The efficacy and safety of topical 10% potassium hydroxide for molluscum contagiosum: a systematic review and meta-analysis

References

• Olsen JR, Gallacher J, Piguet V, et al. Epidemiology of molluscum contagiosum in children: a systematic review. Fam Pract. 2014;31(2):130–136.
   PubMed Web of Science ®Google Scholar
• Robinson G, Townsend S, Jahnke MN. Molluscum contagiosum: review and update on clinical presentation, diagnosis, risk, prevention, and treatment. Curr Derm Rep. 2020;9(1):83–92.
   Web of Science ®Google Scholar
• Basdag H, Rainer BM, Cohen BA. Molluscum contagiosum: to treat or not to treat? Experience with 170 children in an outpatient clinic setting in the northeastern United States. Pediatr Dermatol. 2015;32(3):353–357.
   PubMed Web of Science ®Google Scholar
• Leung AKC, Barankin B, Hon KLE. Molluscum contagiosum: an update. Recent Pat Inflamm Allergy Drug Discov. 2017;11(1):22–31.
   PubMed Web of Science ®Google Scholar
• Van der Wouden JC, Sande R, Kruithof E, et al. Interventions for cutaneous molluscum contagiosum. Cochrane Database Syst Rev. 2017;5:CD004767.
   PubMedGoogle Scholar
• Romiti R, Ribeiro AP, Grinblat BM, et al. Treatment of molluscum contagiosum with potassium hydroxide: a clinical approach in 35 children. Pediatr Dermatol. 1999;16(3):228–231.
   PubMed Web of Science ®Google Scholar
• Can B, Topaloğlu F, Kavala M, et al. Treatment of pediatric molluscum contagiosum with 10% potassium hydroxide solution. J Dermatolog Treat. 2014;25(3):246–248.
   PubMed Web of Science ®Google Scholar
• Romiti R, Ribeiro AP, Romiti N. Evaluation of the effectiveness of 5% potassium hydroxide for the treatment of molluscum contagiosum. Pediatr Dermatol. 2000;17(6):495–495.
   PubMed Web of Science ®Google Scholar
• Pati Aji A, Rowawi R, Fatmasari D, et al. A case series: experience of using 20% potassium hydroxide solution to treat adult sexually transmitted molluscum contagiosum. Clin Cosmet Investig Dermatol. 2020;13:671–676.
   PubMed Web of Science ®Google Scholar
• Teixidó C, Díez O, Marsal JR, et al. Efficacy and safety of topical application of 15% and 10% potassium hydroxide for the treatment of molluscum contagiosum. Pediatr Dermatol. 2018;35(3):336–342.
   PubMed Web of Science ®Google Scholar
• Muzaffar F, F F. Comparison of 5% potassium hydroxide with 10% potassium hydroxide solution in treatment of molluscum contagiosum: a comparative study. J Pakistan Assoc Dermatol. 2014;24:337–341.
   Google Scholar
• Knobloch K, Yoon U, Vogt PM. Preferred reporting items for systematic reviews and meta-analyses (PRISMA) statement and publication bias. J Craniomaxillofac Surg. 2011;39(2):91–92.
   PubMed Web of Science ®Google Scholar
• Giner-Soriano M, Teixidó C, Marsal JR, et al. Randomized placebo-controlled clinical trial on efficacy and safety of topical 10% Potassium hydroxide for molluscum contagiosum treatment in children. J Dermatolog Treat. 2019;30(8):750–756.
   PubMed Web of Science ®Google Scholar
• Short KA, Fuller LC, Higgins EM. Double-blind, randomized, placebo-controlled trial of the use of topical 10% potassium hydroxide solution in the treatment of molluscum contagiosum. Pediatr Dermatol. 2006;23(3):279–281.
   PubMed Web of Science ®Google Scholar
• Qureshi A, Zeb M, Jalal-Ud-Din M, et al. Comparison of efficacy of 10% potassium hydroxide solution versus cryotherapy in treatment of molluscum contagiosum. J Ayub Med Coll Abbottabad. 2016;28(2):382–385.
