140
Views
25
CrossRef citations to date
0
Altmetric
Original

Studies on radiation-induced apoptosis in G0 human lymphocytes

, , , &
Pages 587-599 | Received 18 Feb 2005, Accepted 29 Jul 2005, Published online: 03 Jul 2009

References

  • Ahn J, Murphy M, Kratowicz S, Wang A, Levine A J, George D. Down-regulation of the stathmin/Op18 and FKBP25 genes following p53 induction. Oncogene 1999; 18: 5954–5958
  • Ahnstrom G. Inhibition of DNA strand break rejoining in ultraviolet-irradiated human cells: Comparison of aphidicolin and cytosine arabinoside. Biochim Biophys Acta 1989; 1007: 357–368
  • Bakalkin G, Yakovleva T, Selivanova G, Magnusson K P, Szekely L, Kiseleva A, Klein G, Terenius L, Wiman K G. p53 binds single-stranded DNA ends and catalyzes DNA renaturation and strand transfer. Proc Natl Acad Sci USA 1994; 91: 413–417
  • Barzilay G, Walker L J, Robson C N, Hickson I D. Site-directed mutagenesis of the human DNA repair enzyme HAP1: Identification of residues important for AP endonuclease and RNase H activity. Nucleic Acids Res 1995; 23: 1544–1550
  • Bassi L, Carloni M, Meschini R, Fonti E, Palitti F. X-irradiated human lymphocytes with unstable aberrations and their preferential elimination by p53/survivin-dependent apoptosis. Int J Rad Biol 2003; 79: 943–954
  • Bryant P E. Enzymatic restriction of mammalian cell DNA using Pvu II and Bam HI: Evidence for the double-strand break origin of chromosomal aberrations. Int J Rad Biol 1984; 46: 57–65
  • Bauchinger M, Schmid E, Braselmann H. Cell survival and radiation induced chromosome aberrations. II. Experimental findings in human lymphocytes analysed in first and second post-irradiation metaphases. Rad Envir Biophys 1986; 25: 253–260
  • Buchhop S, Gibson M K, Wang X W, Wagner P, Sturzbecher H W, Harris C C. Interaction of p53 with the human Rad51 protein. Nucleic Acids Res 1997; 25: 3868–3874
  • Chin P L, Momand J, Pfeifer G P. In vivo evidence for binding of p53 to consensus binding sites in the p21 and GADD45 genes in response to ionizing radiation. Oncogene 1997; 15: 87–89
  • Collins A R, Squires S, Johnson R T. Inhibitors of repair DNA synthesis. Nucleic Acids Res 1982; 10: 1203–1213
  • Cory S, Adams J M. The Bcl2 family: Regulators of the cellular life-or-death switch. Nature Rev Cancer 2002; 2: 647–656
  • Cossarizza A, Baccarani-Contri M, Kalashnikova G, Franceschi C. A new method for the cytofluorimetric analysis of mitochondrial membrane potential using the J-aggregate forming lipophilic cation 5,5′,6,6′-tetrachloro-1,1′,3,3′-tetraethylbenzimidazolcarbocyanine iodide (JC-1). Biochem Biophys Res Comm 1993; 197: 40–45
  • Cossarizza A, Ceccarelli D, Masini A. Functional heterogeneity of an isolated mitochondrial population revealed by cytofluorometric analysis at the single organelle level. Exp Cell Res 1996; 222: 84–94
  • Dunn W C, Regan J D. Inhibition of DNA excision repair in human cells by arabinofuranosyl cytosine: Effect on normal and xeroderma pigmentosum cells. Mol Pharmacol 1979; 15: 367–374
  • Ferlini C, Di Cesare S, Rainaldi G, Malorni W, Samoggia P, Biselli R, Fattorossi A. Flowcytometric analysis of the early phases of apoptosis by cellular and nuclear techniques. Cytometry 1996; 24: 106–115
  • Friedberg E C, Walker G C, Siede W. DNA repair and mutagenesis. ASM Press, Washington, DC 1995
  • Hansen R, Oren M. p53: From inductive signal to cellular effect. Curr Opin Genetics Dev 1997; 7: 46–51
  • Harms-Ringdahl M, Nicotera P, Radford I R. Radiation induced apoptosis. Mutation Res 1996; 366: 171–179
  • Hoffman W H, Biade S, Zilfou J T, Chen J, Murphy M. Transcriptional repression of the anti-apoptotic survivin gene by wild type p53. J Biol Chem 2002; 277: 3247–3257
  • Holmberg K, Meijer A E, Harms-Ringdahl M, Lambert B. Chromosomal instability in human lymphocytes after low dose rate γ-irradiation and delayed mitogen stimulation. Int J Rad Biol 1998; 73: 21–34
  • Iliakis G. The role of DNA double-strand breaks in ionizing radiation induced killing of eucaryotic cells. BioEssays 1991; 13: 641–648
  • Innocente S A, Abrahamson J L, Cogswell J P, Lee J M. p53 regulates a G2 checkpoint through cyclin B1. Proc Natl Acad Sci USA 1999; 96: 2147–2152
