Advanced search
Publication Cover
International Journal of Radiation Biology Volume 76, 2000 - Issue 11
Submit an article Journal homepage
20
Views
27
CrossRef citations to date
0
Altmetric
Research Article

Inhibition of repair of X-ray-induced DNA double-strand breaks in human lymphocytes exposed to sodium butyrate

L. Stoilov, F. Darroudi, R. Meschini, G. Van Der Schans, L. H. F. Mullenders, A. T. Natarajan Department of Radiation Genetics and Chemical Mutagenesis; TNO–Medical Biological Laboratory, Rijswijk, The Netherlands
Pages 1485-1491 | Published online: 03 Jul 2009

  • BUNCH, R. T., GEWIRTZ, D. A. and POVIRK, L. F., 1995, Ionising radiation-induced DNA strand breakage and rejoining in specific genomic regions as determined by an alkaline unwinding/Southern blotting method. International Journal of Radiation Biology, 68, 553-562.
  • CHIU, S. M., FRIEDMAN, L. R., XUE, L. Y. and OLEINICK, N. L., 1986, Modification of DNA damage in transcriptionally active vs. bulk chromatin. International Journal of Radiation Oncology and Biological Physics, 12, 1529-1532.
  • CHIU, S. M., OLEINICK, N. L., FRIEDMAN, L. R. and STAMBROOK, P. J., 1982, Hypersensitivity of DNA in transcriptionally active chromatin to ionising radiation. Biochemical Biophysical Acta, 699, 15-21.
  • DARROUDI, F. and NATARAJAN, A. T., 1989, Cytogenetical characterization of Chinese hamster ovary X-ray-sensitive mutant cells xrs 5 and xrs 6. VII. Complementation analysis of X-ray irradiated wild-type CHO-K1 and xrs mutants using the premature chromosome condensation technique. Mutation Research, 213, 249-255.
  • DUNCAN, M. R., ROBINSON, M.J. and DELL'ORCO, R. T., 1983, The kinetics of histone hyperacetylation and deacetylation in human diploid fibroblasts. Biochemical Biophysical Acta, 762, 221-226.
  • KRUH, J., 1982, Effects of sodium butyrate: a new pharmacological agent on cells in culture. Molecular and Cellular Biochemistry, 42, 65-82.
  • LJUNGMAN, M., 1991, The influence of chromatin structure on the frequency of radiation-induced DNA strand breaks: a study using nuclear and nucleoid monolayers. Radiation Research, 126, 58-64.
  • LJUNGMAN, M., 1999, Repair of radiation-induced DNA strand breaks does not occur preferentially in transcriptionally active DNA. Radiation Research, 152, 444-449.
  • LöBRICH, M., RYDBERG, B. and COOPER, P. K., 1994, DNA double strand breaks induced by high-energy neon and iron ions in human fibroblasts: probing individual Not 1 fragments by hybridization. Radiation Research, 139, 142-151.
  • LOPEZ-LARRAZA, D. M. and BIANCHI, N. O., 1993, DNA response to bleomycin in mammalian cells with variable degrees of chromatin condensation. Enviromental Molecular Mutagen, 21, 258-264.
  • NACKERDIEN, Z., MICHIE, J. and BOHM, L., 1989, Chromatin decondensed by acetylation shows an elevated radiation response. Radiation Research, 117, 234-244.
  • NOSE, K. and NIKAIDO, O., 1984, Transcriptionally active and inactive genes are similarly modified by chemical carcinogens and X-rays in normal human fibroblasts. Biochemical Biophysical Acta, 781, 273-278.
  • PANI, B, BABUDRI, N., GIANCOTTI, V. and Russo, E., 1984, Sodium butyrate affects the cytotoxic and mutagenic response of V79 Chinese hamster cells to the genotoxic agents, daunorubicin and U.V. radiation. Mutation Research, 140, 175-179.
  • PERRY, P. and WOLFF, S., 1974, New Giemsa method for differential staining of sister chromatids. Nature (London), 251, 156-158.
