Pharmacological inhibition of DNA repair enzymes differentially modulates telomerase activity and apoptosis in two human leukaemia cell lines

References

• AKIYAMA, M., HIDESIIIIVIA, T., HAYASHI, T., TAI, Y. T., MnsTADEs, C. S., MITSIADES, N., CHAUHAN, D., RICHARDSON, P., MuNsm, N. C. and ANDERSON, K. C., 2002, Cytokines modulate telomerase activity in a human multiple myeloma cell line. Cancer Research, 62, 3876–3882.
   PubMedGoogle Scholar
• AKIYAMA, M., HIDESIIIIVIA, T., HAYASHI, T., TAT, Y. T., MITSIADES, C. S., MITSIADES, N., CHAUHAN, D., RICHARDSON, P., MuNsm, N. C. and ANDERSON, K. C., 2003, Nuclear factor kappaB p65 mediates tumor necrosis factor alpha-induced nuclear translocation of telomerase reverse transcriptase protein. Cancer Research, 63, 18–21.
   PubMed Web of Science ®Google Scholar
• ALDRIDGE, D. R. and RADFORD, I. R., 1998, Explaining differences in sensitivity to killing by ionizing radiation between human lymphoid cell lines. Cancer Research, 58, 2817–2824.
   PubMed Web of Science ®Google Scholar
• BELTZ, L. A., 2002, The 'other' telomerase inhibitors: non-G-quadruplex interactive agent, non-antisense, non-reverse transcriptase telomerase inhibitors. Current Medicinal Chemistry — Anti-Cancer Agents, 2, 589–603.
   PubMedGoogle Scholar
• BLACKBURN, E. H., 2001, Switching and signaling at the telomere. Cell, 106, 661–673.
   PubMed Web of Science ®Google Scholar
• BOUFFLER, S. D., BLASCO, M. A., Cox, R. and SMITH, P. J., 2001, Telomeric sequences, radiation sensitivity and genomic instability. International Journal of Radiation Biology, 77, 995–1005.
   PubMed Web of Science ®Google Scholar
• BOULTON, S., KYLE, S. and DURKACZ, B. W., 1999, Interactive effects of inhibitors of poly(ADP-ribose) polymerase and DNA-dependent protein kinase on cellular responses to DNA damage. Carcinogenesis, 20, 199–203.
   PubMed Web of Science ®Google Scholar
• CARDOSO, R. S., ESPANHOL, A. R., PASSOS, G. A. and SAKAMOTO-HOJO, E. T., 2002, Differential gene expression in gamma-irradiated BALB/3T3 fibroblasts under the influence of 3-aminobenzamide, an inhibitor of PARP enzyme. Mutation Research, 508, 33–40.
   Google Scholar
• CATALDI, A., ZAULI, G., DI PIETRO, R., CASTORINA, S. and RANA, R., 2001, Involvement of the pathway phosphatidylinosito1-3-kinase/AKT-1 in the establishment of the survival response to ionizing radiation. Cell Signalling, 13, 369–375.
   PubMedGoogle Scholar
• CHERNIKOVA, S. B., LINDQUIST, K. L. and ELKIND, M. M., 2001, Cell cycle-dependent effects of wortmannin on radiation survival and mutation. Radiation Research, 155, 826–831.
   PubMedGoogle Scholar
• CHOW, V. T., QUEK, H. H. and Tom, E. P., 1993, Alternative splicing of the p53 tumor suppressor gene in the Molt-4 T-lymphoblastic leukemia cell line. Cancer Letters, 73, 141–148.
   PubMed Web of Science ®Google Scholar
• CLAVE, E., CAROSELLA, E. D., GtucKmAN, E., DUBRAY, B. and SoctE, G., 1996, Ionizing radiation effects on the KG1 a primitive hematopoietic cell line. International Journal of Radiation Oncology, Biology and Physics, 35, 709–719.
   PubMedGoogle Scholar
• Cott's, S. J.5 SWARTZ, M. J., NELSON, W. G. and DEWEESE, T. L., 2003, Enhanced radiation and chemotherapy-mediated cell killing of human cancer cells by small inhibitory RNA silencing of DNA repair factors. Cancer Research, 63, 1550–1554.
