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Original

Radiation response of primary human skin fibroblasts and their bystander cells after exposure to counted particles at low and high LET

, &
Pages 59-67 | Received 01 Feb 2005, Accepted 17 Jan 2006, Published online: 03 Jul 2009

References

  • Adayabalam S B, Ponnaiya B, Baskar B, Geard C R. Induction of replication A in bystander cells. Radiation Research 2004; 162: 677–686
  • Azzam E I, deToledo S M, Gooding T, Little J B. Intercellular communication is involved in the bystander regulation of gene expression in human cells exposed to very low fluences of α particles. Radiation Research 1998; 150: 497–504
  • Azzam E I, deToledo S M, Waker S M, Little J B. High and low fluences of α-particles induce a G1 checkpoint in human diploid fibroblasts. Cancer Research 2000; 60: 2623–2631
  • Azzam E I, deToledo S M, Little J B. Direct evidence for the participation of gap-junction mediated intercellular communication in the transmission of damage signals from alpha-particle irradiated to non-irradiated cells. Proceedings of the National Academy of Sciences of the USA 2001; 98: 473–478
  • Azzam E I, deToledo S M, Spitz D R, Little J B. Oxidative metabolism modulates signal transduction and micronucleus formation in bystander cells from alpha-particle-irradiated normal human fibroblast cultures. Cancer Research 2002; 62: 5436–5442
  • Barcellos-Hoff M H, Brooks A L. Extracellular signalling through the microenvironment: A hypothesis relating carcinogenesis, bystander effects and genomic instability. Radiation Research 2001; 165: 618–627
  • Belyakov O V, Malcomson A M, Folkard M, Prise K M, Michael B D. Direct evidence for a bystander effect of ionizing radiation in primary human fibroblasts. British Journal of Cancer 2001; 84: 674–679
  • Bishayee A, Hill H Z, Stein D, Rao D V, Howell R W. Free-radical initiated and gap junction-mediated bystander effect due to nonuniform distribution of incorporated radioactivity in a three-dimensional tissue culture model. Radiation Research 2001; 155: 335–344
  • Bruzzone R, White T W, Goodenough D A. The cellular internet-on line with connexins. BioEssays 1996; 18: 709–718
  • Buxton G W. Radiation chemistry of the liquid state. (1) Water and homogeneous aqueous solutions. Radiation Chemistry, Farhataziz, Rodgers. John Wiley, New York 1987; 321–350
  • Deshpande A, Goodwin E H, Bailey S M, Marrone B L, Lehnert B E. Alpha-particle-induced sister chromatid exchanges in normal human lung fibroblasts: Evidence for an extracellular target. Radiation Research 1996; 145: 260–267
  • Feinendegen L E, Loken M K, Booz J, Muehlensiepen H, Sondhaus C A, Bond V P. Cellular mechanism of protection and repair induced by radiation exposure and their consequences for cell system responses. Stem Cells 1995; 13(Suppl. 1)7–20
  • Folkard M, Vojnovic B, Prise K M, Bowey A G, Locke R J, Schettino G, Michael B D. A charged particle microbeam: I. Development of an experimental system for targeting cells individually with counted particles. International Journal of Radiation Biology 1997a; 72: 375–385
  • Folkard M, Vojnovic B, Hollis K J, Bowey A G, Watts S J, Schettino G, Prise K M, Michael B D. A charged particle microbeam: II. A single particle micro-collimation and detection system. International Journal of Radiation Biology 1997b; 72: 387–395
  • Greif K -D, Brede H J, Frankenberg D, Giesen U. The PTB single ion microbeam for irradiation of living cells. Nuclear Instruments and Methods B 2004; 217: 505–512
  • Grosh S, Fritz G, Kaina B. Apurinic endonuclease is induced in mammalian cells by oxidative stress and involved in clastogenic adaptation. Cancer Research 1998; 58: 4410–4416
  • Hickman A W, Jaramillo R J, Lechner J F, Johnson N F. Alpha-particle-induced p53 protein expression in a rat lung epithelial cell strain. Cancer Research 1994; 54: 5797–5800
  • Iyer R, Lehnert B E. Factors underlying the cell growth-related bystander responses to alpha particles. Cancer Research 2000; 60: 1290–1298
  • Iyer R, Lehnert B E. Alpha-particle-induced increase in the radioresistance of normal human bystander cells. Radiation Research 2002a; 157: 3–7
  • Iyer R, Lehnert B E. Low dose, low LET ionizing radiation-induced radioadaptation and associated early response in unirradiated cells. Mutation Research 2002b; 503: 1–9
  • Kadhim M A, Macdonald D A, Goodhead D T, Lorimore S A, Marsden S J, Wright E G. Transmission of chromosomal instability after plutonium alpha-particle irradiation. Nature 1992; 355: 738–740
