References
- Cheng L, Lai M D. Aberrant crypt foci as microscopic precursors of colorectal cancer. Journal of Gastroenterology 2003; 9: 2642–2649
- Culling C FA. Handbook of histopathological and histochemical techniques. 3rd ed. Butterworths, London 1974
- de Santa Barbara P, van den Brink G R, Roberts D J. Development and differentiation of the intestinal epithelium. Cellular and Molecular Life Sciences 2003; 60: 1322–1332
- Del Buono R, Lee C Y, Hawkey C J, Wright N A. Isolated crypts form spheres prior to full intestinal differentiation when grown as xenografts: An in vivo model for the study of intestinal differentiation and crypt neogenesis, and for the abnormal crypt architecture of juvenile polyposis coli. Journal of Pathology 2005; 206: 395–401
- Doll R, Wakeford R. Risk of childhood cancer from fetal irradiation. British Journal of Radiology 1997; 70: 130–139
- Ellender M, Harrison J D, Edwards A A, Bouffler S D, Cox R. Direct single gene mutational events account for radiation-induced intestinal adenoma yields in ApcMin/+ mice. Radiation Research 2005; 163: 552–556
- Fodde R, Smits R, Clevers H. APC, signal transduction and genetic instability in colorectal cancer. Nature Reviews, Cancer 2001; 1: 55–67
- Haigis K M, Hoff P D, White A, Shoemaker A R, Halberg R B, Dove W F. Tumor regionality in the mouse intestine reflects the mechanism of loss of Apc function. Proceedings of the National Academy Sciences 2004; 101: 9769–9773
- Haines J, Dunford R, Moody J, Ellender M, Cox R, Silver A. Loss of heterozygosity in spontaneous and X-ray-induced intestinal tumors arising in F1 hybrid Min mice: Evidence for sequential loss of Apc+ and Dpc4 in tumor development. Genes, Chromosomes and Cancer 2000; 28: 387–394
- International Commission on Radiological Protection (ICRP). Recommendations of the International Commission on Radiological Protection, ICRP Publication 60. Pergamon Press, Oxford 1991; 1–3, Annals of the ICRP 21
- International Commission on Radiological Protection (ICRP). Doses to the embryo and fetus from intakes of radionuclides by the mother. Elsevier Sciences, Oxford 2001; 1–3, ICRP Publication 88. Annals of the ICRP 31
- International Commission on Radiological Protection (ICRP). Biological effects after prenatal irradiation (embryo and fetus). Elsevier Sciences, Oxford 2003; 1, ICRP Publication 90. Annals of the ICRP 33
- Kim K M, Shibata D. Tracing ancestry with methylation patterns: Most crypts appear distantly related in normal adult human colon. BMC Gastroenterology 2004; 4: 8
- Kinzler K W, Vogelstein B. Lessons from hereditary colorectal cancer. Cell 1996; 87: 159–170
- Klein R M. Small intestinal cell proliferation during development. Human gastrointestinal development, E Lebenthal. Raven Press, New York 1989
- Luongo C, Dove W F. Somatic genetic events linked to the Apc locus in intestinal adenomas of the Min mouse. Genes, Chromosomes and Cancer 1996; 17: 194–198
- Luongo C, Moser A R, Gledhill S, Dove W F. Loss of Apc in intestinal adenomas from Min mice. Cancer Research 1994; 54: 5947–5952
- Lynch H T, Smyrk T C, Watson P, Lanspa S J, Lynch J F, Lynch P M, Cavalieri R J, Boland C R. Genetics, natural history, tumor spectrum, and pathology of hereditary nonpolyposis colorectal cancer: an updated review. Gastroenterology 1993; 104: 1535–1549
- Moser A R, Pitot H C, Dove W F. A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse. Science 1990; 247: 322–324
- Handbook of Immunocytochemical staining methods, S J Naish, California 1996, Dako, Carpinteria
- Ohtaki K, Kodama Y, Nakano M, Itoh M, Awa A A, Cologne J, Nakamura N. Human fetuses do not register chromosome damage inflicted by radiation exposure in lymphoid precursor cells except for a small but significant effect at low doses. Radiation Research 2004; 161: 373–379
- Okamoto M, Yonekawa H. Intestinal tumorigensis in Min mice is enhanced by x-irradiation in an age-dependent manner. Journal of Radiation Research (Tokyo) 2005; 46: 83–91
