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Journal of Dermatological Treatment Volume 33, 2022 - Issue 7
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Articles

Efficacy and safety of oral methotrexate versus oral mini pulse betamethasone therapy in the treatment of lichen planus: a comparative study

Nour alhuda Gamal Alsakaana Dermatology, Venereology and Andrology Department, Faculty of Medicine, Tanta University, Tanta, Egypt
,
Sherief Abd-Elsalamb Tropical Medicine and Infectious Diseases Department, Faculty of Medicine, Tanta University, Tanta, Egypt
,
Mohamed M. Fawzya Dermatology, Venereology and Andrology Department, Faculty of Medicine, Tanta University, Tanta, EgyptCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-3355-4715
ORCID Icon &
Nagwa Mohammad Elwana Dermatology, Venereology and Andrology Department, Faculty of Medicine, Tanta University, Tanta, Egypt
Pages 3039-3046 | Received 30 May 2022, Accepted 03 Jul 2022, Published online: 31 Jul 2022

References

  • Usatine R, Tinitigan M. Diagnosis and treatment of lichen planus. Am Fam Physician. 2011;84(1):53–60.
  • Gupta S, Jawanda MK. Oral lichen planus: an update on etiology, pathogenesis, clinical presentation, diagnosis and management. Indian J Dermatol. 2015;60(3):222–229.
  • Weston G, Payette M. Update on lichen planus and its clinical variants. Int J Womens Dermatol. 2015;1(3):140–149.
  • Gupta S, et al. Lichen planus – an update. Int J Pharm Biomed Sci. 2013;4:59–65.
  • Ilyas S, et al. Efficacy and safety of methotrexate in lichen planus. J Pakistan Assoc Dermatol. 2016;26(1):41–47.
  • Thandar Y, Maharajh R, Haffejee F, et al. Treatment of cutaneous lichen planus (part 1): a review of topical therapies and phototherapy. Cogent Med. 2019;6(1):1582467–1582421.
  • Malhotra AK, Khaitan BK, Sethuraman G, et al. Betamethasone oral mini-pulse therapy compared with topical triamcinolone acetonide (0.1%) paste in oral lichen planus: a randomized comparative study. J Am Acad Dermatol. 2008;58(4):596–602.
  • Lunge S, Patil S, Manjunathswamy B. A comparative study of methotrexate & low molecular weight heparin for the treatment of generalized lichen planus. Indian J Clin Exp Dermatol. 2016;2:153–158.
  • Saeidi A, Siadat A, Saeidi A, et al. Comparison of therapeutic effect of low-dose low-molecular-weight heparin (enoxaparin) vs. oral prednisone in treatment of patients with lichen planus; a clinical trial. Adv Biomed Res. 2013;2(1):76.
  • More Y, Khatu S, Chavan D, et al. Evaluation of safety and efficacy of low-dose methotrexate as an alternative treatment option to systemic corticosteroids in generalized lichen planus. Med J DY Patil Univ. 2017;10(2):149–155.
  • Rashid M. Betamethasone oral mini-pulse therapy in the treatment of lichen planus. Iran J Dermatol. 2008;11(3):99–101.
  • Malekzad F, Saeedi M, Ayatollahi A. Low dose methotrexate for the treatment of generalized lichen planus. Iran J Dermatol. 2012;14(58):131–135.
  • Katta R. Lichen planus. Am Fam Physician. 2000;61(11):3319–3324.
  • Anbar T-E-D, Barakat M, Ghannam SF. A clinical and epidemiological study of lichen planus among Egyptians of Al-Minya province. Dermatol Online J. 2005;11(2):4.
  • Abdallat SA, Maaita TJ. Epidemiological and clinical features of lichen planus in Jordanian patients. Pak J Med Sci. 2007;23(1):92.
  • Turan H, Baskan EB, Tunali S, et al. Methotrexate for the treatment of generalized lichen planus. J Am Acad Dermatol. 2009;60(1):164–166.
  • Malekzad F, Saeedi M, Ayatollahi A. Low dose methotrexate for the treatment of generalized lichen planus. 2012;25:152–154.
  • Kanwar A, De D. Methotrexate for treatment of lichen planus: old drug, new indication. J Eur Acad Dermatol Venereol. 2013;27(3):e410–e413.
  • Bakhtiar R, Noor SM, Paracha MM. Effectiveness of oral methotrexate therapy versus systemic corticosteroid therapy in treatment of generalised lichen planus. J Coll Physicians Surg Pak. 2018;28(7):505–508.
  • Sachan S. A prospective study comparing therapeutic efficacy and safety of oral methotrexate and oral prednisone in the treatment of generalized cutaneous lichen planus. J Dent Med Sci. 2017;16:143–147.
  • Jang N, Fischer G. Treatment of erosive vulvovaginal lichen planus with methotrexate. Australas J Dermatol. 2008;49(4):216–219.
  • Lajevardi V, Ghodsi SZ, Hallaji Z, et al. Treatment of erosive oral lichen planus with methotrexate. J Dtsch Dermatol Ges. 2016;14(3):286–293.
  • Torti DC, Jorizzo JL, McCarty MA. Oral lichen planus: a case series with emphasis on therapy. Arch Dermatol. 2007;143(4):511–515.
  • Mittal R, Manchanda Y. Lichen planus treated with betamethasone oral mini-pulse therapy. Indian J Dermatol Venereol Leprol. 2000;66(1):34.
  • Hazra SC, Choudhury AM, Khondker L, et al. Comparative efficacy of methotrexate and mini pulse betamethasone in the treatment of lichen planus. Mymensingh Med J. 2013;22(4):787–797.
  • Ramesh M, Balachandran C, Shenoi SD, et al. Efficacy of steroid oral mini-pulse therapy in lichen planus: an open trial in 35 patients. Indian J Dermatol Venereol Leprol. 2006;72(2):156–157.
  • Hazra SC, Choudhury AM, Asaduzzaman ATM, et al. Adverse outcome of methotrexate and mini pulse betamethasone in the treatment of lichen planus. Bangladesh Med Res Counc Bull. 2013;39(1):22–27.
  • Al-Mutairi N, Joshi A, Zaki A, et al. Acute generalized lichen planus treated with weekly betamethasone 5-mg oral mini-pulse therapy. J Drugs Dermatol. 2005;4(2):218–220.

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