  • Lehnert B E, Goodwin E H. Extracellular factor(s) following exposure to alpha particles can cause sister chromatid exchanges in normal human cells. Cancer Research 1997; 57: 2164–2171
  • Lehnert B E, Iyer R. Cell growth-related bystander responses to α particles and γ rays. Radiation research, M Moriarty, C Mothersill, C Seymour, M Edington, J F Ward, R JM Fry. Allen Press, Lawrence, KS 2000; Vol. 2: 488–491
  • Lewis D A, Mayhugh B M, Qin Y, Trott K, Mendonca M S. Production of delayed death and neoplastic transformation in CGL1 cells by radiation-induced bystander effects. Radiation Research 2001; 156: 251–258
  • Littlefield L G, Hollowell J G, Pool W H. Chromosomal aberrations induced by plasma from irradiated patients: An indirect effect of x-irradiation. Radiology 1969; 93: 879–886
  • Lorimore S A, Kadhim M A, Pocock D A, Papworth D, Stevens D L, Goodhead D T, Wright E G. Chromosomal instability in the descendants of unirradiated surviving cells after alpha-particle irradiation. Proceedings of the National Academy of Sciences of the USA 1998; 95: 5730–5733
  • Lyng F M, Seymour C B, Mothersill C. Production of a signal by irradiated cells which leads to a response in unirradiated cells characteristic of initiation of apoptosis. British Journal of Cancer 2000; 83: 1223–1230
  • Maguire P, Mothersill C, Seymour C, Lyng F M. Medium from irradiated cells induces dose-dependent mitochondrial changes and BCL2 responses in unirradiated human keratinocytes. Radiation Research 2005; 163: 384–390
  • Marples B, Lambin P, Skov K A, Joiner M C. Low dose hyper-radiosensitivity and increased radioresistance in mammalian cells. International Journal of Radiation Biology 1997; 71: 721–735
  • Marples B, Joiner M C. The response of Chinese hamster V79 cells to low radiation doses: Evidence of enhanced sensitivity of the whole cell population. Radiation Research 1993; 133: 41–51
  • Marples B, Wouters B G, Collis S J, Chalmers A J, Joiner M C. Low-dose hyper-radiosensitivity: A consequence of ineffective cell cycle arrest of radiation-damaged G2-phase cells. Radiation Research 2004; 161: 247–255
  • Matsumoto H, Hayashi S, Hatashita M, Onishi T, Shioura H, Ohtsubo T, Kitai R, Ohnishi T, Kano E. Induction of radioresistance by a nitric oxide-mediated bystander effect. Radiation Research 2001; 155: 387–396
  • Mitchell S A, Randers-Pehrson G, Brenner D J, Hall E J. The bystander response in C3H10T1/2 cells: The influence of cell-to-cell contact. Radiation Research 2004a; 161: 397–401
  • Mitchell S A, Marino S A, Brenner D J, Hall E J. Bystander effect and adaptive response in C3H10T1/2 cells. International Journal of Radiation Biology 2004b; 80: 465–472
  • Moore S R, Marsden S, Macdonald D, Mitchell S, Folkard M, Michael B, Goodhead D T, Prise K M, Kadhim M A. Genomic instability in human lymphocytes irradiated with individual charged particles: Involvement of tumor necrosis factor α in irradiated cells but not bystander cells. Radiation Research 2005; 163: 183–190
  • Morgan W F. Non-targeted and delayed effects of exposure to ionizing radiation: I. Radiation-induced genomic instability and bystander effects in vitro. Radiation Research 2003a; 159: 567–580
  • Morgan W F. Non-targeted and delayed effects of exposure to ionizing radiation: II. Radiation-induced genomic instability and bystander effects in vivo, clastogenic factors and transgenerational effects. Radiation Research 2003b; 159: 581–596
  • Mothersill C, Seymour C B. Medium from irradiated human epithelial cells but not human fibroblasts reduces the clonogenic survival of unirradiated cells. International Journal of Radiation Biology 1997; 71: 421–427
  • Mothersill C, Seymour C B. Cell-cell contact during gamma irradiation is not required to induce a bystander effect in normal human keratinocytes: Evidence for release during irradiation of a signal controlling survival into the medium. Radiation Research 1998; 149: 256–262
  • Mothersill C, Lyng F, Seymour C, Maguire P, Losimore S, Wright E. Genetic factors influencing bystander signalling in murine bladder epithelium after low dose irradiation in vivo. Radiation Research 2005; 163: 391–399
  • Nagar S, Smith L E, Morgan W F. Characterization of a novel epigenetic effect of ionizing radiation: the death-inducing effect. Cancer Research 2003; 63: 324–328
  • Nagasawa H, Little J B. Induction of sister chromatid exchanges by extremely low doses of alpha-particles. Cancer Research 1992; 52: 6394–6396
