acad Dermatol. 2008;59:1009–16.
   PubMed Web of Science ®Google Scholar
• Richmond NA, Lamel SA, Braun LR, et al. Primary nonadherence (failure to obtain prescribed medicines) among dermatology patients. J Am Acad Dermat. 2014;70:201–3.
   PubMed Web of Science ®Google Scholar
• Iuga AO, McGuire MJ. Adherence and health care costs. Risk Manag Healthc Policy. 2014;7:35–44.
   PubMedGoogle Scholar
• Greenlaw SM, Yentzer BA, O'Neill JL, et al. Assessing adherence to dermatology treatments: a review of self-report and electronic measures. Skin Res Technol. 2010;16:253–8.
   PubMed Web of Science ®Google Scholar
• Morisky DE, Ang A, Krousel-Wood M, Ward HJ. Predictive validity of a medication adherence measure in an outpatient setting. J Clin Hypert. 2008;10:348–54.
   PubMed Web of Science ®Google Scholar
• Furue M, Onozuka D, Takeuchi S, et al. Poor adherence to oral and topical medication in 3096 dermatological patients as assessed by the Morisky Medication Adherence Scale-8. Br J Dermat. 2015;172:272–5.
   PubMed Web of Science ®Google Scholar
• Hodari KT, Nanton JR, Carroll CL, et al. Adherence in dermatology: a review of the last 20 years. J Dermatol Treat. 2006;17:136–42.
   PubMed Web of Science ®Google Scholar
• Osterberg L, Blaschke T. Adherence to medication. New Engl J Med. 2005;353:487–97.
   PubMed Web of Science ®Google Scholar
• MacLaughlin EJ, Raehl CL, Treadway AK, et al. Assessing medication adherence in the elderly: which tools to use. In Clinical Practice? Drug Aging. 2005;22:231–55.
   PubMed Web of Science ®Google Scholar
• Haddad PM, Brain C, Scott J. Nonadherence with antipsychotic medication in schizophrenia: challenges and management strategies. Patient Relat Outcome Meas. 2014;5:43–62.
   PubMedGoogle Scholar
• Velligan DI, Weiden PJ, Sajatovic M, et al. Assessment of adherence problems in patients with serious and persistent mental illness: recommendations from the Expert Consensus Guidelines. J Psychiatr Pract. 2010;16:34–45.
   PubMed Web of Science ®Google Scholar
• Ho PM, Bryson CL, Rumsfeld JS. Medication adherence: its importance in cardiovascular outcomes. Circulation. 2009;119:3028–35.
   PubMed Web of Science ®Google Scholar
• Zschocke I, Mrowietz U, Karakasili E, Reich K. Non-adherence and measures to improve adherence in the topical treatment of psoriasis. J Eur Acad Dermatol Venereol. 2014;28:4–9.
   PubMed Web of Science ®Google Scholar
• Clifford S, Perez-Nieves M, Skalicky AM, et al. A systematic literature review of methodologies used to assess medication adherence in patients with diabetes. Curr Med Res Opin. 2014;30:1071–85.
   PubMed Web of Science ®Google Scholar
• Dobbels F, Berben L, De Geest S, et al. The psychometric properties and practicability of self-report instruments to identify medication nonadherence in adult transplant patients: a systematic review. Transplantation. 2010;90:205–19.
   PubMed Web of Science ®Google Scholar
• Lareau SC, Yawn BP. Improving adherence with inhaler therapy in COPD. Int J Chron Obstruct Pulmon Dis. 2010;5:401–6.
   PubMedGoogle Scholar
• Shemesh E, Annunziato RA, Arnon R, et al. Adherence to medical recommendations and transition to adult services in pediatric transplant recipients. Curr Opin Organ Transplant. 2010;15:288–92.
   PubMed Web of Science ®Google Scholar
• van Mierlo T, Fournier R, Ingham M. Targeting medication non-adherence behavior in selected autoimmune diseases: a systematic approach to digital health program development. PLoS One. 2015;10:e0129364.
   PubMed Web of Science ®Google Scholar
• Costa E, Giardini A, Savin M, et al. Interventional tools to improve medication adherence: review of literature. Patient Prefer Adherence. 2015;9:1303–14.
   PubMed Web of Science ®Google Scholar
• Zschocke I, Mrowietz U, Lotzin A, et al. Assessing adherence factors in patients under topical treatment: development of the Topical Therapy Adherence Questionnaire (TTAQ). Arch Dermatol Res. 2014;306:287–97.
