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Original

No correlation between radiosensitivity or double-strand break repair capacity of normal fibroblasts and acute normal tissue reaction after radiotherapy of breast cancer patients

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Pages 501-508 | Received 04 Feb 2005, Accepted 05 Jul 2005, Published online: 03 Jul 2009

References

  • Barber J BP, Burril W, Spreadborough A R, Levine E, Warren C, Kiltie A E, Roberts S A, Scott D. Relationship between in vitro chromosomal radiosensitivity of peripheral blood lymphocytes and the expression of normal tissue damage following radiotherapy for breast cancer. Radiotherapy and Oncology 2000; 55: 179–186
  • Baria K, Warren C, Eden O B, Roberts S A, West C M, Scott D. Chromosomal radiosensitivity in young cancer patients: possible evidence of genetic predisposition. International Journal of Radiation Biology 2002; 78: 341–346
  • Begg A C, Russell N S, Knaken H, Lebesque J V. Lack of correlation of human fibroblast radiosensitivity in vitro with early skin reactions in patients undergoing radiotherapy. International Journal of Radiation Biology 1993; 64: 393–405
  • Borgmann K, Dede M, Wrona A, Brammer I, Overgaard J, Dikomey E. For X-irradiated normal human fibroblasts only half of cell inactivation results from chromosomal damage. International Journal of Radiation Oncology, Biology, Physics 2004; 58: 445–452
  • Borgmann K, Röper B, El-Awady R A, Brackrock S, Bigalke M, Dörk T, Alberti W, Dikomey E, Dahm-Daphi J. Indicators of late normal tissue response after radiotherapy for head and neck cancer: fibroblasts, lymphocytes, genetics, DNA repair, and chromosome aberrations. Radiotherapy and Oncology 2002; 64: 141–152
  • Brock W A, Tucker S L, Geara F B, Turesson I, Wike J, Nyman J, Peters L J. Fibroblast radiosensitivity versus acute and late normal skin responses in patients treated for breast cancer. International Journal of Radiation Oncology, Biology, Physics 1995; 32: 1371–1379
  • Dikomey E, Borgmann K, Brammer I, Kasten-Pisula U. Molecular mechanisms of individual radiosensitivity studied in normal diploid human fibroblasts. Toxicology 2003; 193: 125–135
  • Dikomey E, Borgmann K, Jung H, Peacock J. Why recent studies relating normal tissue response to individual radiosensitivity might have failed and how new studies should be performed. International Journal of Radiation Oncology, Biology, Physics 2003; 56: 1194–1200
  • Dikomey E, Brammer I, Johansen J, Bentzen S M, Overgaard J. Relationship between DNA double-strand breaks, cell killing, and fibrosis studied in confluent skin fibroblasts derived from breast cancer patients. International Journal of Radiation Oncology, Biology, Physics 2000; 46: 481–490
  • El-Awady R A, Dikomey E, Dahm-Daphi J. Heat effects on DNA repair after ionizing radiation. Hyperthermia commonly increases the number of non-repaired double strand breaks and structural rearrangements. Nucleic Acid Research 2001; 29: 1960–1966
  • El-Awady R A, Dikomey E, Dahm-Daphi J. Radiosensitivity of human tumour cells is associated with the induction but not with the repair of DNA double-strand breaks. British Journal of Cancer 2003; 89: 593–601
  • Fertil B, Dertinger H, Courdi A, Malaise E P. Mean inactivation dose: a useful concept for intercomparison of human cell survival curves. Radiation Research 1984; 99: 73–84
  • Fischer B, Anderson S, Bryant J, Margolese R G, Deutsch M, Fisher E R, Jeong J -H, Wolmark N. Twenty-year follow-up of a randomized trial comparing total mastectomy, lumectomy, and lumphectomy plus irradiation for the treatment of invasive breast cancer. New England Journal of Medicine 2002; 347: 1233–1241
  • Fourquet B, Campana F, Zafrani B MV, Vielh P, Durand J C, Vilcoq J R. Prognostic factors for breast recurrence in the conservative management of early breast cancer: a 25-year follow-up. International Journal of Radiation Oncology, Biology, Physics 1989; 17: 719–725