  • Nagasawa H, Little J B. Unexpected sensitivity to the induction of mutations by very low doses of alpha-particle irradiation: Evidence for a bystander effect. Radiation Research 1999; 152: 552–557
  • Nagasawa H, Cremesti A, Kolesnick R, Fuks Z, Little J B. Involvement of membrane signalling in the bystander effect in irradiated cells. Cancer Research 2002; 62: 2531–2534
  • Narayanan P K, Goodwin E H, Lehnert B E. Alpha particles initiate biological production of superoxide anions and hydrogen peroxide in human cells. Cancer Research 1997; 57: 3963–3397
  • Nelson J M, Brooks A L, Metting N F, Khan M A, Buschbom R L, Duncan A, Miick R, Braby L A. Clastogenic effects of defined numbers of 3.2 MeV alpha particles on individual CHO-K1 cells. Radiation Research 1996; 145: 568–574
  • Petkau A. Role of superoxide dismutase in modification of radiation injury. British Journal of Cancer 1987; 8(Suppl.)87–95
  • Ponnaiya B, Jenkins-Baker G, Brenner D J, Hall E J, Rander-Pehrson G, Geard C R. Biological responses in known bystander cells relative to known microbeam-irradiated cells. Radiation Research 2004; 162: 426–432
  • Prise K M, Belyakov O V, Folkard M, Michael B D. Studies of bystander effects in human fibroblasts using a charged particle microbeam. International Journal of Radiation Biology 1998; 74: 793–798
  • Pugliese M, Durante M, Grossi G F, Monforti F, Orlando D, Ottolenghi A, Scampoli P, Gialanella G. Inactivation of individual mammalian cells by single alpha-particles. International Journal of Radiation Biology 1997; 72: 397–407
  • Ramana C V, Boldogh I, Izumi T, Mitra S. Activation of apurinic/apyrimidinic endonuclease in human cells by reactive oxygen species and its correlation with their adaptive response to genotoxicity of free radicals. Proceedings of the National Academy of Sciences of the USA 1998; 95: 5061–5066
  • Randers-Pehrson G, Geard C R, Johnson G, Elliston C D, Brenner D. The Columbia University single-ion microbeam. Radiation Research 2001; 156: 210–214
  • Sawant S, Randers-Pehrson G, Geard C R, Brenner D J, Hall E J. The bystander effect in radiation oncogenesis I. Transformation can be initiated in the unirradiated neighbours of irradiated cells. Radiation Research 2001; 155: 397–401
  • Sawant S, Zengh W, Hopkins K M, Randers-Pehrson G, Lieberman H B, Hall E J. The radiation-induced bystander effect for clonogenic survival. Radiation Research 2002; 157: 361–364
  • Schettino G, Folkard M, Michael B D, Prise K M. Low-dose binary behaviour of bystander cell killing after microbeam irradiation of a single cell with focused CK x rays. Radiation Research 2005; 163: 332–336
  • Shao C, Furusawa Y, Aoki M, Ando K. Role of gap junctional intercellular communication in radiation-induced bystander effects in human fibroblasts. Radiation Research 2003; 160: 318–323
  • Short S, Mayes C, Woodcock M, Johns H, Joiner M C. Low dose hypersensitivity in the T98G human glioblastoma cell line. International Journal of Radiation Biology 1999; 75: 847–855
  • Singh B, Arrand J E, Joiner M C. Hypersensitivity response of normal human lung epithelial cells at low radiation doses. International Journal of Radiation Biology 1994; 65: 457–464
  • Soyland C, Hassfjell S P, Steen H B. A new alpha-particle irradiator with absolute dosimetric determination. Radiation Research 2000; 153: 9–15
  • Suzuki M, Zhou H, Geard C R, Hei T K. Effect of medium on chromatin damage in bystander mammalian cells. Radiation Research 2004; 162: 264–269
  • Wang B, Ohyama H, Shang Y, Fujita K, Tanaka K, Nakajima T, Aizawa S, Yukawa O, Hayata I. Adaptive response in embryogenesis: IV. Protective and detrimental bystander effects induced by X radiation in cultured limb bud cells of foetal mice. Radiation Research 2004; 161: 9–16
  • Wu L J, Randers-Pehrson G R, Xu A, Waldren C A, Geard C R, Yu Z L, Hei T K. Targeted cytoplasmic irradiaton with alpha particles induces mutations in mammalian cells. Proceedings of the National Academy of Sciences of the USA 1999; 96: 4959–4964
  • Zhou H, Randers-Pehrson G, Waldren C A, Vannais D, Hall E J, Hei T K. Induction of a bystander mutagenic effect of alpha particles in mammalian cells. Proceedings of the National Academy of Sciences of the USA 2000; 97: 2099–2104
  • Zhou H, Randers-Pehrson G, Suzuki M, Waldren C A, Hei T K. Genotoxic damage in non-irradiated cells: Contribution from the bystander effect. Radiation Protection Dosimetry 2002; 99: 227–232

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