  • Kastan M B, Onyekwere O, Sidransky D, Vogelstein B, Craig R W. Participation of p53 protein in the cellular response to DNA damage. Cancer Res 1991; 51: 6304–6311
  • Krause K, Haugwitz U, Wasner M, Wiedmann M, Mossner J, Engeland K. Expression of the cell cycle phosphatase cdc25C is down-regulated by the tumor suppressor protein p53 but not by p73. Biochim Biophys Res Comm 2001; 284: 743–750
  • Ko L J, Prives C. p53: Puzzle and paradigm. Genes Dev 1996; 10: 1054–1072
  • Levine A J. p53, the cellular gatekeeper for growth and division. Cell 1997; 88: 323–331
  • Liu Y, Kulesz-Martin M. p53 protein at the hub of cellular DNA damage response pathways through sequence-specific and non-sequence-specific DNA binding. Carcinogenesis 2001; 22: 851–860
  • Livingstone L R, White A, Sprouse J, Livanos E, Jacks T, Tlsty T. Altered cell cycle arrest and gene amplification potential accompanying loss of wild-type p53. Cell 1992; 70: 923–935
  • Meijer A E, Bäckbro Saeidi A B, Zelenskaya A, Czene S, Granath F, Harms-Ringdahl M. Influence of dose-rate, post-irradiation incubation time and growth factors on interphase cell death by apoptosis and clonogenic survival of human peripheral lymphocytes. Int J Rad Biol 1999; 75: 1265–1273
  • Natarajan A T, Balajee A S, Boei J JWA, Chatterjee S, Darroudi F, Grigorova M, Noditi M, Oh H J, Slijepcevic P, Vermeulen S. Recent developments in the assessment of chromosomal damage. Int J Rad Biol 1994; 66: 615–623
  • Natarajan A T, Obe G. Molecular mechanisms involved in the production of chromosomal aberrations. I. Utilisation of Neurospora and nuclease for the study of the aberrations production in G2 stage of the cell cycle. Mutation Res 1978; 52: 137–149
  • Natarajan A T, Obe G. Molecular mechanisms involved in the production of the chromosomal aberrations. III. Restriction endonucleases. Chromosoma 1984; 90: 120–127
  • Nickias R B, Ward S C, Gorbsky G J. Kinetochore chemistry is sensitive to tension and may link mitotic forces to a cell cycle checkpoint. J Cell Biol 1995; 130: 929–939
  • Oren M. Regulation of the p53 tumor suppressor protein. J Biol Chem 1999; 274: 36031–36034
  • Perry P, Wolff S. New Giemsa method for differential staining of sister chromatid exchanges. Nature 1974; 251: 156–158
  • Preston R J. The effect of cytosine arabinoside on the frequency of X-rays induced chromosome aberrations in normal human leucocytes. Mutation Res 1980; 69: 71–99
  • Reers M, Smith T W, Chen L B. J-aggregate formation of a carbocyanine as a quantitative fluorescent indicator of membrane potential. Biochemistry 1991; 30: 4480–4486
  • Savage J RK. Classification and relationships of induced chromosomal structural changes. Journal of Medical Genetics 1975; 13: 103–122
  • Schwartz J L, Jordan R. Selective elimination of human lymphoid cells with unstable chromosome aberrations by p53-dependent apoptosis. Carcinogenesis 1997; 18: 201–205
  • Sionov R V, Haupt Y. The cellular responce to p53: The decision between life and death. Oncogene 1999; 18: 6145–6157
  • Smiley S T, Reers M, Mottola-Hartshom C, Lin M, Chen A, Smith T W, Steele G D, Chen L B. Intracellular heterogeneity in mitochondrial membrane potentials revealed by a J-aggregate-forming lipophilic cation JC-1. Proc Natl Acad Sci USA 1991; 88: 3671–3675
  • Sturzbecher H W, Donzelmann B, Henning W, Knipp-Schild U, Buchhop S. p53 is linked directly to homologous recombination processes via RAD51/RecA protein interaction. Eur Mol Biol Org J 1996; 15: 1992–2002
  • Szumiel I. Monitoring and signalling of radiation-induced damage in mammlian cell. Rad Res 1998; 150: 92–101
  • Taylor W R, Schontal A H, Galente J, Stark G R. p130/E2F4 binds to and represses the cdc2 promoter in responce to p53. J Biol Chem 2001; 276: 1998–2006
  • Vousden K H. p53: Death star. Cell 2000; 103: 691–694
  • Zhao R, Gish K, Murphy M, Yin Y, Notterman D, Hoffman W H, Tom E, Mack D H, Levine A J. Analysis of p53-regulated gene expression patterns using oligonucleotide arrays. Genes Dev 2000; 14: 981–993
  • Zittoun J, Marquet J, David J C. Mechanism of inhibition of DNA ligase in Ara-C treated cells. Leukemia Res 1991; 15: 157–164

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.