  • Fowble B, Solin L, Schultz D, Goodman R L. Ten-year results of conservative surgery and irradiation for stage I and II breast cancer. International Journal of Radiation Oncology, Biology, Physics 1991; 21: 269–277
  • Gage J, Recht A, Gelman R, Nixon A J, Silver B, Bornstein B A, Harris J R. Long-term outcome following breast conserving surgery and radiation therapy. International Journal of Radiation Oncology, Biology, Physics 1995; 33: 245–251
  • Geara F B, Peters L J, Ang K, Wike J L, Brock W A. Prospective comparison of in vitro normal cell radiosensitivity and normal tissue reactions in radiotherapy patients. International Journal of Radiation Oncology, Biology, Physics 1993; 27: 1173–1179
  • Hanawalt P C. The bases for Cockayne syndrome. Nature 2000; 405: 415–416
  • Hoeller U, Borgmann K, Bonacker M, Kuhlmey A, Bajrovic A, Jung H, Alberti W, Dikomey E. Individual radiosensitivity measured with lymphocytes may be used to predict the risk of fibrosis after radiotherapy for breast cancer. Radiotherapy and Oncology 2003; 69: 137–144
  • Jones L A, Scott D, Cowan R, Roberts S A. Abnormal radiosensitivity of lymphocytes from breast cancer patients with excessive normal tissue damage after radiotherapy: chromosome aberrations after low dose-rate irradiation. International Journal of Radiation Biology 1995; 67: 519–528
  • Kurtz J, Amalric R, Brandone H. Local recurrence after breast conserving surgery and radiation: frequency, time course, and prognosis. Cancer 1989; 63: 1912
  • Neubauer S, Gebhart E, Schmitt G, Birkenhake S, Dunst J. Is chromosome in situ suppression (CISS) hybridization suited as a predictive test for intrinsic radiosensitivity in cancer patients?. International Journal of Oncology 1996; 8: 707–712
  • Oppitz U, Baier K, Wulf J, Schakowski R, Flentje M. The in-vitro colony assay: a predictor of clinical outcome. International Journal of Radiation Biology 2001; 77: 105–110
  • Oppitz U, Schulte S, Stopper H, Baier K, Müller M, Wulf J, Schakowski R, Flentje M. In vitro radiosensitivity measured in lymphocytes and fibroblasts by colony formation and comet assay: comparison with clinical acute reactions to radiotherapy in breast cancer patients. International Journal of Radiation Biology 2002; 78: 611–616
  • Ramsay J, Birrell G. Normal tissue radiosensitivity in breast cancer patients. International Journal of Radiation Oncology, Biology, Physics 1995; 32: 339–344
  • Rudat V, Dietz A, Conradt C, Weber K -J, Flentje M. In vitro radiosensitivity of primary human fibroblasts. Lack of correlation with acute radiation toxicity in patients with head and neck cancer. Radiotherapy and Oncology 1997; 43: 181–188
  • Tucker S L, Turesson I, Thames H D. Evidence for individual differences in the radiosensitivity of human skin. European Journal of Cancer 1992; 28A: 1783–1791
  • Turesson I, Nyman J, Holmberg E, Oden A. Prognostic factors for acute and late skin reactions in radiotherapy patients. International Journal of Radiation Oncology, Biology, Physics 1996; 36: 1065–1075
  • Veronesi U, Cascinelli N, Mariani L, Greco M, Saccozzi R, Luini A, Aguilar M, Marubini E. Twenty-year follow-up of a randomized study comparing breast-conserving surgery with radical mastectomy for early breast cancer. New England Journal of Medicine 2002; 347: 1227–1232
  • Vinh-Hung V, Verschraegen C. Breast-conserving surgery with or without radiotherapy: pooled-analysis for risks of ipsilateral breast tumor recurrence and mortality. Journal of the National Cancer Institute 2004; 96: 115–121
  • West C ML, Davidson S E, Elyan S AG, Valentine H, Roberts S A, Swindell R, Hunter R D. Lymphocyte radiosensitivity is a significant prognostic factor for morbidity in carcinoma of the cervix. International Journal of Radiation Oncology, Biology, Physics 2001; 51: 10–15

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