Reduction of oral mucositis by palifermin (rHuKGF): Dose-effect of rHuKGF

References

• Baatar D, Kawanaka H, Szabo I L, Pai R, Jones M K, Kitano S, Tarnawski A S. Esophageal ulceration activates keratinocyte growth factor and its receptor in rats: implications for ulcer healing. Gastroenterology 2002; 122: 458–468
   PubMed Web of Science ®Google Scholar
• Bernier J, Thames H D, Smith C D, Horiot J C. Tumor response, mucosal reactions and late effects after conventional and hyperfractionated radiotherapy. Radiother Oncol 1998; 47: 137–143
   PubMed Web of Science ®Google Scholar
• Brizel D M, Herman T, Goffinet D, Sailer S, Agarwala S, Schwartz G, Venkatesan V, Cripps C, Meredith R F, Logan E, Yao B. A phase I/II trial of escalating doses of recombinant human keratinocyte growth factor (rHuKGF) in head and neck cancer (HNC) patients receiving radiotherapy (RT) with concurrent chemotherapy (CCT). Int J Radiat Oncol Biol Phys 2001; 51(Suppl. 1)40, (Abstract)
   Google Scholar
• Bourhis J, Etessami A, Wilbault P, Lusinchi A, Calais G, Lapeyre M, Pignon J P. Altered fractionated radiotherapy in the management of head and neck carcinomas: Advantages and limitations. Curr Opin Oncol 2004; 16: 215–219
   PubMed Web of Science ®Google Scholar
• Denham J W, Peters L J, Johansen J, Poulsen M, Lamb D S, Hindley A, O'Brien P C, Spry N A, Penniment M, Krawitz H, Williamson S, Bear J, Tripcony L. Do acute mucosal reactions lead to consequential late reactions in patients with head and neck cancer?. Radiother Oncol 1999; 52: 157–164
   PubMed Web of Science ®Google Scholar
• Denham J W, Walker Q J, Lamb D S, Hamilton C S, O'Brien P C, Spry N A, Hindley A, Poulsen M, O'Brien M, Tripcony L. Mucosal regeneration during radiotherapy. Radiother Oncol 1996; 41: 109–118
   PubMed Web of Science ®Google Scholar
• Dörr W. Three A's of repopulation during fractionated irradiation of squamous epithelia: Asymmetry loss, Acceleration of stem-cell divisions and Abortive divisions. Int J Radiat Biol 1997; 72: 635–643
   PubMed Web of Science ®Google Scholar
• Dörr W. Oral mucosa: Response modification by keratinocyte growth factor. Biological modification of radiation response, C Nieder, L Milas, K K Ang. Springer, Berlin-Heidelberg-New York 2003a; 113–122
   Google Scholar
• Dörr W. Modulation of repopulation processes in oral mucosa: Experimental results. Int J Radiat Biol 2003b; 79: 531–537
   PubMed Web of Science ®Google Scholar
• Dörr W, Bässler S, Reichel S, Spekl K. Reduction of radiochemotherapy-induced early oral mucositis by recombinant human Keratinocyte Growth Factor (KGF): Experimental studies in mice. Int J Radiat Oncol Biol Phys 2005a; 62: 881–887
   PubMed Web of Science ®Google Scholar
• Dörr W, Brankovic K, Hartmann B. Repopulation in mouse oral mucosa: Changes in the effect of dose fractionation. Int J Radiat Biol 2000; 76: 383–390
   PubMed Web of Science ®Google Scholar
• Dörr W, Breitner A, Kummermehr J. Capacity and kinetics of SLD repair in mouse tongue epithelium. Radiother Oncol 1993; 27: 36–45
   PubMed Web of Science ®Google Scholar
• Dörr W, Hendry J H. Consequential late effects in normal tissues. Radiother Oncol 2001; 61: 223–231
   PubMed Web of Science ®Google Scholar
• Dörr W, Emmendörfer H, Weber-Frisch M. Tissue kinetics in mouse tongue mucosa during daily fractionated radiotherapy. Cell Prolif 1996; 29: 495–504
   PubMed Web of Science ®Google Scholar