- Oshima H, Oshima M, Kobayashi M, Tsutsumi M, Taketo M M. Morphological and molecular processes of polyp formation in Apc (delta 716) knockout mice. Cancer Research 1997; 57: 1644–1649
- Pacha J. Development of intestinal transport function in mammals. Physiological Reviews 2000; 80: 1633–1667
- Potten C S, Owen G, Booth D. Intestinal stem cells protect their genome by selective segregation of template DNA strands. Journal of Cell Science 2002; 115: 2381–2388
- Potten C S, Booth C, Tudor G L, Booth D, Brady G, Hurley P, Ashton G, Clarke R, Sakakibara S, Okano H. Identification of a putative intestinal stem cell and early lineage marker: Musashi-1. Differentiation 2003; 71: 28–41
- Powell S M, Zilz N, Beazer-Barclay Y, Bryan T M, Hamilton S R, Thibodeau S N, Vogelstein B, Kinzler K W. APC mutations occur early during colorectal tumorigenesis. Nature 1992; 359: 235–237
- Rustgi A K. Hereditary gastrointestinal polyposis and non-polyposis syndromes. New England Journal of Medicine 1994; 331: 1694–1702
- Sasaki S, Fukuda N. Temporal variation of excess mortality rate from solid tumors in mice irradiated at various ages with gamma rays. Journal of Radation Research (Tokyo) 2005; 46: 1–19
- Schmidt G H, Winton D J, Ponder B AJ. Development of the pattern of cell renewal in the crypt-villus unit of chimeric mouse small intestine. Development (Cambridge) 1988; 103: 785–790
- Sheng H, Shao J, Williams C S, Pereira M A, Taketo M M, Oshima M, Reynolds A B, Washington M K, Dubois R N, Beauchamp R D. Nuclear transformation of β-catenin in hereditary and carcinogen-induced intestinal adenomas. Carcinogenesis 1998; 19: 543–549
- Shoemaker A R, Moser A R, Dove W F. N-ethyl-N-nitrosurea treatment of multiple intestinal neoplasia (Min) mice: age-related effects on the formation of intestinal adenomas, cystic crypts and epidermoid cysts. Cancer Research 1995; 55: 4479–4485
- Shoemaker A R, Gould K A, Luongo C, Moser A R, Dove W F. Studies of neoplasia in the Min mouse. Biochimica et Biophysica Acta 1997; 1332: F25–F48
- Silver A, Moody J, Dunsford R, Clark D, Ganz S, Bulman R, Bouffler S, Finnon P, Meijne E, Husikamp R, Cox R. Molecular mapping of chromosome 2 deletions in murine radiation-induced AML localizes a putative tumor suppressor gene to a 1.0 cM region homologous to human chromosome segment 11p11 – 12. Genes, Chromosomes and Cancer 1999; 24: 95–104
- St Clair W H, Osborne J W. Crypt fission and crypt number in the small and large bowel of postnatal rats. Cell and Tissue Kinetics 1985; 18: 255–262
- Steffensen I -L, Paulsen J E, Eide T J, Aexander J. 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine increases the numbers of tumors, cystic crypts and aberrant crypt foci in multiple intestinal neoplasia mice. Carcinogenesis 1997; 18: 1049–1054
- Su L K, Kinzler K W, Vogelstein B, Preisinger A C, Moser A R, Luongo C, Gould K A, Dove W F. Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene. Science 1992; 256: 668–670
- Thomson A BR, Keelan M. The development of the small intestine. Canadian Journal of Physiology and Pharmacology 1986; 64: 13–29
- United Nations Scientific Committee on the Effects of Atomic Radiation (UNSCEAR). Sources, effects and risks of ionising radiation. United Nations, New York 1988, Report to the General Assembly with Annexes
- United Nations Scientific Committee on the Effects of Atomic Radiation (UNSCEAR). Sources and effects of ionising radiation. Report to the General Assembly with Annexes. United Nations, New York 2000; Vol. II
- van der Houven van Oordt C W, Smits R, Schouten T G, Houwing-Duistermaat J J, Williamson S LH, Luz A, Meera Khan P, van der Eb A J, Breuer M L, Fodde R. The genetic background modifies the spontaneous and x ray-induced tumour spectrum in the Apc 1638N mouse model. Genes, Chromosomes and Cancer 1999; 24: 191–198
- Winton D J, Peacock J H, Ponder B A. Effect of gamma radiation at high- and low-dose rate on a novel in vivo mutation assay in mouse intestine. Mutagenesis 1989; 4: 404–406
- Winton D J, Ponder B AJ. Stem-cell organisation in mouse small intestine. Proceedings of the Royal Society, London 1990; 241: 13–18