   Google Scholar
• COSI, C., 2002, New inhibitors of poly(ADP ribose)polymerase and their potential therapeutic targets. Expert Opinion in Therapeutic Patents, 12, 1047–1071.
   Web of Science ®Google Scholar
• DARZYNKIEWICZ, Z., JUAN, G., Li, X., GORCZYCA, W., MURAKAMI, T. and TRAGANOS, F., 1997, Cytometry in cell necro-biology: analysis of apoptosis and accidental cell death (necrosis). Cytometry, 27, 1–20.
   PubMedGoogle Scholar
• DENT, P., YACOUR, A., CONTESSA, J., CARON, R., AMORINO, G., VALERIE, K., HAGAN, M. P., GRANT, S. and SCHMIDT-ULLRICH, R., 2003, Stress and radiation-induced activation of multiple intracellular signaling pathways. Radiation Research, 159, 283–300.
   Google Scholar
• EDWARDS, E., GENG, L., TAN, J., ONISHKO, H., DONNELLY, E. and HALLAHAN, D. E., 2002, Phosphatidylinositol 3-kinase/Akt signaling in the response of vascular endothelium to ionizing radiation. Cancer Research, 62, 4671–4677.
   PubMed Web of Science ®Google Scholar
• ENNs, L., MuRRAY, D. and MIRZAYANS, R., 1999, Effects of the protein kinase inhibitors wortmannin and KN62 on cellular radiosensitivity and radiation-activated S phase and G1 /S checkpoints in normal human fibroblasts. British Journal of Cancer, 81, 959–965.
   PubMedGoogle Scholar
• FEI, P. and Et-DEIRY, W. S., 2003, P53 and radiation responses. Oncogene, 22, 5774–5783.
   PubMed Web of Science ®Google Scholar
• HARMS-RINGDAHL, M., NICOTERA, P. and RADFORD, I. R., 1996, Radiation induced apoptosis. Mutation Research, 366, 171–179.
   PubMed Web of Science ®Google Scholar
• INANAMI, O., TAKAHASHI, K. and KUWABARA, M., 1999, Attenuation of caspase-3-dependent apoptosis by Trolox post-treatment of X-irradiated MOLT-4 cells. International Journal of Radiation Biology, 75, 155–163.
   PubMed Web of Science ®Google Scholar
• KLEJMAN, A., RUSHEN, L., MORRIONE, A., SLUPIANEK, A. and SKORSKI, T., 2002, Phosphatidylinosito1-3 kinase inhibitors enhance the anti-leukemia effect of STI571. Oncogene, 21, 5868–5876.
   PubMed Web of Science ®Google Scholar
• KYO, S. and INouE, M., 2002, Complex regulatory mechanisms of telomerase activity in normal and cancer cells: how can we apply them for cancer therapy? Oncogene, 21, 688–697.
   PubMed Web of Science ®Google Scholar
• LETEURTRE, F., Li, X., GtuciotAN, E. and CAROSELLA, E. D., 1997, Telomerase activity during the cell cycle and in gamma-irradiated hematopoietic cells. Leukemia, 11, 1681–1689.
   PubMed Web of Science ®Google Scholar
• Li, H., ZHAO, L. L., FuNDER, J. W. and Liu," P., 1997, Protein phosphatase 2A inhibits nuclear telomerase activity in human breast cancer cells. Journal of Biological Chemistry, 272, 16729–16732.
   Google Scholar
• MARPLES, B. and JOINER, M. C., 2000, Modification of survival by DNA repair modifiers: a probable explanation for the phenomenon of increased raclioresistance. International Journal of Radiation Biology, 76, 305–312.
   PubMed Web of Science ®Google Scholar
• NAKAptA, A., TAUGHT, T., SASHIDA, G., Sumt, M., ABE, K., YAMAMOTO, K., OHYASHIKI, J. H. and OHYASHIKI, K., 2003, Telomerase inhibition enhances apoptosis in human acute leukemia cells: possibility of antitelomerase therapy. Leukemia, 17, 560–567.