• Dörr W, Noack R, Spekl K, Farrell C L. Modification of oral mucositis by keratinocyte growth factor: Single radiation exposure. Int J Radiat Biol 2001; 77: 341–347
   PubMed Web of Science ®Google Scholar
• Dörr W, Reichel S, Spekl K. Effects of Keratinocyte Growth Factor (palifermin) administration protocols on oral mucositis (mouse) induced by fractionated irradiation. Radiother Oncol 2005b; 75: 99–105
   PubMed Web of Science ®Google Scholar
• Dörr W, Spekl K, Farrell C L. Amelioration of acute oral mucositis by keratinocyte growth factor: Fractionated irradiation. Int J Radiat Oncol Biol Phys 2002a; 54: 245–251
   PubMed Web of Science ®Google Scholar
• Dörr W, Spekl K, Farrell C L. The effect of Keratinocyte Growth Factor on healing of manifest radiation ulcers in mouse tongue epithelium. Cell Prolif 2002b; 35(Suppl. 1)86–92
   PubMedGoogle Scholar
• Farrell C L, Bready J V, Rex K L, Chen J N, Dipalma C R, Whitcomb K L, Yin S, Hill D C, Wiemann B, Starnes C O, Havill A M, Lu Z N, Aukerman S L, Pierce G F, Thomason A, Potten C S, Ulich T R, Lacey D L. Keratinocyte growth factor protects mice from chemotherapy and radiation-induced gastrointestinal injury and mortality. Cancer Res 1998; 58: 933–939
   PubMed Web of Science ®Google Scholar
• Guttenberger R, Feng Y, Hunter N, Ang K K, Price R. Effects of TGF-α on radiation response in lip and jejunal mucosa in mice. Radiation research: A twentieth-century perspective, vol. I, J D Chapman, W C Dewey, G F Whitmore. Academic Press, San Diego-New York-Boston 1991; 151, (Abstract)
   Google Scholar
• Hille A, Rave-Fränk M, Pradier O, Damm C, Dörr W, Jäckel M C, Christiansen H, Hess C F, Schmidberger H. Effect of Keratinocyte Growth Factor on the proliferation, clonogenic capacity and colony size of human epithelial tumour cells in vitro. Int J Radiat Biol 2003; 79: 119–128
   PubMed Web of Science ®Google Scholar
• Köstler W J, Hejna M, Wenzel C, Zielinski C C. Oral mucositis complicating chemotherapy and/or radiotherapy: Options for prevention and treatment. CA Cancer J Clinicians 2001; 51: 290–315
   PubMed Web of Science ®Google Scholar
• Liu K, Kasper M, Trott K R. Changes in keratinocyte differentiation during accelerated repopulation of the irradiated mouse epidermis. Int J Radiat Biol 1996; 69: 763–769
   PubMed Web of Science ®Google Scholar
• Maciejewski B, Withers H R, Taylor J M, Hliniak A. Dose fractionation and regeneration in radiotherapy for cancer of the oral cavity and oropharynx. Part 2. Normal tissue responses: Acute and late effects. Int J Radiat Biol Oncol Phys 1990; 18: 101–111
   PubMed Web of Science ®Google Scholar
• Marks J E. Mucosal protectants and their application for head and neck chemoirradiation. Curr Opin Oncol 1997; 9: 267–273
   PubMedGoogle Scholar
• Nickstadt T. Capacity and kinetics of recovery from sublethal radiation damage in oral mucosa (mouse) after irradiation with 200 kV X-rays. Technical University of Dresden. 2000, MDS Thesis (Diss. Med. Dent.), 2000
   Google Scholar
• Ning S, Shui C, Khan W B, Benson W, Lacey D L, Knox S J. Effects of keratinocyte growth factor on the proliferation and radiation survival of human squamous cell carcinoma cell lines in vitro and in vivo. Int J Radiat Biol Oncol Phys 1998; 40: 177–187
   PubMed Web of Science ®Google Scholar
