Chromosomal radiosensitivity in BRCA1 and BRCA2 mutation carriers

References

• BAEYENS, A., THIERENS, H., CLAES, K., POPPE, B., MESSIAEN, L., DE RIDDER, L. and Vii, A., 2002, Chromosomal radiosensitivity in breast cancer patients with a known or putative genetic predisposition. British Journal of Cancer, 87, 1379–1385.
   PubMed Web of Science ®Google Scholar
• BAEYENS, A., THIERENS, H., VANDENBULCKE, K., DE RIDDER, L. and Vii, A., 2004, The use of EBV-transformed cell lines of breast cancer patients to measure chromosomal radiosensitivity. Mutagenesis, 19, 1–6.
   PubMed Web of Science ®Google Scholar
• BALDEYRON, C., JACQUEMIN, E., SMITH, J., JACQUEMONT, C., DE OLIVEIRA, I., GAD, S., FEUNTEUN, J., STOPPA-LYONNET, D. and PAPADOPOULO, D., 2002, A single mutated BRCA1 allele leads to impaired fidelity of double strand break end-joining. Oncogene, 21, 1401–1410.
   Google Scholar
• BAN, S., SHINOHARA, T., HIRAI, Y., MORITAKU, Y., COLOGNE, J. B. and MACPHEE, D. G., 2001, Chromosomal instability in BRCA1- or BRCA2- defective human cancer cells detected by spontaneous micronucleus assay. Mutation Research, 474, 15–23.
   PubMed Web of Science ®Google Scholar
• BARIA, K., WARREN, C., ROBERTS, S. A., WEST, C. M. and SCOTT, D., 2001a, Chromosomal radiosensitivity as a marker of predisposition to common cancers? British Journal of Cancer, 84, 892–896.
   Google Scholar
• BARIA, K., WARREN, C., ROBERTS, S. A., WEST, C. M., EVANS, D. G. R., VARLEY, J. M. and ScoiT, D., 2001b, Letters to the Editor, Correspondence re: A. Rothfuss et at., Induced micronucleus frequencies in peripheral blood lymphocytes as a screening test for carriers of a BRCA1 mutation in breast cancer families. Cancer Research, 60, 390–394,2000, Cancer Research, 61, 5948–5949.
   Google Scholar
• BARIA, K., WARREN, C., EDEN, 0. B., ROBERTS, S. A., WEST, C. M. and SCOTT, D., 2002, Chromosomal radiosensitivity in young cancer patients: possible evidence of genetic predisposition. International Journal of Radiation Biology, 78, 341–346.
   Google Scholar
• BUCHHOLZ, T. A. and Wu, X., 2001, Radiation-induced chromatid breaks as a predictor of breast cancer risk. International Journal of Radiation Oncology, Biology, Physics, 49, 533–537.
   PubMed Web of Science ®Google Scholar
• BUCHHOLZ, T. A., Wu, X., HUSSAIN, A., TucKER, S. L., HAFITY, B., BERGH, S., STORY, M., GEARA, F. B. and BROCK, W. A., 2002, Evidence of haplotype insufficiency in human cells containing a germline mutation in BRCA1 or BRCA2. International Journal of Cancer, 97, 557–561.
   PubMed Web of Science ®Google Scholar
• BURRILL, W., BARBER, J. B. P., ROBERTS, S. A., BULMAN, B. and Scurr, D., 2000, Heritability of chromosomal radiosensitivity in breast cancer patients: a pilot study with the lymphocyte micronucleus assay. International Journal of Radiation Biology, 76, 1617–1619.
   Google Scholar
• CIAES, K., POPPE, B., COENE, I., DE PAEPE, A. and MESSIAEN, L., 2004, BRCA1 and BRCA2 germline mutation spectrum and frequencies in Belgian breast/ovarian cancer families. British Journal of Cancer, 90, 1244–1251.
   PubMed Web of Science ®Google Scholar
• FENECH, M., 1993, The cytokinesis-block micronucleus technique: a detailed description of the method and its application to genotoxicity studies in human populations. Mutation Research, 285, 35–44.
