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Original

DNA DSB induced in human cells by charged particles and gamma rays: Experimental results and theoretical approaches

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Pages 841-854 | Received 04 Feb 2005, Accepted 18 Oct 2005, Published online: 03 Jul 2009

References

  • Anderson R M, Marsden S J, Wright E G, Kadhim M A, Goodhead D T, Griffin C S. Complex chromosome aberrations in peripheral blood lymphocytes as a potential biomarker of exposure to high-LET α-particles. International Journal of Radiation Biology 2000; 76: 31–42
  • Ballarini F, Biaggi M, Merzagora M, Ottolenghi A, Dingfelder M, Friedland W, Jacob P, Paretzke H G. Stochastic aspects and uncertainties in the prechemical and chemical stages of electron tracks in liquid water: A quantitative analysis based on Monte Carlo simulations. Radiation and Environmental Biophysics 2000; 39: 179–188
  • Begusova M, Sy D, Charlier M, Spotheim-Maurizot M. Radiolysis of nucleosome core DNA: A modelling approach. International Journal of Radiation Biology 2000; 76: 1063–1073
  • Belli M, Cera F, Cherubini R, Ianzini F, Moschini G, Sapora O, Simone G, Tabocchini M A, Tiveron P. DNA double-strand breaks induced by low energy protons in V79 cells. International Journal of Radiation Biology 1994; 65: 529–536
  • Belli M, Cherubini R, Dalla Vecchia M, Dini V, Esposito G, Moschini G, Sapora O, Signoretti C, Simone G, Sorrentino E, Tabocchini M A. DNA fragmentation in mammalian cells exposed to various light ions. Advances in Space Research 2001; 27: 393–399
  • Belli M, Cherubini R, Dalla Vecchia M, Dini V, Esposito G, Moschini G, Sapora O, Simone G, Tabocchini M A. DNA fragmentation in V79 cells irradiated with light ions as measured by pulsed-field gel electrophoresis. I. Experimental results. International Journal of Radiation Biology 2002; 78: 475–482
  • Belli M, Cherubini R, Galeazzi G, Mazzuccato S, Moschini G, Sapora O, Simone G, Tabocchini M A. Proton irradiation facility for radiobiological studies at a 7 MeV Van de Graaf accelerator. Nuclear Instruments and Methods in Physics Research A 1987; 256: 476–480
  • Belloni F, Bettega D, Calzolari P, Cherubini R, Massariello P, Tallone L. Inactivation cross sections for mammalian cells exposed to charged particles: A phenomenological approach. Radiation Protection Dosimetry 2002; 99: 199–202
  • Boudaiffa B, Cloutier P, Hunting D, Huels M A, Sanche L. Resonant formation of DNA strand breaks by low-energy (3 to 20 eV) electrons. Science 2000; 287: 1658–1660
  • Bryant P E. Enzymatic restriction of mammalian cell DNA: evidence of double-strand breaks as potentially lethal lesions. International Journal of Radiation Biology 1985; 48: 55–60
  • Buxton G V, Greenstock C L, Helman W P, Ross A B. Critical review of rate constants for reactions of hydrated electrons, hydrogen atoms and hydroxyl radicals (OH/O−) in aqueous solution. Journal of Physical Chemistry Reference Data 1988; 17: 513–885
  • Campa A, Esposito G, Belli M, Simone G, Tabocchini M A. DNA fragmentation in V79 cells irradiated with light ions as measured by pulsed-field gel electrophoresis. II. Simulation with a generalized broken stick model. International Journal of Radiation Biology 2004; 80: 229–238
  • Cook V E, Mortimer R K. A quantitative model of DNA fragments generated by ionizing radiation, and possible experimental applications. Radiation Research 1991; 125: 102–106
  • Dingfelder M, Hantke D, Inokuti M, Paretzke H G. Electron inelastic-scattering cross sections in liquid water. Radiation Physics and Chemistry 1998; 53: 1–18
  • Dingfelder M, Inokuti M, Paretzke H G. Inelastic-collision cross sections of liquid water for interactions of energetic protons. Radiation Physics and Chemistry 2000; 59: 255–275
  • Frankenberg D, Frankenberg-Schwager M, Blöcher D, Harbich R. Evidence for DNA double-strand breaks as critical lesions in yeast cells irradiated with sparsely or densely ionizing radiation under oxic or anoxic conditions. Radiation Research 1981; 88: 524–532
  • Frankenberg D, Brede H J, Schrewe U, Steinmetz C, Frankenberg-Schwager M, Kasten G, Pralle E. Induction of DNA double-strand breaks by 1H and 4He ions in primary human skin fibroblasts in the LET range of 8 to 124 keV μm−1. Radiation Research 1999; 151: 540–549
  • Frankenberg D, Brede H J, Schrewe U, Steinmetz C, Frankenberg-Schwager M, Kasten G, Pralle E. Induction of DNA double-strand breaks in mammalian cells and yeast. Advances in Space Research 2000; 25: 2085–2094
  • Friedland W, Dingfelder M, Jacob P, Paretzke H G. Calculated DNA double-strand break and fragmentation yields after irradiation with He ions. Radiation Physics and Chemistry 2005; 72: 279–286
  • Friedland W, Jacob P, Bernhardt P, Paretzke H G, Dingfelder M. Simulation of DNA damage after proton irradiation. Radiation Research 2003; 159: 401–410
  • Friedland W, Jacob P, Paretzke H G, Merzagora M, Ottolenghi A. Simulation of DNA fragment distributions after irradiation with photons. Radiation and Environmental Biophysics 1999; 38: 39–47