   PubMed Web of Science ®Google Scholar
• Tan X, Feldman SR, Chang J, Balkrishnan R. Topical drug delivery systems in dermatology: a review of patient adherence issues. Exp Opin Drug Deliv. 2012;9:1263–71.
   PubMed Web of Science ®Google Scholar
• Fukaya M. Why do patients with atopic dermatitis refuse to apply topical corticosteroids? Dermatology (Basel). 2000;201:242–5.
   PubMed Web of Science ®Google Scholar
• Robin X, Turck N, Hainard A, et al. pROC: an open-source package for R and S+ to analyze and compare ROC curves. BMC Bioinform. 2011;12:77.
   PubMed Web of Science ®Google Scholar
• Team RC. A language and environment for statistical computing. R Foundation for Statistical Computing. Vienna, Austria, 2015.
   Google Scholar
• Atreja A, Bellam N, Levy SR. Strategies to enhance patient adherence: making it simple. Med Gen Med. 2005;7:4.
   PubMedGoogle Scholar
• Medicine ACoP. Medication adherence time tool: improving health outcomes. A resource from the American College of Preventive Medicine. Available from: http://www.acpm.org/?MedAdhereTTProviders. Accessed June 28, 2016.
   Google Scholar
• Barbarot S. Personal communication from S.Barbarot to S. Euler 2015.
   Google Scholar
• Tuft L. “Steroid-phobia” in asthma management. Ann Allergy. 1979;42:152–9.
   PubMedGoogle Scholar
• Association AP. Diagnostic and Statistical Manual of Mental Disorders (DSM-5). Arlington: American Psychiatric Publishing; 2013.
   Google Scholar
• WHO. The ICD-10 classification of mental and behavioural disorders: clinical description and diagnostic guidelines: clinical description and diagnostic guidelines. Geneva: WHO Library, 1992.
   Google Scholar
• Krejci-Manwaring J, Tusa MG, Carroll C, et al. Stealth monitoring of adherence to topical medication: adherence is very poor in children with atopic dermatitis. J Am Acad Dermatol. 2007;56:211–6.
   PubMed Web of Science ®Google Scholar
• Augustin M, Holland B, Dartsch D, et al. Adherence in the treatment of psoriasis: a systematic review. Dermatology (Basel). 2011;222:363–74.
   PubMed Web of Science ®Google Scholar
• Feldman SR, Camacho FT, Krejci-Manwaring J, et al. Adherence to topical therapy increases around the time of office visits. J Am Acad Dermatol. 2007;57:81–3.
   PubMed Web of Science ®Google Scholar
• Cork MJ, Britton J, Butler L, et al. Comparison of parent knowledge, therapy utilization and severity of atopic eczema before and after explanation and demonstration of topical therapies by a specialist dermatology nurse. Br J Dermatol. 2003;149:582–9.
   PubMed Web of Science ®Google Scholar
• Zirwas MJ, Holder JL. Patient education strategies in dermatology: part 2: methods. J Clin Aesthet Dermatol. 2009;2:28–34.
   PubMedGoogle Scholar
• Choudhry NK, Avorn J, Glynn RJ, et al. Full coverage for preventive medications after myocardial infarction. New Engl J Med. 2011;365:2088–97.
   PubMed Web of Science ®Google Scholar
• Yach D WHO. Adherence to long term therapies: policy for action. Available from: http://www.who.int/chp/knowledge/publications/adherencerep.pdf; 2001. Accessed June 28, 2016.
   Google Scholar
• Horne R, Chapman SC, Parham R, et al. Understanding patients‘ adherence-related beliefs about medicines prescribed for long-term conditions: a meta-analytic review of the Necessity-Concerns Framework. PLoS One. 2013;8:e80633.
   PubMed Web of Science ®Google Scholar
• Marzec LN, Maddox TM. Medication adherence in patients with diabetes and dyslipidemia: associated factors and strategies for improvement. Curr Cardiol Reports. 2013;15:418.
   PubMed Web of Science ®Google Scholar
• O'Carroll R, Whittaker J, Hamilton B, et al. Predictors of adherence to secondary preventive medication in stroke patients. Ann Behav Med. 2011;41:383–90.
   PubMed Web of Science ®Google Scholar
• Zeber JE, Manias E, Williams AF, et al. A systematic literature review of psychosocial and behavioral factors associated with initial medication adherence: a report of the ISPOR medication adherence & persistence special interest group. J Int Soc Pharmacoeconom Outcom Res. 2013;16:891–900.
   Google Scholar
• Turin A, Pandit J, Stone NJ. Statins and nonadherence: should we relate better? J Cardiovasc Pharmacol Ther. 2015;20:447–56.
   PubMed Web of Science ®Google Scholar