   PubMed Web of Science ®Google Scholar
• FORAY, N., RANDRIANARISON, V., MAROT, D., PERRICAUDET, M., LENOIR, G. and FEUNTEUN, J., 1999, Gamma-rays-induced death of human cells carrying mutations of BRCA1 or BRCA2. Oncogene, 18, 7334–7342.
   PubMed Web of Science ®Google Scholar
• GAFFNEY, D. K., BROHET, R. M., LEWIS, C. M., HOLDEN, J. A., BUYS, S. S., NEUHAUSEN, S. L., STEELE, L., AVIZONIS, V., STEWART, J. R. and CANNON-ALBRIGHT, L. A., 1998, Response to radiation and prognosis in breast cancer patients with BRCA1 and BRCA2 mutations. Radiotherapy and Oncology, 47, 129–136.
   Google Scholar
• JoNEs, L. A., Scurr, D., COWAN, R. and ROBERTS, S. A., 1995, Abnormal radiosensitivity of lymphocytes from breast cancer patients with excessive normal tissue damage after radiotherapy: chromosome aberrations after low dose-rate irradiation. International Journal of Radiation Biology, 67, 519–528.
   PubMed Web of Science ®Google Scholar
• KHANNA, K. K. and JACKSON, S. P., 2001, DNA double-strand breaks: signalling, repair and the cancer connection. Nature Genetics, 27, 247–254.
   PubMed Web of Science ®Google Scholar
• LEONG, T., WHITTY, J., KELLAR, M., MIFSUD, S., RAMSAY, J., BIRREIT, G., VENTER, D., SOUTHEY, M. and MCKAY, M., 2000, Mutation analysis of BRCA1 and BRCA2 cancer predisposition genes in radiation hypersensitive cancer patients. International Journal of Radiation Oncology, Biology, Physics, 48, 959–965.
   PubMed Web of Science ®Google Scholar
• MOYNAHAN, M. E., Cum, J. W., KOLLER, B. H. and JAKN, M., 1999, BRCA1 controls homology-directed DNA repair. Molecular Cell, 4, 511–518.
   PubMed Web of Science ®Google Scholar
• MoyNAHAN, M. E., PIERCE, A. J. and JAsIN, M., 2001, BRCA2 is required for homoly-directed repair of chromosomal breaks. Molecular Cell, 7, 263–272.
   PubMed Web of Science ®Google Scholar
• NIEUWENHUIS, B., VAN ASSEN-BOLT, A. J., VAN WAARDE-VERHAGEN, M. A. W. H., SIJMONS, R. H., VAN DER Hour, A. H., BAUCH, T., STREFFER, C. and KAMPINGA, H. H., 2002, BRCA1 and BRCA2 heterozygosity and repair of X-ray-induced DNA damage. International Journal of Radiation Biology, 78, 285–295.
   Google Scholar
• PAPWORTH, R., SLEVIN, N., ROBERTS, S. A. and SCOTT, D., 2001, Sensitivity to radiation-induced chromosome damage may be a marker of genetic predisposition in young head and neck cancer patients. British Journal of Cancer, 84(6), 776–782.
   PubMed Web of Science ®Google Scholar
• PARSHAD, R., PRICE, F. M., Boxit, V. A., COWANS, K. H., ZujEwsm, J. A. and SANFORD, K. K., 1996, Deficient DNA repair capacity, a predisposing factor in breast cancer. British Journal of Cancer, 74, 1–5.
   PubMed Web of Science ®Google Scholar
• PATEL, K. 15 Yu, V. P. C. C., LEE, H., CORCORAN, A.5 THISTLETHWAITE, F. C., EVANS, M. J., COITYDGE, W. fl" FlUEDMAN, L. S., PONDER, B. A. and VENKrrARAmAN, A. R., 1998, Involvement of BRCA2 in DNA repair. Molecular Cell, 1, 347–357.
   Google Scholar
• PATEL, R. K., TRIVEDI, A. H., ARORA, D. C., BHATAVDEKAR, J. M. and PATEL, D. D., 1997, DNA repair proficiency in breast cancer patients and their first-degree relatives. International Journal of Cancer, 73, 20–24.