   PubMedGoogle Scholar
• NAKANO, H., KOHARA, M. and SHINOHARA, K., 2001, Evaluation of the relative contribution of p53-mediated pathway in X-ray induced apoptosis in human leukemic MOLT-4 cells by transfection with a mutant p53 gene at different expression levels. Cell Tissue Research, 306, 101–106.
   PubMed Web of Science ®Google Scholar
• NAKANo, H. and SHINOHARA, K., 1999, Correlation between unirradiated cell TP53 protein levels and racliosensitivity in MOLT-4 cells. Radiation Research, 151, 686–693.
   PubMedGoogle Scholar
• NATI, L. M., BORGATTI, P., TAZZARI, P. L., BORTUL, R., CAPELLINI, A., TABELLINI, G., BELLACOSA, A., CAPITANI, S. and MARTELL', A. M., 2003, The phosphoinositide 3-kinase/AKT1 pathway involvement in drug and all-trans-retinoic acid resistance of leukemia cells. Molecular Cancer Research, 1, 234–246.
   Google Scholar
• NEUHOF, D., RuEss, A., WENZ, F. and WEBER, K. J., 2001, Induction of telomerase activity by irradiation in human lymphoblasts. Radiation Research, 155, 693–697.
   PubMed Web of Science ®Google Scholar
• PEREZ, M. R., DUBNER, D., MICHELIN, S., LETEURTRE, F., GISONE, P. A. and CAROSELLA, E. D., 2002b, Radiation-induced up-regulation of telomerase activity in KG1 a cells is dependent of the dose-rate and radiation quality. International Journal of Radiation Biology, 78, 1175–1183.
   PubMed Web of Science ®Google Scholar
• PEREZ, M. R., DUBNER, D., MICHELIN, S., GISONE, P. and CAROSELLA, E. D., 2002a, Telómeros y reparación de clan() genómico: su implicancia en patologia humana. Medicina (Buenos Aires), 62, 593–603.
   PubMedGoogle Scholar
• PINERO, J., LOPEZ BAENA, M., ORTIZ, T. and CORTES, F., 1997, Apoptotic and necrotic cell death are both induced by electroporation in HL60 human promyeloid leukaemia cells. Apoptosis, 2, 330–336.
   PubMedGoogle Scholar
• RADFORD, I. R. and MURPHY, T. K., 1994, Radiation response of mouse lymphoid and myeloid cell lines. Part III. Different signals can lead to apoptosis and may influence sensitivity to killing by DNA double-strand breakage. International Journal of Radiation Biology, 65, 229–239.
   PubMed Web of Science ®Google Scholar
• RANKIN, P. W., JACOBSON, E. L., BENJAMIN, R. C., Moss, J. and JACOBSON, M. K., 1989, Quantitative studies of inhibitors of ADP-ribosylation in vitro and in vivo. Journal of Biological Chemistry, 264, 4312–4317.
   PubMed Web of Science ®Google Scholar
• RICCIARELLI, R., PALOMBA, L., CANTON', O. and Azzi, A., 1998, 3-Aminobenzamide inhibition of protein kinase C at a cellular level. FEBS Letters, 431, 465–467.
   Google Scholar
• ROBERTS, E. C., SHAPIRO, P. S., NAHREINI, T. S., PAGES, G., POUYSSEGUR, J. and AHN, N. G., 2002, Distinct cell cycle timing requirements for extracellular signal-regulated kinase and phosphoinositide 3-kinase signaling pathways in somatic cell mitosis. Molecular and Cellular Biology, 22, 7226–7241.
   PubMedGoogle Scholar
• SAWANT, S. G., GREGOIRE, V., DHAR, S., UM BRIGHT, C. B., Clam, S., SUKUMAR, S. and PANDrrA, T. K., 1999, Telomerase activity as a measure for monitoring radiocurability of tumor cells. FASEB Journal, 13, 1047–1054.
   PubMed Web of Science ®Google Scholar
• SHALL, S. and DE MURCIA, G., 2000, Poly(ADP-ribose) polymerase-1: what have we learned from the deficient mouse model? Mutation Research, 460, 1–15.