• Pabst S, Spekl K, Dörr W. Changes in the effect of dose fractionation during daily fractionated irradiation: studies in mouse oral mucosa. Int J Radiat Biol Oncol Phys 2004; 58: 485–492
   PubMed Web of Science ®Google Scholar
• Plevova P. Prevention and treatment of chemotherapy- and radiotherapy-induced oral mucositis: A review. Oral Oncol 1999; 35: 453–470
   PubMed Web of Science ®Google Scholar
• Potten C S, Owen G, Hewitt D, Chadwick C A, Hendry H, Lord B I, Woolford L B. Stimulation and inhibition of proliferation in the small intestineal crypts of the mouse after in vivo administration of growth factors. Gut 1995; 36: 864–873
   PubMed Web of Science ®Google Scholar
• Rubin J S, Bottaro D B, Chedid M, Miki T, Ron D, Cheon H G, Taylor W G, Fortney E, Sakata H, Finch P W, La Rochelle W J. Keratinocyte growth factor. Cell Biol Int 1995; 19: 399–411
   PubMed Web of Science ®Google Scholar
• SAS Institute Inc. SAS/STAT Users Guide Version 6. Author, Cary, NC 1990
   Google Scholar
• Sonis S T, Costa J W, Jr, Evitts S M, Lindquist L E, Nicolson M. Effect of epidermal growth factor on ulcerative mucositis in hamsters that receive cancer chemotherapy. Oral Surg Oral Med Oral Pathol 1992; 74: 749–755
   PubMedGoogle Scholar
• Sonis S T, Lindquist L, Van Vugt A, Stewart A A, Stam K, Qu G Y, Iwata K K, Haley J D. Prevention of chemotherapy-induced ulcerative mucositis by transforming growth factor beta 3. Cancer Res 1994; 54: 1135–1138
   PubMed Web of Science ®Google Scholar
• Spielberger R T, Stiff P, Emmanoulides C, Yanovich S, Bensinger W, Hedrick E, Noga S, Ziegler T, Keating A, Frankel S, Gentile T, Heard R, Yao B, Elhardt D. Efficacy of recombinant human Keratinocyte Growth Factor (rHuKGF) in reducing mucositis in patients with hematologic malignancies undergoing autologous peripheral blood progenitor cell transplantation (auto-PBPCT) after radiation-based conditioning - results of a phase 2 trial. J Clin Oncol 2001; 20: 7a, (Abstract 25)
   Web of Science ®Google Scholar
• Spielberger R, Stiff P, Bensinger W, Gentile T, Weisdorf D, Kewalramani T, Shea T, Yanovich S, Hansen K, Noga S, McCarty J, Lemaistre C F, Sung E C, Blazar B R, Elhardt D, Chen M G, Emmanouilides C. Palifermin for oral mucositis after intensive therapy for hematologic cancers. New Engl J Med 2004; 351: 2590–2598
   PubMed Web of Science ®Google Scholar
• Tarnawski R, Fowler J, Skladowski K, Swiernak A, Suwinski R, Maciejewski B, Wygoda A. How fast is repopulation of tumour cells during the treatment gap?. Int J Radiat Oncol Biol Phys 2002; 54: 229–236
   PubMed Web of Science ®Google Scholar
• Trotti A. Toxicity antagonists in head and neck cancer. Sem Radiat Oncol 1998; 8: 282–291
   PubMed Web of Science ®Google Scholar
• Trotti A, Klotch D, Endicott J, Ridley M, Cantor A. Postoperative accelerated radiotherapy in high-risk squamous cell carcinoma of the head and neck: Long-term results of a prospective trial. Head Neck 1998; 20: 119–123
   PubMed Web of Science ®Google Scholar
• Van Der Schueren E, Van Den Bogaert W, Vanuytsel L, Van Limbergen E. Radiotherapy by multiple fractions per day (MFD) in head and neck cancer: Acute reactions of skin and mucosa. Int J Radiat Oncol Biol Phys 1990; 19: 301–311
   PubMed Web of Science ®Google Scholar
• Zaghloul M S, Dorie M J, Kallman R F. Interleukin 1 increases thymidine labeling index of normal tissues of mice but not the tumor. Int J Radiat Oncol Biol Phys 1994; 29: 805–811
   PubMed Web of Science ®Google Scholar