   PubMed Web of Science ®Google Scholar
• PETO, J., COLLINS, N., BARFOOT, R., SEAL, S., WARREN, W., RAHMAN, N., EASTON, D. F., EVANS, C., DEACON, J. and STRATTON, M. R., 1999, Prevalence of BRCA1 and BRCA2 Gene Mutations in patients with early-onset breast cancer. Journal of the National Cancer Institute, 91, 943–949.
   PubMed Web of Science ®Google Scholar
• PIERCE, L. J., STRAWDERMAN, M., NAROD, S. A., OLIVIOTIO, I., EISEN, A., DAWSON, L., GAFFNEY, D., SOLIN, L. J., NIXON, A., GARBER, J., BERG, C., ISAACS, C., HEIMANN, R., OLOPADE, 0. I., HAFFTY, B. and WEBER, B. L., 2000, Effect of radiotherapy after breast-conserving treatment in women with breast cancer and germline BRCA1/2 mutations Journal of Clinical Oncology, 18, 3360–3369.
   Google Scholar
• RICHES, A. C., BRYANT, P. E., STEEL, C. M., GIFIG, A., ROBERTSON, A. J., PREECE, P. E. and THOMPSON, A. M., 2001, Chromosomal radiosensitivity in G2-phase lymphocytes identifies breast cancer patients with distinctive tumour characteristics. British Journal of Cancer, 85, 1157–1161.
   PubMed Web of Science ®Google Scholar
• ROBERTS, S. A., SPREADBOROUGH, A. R., BULMAN, B., BARBER," B. P., EVANS, D. G. R. and ScoTr, D., 1999, Heritability of cellular radiosensitivity: A marker of Low-Penetrance Predisposition genes in breast cancer? American Journal of human genetics, 65, 784–794.
   Google Scholar
• ROTHFUI3, A., SCHUTZ, P., BOCHUM, S., VOLM, T., EBERHARDT, E., KREIENBERG, R., VOGEL, W. and SPErr, G., 2000, Induced micronucleus frequencies in peripheral lymphocytes as a screening test for carriers of a BRCA1 mutation in breast cancer families. Cancer Research, 60, 390–394.
   Google Scholar
• ROTHKAMM, K., KUHNE, M., JEGGO, P. A. and LoBRicH, M., 2001, Radiation-induced genomic rearrangements formed by non homologous end-joining of DNA double-strand breaks. Cancer Research, 61, 3886–3893.
   PubMed Web of Science ®Google Scholar
• SCOTT, D., SPREADBOROUGH, A., LEVINE, E. L. and ROBERT SS. A" 1994, Genetic predisposition in breast cancer. Lancet, 344, 1444.
   Google Scholar
• ScoTr, D., BARBER, J. B. P., LEVINE, E. L., BURRILL, W. and ROBERTS, S. A., 1998, Radiation-induced micronucleus induction in lymphocytes identifies a high frequency of radiosensitive cases among breast cancer patients: a test for predisposition?. British Journal of Cancer, 77, 614–620.
   Google Scholar
• SCOTT', D., BARBER, J. B. P., SPREADBOROUGH, A. R., BURRILL, W. and ROBERTS, S. A., 1999, Increased chromosomal radiosensitivity in breast cancer patients: a comparison of two assays. International Journal of Radiation Biology, 75, 1–10.
   PubMed Web of Science ®Google Scholar
• SHORROCKS, J., TOBI, S. E., LATHAM, H., PEACOCK, J. fl" EELES, M. A., ECCLES, D. and McMruAN, T. V., 2004, Primary fibroblasts from BRCA1 heterozygotes display an abnormal G1 /S cell cycle checkpoint following UVA irradiation but show normal levels of micronuclei following oxidative stress or mitomycin C treatment. International Journal of Radiation Oncology, Biology, Physics, 58, 470–478.
