References
- BAEYENS, A., THIERENS, H., CLAES, K., POPPE, B., MESSIAEN, L., DE RIDDER, L. and Vii, A., 2002, Chromosomal radiosensitivity in breast cancer patients with a known or putative genetic predisposition. British Journal of Cancer, 87, 1379–1385.
- BAEYENS, A., THIERENS, H., VANDENBULCKE, K., DE RIDDER, L. and Vii, A., 2004, The use of EBV-transformed cell lines of breast cancer patients to measure chromosomal radiosensitivity. Mutagenesis, 19, 1–6.
- BALDEYRON, C., JACQUEMIN, E., SMITH, J., JACQUEMONT, C., DE OLIVEIRA, I., GAD, S., FEUNTEUN, J., STOPPA-LYONNET, D. and PAPADOPOULO, D., 2002, A single mutated BRCA1 allele leads to impaired fidelity of double strand break end-joining. Oncogene, 21, 1401–1410.
- BAN, S., SHINOHARA, T., HIRAI, Y., MORITAKU, Y., COLOGNE, J. B. and MACPHEE, D. G., 2001, Chromosomal instability in BRCA1- or BRCA2- defective human cancer cells detected by spontaneous micronucleus assay. Mutation Research, 474, 15–23.
- BARIA, K., WARREN, C., ROBERTS, S. A., WEST, C. M. and SCOTT, D., 2001a, Chromosomal radiosensitivity as a marker of predisposition to common cancers? British Journal of Cancer, 84, 892–896.
- BARIA, K., WARREN, C., ROBERTS, S. A., WEST, C. M., EVANS, D. G. R., VARLEY, J. M. and ScoiT, D., 2001b, Letters to the Editor, Correspondence re: A. Rothfuss et at., Induced micronucleus frequencies in peripheral blood lymphocytes as a screening test for carriers of a BRCA1 mutation in breast cancer families. Cancer Research, 60, 390–394,2000, Cancer Research, 61, 5948–5949.
- BARIA, K., WARREN, C., EDEN, 0. B., ROBERTS, S. A., WEST, C. M. and SCOTT, D., 2002, Chromosomal radiosensitivity in young cancer patients: possible evidence of genetic predisposition. International Journal of Radiation Biology, 78, 341–346.
- BUCHHOLZ, T. A. and Wu, X., 2001, Radiation-induced chromatid breaks as a predictor of breast cancer risk. International Journal of Radiation Oncology, Biology, Physics, 49, 533–537.
- BUCHHOLZ, T. A., Wu, X., HUSSAIN, A., TucKER, S. L., HAFITY, B., BERGH, S., STORY, M., GEARA, F. B. and BROCK, W. A., 2002, Evidence of haplotype insufficiency in human cells containing a germline mutation in BRCA1 or BRCA2. International Journal of Cancer, 97, 557–561.
- BURRILL, W., BARBER, J. B. P., ROBERTS, S. A., BULMAN, B. and Scurr, D., 2000, Heritability of chromosomal radiosensitivity in breast cancer patients: a pilot study with the lymphocyte micronucleus assay. International Journal of Radiation Biology, 76, 1617–1619.
- CIAES, K., POPPE, B., COENE, I., DE PAEPE, A. and MESSIAEN, L., 2004, BRCA1 and BRCA2 germline mutation spectrum and frequencies in Belgian breast/ovarian cancer families. British Journal of Cancer, 90, 1244–1251.
- FENECH, M., 1993, The cytokinesis-block micronucleus technique: a detailed description of the method and its application to genotoxicity studies in human populations. Mutation Research, 285, 35–44.
- FORAY, N., RANDRIANARISON, V., MAROT, D., PERRICAUDET, M., LENOIR, G. and FEUNTEUN, J., 1999, Gamma-rays-induced death of human cells carrying mutations of BRCA1 or BRCA2. Oncogene, 18, 7334–7342.
- GAFFNEY, D. K., BROHET, R. M., LEWIS, C. M., HOLDEN, J. A., BUYS, S. S., NEUHAUSEN, S. L., STEELE, L., AVIZONIS, V., STEWART, J. R. and CANNON-ALBRIGHT, L. A., 1998, Response to radiation and prognosis in breast cancer patients with BRCA1 and BRCA2 mutations. Radiotherapy and Oncology, 47, 129–136.
- JoNEs, L. A., Scurr, D., COWAN, R. and ROBERTS, S. A., 1995, Abnormal radiosensitivity of lymphocytes from breast cancer patients with excessive normal tissue damage after radiotherapy: chromosome aberrations after low dose-rate irradiation. International Journal of Radiation Biology, 67, 519–528.
- KHANNA, K. K. and JACKSON, S. P., 2001, DNA double-strand breaks: signalling, repair and the cancer connection. Nature Genetics, 27, 247–254.