   PubMedGoogle Scholar
• Handjani F, Behazin E, Sadati MS. Comparison of 10% potassium hydroxide solution versus cryotherapy in the treatment of molluscum contagiosum: an open randomized clinical trial. J Dermatolog Treat. 2014;25(3):249–250.
   PubMed Web of Science ®Google Scholar
• Nguyen Huu S, Nguyen Quang M, Nguyen Van T, et al. Efficacy of 10% potassium hydroxide solution versus 10% salicylic acid ointment in treatment of molluscum contagiosum – the low – Cost dermatologic therapy in Vietnam. Open Access Maced J Med Sci. 2019;7(2):269–271.
   PubMedGoogle Scholar
• Kibar Ozturk M. Efficacy and side effects of topical applications of two different solutions in the treatment of molluscum contagiosum in a city in Africa: an open, randomized, comparative clinical trial. J Pediatr Infect Dis. 2019;14(05):248–252.
   Google Scholar
• Köse O, Özmen İ, Arca E. An open, comparative study of 10% potassium hydroxide solution versus salicylic and lactic acid combination in the treatment of molluscum contagiosum in children. J Dermatolog Treat. 2013;24(4):300–304.
   PubMed Web of Science ®Google Scholar
• Chathra N, Sukumar D, Bhat RM, et al. A comparative study of 10% KOH solution and 5% imiquimod cream for the treatment of molluscum contagiosum in the pediatric age group. Indian Dermatol Online J. 2015;6(2):75–80.
   PubMedGoogle Scholar
• Seo S-H, Chin H-W, Jeong D-W, et al. An open, randomized, comparative clinical and histological study of imiquimod 5% cream versus 10% potassium hydroxide solution in the treatment of molluscum contagiosum. Ann Dermatol. 2010;22(2):156–162.
   PubMed Web of Science ®Google Scholar
• Bozzetto MR, Ferreira LT, Bonfá R, et al. Molusco contagioso em crianças: tratamentos comparativos. Surg Cosmet Dermatol. 2010;2:272–275.
   Google Scholar
• Simonart T, De Maertelaer V. Curettage treatment for molluscum contagiosum: a follow-up survey study. Br J Dermatol. 2008;159:1144–1147.
   PubMed Web of Science ®Google Scholar
• Bayerl C, Feller G, Goerdt S. Experience in treating molluscum contagiosum in children with imiquimod 5% cream. Br J Dermatol. 2003;149(Suppl 66):25–29.
   PubMedGoogle Scholar
• Sequeira F, Bala N, Hundi G, et al. A study on the efficacy of topical 10% potassium hydroxide in the treatment of molluscum contagiosum. Muller J Med Sci Res. 2016;7(1):1.
   Google Scholar
• Brady G, Bowie AG. Innate immune activation of NFκB and its antagonism by poxviruses. Cytokine Growth Factor Rev. 2014;25(5):611–620.
   PubMed Web of Science ®Google Scholar
• Al-Mutairi N, Al-Doukhi A, Al-Farag S, et al. Comparative study on the efficacy, safety, and acceptability of imiquimod 5% cream versus cryotherapy for molluscum contagiosum in children. Pediatr Dermatol. 2010;27(4):388–394.
   PubMed Web of Science ®Google Scholar
• Hanna D, Hatami A, Powell J, et al. A prospective randomized trial comparing the efficacy and adverse effects of four recognized treatments of molluscum contagiosum in children. Pediatr Dermatol. 2006;23(6):574–579.
   PubMed Web of Science ®Google Scholar
• Leslie KS, Dootson G, Sterling JC. Topical salicylic acid gel as a treatment for molluscum contagiosum in children. J Dermatolog Treat. 2005;16(5–6):336–340.
   PubMed Web of Science ®Google Scholar