   Google Scholar
• SPEIT, G., TRENZ, K., SCHUTZ, P., BENDIN, R. and DORK, T., 2000, Mutagen sensitivity of human lymphoblastoid cells with a BRCA1 mutation in comparison to ataxia telangiectasia heterozygote cells. Cytogenetics and cell genetics, 91, 261–266.
   PubMedGoogle Scholar
• SPEIT, G. and TRENZ, K., 2004, Chromosomal mutagen sensitivity associated with mutations in BRCA genes. Cytogenetic and Genome Research, 104, 325–332.
   PubMed Web of Science ®Google Scholar
• TAKATA, M., SASAKI, M. S., SONODA, E., MORRISON, C., HASHIMOTO, M., UTSUMI, H., YAMAGUCHI-IWAI, Y., SHINOHARA, A. and TAKEDA, S., 1998, Homologous recombination and nonhomologous end-joining pathways of DNA double-strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells. EMBO Journal, 17, 5497–5508.
   Google Scholar
• TERZOUDI, G. I., JUNG, T., HAIN, J., VROUVAS, J., MARGARITIS, K., DONTA-BAKOYIANNIS, C., MAKROPOULOS, V., ANGELAKIS, P. H. and PANTELIAS, G. E., 2000, Increased chromosomal racliosensitivity in cancer patients: the role of cdkl / cyclin-B activity level in the mechanisms involved. International Journal of Radiation Biology, 76, 607–615.
   Google Scholar
• THIERENS, H., VRAL, A., MORTHIER, R., AOUSALAH, B. and DE RIDDER, L., 2000, Cytogenetic monitoring of hospital workers occupationally exposed to ionising radiation using the micronucleus centromere assay. Mutagenesis, 15, 245–249.
   PubMed Web of Science ®Google Scholar
• TRENZ, K., ROTHFU13, A., SCHUTZ, P. and SPEIT, G., 2002, Mutagen sensitivity of peripheral blood from women carrying a BRCA1 or BRCA2 mutation. Mutation Research, 500, 89–96.
   Google Scholar
• TRENZ, K., LANDGRAF, J. and SPErr, G., 2003a, Mutagen sensitivity of human lymphoblastoid cells with a BRCA1 mutation. Breast Cancer Research Treatment, 78, 69–79.
   PubMed Web of Science ®Google Scholar
• TRENZ, K., LUGOWSKI, S., JAHRSDORFER, U., JAINTTA, S., VOGEL, W. and SPErr, G., 2003b, Enhanced sensitivity of peripheral blood lymphocytes from women carrying a BRCA1 mutation towards the mutagenic effects of various cytostatics. Mutation Research, 544, 279–288.
   PubMed Web of Science ®Google Scholar
• VENKrrARAmAN, A. R., 2001, Functions of BRCA1 and BRCA2 in the biological response to DNA damage. Journal of Cell Science, 114, 3591–3598.
   PubMed Web of Science ®Google Scholar
• VRAL, A., VERHAEGEN, F., THIERENS, H. and DE RIDDER, L., 1994, The in vitro cytokinesis-block micronucleus assay: a detailed description of an improved slide preparation technique for the automated detection of micronuclei in human lymphocytes. Mutagenesis, 9, 439–443.
   PubMed Web of Science ®Google Scholar
• VRAL, A., THIERENS, H., BAEYENS, A. and DE RIDDER, L., 2002, The micronucleus and G2-phase assays for human blood lymphocytes as biomarkers of individual sensitivity to ionising radiation: limitations imposed by intra individual variability. Radiation Research, 157, 472–477.
   PubMed Web of Science ®Google Scholar
• WANG, H., ZENG, Z. C., Bur, T. A., DIBIASE, S. J., Qmr, W., XIA, F., POWELL, S. N. and iLIAKIS, G., 2001, Nonhomologous endjoining of ionising radiation-induced DNA double-stranded breaks in human tumour cells deficient in BRCA1 or BRCA2. Cancer Research, 145, 281–288.
   Google Scholar
• WOOSTER, R. and WEBER, B. L., 2003, Breast and Ovarian Cancer. The New England journal of Medicine, 348, 2339–2347.
   PubMed Web of Science ®Google Scholar