- LEONG, T., WHITTY, J., KELLAR, M., MIFSUD, S., RAMSAY, J., BIRREIT, G., VENTER, D., SOUTHEY, M. and MCKAY, M., 2000, Mutation analysis of BRCA1 and BRCA2 cancer predisposition genes in radiation hypersensitive cancer patients. International Journal of Radiation Oncology, Biology, Physics, 48, 959–965.
- MOYNAHAN, M. E., Cum, J. W., KOLLER, B. H. and JAKN, M., 1999, BRCA1 controls homology-directed DNA repair. Molecular Cell, 4, 511–518.
- MoyNAHAN, M. E., PIERCE, A. J. and JAsIN, M., 2001, BRCA2 is required for homoly-directed repair of chromosomal breaks. Molecular Cell, 7, 263–272.
- NIEUWENHUIS, B., VAN ASSEN-BOLT, A. J., VAN WAARDE-VERHAGEN, M. A. W. H., SIJMONS, R. H., VAN DER Hour, A. H., BAUCH, T., STREFFER, C. and KAMPINGA, H. H., 2002, BRCA1 and BRCA2 heterozygosity and repair of X-ray-induced DNA damage. International Journal of Radiation Biology, 78, 285–295.
- PAPWORTH, R., SLEVIN, N., ROBERTS, S. A. and SCOTT, D., 2001, Sensitivity to radiation-induced chromosome damage may be a marker of genetic predisposition in young head and neck cancer patients. British Journal of Cancer, 84(6), 776–782.
- PARSHAD, R., PRICE, F. M., Boxit, V. A., COWANS, K. H., ZujEwsm, J. A. and SANFORD, K. K., 1996, Deficient DNA repair capacity, a predisposing factor in breast cancer. British Journal of Cancer, 74, 1–5.
- PATEL, K. 15 Yu, V. P. C. C., LEE, H., CORCORAN, A.5 THISTLETHWAITE, F. C., EVANS, M. J., COITYDGE, W. fl" FlUEDMAN, L. S., PONDER, B. A. and VENKrrARAmAN, A. R., 1998, Involvement of BRCA2 in DNA repair. Molecular Cell, 1, 347–357.
- PATEL, R. K., TRIVEDI, A. H., ARORA, D. C., BHATAVDEKAR, J. M. and PATEL, D. D., 1997, DNA repair proficiency in breast cancer patients and their first-degree relatives. International Journal of Cancer, 73, 20–24.
- PETO, J., COLLINS, N., BARFOOT, R., SEAL, S., WARREN, W., RAHMAN, N., EASTON, D. F., EVANS, C., DEACON, J. and STRATTON, M. R., 1999, Prevalence of BRCA1 and BRCA2 Gene Mutations in patients with early-onset breast cancer. Journal of the National Cancer Institute, 91, 943–949.
- PIERCE, L. J., STRAWDERMAN, M., NAROD, S. A., OLIVIOTIO, I., EISEN, A., DAWSON, L., GAFFNEY, D., SOLIN, L. J., NIXON, A., GARBER, J., BERG, C., ISAACS, C., HEIMANN, R., OLOPADE, 0. I., HAFFTY, B. and WEBER, B. L., 2000, Effect of radiotherapy after breast-conserving treatment in women with breast cancer and germline BRCA1/2 mutations Journal of Clinical Oncology, 18, 3360–3369.
- RICHES, A. C., BRYANT, P. E., STEEL, C. M., GIFIG, A., ROBERTSON, A. J., PREECE, P. E. and THOMPSON, A. M., 2001, Chromosomal radiosensitivity in G2-phase lymphocytes identifies breast cancer patients with distinctive tumour characteristics. British Journal of Cancer, 85, 1157–1161.
- ROBERTS, S. A., SPREADBOROUGH, A. R., BULMAN, B., BARBER," B. P., EVANS, D. G. R. and ScoTr, D., 1999, Heritability of cellular radiosensitivity: A marker of Low-Penetrance Predisposition genes in breast cancer? American Journal of human genetics, 65, 784–794.
- ROTHFUI3, A., SCHUTZ, P., BOCHUM, S., VOLM, T., EBERHARDT, E., KREIENBERG, R., VOGEL, W. and SPErr, G., 2000, Induced micronucleus frequencies in peripheral lymphocytes as a screening test for carriers of a BRCA1 mutation in breast cancer families. Cancer Research, 60, 390–394.
- ROTHKAMM, K., KUHNE, M., JEGGO, P. A. and LoBRicH, M., 2001, Radiation-induced genomic rearrangements formed by non homologous end-joining of DNA double-strand breaks. Cancer Research, 61, 3886–3893.
- SCOTT, D., SPREADBOROUGH, A., LEVINE, E. L. and ROBERT SS. A" 1994, Genetic predisposition in breast cancer. Lancet, 344, 1444.