  • Gauter B, Zlobinskaya O, Weber K J. Rejoining of radiation-induced DNA double-strand breaks: Pulsed-field electrophoresis analysis of fragment size distributions after incubation for repair. Radiation Research 2002; 157: 721–733
  • Goodhead D T. Initial events in the cellular effects of ionising radiations: Clustered damage in DNA. International Journal of Radiation Biology 1994; 65: 7–17
  • Höglund E, Blomquist E, Carlsson J, Stenerlöw B. DNA damage induced by radiation of different linear energy transfer: initial fragmentation. International Journal of Radiation Biology 2000; 76: 539–547
  • International Commission on Radiation Units and Measurements. Stopping powers and ranges for protons and α-particles. Washington 1993, ICRU Report 49
  • Johnston P J, MacPhail S H, Stamato T D, Kirchgessner C U, Olive P L. Higher-order chromatin structure-dependent repair of DNA double-strand breaks: Involvement of the V(D)J recombination double-strand break repair pathway. Radiation Research 1998; 149: 455–462
  • Litwin S. Distribution of radioactive recovery in randomly cut sediment DNA. Journal of Applied Probability 1969; 6: 275–284
  • Löbrich M, Cooper P K, Rydberg B. Non-random distribution of DNA double-strand breaks induced by particle irradiation. International Journal of Radiation Biology 1996; 70: 493–503
  • Milligan J R, Aguileira J A, Ward J F. Variation of single-strand break yield with scavenger concentration for the SV40 minichromosome irradiated in aqueous solution. Radiation Research 1993; 133: 158–162
  • Moiseenko V V, Hamm R N, Waker A J, Prestwich W V. Modelling DNA damage induced by different energy photons and tritium beta-particles. International Journal of Radiation Biology 1998; 74: 533–550
  • Montroll E W, Simha R. Theory of depolimerization of long chain molecules. Journal of Chemical Physics 1940; 8: 721–727
  • Newman H C, Prise K M, Michael B D. The role of higher-order chromatin structure in the yield and distribution of DNA double-strand breaks in cells irradiated with X-ray and α-particles. International Journal of Radiation Biology 2000; 76: 1085–1093
  • Nikjoo H, O'Neill P, Goodhead D T, Terrissol M. Computational modelling of low-energy electron-induced DNA damage by early physical and chemical events. International Journal of Radiation Biology 1997; 71: 467–483
  • Nygren J, Ljungman M, Ahnstroem G. Chromatin structure and radiation-induced DNA strand breaks in human cells: Soluble scavengers and DNA bound proteins offer a better protection against single strand breaks than double strand breaks. International Journal of Radiation Biology 1995; 68: 11–18
  • Obe G, Johannes C, Schulte-Frohlinde D. DNA double-strand breaks induced by sparsely ionizing radiation and endonucleases as critical lesions for cell death, chromosomal aberrations, mutation and oncogenic transformation. Muta genesis 1992; 7: 3–12
  • Ottolenghi A, Merzagora M, Tallone L, Durante M, Paretzke H G, Wilson W E. The quality of DNA double-strand breaks: A Monte Carlo simulation of the end-structure of strand breaks produced by protons and alpha particles. Radiation and Environmental Biophysics 1995; 34: 239–244
  • Pinto M, Newman H C, Prise K M, Michael B D. Quantification of DNA damage by PFGE: Development of an analytical approach to correct for the background distribution. International Journal of Radiation Biology 2000; 76: 741–748
  • Pinto M, Prise K M, Michael B D. A Monte Carlo model of DNA double-strand break clustering and rejoining kinetics for the analysis of pulsed-field gel electrophoresis data. Radiation Research 2004; 162: 453–463
  • Prise K M, Davies S, Michael B D. Evidence for induction of DNA double-strand breaks at paired radical sites. Radiation Research 1993; 134: 102–106
  • Prise K M, Folkard M, Michael B D, Vojnovic B, Brocklehurst B, Hopkirk A, Munro I H. Critical energies for SSB and DSB induction in plasmid DNA irradiated in vacuum. International Journal of Radiation Biology 2000; 76: 881–890
  • Rydberg B. Radiation-induced heat-labile sites that convert into DNA double-strand breaks. Radiation Research 2000; 153: 805–812
  • Siddiqi M A, Bothe E. Single- and double-strand break formations in DNA irradiated in aqueous solution: dependence on dose and OH radical scavenger concentration. Radiation Research 1987; 112: 449–463
  • Stenerlöw B, Karlsson K H, Cooper B, Rydberg B. Measurement of prompt DNA double-strand breaks in mammalian cells without including heat-labile sites: Results for cells deficient in nonhomologous end joining. Radiation Research 2003; 159: 502–510
  • Van der Schans G P, Aten J BT, Blok J. Determination of molecular weight distributions of DNA by means of sedimentation in a sucrose gradient. Analytical Biochemistry 1969; 32: 14–30
  • Von Sonntag C. The Chemical Basis of Radiation Biology. Taylor and Francis, London and New York 1987
  • Ward J F. Biochemistry of DNA lesions. Radiation Research 1985; 8: S103–S111

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