  • PFEIFFER, P., GOTTLICH, B., REICHENBERGER, S., FELDMANN, E., DAZA, P., WARD, J. F., MILLIGAN, J. R., MULLENDERS, L. H. and NATARAJAN, A. T., 1996, DNA lesions and repair. Mutation Research, 366, 69-80.
  • RAMANATHAN, B. and SMERDON, M. J., 1989, Enhanced repair synthesis in hyperacetylated nucleosomes. Journal of Biological Chemistry, 264, 11026-11034.
  • REEVES, R. and CSERJESI, P., 1979, Sodium butyrate induces new gene expression in Friend erythroleukemic cells. Journal of Biological Chemistry, 254, 4283-4290.
  • ROGAKOU, E. P., PILCH, D. R., ORR, A. H., IVANOVA, V. S. and BONNER, W. M., 1998, DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. Journal of Biological Chemistry, 273, 5858-5868.
  • ROTHKAMM, K. and LöBRICH, M., 1999, Misrejoining of DNA double-strand breaks in primary and transformed human and rodent cells: a comparison between the HPRT region and other genomic locations. Mutation Research, 433, 193-205.
  • SANKARANARAYANAN, K., NATARAJAN, A. T., MULLENDERS, L. H. and VAN RIJN, J. L., 1985, Effects of pre-treatment with sodium butyrate on the frequencies of X-ray-induced chromosomal aberrations in human peripheral blood lymphocytes. Mutation Research, 151, 269-274.
  • SANKARANARAYANAN, K., VAN DUYN, A., Loos, M. J., MESCHINI, R. and NATARAJAN, A. T., 1990, Effects of sodium butyrate on X-ray and bleomycin-induced chromosome aberrations in human peripheral blood lymphocytes. Genetic Research, 56, 267-276.
  • SCHUTTE, H. H., VAN DER SCHANS, G. P. and LOHMAN, P. H. M., 1988, Comparison of induction and repair of adducts and of alkali-labile sites in human lymphocytes and granulocytes after exposure to ethylating agents. Mutation Research, 194, 23-37.
  • SIMPSON, R. T., 1978, Structure of chromatin containing extensively acetylated H3 and H4. Cell, 13, 691-699.
  • SMERDON, M. J., LAN, S. Y., CALZA, R. E. and REEVES, R., 1982, Sodium butyrate stimulates DNA repair in UV-irradiated normal and xeroderma pigmentosum human fibroblasts. Journal of Biological Chemistry, 257, 13441-13447.
  • SMITH, P. J., 1986, N-butyrate alters chromatin accessibility to DNA repair enzymes. Carcinogmesis, 7, 423-429.
  • TURNER, B. M., 1991, Histone acetylation and control of gene expression. Journal of Cell Science, 99, 13-20.
  • VANDER SCHANS, G. P., VANLOON, A. A., GROENENDIJK, R. H. and BAAN, R. A., 1989, Detection of DNA damage in cells exposed to ionizing radiation by use of anti-single-stranded DNA monoclonal antibody. International Journal of Radiation Biology, 55, 747-760.
  • VAN LOON, A. A., GROENENDIJK, R. H., TIMMERMAN, A. J., VAN DER SCHANS, G. P., LOHMAN, P. H. M. and BAAN, R. A., 1992, Quantitative detection of DNA damage in cells after exposure to ionizing radiation by means of an improved immunochemical assay. Mutation Research, 274, 19-27.
  • VIDALI, G., BOFFA, L. C., BRADBURY, E. M. and ALLFREY, V. G., 1978, Butyrate suspression of histone deacetylation leads to accumulation of multiacetylated forms of histones H 3 and H4 and increased DNAaseI sensitivity of the associated sequences. Proceedings of the National Academy of Sciences of the United States of America, 75, 2239-2243.
  • VYAS, R. C., DARROUDI, F. and NATARAJAN, A. T., 1991, Radiation-induced chromosomal breakage and rejoining in interphase-metaphase chromosomes of human lymphocytes. Mutation Research, 249, 29-35.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.