   Google Scholar
• SHARMA, G. G., GuETA, A., WANG, H., SCHERTHAN, H., DHAR, S., GANDHI, V., "Luaus, G., SHAY, J. W., YOUNG, C. S. and PANDrrA, T. K., 2003, hTERT associates with human telomeres and enhances genomic stability and DNA repair. Oncogene, 22, 131–146.
   Google Scholar
• SHENG, W. Y., CHIEN, Y. L. and WANG, T. C., 2003, The dual role of protein kinase C in the regulation of telomerase activity in human lymphocytes. FEBS Letters, 540, 91–95.
   PubMedGoogle Scholar
• SLIJEPCEVIC, P. and BRYANT, P. E., 1998, Chromosome healing, telomere capture and mechanisms of radiation-induced chromosome breakage. International Journal of Radiation Biology, 73, 1–13.
   PubMedGoogle Scholar
• SOUTHAN, G. J. and SZABO, C., 2003, Poly(ADP-ribose) poly-merase inhibitors. Current Medicinal Chemistry, 10, 321–340.
   PubMed Web of Science ®Google Scholar
• STRUNZ, A. M., PESCHKE, P., WALDECK, W., EHEMANN, V., KISSEL, M. and DEBus, J., 2002, Preferential racliosensitization in p53-mutated human tumour cell lines by pentoxifylline-mediated disruption of the G2/M checkpoint control. International Journal of Radiation Biology, 78, 721–732.
   PubMed Web of Science ®Google Scholar
• STUSCHKE, M., SAK, A., WURM, R., SINN, B., WOLF, G., STUB, G. and BUDACH, V., 2002, Radiation-induced apoptosis in human non-small-cell lung cancer cell lines is secondary to cell-cycle progression beyond the G2-phase checkpoint. International Journal of Radiation Biology, 78, 807–819.
   PubMed Web of Science ®Google Scholar
• SZEKELY, J. G. and LOBREAU, A. U., 1985, High radiosensitivity of the MOLT-4 leukaemic cell line. International Journal of Radiation Biology and Related Studies in Physics and Chemistry Medicine, 48, 277–284.
   Web of Science ®Google Scholar
• SZKANDEROVA, S., VAVROVA, J., REZACOVA, M., VOKURKOVA, D., PAVLOVA, S., SMARDOVA, J. and STULIK, J., 2003, Gamma irradiation results in phosphorilation of p53 at serine-392 in human T-lymphocyte leukaemia cell line MOLT-4. Folia Biologica (Prague), 49, 183–188.
   PubMedGoogle Scholar
• TOMITA, M., SUZUKI, N., MATSUMOTO, Y., ATSUSHI, E., YIN, H. L., HOSOI, Y., HIRANO, K. and SAKAI, K., 2003, Wortmannin-enhanced X-ray-induced apoptosis of human T-cell leukemia MOLT-4 cells possibly through the JNK/ SAPK pathway. Radiation Research, 160, 467–477.
   PubMed Web of Science ®Google Scholar
• VIRAG, L. and SzABo, C., 2002, The therapeutic potential of poly(ADP-ribose) polymerase inhibitors. Pharmacological Reviews, 54, 375–429.
   PubMed Web of Science ®Google Scholar
• WONG, J. M., KUSDRA, L. and COLLINS, K., 2002, Subnuclear shuttling of human telomerase induced by transformation and DNA damage. Nature Cell Biology, 4, 731–736.
   PubMed Web of Science ®Google Scholar
• YOSHIDA, M., HOSOI, Y., MIYACHI, H., Ism', N., MATSUMOTO, Y., ENOMOTO, A., NAKAGAWA, K., YAMADA, S., SUZUKI, N. and ONO, T., 2002, Roles of DNA-dependent protein kinase and ATM in cell-cycle-dependent radiation sensitivity in human cells. International Journal of Radiation Biology, 78, 503–512.
   Google Scholar
• YU, C. C., Lo, S. C. and WANG, T. C., 2001, Telomerase is regulated by protein kinase C-zeta in human nasopharyngeal cancer cells. Biochemical Journal, 355, 459–464.
   PubMedGoogle Scholar