- ScoTr, D., BARBER, J. B. P., LEVINE, E. L., BURRILL, W. and ROBERTS, S. A., 1998, Radiation-induced micronucleus induction in lymphocytes identifies a high frequency of radiosensitive cases among breast cancer patients: a test for predisposition?. British Journal of Cancer, 77, 614–620.
- SCOTT', D., BARBER, J. B. P., SPREADBOROUGH, A. R., BURRILL, W. and ROBERTS, S. A., 1999, Increased chromosomal radiosensitivity in breast cancer patients: a comparison of two assays. International Journal of Radiation Biology, 75, 1–10.
- SHORROCKS, J., TOBI, S. E., LATHAM, H., PEACOCK, J. fl" EELES, M. A., ECCLES, D. and McMruAN, T. V., 2004, Primary fibroblasts from BRCA1 heterozygotes display an abnormal G1 /S cell cycle checkpoint following UVA irradiation but show normal levels of micronuclei following oxidative stress or mitomycin C treatment. International Journal of Radiation Oncology, Biology, Physics, 58, 470–478.
- SPEIT, G., TRENZ, K., SCHUTZ, P., BENDIN, R. and DORK, T., 2000, Mutagen sensitivity of human lymphoblastoid cells with a BRCA1 mutation in comparison to ataxia telangiectasia heterozygote cells. Cytogenetics and cell genetics, 91, 261–266.
- SPEIT, G. and TRENZ, K., 2004, Chromosomal mutagen sensitivity associated with mutations in BRCA genes. Cytogenetic and Genome Research, 104, 325–332.
- TAKATA, M., SASAKI, M. S., SONODA, E., MORRISON, C., HASHIMOTO, M., UTSUMI, H., YAMAGUCHI-IWAI, Y., SHINOHARA, A. and TAKEDA, S., 1998, Homologous recombination and nonhomologous end-joining pathways of DNA double-strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells. EMBO Journal, 17, 5497–5508.
- TERZOUDI, G. I., JUNG, T., HAIN, J., VROUVAS, J., MARGARITIS, K., DONTA-BAKOYIANNIS, C., MAKROPOULOS, V., ANGELAKIS, P. H. and PANTELIAS, G. E., 2000, Increased chromosomal racliosensitivity in cancer patients: the role of cdkl / cyclin-B activity level in the mechanisms involved. International Journal of Radiation Biology, 76, 607–615.
- THIERENS, H., VRAL, A., MORTHIER, R., AOUSALAH, B. and DE RIDDER, L., 2000, Cytogenetic monitoring of hospital workers occupationally exposed to ionising radiation using the micronucleus centromere assay. Mutagenesis, 15, 245–249.
- TRENZ, K., ROTHFU13, A., SCHUTZ, P. and SPEIT, G., 2002, Mutagen sensitivity of peripheral blood from women carrying a BRCA1 or BRCA2 mutation. Mutation Research, 500, 89–96.
- TRENZ, K., LANDGRAF, J. and SPErr, G., 2003a, Mutagen sensitivity of human lymphoblastoid cells with a BRCA1 mutation. Breast Cancer Research Treatment, 78, 69–79.
- TRENZ, K., LUGOWSKI, S., JAHRSDORFER, U., JAINTTA, S., VOGEL, W. and SPErr, G., 2003b, Enhanced sensitivity of peripheral blood lymphocytes from women carrying a BRCA1 mutation towards the mutagenic effects of various cytostatics. Mutation Research, 544, 279–288.
- VENKrrARAmAN, A. R., 2001, Functions of BRCA1 and BRCA2 in the biological response to DNA damage. Journal of Cell Science, 114, 3591–3598.
- VRAL, A., VERHAEGEN, F., THIERENS, H. and DE RIDDER, L., 1994, The in vitro cytokinesis-block micronucleus assay: a detailed description of an improved slide preparation technique for the automated detection of micronuclei in human lymphocytes. Mutagenesis, 9, 439–443.
- VRAL, A., THIERENS, H., BAEYENS, A. and DE RIDDER, L., 2002, The micronucleus and G2-phase assays for human blood lymphocytes as biomarkers of individual sensitivity to ionising radiation: limitations imposed by intra individual variability. Radiation Research, 157, 472–477.
- WANG, H., ZENG, Z. C., Bur, T. A., DIBIASE, S. J., Qmr, W., XIA, F., POWELL, S. N. and iLIAKIS, G., 2001, Nonhomologous endjoining of ionising radiation-induced DNA double-stranded breaks in human tumour cells deficient in BRCA1 or BRCA2. Cancer Research, 145, 281–288.
- WOOSTER, R. and WEBER, B. L., 2003, Breast and Ovarian Cancer. The New England journal of Medicine, 348, 2339–2347.